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Physiology
Raquel Gonzalez-Blazquez, Marta Gil-Ortega, Martin Alcala, Daniel Gonzalez-Moreno, Marta Viana, Julie A. Chowen, Marta Sanz-Gomez, Maria S. Fernandez-Alfonso, Beatriz Somoza
Summary: This study aimed to investigate if replacing a high-fat diet with a standard diet for a short period could reverse obesity-induced endothelial dysfunction through AMPK-CREB activation. The results showed that improving dietary intake significantly improved vascular function and the antioxidant system mediated by the AMPK/CREB signaling pathway.
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Cell Biology
Wenfeng Li, Chenggao Wang, Dandan Zhang, Kanghua Zeng, Shihui Xiao, Feng Chen, Jun Luo
Summary: Azilsartan may ameliorate ox-LDL-induced endothelial damage through elevating the expression of KLF2.
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Biochemistry & Molecular Biology
Cunyao Pan, Chongyi Ai, Lanlan Liang, Baoyi Zhang, Qionglin Li, Lingling Pu, Zirou Wang, Weili Liu, Zhaoli Chen, Hui Liu, Xinxing Wang
Summary: Hypoxia induced by high altitude can cause severe neurological dysfunction, and mitophagy plays a crucial role in this process. The stress-inducible protein Sestrin2 (SESN2) has been found to protect nerve cells against hypoxic injury, and it may regulate mitophagy in synergy with other pathways.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
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Biochemistry & Molecular Biology
Pei Wang, Ying Yang, Jiabao Guo, Tingting Ma, Youcheng Hu, Luyao Huang, Yonggui He, Jinkun Xi
Summary: Resveratrol has beneficial effects on cardiomyocytes by inhibiting mitophagy and preventing mitochondrial permeability transition pore (mPTP) opening through the AMPK-Mfn2 axis.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
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Immunology
Huilin Yu, Qian Liu, Guodong Chen, Longxiang Huang, Minghao Luo, Dingyi Lv, Suxin Luo
Summary: This study found that the SIRT3-AMPK signaling pathway plays an important role in inhibiting vascular inflammation and endothelial dysfunction during early sepsis. Activation of AMPK can reverse the reduction of eNOS expression, prevent endothelial dysfunction, and improve survival. Inhibition of AMPK has opposite effects.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
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Immunology
Xiaohong Fei, Xuejiang Cen, Ruochi Zhao, Jian Wang, Hanbin Cui
Summary: Atherosclerosis is the pathological basis of cardiovascular disease, which begins with endothelial dysfunction caused by vascular endothelial cell injury. PRMT5, a protein arginine methyltransferase, is highly related to cardiovascular events. This study aimed to explore the biological roles of PRMT5/PDCD4 in vascular endothelial cell injury during atherosclerosis. Results showed that PRMT5 was highly expressed in ox-LDL-stimulated HUVECs. Knockdown of PRMT5 enhanced cell viability and inhibited apoptosis, oxidative stress, inflammation, and endothelial dysfunction in HUVECs. PRMT5 was found to interact and bind with PDCD4. In conclusion, down-regulation of PRMT5 exerts protective effects against vascular endothelial cell injury during atherosclerosis by suppressing PDCD4 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
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Biochemistry & Molecular Biology
Zhi Wang, Tianji Xia, Suwei Jin, Xinmin Liu, Ruile Pan, Mingzhu Yan, Qi Chang
Summary: The study aimed to simulate fatigue occurrence in a chronic restraint stress (CRS) model and reveal its dynamic processes and molecular mechanisms. Findings showed that CRS treatment led to decreased physical performance, muscle atrophy, and mitochondrial dysfunction in mice, ultimately inducing fatigue.
