Article
Biochemistry & Molecular Biology
Ding Yang, Zixu Wang, Yaoxing Chen, Qingyun Guo, Yulan Dong
Summary: The role of the gut-brain axis in maintaining homeostasis of the brain and gut has been recognized. The NLRP3 inflammasome plays a crucial role in coordinating host physiology and immunity. More research is needed to determine the causal link between gut microbiota structure and NLRP3 activation.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Jiangyue Lu, Shuang Zhang, Yuezhen Huang, Jun Qian, Baochun Tan, Xueshen Qian, Jia Zhuang, Xihong Zou, Yanfen Li, Fuhua Yan
Summary: Periodontitis-related salivary microbiota may exacerbate the pathogenesis of Alzheimer's disease through the gut-brain axis. In this study, the gavage of periodontitis-related salivary microbiota in APP(swe)/PS1(Delta E9) transgenic mice impaired cognitive function, increased beta-amyloid accumulation and neuroinflammation, along with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation.
Article
Pharmacology & Pharmacy
Sonali R. Kamble, Manoj P. Dandekar
Summary: Recent research has shown that gut microbiota plays a key role in the development of psychiatric disorders, including obsessive-compulsive disorder (OCD). OCD-related changes in neurotransmitters, the hypothalamic-pituitary-adrenal axis, and inflammatory pathways are connected with alterations in the microbiota-gut-brain axis. Administration of certain probiotics has shown positive effects in managing OCD symptoms, suggesting that targeting gut microbiota may offer new treatment approaches for OCD.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Katleen Pinchaud, Zeeshan Hafeez, Sandrine Auger, Jean-Marc Chatel, Sead Chadi, Philippe Langella, Justine Paoli, Annie Dary-Mourot, Katy Maguin-Gate, Jean Luc Olivier
Summary: The study found that dietary arachidonic acid can alter gut microbiota, induce low-grade colic inflammation, and cause astrogliosis in the brain.
Editorial Material
Microbiology
Melanie G. Gareau
Summary: The gut microbiota plays a significant role in the development and severity of various diseases, including those affecting the central nervous system. The microbiota-gut-brain axis enables communication between gut microbes and the brain to regulate behavior. This commentary highlights recent findings on the role of gut microbiota and bacterial metabolites in sepsis-associated encephalopathy using a mouse model.
Review
Immunology
Haoran Wang, Tingting Zhao, Zhenjiang Liu, Danzengquzhen, Cisangzhuoma, Jinying Ma, Xin Li, Xiaodan Huang, Bin Li
Summary: Recent investigations suggest that dietary consumption of flavonoids has neuroprotective effects by inhibiting neuroinflammatory and oxidative stress responses. Flavonoids may also shape gut microbiota composition and promote the growth of beneficial bacteria that produce neuroprotective metabolites. By influencing the microbiota-gut-brain axis, flavonoids indirectly improve brain health.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Nutrition & Dietetics
Giuseppe Marano, Marianna Mazza, Francesco Maria Lisci, Michele Ciliberto, Gianandrea Traversi, Georgios Demetrios Kotzalidis, Domenico De Berardis, Lucrezia Laterza, Gabriele Sani, Antonio Gasbarrini, Eleonora Gaetani
Summary: There is increasing interest in the role of intestinal microbiota and autoimmune processes in psychiatric diseases. Altered communication between the microbiota-gut-brain axis may be a cause of psychiatric disorders. This review explores the evidence for the involvement of gut microbiota in psychiatric diseases and the impact of diet on microbiota and mental health. Changes in gut microbiota composition can lead to increased intestinal permeability, resulting in a cytokine storm, systemic inflammation, and immune response. These events can affect neurotransmitter release, alter the hypothalamic-pituitary-adrenal axis, and reduce trophic brain factors. Further research is needed to understand the underlying mechanisms connecting gut microbiota and psychiatric disorders.
