Article
Biochemistry & Molecular Biology
Wen-Kuan Huang, Yi Chen, Huafang Su, Tung-Ying Chen, Jiwei Gao, Yaxuan Liu, Chun-Nan Yeh, Shuijie Li
Summary: ARHGAP25 acts as a tumor suppressor in pancreatic adenocarcinoma by inhibiting the AKT/mTOR signaling pathway. Its overexpression can suppress tumor growth by regulating Rac1/PAK1 signaling, as shown in both in vitro and in vivo experiments. Furthermore, ARHGAP25 reduces HIF-1 alpha-mediated glycolysis in PAAD cells, suggesting it as a potential therapeutic target for PAAD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Endocrinology & Metabolism
Kai Wang, Jinxiao Li, Botao Zhou
Summary: KIAA0101 is overexpressed in glioma tissues and cells, and high expression indicates a poor prognosis for glioma patients. Silencing KIAA0101 inhibits cell proliferation, migration, invasion, and promotes apoptosis in glioma cells. Additionally, KIAA0101 knockdown reduces glycolytic flux and inhibits the PI3K/AKT/mTOR pathway in glioma cells.
METABOLIC BRAIN DISEASE
(2022)
Article
Cell Biology
Yanyi Xiao, Yilong Liu, Zhiwei Gao, Xian Li, Min Weng, Chenghao Shi, Cheng Wang, Linxiao Sun
Summary: Pancreatic cancer is a highly malignant tumor with increasing chemotherapeutic resistance, posing a challenge in clinical treatment. Fisetin, extracted from vegetables and fruits, shows potential as an anti-cancer agent for pancreatic cancer by targeting the PI3K/AKT/mTOR signaling cascade. Further research is needed to better understand the molecular mechanisms underlying fisetin's anti-cancer effects on pancreatic cancer.
Article
Oncology
Xueyi Jiang, Jie Wang, Peng Chen, Zhiwei He, Jian Xu, Yankun Chen, Xinyuan Liu, Jianxin Jiang
Summary: The study found that 6-P can suppress the proliferation and metastasis of pancreatic cancer cells by decreasing EGFR protein expression level and inducing EGFR degradation, leading to inactivation of the PI3K/AKT signaling pathway. Additionally, ectopic expression of EGFR protein results in resistance to the therapeutic effects of 6-P. Furthermore, erlotinib can enhance the anticancer activity of 6-P.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Lan Ma, Ruixue Zhang, Demin Li, Tingting Qiao, Xiaoying Guo
Summary: Fluoride inhibits chondrocyte proliferation and promotes autophagy through the PI3K/AKT/mTOR signaling pathway in chondrogenesis. The study also showed that fluoride downregulates the mTOR signaling pathway-related genes and is associated with changes in autophagy-related gene expressions. MHY1485, a small-molecular mTOR activator, can reverse the fluoride-induced promotion of autophagy and recover the downregulation of proliferative chondrocyte markers induced by fluoride in chondrogenic cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Cell Biology
Jun Chen, Fuqiang Liu, Jiao Wu, Yichun Yang, Jin He, Fan Wu, Kun Yang, Junfeng Li, Zhongxiang Jiang, Zheng Jiang
Summary: Pancreatic cancer is a highly lethal malignant tumor, and understanding its development mechanisms and finding suitable targets for diagnosis and treatment is crucial. This study demonstrates that STK3 plays a role in the growth, apoptosis, and metastasis of pancreatic cancer cells. STK3 promotes apoptosis and inhibits cell migration, invasion, and proliferation in pancreatic cancer through the suppression of the PI3K/AKT/mTOR pathway with the assistance of RASSF1.
CELLULAR SIGNALLING
(2023)
Article
Plant Sciences
Li Li, Chuting Wang, Zhenpeng Qiu, Dongjie Deng, Xin Chen, Qi Wang, Yan Meng, Baohui Zhang, Guohua Zheng, Junjie Hu
Summary: This study revealed that triptolide suppresses the growth of ICC by inhibiting glycolysis via the AKT/mTOR pathway, offering a potential therapeutic target for ICC treatment.
Article
Oncology
Yongmeng Li, Shuai Wang, Kai Jin, Wenxing Jin, Libo Si, Huiying Zhang, Hui Tian
Summary: UHMK1 is a potent oncogene in lung adenocarcinoma, promoting tumor progression through the PI3K/AKT/mTOR signaling pathway. Its high expression is associated with larger tumor size and unfavorable prognosis. Targeting UHMK1 may significantly improve the efficacy of lung adenocarcinoma treatment.