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Biochemistry & Molecular Biology
Bo Xu, Zezhu Zhou, Jiaqi Fang, Jianguang Wang, Kun Tao, Junjian Liu, Shuhao Liu
Summary: This study investigated the efficiency of exosomes produced from Schwann cells (SCDEs) in protecting against mitochondrial dysfunction and alleviating the deleterious consequences of spinal cord injury (SCI). The results showed that SCDEs effectively mitigated oxidative stress, inflammation, and necroptosis, while enhancing mitophagy. Mechanistically, SCDEs facilitated cellular mitophagy through activation of the AMPK signaling pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jia Liu, Jingjing Jiang, Jingru Qiu, Liyan Wang, Jing Zhuo, Baozhu Wang, Deqing Sun, Shuyan Yu, Haiyan Lou
Summary: UA, a gut metabolite produced from ellagic acid-containing foods, shows potential protective effects against PD by promoting mitochondrial biogenesis and preventing neurotoxicity induced by 6-OHDA. This study provides new insights into the role of UA in regulating mitochondrial dysfunction in PD and suggests potential therapeutic applications.
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Oncology
Yiming Zhao, Yuxia Li, Hongxia Li, Sa Shi
Summary: Endothelial cell senescence and dysfunctional vascular aging are linked, and D1-like dopamine receptor (DR1) is being considered as a potential therapeutic target for atherosclerosis prevention. However, the role of DR1 in regulating ox-LDL-stimulated endothelial cell senescence is unknown.
EXPERIMENTAL CELL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xi Sun, Yanna Han, Chaorun Dong, Huan Qu, Yahan Yu, Jiaming Ju, Yunlong Bai, Baofeng Yang
Summary: The study found that Daming capsule (DMC) improves cardiac function by increasing mitophagy, inhibiting oxidative stress and inflammatory response in cardiomyocytes, and activating the SIRT1/AMPK signaling pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Dingwei Yang, Xueyan Yang, Sha Chen, Meiling Lv, Jin Tan, Dingping Yang
Summary: Hypercholesterolemia exacerbates contrast-induced acute kidney injury by increasing mitochondrial damage and oxidative stress, which may involve the relative insufficiency of PINK1/Parkin-dependent mitophagy.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Xiao-Hong Chen, Yu Tan, ShuQin Yu, Lijun Lu, Youqing Deng
Summary: This study found that pinitol has the potential to reduce endothelial dysfunction caused by oxidized low-density lipoprotein (ox-LDL). Pinitol can decrease the production of reactive oxygen species, reduce the expression of IL-6 and monocyte chemoattractant protein-1, and decrease the attachment of monocytes to endothelial cells. Additionally, pinitol decreases the expression of LOX-1 and rescues the expression of KLF2.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liang Chen, Xiang Shi, Jun Xie, She-Ji Weng, Zhong-Jie Xie, Jia-Hao Tang, De-Yi Yan, Bing-Zhang Wang, Kang-Hao Fang, Chen-Xuan Hong, Zong-Yi Wu, Lei Yang
Summary: Apelin plays a crucial role in regulating bone metabolism and mitigating the effects of osteoporosis. Through activation of mitophagy, Apelin-13 treatment was able to improve bone health and function in both in vitro and in vivo models of osteoporosis, suggesting its potential as a therapeutic target for osteoporosis.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Xiaohui Jin, Leilei Zhu, Shuaifei Lu, Caiyin Li, Ming Bai, Erping Xu, Jiduo Shen, Yucheng Li
Summary: This study investigated the effect of baicalin on mitophagy in the hippocampus of mice exposed to chronic unpredictable mild stress (CUMS) and explored its potential mechanism. The results showed that baicalin improved depressive-like behaviors in CUMS mice and ameliorated mitochondrial structural impairment in the hippocampus neuron. Baicalin increased NIX and AMPK, and improved mitophagy level and mitochondrial function in HT22 cells by directly binding to AMPK.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
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Biochemistry & Molecular Biology
Jing Wang, Yuzhi Bai, Xia Zhao, Jing Ru, Ning Kang, Tian Tian, Liying Tang, Yun An, Pei Li
BIOSCIENCE REPORTS
(2018)
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Cell Biology
Pei Li, Yuzhi Bai, Xia Zhao, Tian Tian, Liying Tang, Jing Ru, Yun An, Jing Wang
CELL STRESS & CHAPERONES
(2018)