Review
Pharmacology & Pharmacy
De-ta Chen, Wu Rao, Xue Shen, Lin Chen, Zi-jian Wan, Xiao-ping Sheng, Tian-you Fan
Summary: This review summarizes the pharmacological effects and targets of Higenamine, focusing on its potential as a naturally extracted drug. It possesses multiple mechanisms of action, including antioxidant, anti-inflammatory, and anti-apoptotic activities.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Agronomy
Beatriz Val-Torregrosa, Mireia Bundo, Blanca San Segundo
Summary: Rice production is affected by various stresses, including nutrient stress. Improper use of pesticides can have harmful effects on the environment and human health. Understanding the interaction between nutrient stress and disease resistance is essential for optimizing fertilizer and pesticide use in rice production.
Review
Geriatrics & Gerontology
Min Hao, Yue Chu, Jingxuan Lei, Zhouhui Yao, Pingping Wang, Ziyan Chen, Kuilong Wang, Xianan Sang, Xin Han, Lu Wang, Gang Cao
Summary: Curcumin, a polyphenol extracted from turmeric, has shown extensive pharmacological activities. However, its clinical application is limited due to low bioavailability. Dosage form transformations can improve the druggability of curcumin and enhance its clinical prospects.
Review
Neurosciences
Jeremy M. Henley, Jithin D. Nair, Richard Seager, Busra P. Yucel, Gavin Woodhall, Benjamin S. Henley, Karolina Talandyte, Hope I. Needs, Kevin A. Wilkinson
Summary: Epilepsy is caused by abnormal neuronal network activity. The review focuses on the role and regulation of kainate and AMPA receptors in seizure activity, discussing the impact of GluK2 and GluA2 subunits on their respective receptors' properties.
Article
Clinical Neurology
Juanjuan Luo, Pei Liu, Chunjiao Lu, Wanping Bian, Dongsheng Su, Chenchen Zhu, Shaolin Xie, Yihang Pan, Ningning Li, Wei Cui, De-Sheng Pei, Xiaojun Yang
Summary: The molecular pathogenesis of glioblastoma is critical for human gliomagenesis, with RTK/Ras/PI3K, RB, and TP53 pathways playing key roles. Using transgenic zebrafish with single or multiple gene deletions, researchers induced gliomagenesis and found that nf1 mutation alone had low efficiency, but combined deletions of nf1;tp53 and rb1;tp53 resulted in higher tumor incidences with advanced histology. Bioinformatics analysis revealed alterations in critical pathways like RTK/Ras/PI3K, cell cycle, and focal adhesion, highlighting their importance in gliomagenesis initiation and development. Tumors in zebrafish models showed significant similarities to human gliomas, and temozolomide treatment effectively suppressed gliomagenesis, mimicking responses seen in clinical glioma treatment. This study provides a potential tool for genetically studying gliomagenesis and screening targeted anti-tumor compounds for glioma treatment.
Article
Clinical Neurology
Juanjuan Luo, Pei Liu, Chunjiao Lu, Wanping Bian, Dongsheng Su, Chenchen Zhu, Shaolin Xie, Yihang Pan, Ningning Li, Wei Cui, De-Sheng Pei, Xiaojun Yang
Summary: The research indicates that combined deletions of nf1, tp53, and rb1 genes in zebrafish greatly promote gliomagenesis, with these glioma models showing relevance to temozolomide treatment.
Review
Biochemistry & Molecular Biology
Arshad Husain Rahmani, Ahmad Almatroudi, Amjad Ali Khan, Ali Yousif Babiker, Malak Alanezi, Khaled S. Allemailem
Summary: Baicalein, an active polyphenolic compound isolated from Scutellaria baicalensis, exhibits anticancer activity by modulating various cell-signaling pathways such as induction of apoptosis, autophagy, cell cycle arrest, inhibition of angiogenesis, and regulation of other molecular targets.
Review
Plant Sciences
Jingzi Chen, Yanchao Zheng, Sihan Gong, Zhigang Zheng, Jing Hu, Lin Ma, Xiankuan Li, Hongjian Yu
Summary: This review comprehensively analyzes the mechanisms of the anti-gout action of theaflavins through a literature review and network pharmacology prediction, and summarizes strategies for improving the bioavailability of theaflavins. Theaflavins exert anti-gout effects by regulating multiple targets, such as GLUT9, URAT1, OAT1, OCTN1, Oct1/2, and OAT2. Network pharmacology prediction suggests that theaflavins can regulate the AGE-RAGE and cancer signaling pathways through multiple targets for their anti-gout effects.