Article
Cell Biology
Chaoyang Zhou, Aijun Liang, Jianzhong Zhang, Jingxing Leng, Bin Xi, Bin Zhou, Yu Yang, Ronglan Zhu, Liangchen Zhong, Xingxing Jiang, Dengfeng Wan
Summary: ANTXR1 plays a crucial role in glioma tumorigenesis by regulating cell proliferation through activating the PI3K/AKT pathway, affecting cell growth, migration, apoptosis, and the cell cycle. Targeting ANTXR1 could serve as a molecular target in clinical therapeutics for gliomas.
Article
Oncology
Qianxu Jin, Jiahui Zhao, Zijun Zhao, Shiyang Zhang, Zhimin Sun, Yunpeng Shi, Hongshan Yan, Yizheng Wang, Liping Liu, Zongmao Zhao
Summary: CAMK1D is expressed at lower levels in glioma tissues and is positively correlated with the WHO classification of gliomas. Knockdown of CAMK1D promotes the proliferation, migration, and invasion of glioma cells, while overexpression has the opposite effect. Mechanistically, CAMK1D regulates glioma cell function through the PI3K/AKT/mTOR pathway. These findings suggest that CAMK1D may serve as a prognostic predictor and a potential therapeutic target for glioma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Maryam Akbarzadeh, Ainaz Mihanfar, Shabnam Akbarzadeh, Bahman Yousefi, Maryam Majidinia
Summary: The PI3K/AKT/mTOR signaling pathway plays a crucial role in cancer and has been found to interact with miRNAs, which is important for understanding cancer biology.
Article
Oncology
Haowei Wang, Yujia Chen, Qinzi Yuan, Lixia Chen, Peiling Dai, Xuenong Li
Summary: This study found that HRK is lowly expressed in colorectal cancer tissues. For the first time, it was shown that HRK promotes apoptosis and inhibits proliferation of colorectal cancer cells by inhibiting the PI3K/AKT/mTOR signaling pathway. HRK represents a potential target for the treatment of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Xiaoying Jin, Dandan Wang, Mengxia Lei, Yan Guo, Yuqing Cui, Fengzhi Chen, Weiling Sun, Xuesong Chen
Summary: The study reveals that TPI1 is highly expressed in breast cancer and is associated with clinicopathological characteristics and prognosis. TPI1 promotes breast cancer progression by regulating the PI3K/AKT/mTOR pathway, with CDCA5 and P62 being important mediators.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Cell Biology
Chunlei Guo, Shuang Li, Ang Liang, Mengchao Cui, Yunwei Lou, Hui Wang
Summary: PPA1 is highly expressed in breast cancer and correlated with poor survival in patients. Silencing PPA1 can inhibit breast cancer proliferation and metastasis. PPA1 serves as an activator of the PI3K/AKT/GSK3 beta/Slug-mediated breast cancer progression and is a potential therapeutic target for inhibiting tumor progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiang Gao, Wenqu Jiang, Zunliang Ke, Qiwei Huang, Liang Chen, Guobin Zhang, Chao Li, Xiaojun Yu
Summary: Molecular biomarker TRAM2 is overexpressed in glioma and associated with malignancy properties and poorer survival. Silencing of TRAM2 inhibits glioma cell proliferation, invasion, migration, and EMT. TRAM2 is positively associated with the activation of the PI3K/AKT/mTOR signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Gastroenterology & Hepatology
Shu-Heng Jiang, Jun Li, Fang-Yuan Dong, Jian-Yu Yang, De-Jun Liu, Xiao-Mei Yang, Ya-Hui Wang, Min-Wei Yang, Xue-Liang Fu, Xiao-Xin Zhang, Qing Li, Xiu-Feng Pang, Yan-Miao Huo, Jiao Li, Jun-Feng Zhang, Ho-Young Lee, Su-Jae Lee, Wen-Xin Qin, Jian-Ren Gu, Yong-Wei Sun, Zhi-Gang Zhang
Article
Biochemistry & Molecular Biology
S-J Zhao, Y-Q Jiang, N-W Xu, Q. Li, Q. Zhang, S-Y Wang, J. Li, Y-H Wang, Y-L Zhang, S-H Jiang, Y-J Wang, Y-J Huang, X-X Zhang, G-A Tian, C-C Zhang, Y-Y Lv, M. Dai, F. Liu, R. Zhang, D. Zhou, Z-G Zhang