Article
Agriculture, Multidisciplinary
Xiaoyu Chen, Hongyuan Zhao, Yajun Lu, Fanqiang Meng, Zhaoxin Lu, Yingjian Lu
Summary: Oral surfactin significantly improved colitis and depression-like behavior in a mouse model, and it also improved barrier dysfunction in the gut and brain. It suppressed inflammatory responses and increased the levels of neurotransmitters and neurotrophic factors. In addition, surfactin reduced the abundance of colitis-related gut microbes and increased the abundance of beneficial bacteria.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Thomas M. Barber, Georgios Valsamakis, George Mastorakos, Petra Hanson, Ioannis Kyrou, Harpal S. Randeva, Martin O. Weickert
Summary: Our gut microbiota have co-evolved with us over a long period of time, playing a crucial role in our overall health and influencing various bodily processes. The microbiota-gut-brain axis is a dominant communication pathway with far-reaching implications for our well-being. Dietary composition, particularly in modern Western diets, can directly impact the abundance and diversity of gut microbiota, leading to dysbiosis and potential health issues.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Carolina Gubert, Juciano Gasparotto, H. Livia Morais
Summary: Recent research has focused on the role of gut microbiota in brain health and disease, highlighting its regulation of brain function and behavior through immune, metabolic, and neuronal pathways. The gut microbiota may act as an intermediate factor between the host and the environment to mediate disease onset and neuropathology.
GASTROENTEROLOGY REPORT
(2022)
Review
Cell Biology
Szu-Ju Chen, Chin-Hsien Lin
Summary: Parkinson's disease is the second most common neurodegenerative disease, influenced by both genetic risk and environmental factors. While motor dysfunction is the main characteristic, the disease process involves multiple systems and shows heterogenous clinical presentation and progression. Genetic predisposition to Parkinson's disease includes abnormal immune responses, protein aggregation, autophagolysosomal impairment, and mitochondrial dysfunction, leading to vulnerable neurons that are sensitive to environmental triggers. Changes in the gut microenvironment may potentially act as a trigger in genetically susceptible individuals.
JOURNAL OF BIOMEDICAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Cinzia Garofalo, Costanza Maria Cristiani, Sara Ilari, Lucia Carmela Passacatini, Valentina Malafoglia, Giuseppe Viglietto, Jessica Maiuolo, Francesca Oppedisano, Ernesto Palma, Carlo Tomino, William Raffaeli, Vincenzo Mollace, Carolina Muscoli
Summary: Fibromyalgia and Irritable Bowel Syndrome share similar symptoms and may have a common etiology related to alterations in gut microbiota. This review will discuss the similarities between FM and IBS and the potential therapeutic approaches based on microbiota manipulations.
Article
Environmental Sciences
Zhenxin Wang, Dan Shao, Shu Wu, Zhigang Song, Shourong Shi
Summary: This study demonstrates the beneficial effects of dietary dimethylglycine (DMG) in reducing heat stress-induced intestine injury. DMG supplementation improves growth performance and repairs gut barrier integrity, while modulating the composition of gut microbiota and enhancing microbiota-gut-brain axis metabolism function. These findings provide insights into a novel mechanism by which gut microbiota can improve host health.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Review
Plant Sciences
Maciej Korczak, Maciej Pilecki, Sebastian Granica, Aleksandra Gorczynska, Karolina A. Pawlowska, Jakub P. Piwowarski
Summary: Clinical research has identified promising herbal medicines for the treatment of mild mood disorders, but the active constituents are still unclear. The role of the microbiota-gut-brain axis offers new possibilities for treatment and prevention.
Review
Oncology
Giuseppina D'Alessandro, Clotilde Lauro, Deborah Quaglio, Francesca Ghirga, Bruno Botta, Flavia Trettel, Cristina Limatola
Summary: Recent evidence has shown bidirectional communication between gut microbiota and the brain, with microbiota-derived molecules potentially impacting the nervous system. Modulation of neurotransmitters could influence neuronal precursor cells and brain tumor development. Further research is needed to understand the mechanisms of gut-brain communication and its implications for brain tumors.
