期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 24, 期 16, 页码 3396-3405出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2016.05.031
关键词
Sulfoquinovose; Phosphatidyl inositol analogues; Inhibitors; Akt; Cancer
资金
- Fondazione Cariplo, Italy [2011-0490]
- 'Fondo Per La Promozione di Accordi Istituzionali'-Regione Lombardia, under project NEDD (Network Enabled Drug Design) [14546/2010]
- Associazione Italiana per la Ricerca sul Cancro, Italy [IG15333]
The serine-threonine protein kinase Akt, also known as protein kinase B, is a key component of the phosphoinositide 3-kinase (PI3K)-Akt-mTOR axis. Deregulated activation of this pathway is frequent in human tumors and Akt-dependent signaling appears to be critical in cell survival. PI3K activation generates 3-phosphorylated phosphatidylinositols that bind Akt pleckstrin homology (PH) domain. The blockage of Akt PH domain/phosphoinositides interaction represents a promising approach to interfere with the oncogenic potential of over-activated Akt. In the present study, phosphatidyl inositol mimics based on a beta-glucoside scaffold have been synthesized as Akt inhibitors. The compounds possessed one or two lipophilic moieties of different length at the anomeric position of glucose, and an acidic or basic group at C-6. Docking studies, ELISA Akt inhibition assays, and cellular assays on different cell models highlighted 1-O-octadecanoyl-2-O-beta-D-sulfoquinovopyranosyl-sn-glycerol as the best Akt inhibitor among the synthesized compounds, which could be considered as a lead for further optimization in the design of Akt inhibitors. (C) 2016 Elsevier Ltd. All rights reserved.
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