Article
Multidisciplinary Sciences
Miao Dai, Xiao-Lu Zhu, Fei Liu, Qin-Yang Xu, Qiu-Lin Ge, Shu-Heng Jiang, Xiao-Mei Yang, Jun Li, Ya-Hui Wang, Qing-Kai Wu, Zhi-Hong Ai, Yin-Cheng Teng, Zhi-Gang Zhang
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Xiao-Yan Cao, Xiao-Xin Zhang, Min-Wei Yang, Li-Peng Hu, Shu-Heng Jiang, Guang-Ang Tian, Li-Li Zhu, Qing Li, Yong-Wei Sun, Zhi-Gang Zhang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Oncology
Yan-Li Zhang, Qing Li, Xiao-Mei Yang, Fang Fang, Jun Li, Ya-Hui Wang, Qin Yang, Lei Zhu, Hui-Zhen Nie, Xue-Li Zhang, Ming-Xuan Feng, Shu-Heng Jiang, Guang-Ang Tian, Li-Peng Hu, Ho-Young Lee, Su-Jae Lee, Qiang Xia, Zhi-Gang Zhang
Article
Biochemistry & Molecular Biology
Fei Liu, Miao Dai, Qinyang Xu, Xiaolu Zhu, Yang Zhou, Shuheng Jiang, Yahui Wang, Zhihong Ai, Li Ma, Yanli Zhang, Lipeng Hu, Qin Yang, Jun Li, Shujie Zhao, Zhigang Zhang, Yincheng Teng
Article
Multidisciplinary Sciences
He-Lin Yu, Shu-Heng Jiang, Xu-Liang Bu, Jia-Hua Wang, Jing-Yi Weng, Xiao-Mei Yang, Kun-Yan He, Zhi-Gang Zhang, Ping Ao, Jun Xu, Min-Juan Xu
SCIENTIFIC REPORTS
(2017)
Article
Oncology
Qin Yang, Chunchao Zhu, Yanli Zhang, Yangyang Wang, Yahui Wang, Lei Zhu, Xiaomei Yang, Jun Li, Huizhen Nie, Shuheng Jiang, Xiaoxin Zhang, Xiaoyan Cao, Qing Li, Xueli Zhang, Guangang Tian, Lipeng Hu, Lili Zhu, Gang Zhao, Zhigang Zhang
Article
Gastroenterology & Hepatology
Xiao-Mei Yang, Xiao-Yan Cao, Ping He, Jun Li, Ming-Xuan Feng, Yan-Li Zhang, Xue-Li Zhang, Ya-Hui Wang, Qin Yang, Lei Zhu, Hui-Zhen Nie, Shu-Heng Jiang, Guang-Ang Tian, Xiao-Xin Zhang, Qiang Liu, Jianguang Ji, Xuefeng Zhu, Qiang Xia, Zhi-Gang Zhang
Article
Cell Biology
Ye Du, Na Wei, Ruolin Ma, Shuheng Jiang, Dong Song
CELL DEATH & DISEASE
(2020)
Review
Oncology
Shu-Heng Jiang, Shan Zhang, Hao Wang, Jun-Li Xue, Zhi-Gang Zhang
Summary: Cancer neuroscience is a growing field that focuses on the interactions between cancer and the nervous system. Perineural invasion (PNI), in which cancer cells invade and surround nerves in the tumor microenvironment, is associated with increased tumor recurrence and decreased survival. Various in vitro, ex vivo, and in vivo models have been developed to study PNI, revealing the role of factors such as neurotrophins, chemokines, exosomes, and inflammatory cells in the reciprocal crosstalk between nerves and cancer cells. These models allow the study of isolated factors, neuroaffinity, and the complex pathophysiological processes of PNI.
Article
Biochemistry & Molecular Biology
Guang-Ang Tian, Wen-Ting Xu, Xue-Li Zhang, Yao-Qi Zhou, Yue Sun, Li-Peng Hu, Shu-Heng Jiang, Hui-Zhen Nie, Zhi-Gang Zhang, Lei Zhu, Jun Li, Xiao-Mei Yang, Lin -Li Yao
Summary: This study found that the extracellular matrix-related protein CCBE1 promotes mitochondrial fusion in hepatocellular carcinoma (HCC) and inhibits mitochondrial fission by preventing the localization of DRP1 on mitochondria through inhibiting its phosphorylation at Ser616 by directly binding with TGF3R2 to inhibit TGF3 signaling activity. Increased CCBE1 expression or treatment with recombinant CCBE1 protein significantly inhibited HCC cell proliferation, migration, and invasion in vitro and in vivo, suggesting CCBE1 as a potential therapeutic strategy for HCC.
Article
Biochemistry & Molecular Biology
Shuheng Jiang, Lili Zhu, Jianyu Yang, Lipeng Hu, Jianren Gu, Xin Xing, Yongwei Sun, Zhigang Zhang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Oncology
Li Zhou, Da Yuan, Zhi-Gang Zhang, Zhi-Yong Liang, Wei-Xun Zhou, Jian-Yu Yang, Shu-Heng Jiang, Jun Lu, Tai-Ping Zhang, Lei You, Jun-Chao Guo, Yu-Pei Zhao