Article
Radiology, Nuclear Medicine & Medical Imaging
Fatima Tensaouti, Franck Desmoulin, Julia Gilhodes, Elodie Martin, Soleakhena Ken, Jean-Albert Lotterie, Georges Noel, Gilles Truc, Marie-Pierre Sunyach, Marie Charissoux, Nicolas Magne, Vincent Lubrano, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: In this study, automatic quality control of glioblastoma MRSI data using random forest analysis was successfully implemented, demonstrating the ability to distinguish between good and poor-quality spectra. The research revealed a novel set of MRSI signal features closely correlated with spectral quality.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Neurosciences
Marina Fortea, Piyush Jain, Ingrid Demedts, Jan Tack, Tim Vanuytsel, Carla Cirillo, Pieter Vanden Berghe
Summary: Tissue cryopreservation provides a solution for the scarcity of human nerve tissues, especially live ones in neuroscience research. This study demonstrates that primary neurons from the enteric nervous system can be successfully preserved over long periods, maintaining functionality and morphology even up to one year after cryopreservation. The viability and responsiveness of human primary neurons, as well as the retention of nerve structure and neuronal morphology, were confirmed through live imaging, histology, and immunohistochemistry.
Review
Neurosciences
Nabila Brihmat, Didier Allexandre, Soha Saleh, Jian Zhong, Guang H. Yue, Gail F. Forrest
Summary: There is a growing interest in using non-invasive stimulation interventions, such as repetitive transcranial magnetic stimulation (rTMS), to improve functional outcomes and recovery after spinal cord injury (SCI). This scoping review focuses on the stimulation parameters used in 20 rTMS protocols and explores their potential associations with observed effects. Future studies should consider timing, intervention duration, and dosage in relation to the stage, level, and severity of the injury. More real vs. sham rTMS studies with similar designs and replication information are needed to establish a significant level of evidence for the use of rTMS in SCI.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Review
Clinical Neurology
Sirine Hacene, Alice Le Friec, Franck Desmoulin, Lorenne Robert, Nina Colitti, Juliette Fitremann, Isabelle Loubinoux, Carla Cirillo
Summary: Cell therapy is a promising strategy in regenerative medicine, but the lack of valid cell sources is a limiting factor. The gastrointestinal tract, specifically the enteric nervous system (ENS), has been identified as a valuable source of nerve cells for therapy. Enteric glial cells, with their neurotrophic and neurogenic potential, have shown promise in treating intestinal neuropathies. Additionally, the ENS has therapeutic potential for brain repair, particularly in cases of stroke. The urgency for alternative treatments to rehabilitation in chronic stroke patients is evident. This review explores the pathophysiology of stroke and discusses current therapeutic strategies, with a focus on cell- and biomaterial-based approaches. The anatomical and functional characteristics of the ENS, particularly glial cells, are also presented, highlighting their neurotrophic and neurogenic properties. Preliminary data on a possible therapeutic approach combining ENS-derived cells and a biomaterial are discussed.