Review
Pharmacology & Pharmacy
Xiaohu Wang, Xingwen Wang, Hui Yao, Chaozhuang Shen, Kuo Geng, Haitang Xie
Summary: Schisandrin, the primary active compound in Schisandra chinensis, exhibits various pharmacological effects in liver diseases, although its clinical efficacy is limited by hepatic and intestinal first-pass metabolism.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Kexun Zhou, Yingping Liu, Shiman Yuan, Ziyu Zhou, Pengfei Ji, Qianhan Huang, Feng Wen, Qiu Li
Summary: Pancreatic cancer is a common malignant tumor in the digestive system, closely related to various signaling pathways. Breakthroughs have been made in understanding the mechanism of pancreatic carcinogenesis and developing novel therapies through the study of these signaling pathways.
JOURNAL OF DRUG TARGETING
(2023)
Article
Biochemistry & Molecular Biology
Tillmann Bork, Wei Liang, Oliver Kretz, Simon Lagies, Kosuke Yamahara, Camila Hernando-Erhard, Martin Helmstadter, Christoph Schell, Bernd Kammerer, Tobias B. Huber
Summary: This study demonstrates the importance of a secretory pathway for podocyte integrity and function, and identifies the key role of BECLIN1 in this process. By promoting VEGFA secretion, BECLIN1 maintains endothelial integrity within the glomerular filtration barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Harry Collier, Adam Albanese, Chun-Sui Kwok, Jiahua Kou, Sonia Rocha
Summary: Chromatin, consisting of DNA and histone proteins, plays a crucial role in regulating gene expression. Recent studies have revealed the intricate connection between chromatin and oxygen, particularly in the context of hypoxia. This review focuses on the mechanisms that control chromatin in hypoxia, including histone modifications, chromatin remodellers, and their integration with hypoxia inducible factors.
CELLULAR SIGNALLING
(2023)
Review
Biochemistry & Molecular Biology
Harmeet Gurm, Jeremy A. Hirota, Sandeep Raha
Summary: Despite its intricate involvement in various physiological processes, the endocannabinoid system remains one of the most under-studied biological systems in the human body. Cannabinoid receptors are widely distributed in reproductive tissues and are crucial for regulating immune-reproductive interactions, while excessive cannabis use during pregnancy may lead to clinical complications.
Review
Oncology
Vincenzo Formica, Silvia Riondino, Cristina Morelli, Simona Guerriero, Federica D'Amore, Antonio Di Grazia, Giovanna Del Vecchio Blanco, Giuseppe Sica, Hendrik-Tobias Arkenau, Giovanni Monteleone, Mario Roselli
Summary: Not all aspects of the disruption of iron homeostasis in cancer have been fully elucidated. Iron accumulation in cancer cells is frequent for many solid tumours, and this is often accompanied by the contemporary rise of two key iron regulators, HIF2 alpha and Hepcidin. This scenario is different from what happens under physiological conditions, where Hepcidin parallels systemic iron concentrations while HIF2 alpha levels are inversely associated to Hepcidin. The present review highlights the increasing body of evidence for the pro-tumoral effect of HIF2 alpha and Hepcidin, discusses the possible imbalance in HIF2 alpha, Hepcidin and iron homeostasis during cancer, and explores therapeutic options relying on these pathways as anticancer strategies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Cell Biology
Priyanka Shivnani, Saroj Shekhawat, Akhilesh Prajapati
Summary: Cancer cachexia is a syndrome characterized by lean body mass loss, negative protein and energy balance, and systemic inflammation, which significantly impacts the quality of life and treatment outcomes of cancer patients. The molecular mechanisms and clinical endpoints of cachexia are not yet well-defined, and there is a need for further research, especially in breast cancer-induced cachexia. Breast cancer stem cells (BCSCs) play a crucial role in breast cancer progression and resistance to chemotherapy, and cytokines in the tumor microenvironment affect their development and self-renewal. The common pathways between cachexia and BCSC signaling could be potential therapeutic targets for both conditions.