Article
Neurosciences
Nina Colitti, Franck Desmoulin, Alice Le Friec, Wafae Labriji, Lorenne Robert, Amandine Michaux, Fabrice Conchou, Carla Cirillo, Isabelle Loubinoux
Summary: This study demonstrates the importance of long-term treatment with nerve growth factor (NGF) delivered intranasally in promoting neurogenesis and tissue reconstruction after stroke. However, it also indicates that NGF treatment may limit motor recovery. Additionally, the study establishes the use of MRI as a biomarker for evaluating neurogenesis and tissue reconstruction.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wafae Labriji, Julien Clauzel, Jean-Louis Mestas, Maxime Lafond, Cyril Lafon, Anne-Sophie Salabert, Lydiane Hirschler, Jan M. Warnking, Emmanuel L. Barbier, Isabelle Loubinoux, Franck Desmoulin
Summary: The purpose of this study was to investigate the effect of Blood Brain Barrier (BBB) opening using ultrasound combined with microbubbles injection on cerebral blood flow in rats. The results showed that BBB opening induced by microbubble intravenous injection led to transient hypoperfusion, which shared some similarities with cortical spreading depression phenomenon.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Marjorie Yon, Laure Gibot, Stephane Gineste, Pascale Laborie, Christian Bijani, Christophe Mingotaud, Olivier Coutelier, Franck Desmoulin, Carine Pestourie, Mathias Destarac, Diana Ciuculescu-Pradines, Jean-Daniel Marty
Summary: Due to the potential life-threatening side effects caused by specific antibodies to poly(ethylene glycol) (PEG), it is necessary to develop alternatives to PEGylated copolymers for treatment and diagnostic methods. A new approach involves block copolymers containing a poly(N-vinyl-2-pyrrolidone) (PVP) segment as vectors without PEG block. A synthesized poly(acrylic acid)-block-poly(N-vinyl-2-pyrrolidone) (PAA-b-PVP) copolymer, when combined with lanthanide cations (Gd3+, Eu3+, Y3+), forms stable hybrid polyion complexes that prevent lanthanide cytotoxicity and enhance in vitro cell penetration, resulting in enhanced T-1 MRI contrast when administered to mice intravenously without leaching of gadolinium ions.
Article
Oncology
Ingrid Sidibe, Fatima Tensaouti, Julia Gilhodes, Bastien Cabarrou, Thomas Filleron, Franck Desmoulin, Soleakhena Ken, Georges Noel, Gilles Truc, Marie Pierre Sunyach, Marie Charissoux, Nicolas Magne, Jean -Albert Lotterie, Margaux Roques, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: This study investigates the feasibility of using a multiapproach analysis to distinguish true tumor progression (TP) from pseudoprogression (PSP) in glioblastoma patients. The results suggest that three spectroscopic ratios can differentiate PSP from TP, and tumor volume at relapse is the most predictive factor in the multivariate analysis. Patients with PSP have a higher overall survival compared to TP patients.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Oncology
Fatima Tensaouti, Franck Desmoulin, Julia Gilhodes, Margaux Roques, Soleakhena Ken, Jean -Albert Lotterie, Georges Noel, Gilles Truc, Marie -Pierre Sunyach, Marie Charissoux, Nicolas Magne, Vincent Lubrano, Patrice Peran, Elizabeth Cohen-Jonathan Moyal, Anne Laprie
Summary: This study aimed to identify different components of glioblastoma subtypes using a large MRSI dataset and determine their association with progression-free survival. The results showed that pre-radiotherapy MRSI can reveal tumor heterogeneity and clusters with metabolic abnormalities and high lactate are predictive of PFS.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Nabila Brihmat, Evelyne Castel-Lacanal, Mohamed Tarri, Benoit Lepage, Emmeline Montane, Camile Cormier, Xavier de Boissezon, David Gasq, Isabelle Loubinoux, Philippe Marque
Summary: This study aimed to evaluate the possible synergistic effect of combining Paired Associative Stimulation (PAS) and Motor Imagery (MI) interventions for motor recovery in post-stroke patients. A randomized controlled trial was conducted with 24 hemiparetic participants, and three interventions were tested. The results showed no significant advantage in combining PAS and MI interventions for motor recovery in post-stroke rehabilitation.
APPLIED SCIENCES-BASEL
(2023)
Review
Neurosciences
Mukhamad Sunardi, Carla Cirillo
Summary: In the body, nerve tissue is found in both the central and peripheral nervous systems. The enteric nervous system (ENS) is a highly organized network of neurons and glial cells that form interconnected ganglia. Glial cells in the ENS have neurotrophic roles and retain neurogenic potential. Understanding the molecular basis of glia-derived neurogenesis may have important implications for biological and clinical purposes. This review discusses the potential use of gene-editing and cell transplantation as therapies for enteric neuropathies, focusing on the role of glial cells in nerve tissue repair.
NEUROSCIENCE LETTERS
(2023)