CELLULAR SIGNALLING
(2023)
Article
Multidisciplinary Sciences
Yingfan Hu, Li Wang, Li Xiang, Jiasi Wu, Wen'ge Huang, Chensi Xu, Xianli Meng, Ping Wang
SCIENTIFIC REPORTS
(2019)
Article
Plant Sciences
Xiaopeng Ai, Ya Hou, Xiaobo Wang, Xiaoyan Wang, Yusheng Liang, Zhengwen Zhu, Ping Wang, Yong Zeng, Xianjia Li, Xianrong Lai, Xianli Meng, Qi'en Li
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Hai-Jiao Li, Chuan-Tao Zhang, Huan Du, Tong Xu, Qi Li, Ping Wang, Gang Fang, Gang Fan
CHEMISTRY & BIODIVERSITY
(2019)
Article
Pharmacology & Pharmacy
Jiasi Wu, Yu Luo, Qing Jiang, Sheng Li, Wenge Huang, Li Xiang, Deming Liu, Yingfan Hu, Ping Wang, Xiaoxia Lu, Guolin Zhang, Fei Wang, Xianli Meng
PHARMACOLOGICAL RESEARCH
(2019)
Article
Integrative & Complementary Medicine
Huan Chen, Ting Pan, Panwang Liu, Ping Wang, Shijun Xu
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Plant Sciences
Yingfan Hu, Wen'ge Huang, Yu Luo, Li Xiang, Jiasi Wu, Yan Zhang, Yong Zeng, Chensi Xu, Xianli Meng, Ping Wang
Summary: This study aimed to quantify the effects of three rhubarb anthraquinones on inflammation and explore the structure-activity relationships of these compounds. The results indicated that aloe-emodin had the strongest anti-inflammatory effect and the highest hydrophobic effect among the three anthraquinones.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Integrative & Complementary Medicine
Le-Le Zhang, Yan He, Feiya Sheng, Ying-Fan Hu, Yu Song, Wei Li, Jiarong Chen, Jinming Zhang, Liang Zou
Summary: Fagopyrum dibotrys, a well-known edible herbal medicine in Asian countries, is rich in flavonoids and phenolic compounds, which are considered as the main active ingredients. Previous studies have shown its various pharmacological activities including anti-inflammatory, anti-cancer, and anti-oxidant effects. Further research on functional genes related to the synthesis of active ingredients will contribute to the development and utilization of F. dibotrys.
Article
Chemistry, Applied
Yan Zhang, Ying-Fan Hu, Wei Li, Guang-Ya Xu, Kun-Rong Wang, Lin Li, Hao Luo, Liang Zou, Jia-Si Wu
Summary: Taraxacum mongolicum Hand.-Mazz (TMHM) is a well-known dietary and medicinal plant with multiple biological effects, including anti-inflammatory, antioxidant, antibacterial, and gastric-protective effects. It has the potential to be applied in clinical practice, food, and nutraceutical industry. However, further research is needed to fully understand its mechanisms and potential applications.
Article
Plant Sciences
Le-Le Zhang, Feiya Sheng, Yan He, Yong Yang, Ying-Fan Hu, Wei Li, Peng Li, Meng-Yao Wu, Yun Gong, Yamei Zhang, Liang Zou
Summary: Buxue Yimu Pills (BYP) have therapeutic effects in promoting angiogenesis and blood circulation, and mitigating blood stasis, supporting its clinical application for postpartum or abortion complications.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Cell Biology
Yanqin Luo, Jingyang Li, Peng Yu, Jiayi Sun, Yingfan Hu, Xianli Meng, Li Xiang
Summary: Lung cancer, particularly non-small cell lung cancer (NSCLC), is a major cause of cancer-related deaths worldwide. Long non-coding RNAs (lncRNAs), which are non-protein-coding RNA molecules longer than 200 nucleotides, play a crucial role in the development and progression of NSCLC. Programmed cell death (PCD) is the main mechanism leading to tumor cell death in most cancer treatments, and recent studies have shown that lncRNAs are closely associated with PCD and can regulate various death pathways in NSCLC. This review focuses on the function of lncRNAs in PCD of NSCLC and summarizes the therapeutic role of targeting lncRNAs in PCD for NSCLC treatment.
CELL DEATH DISCOVERY
(2022)
Article
Biochemistry & Molecular Biology
Wen'ge Huang, Yingzhuo Yang, Wen Wen, Yu Luo, Jiasi Wu, Li Xiang, Yinfan Hu, Shijun Xu, Simin Chen, Ping Wang