Article
Pharmacology & Pharmacy
Claudia Rodriguez, Ana Sanchez, Javier Saenz-Medina, Mercedes Munoz, Medardo Hernandez, Miguel Lopez, Luis Rivera, Cristina Contreras, Dolores Prieto
Summary: Obesity-induced dysregulation of AMPK activity is the underlying cause of kidney vascular dysfunction, and activation of AMPK improves metabolic state, protects renal endothelial function, and exerts potent vascular antioxidant and anti-inflammatory effects.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Min Zhang, Ruoxuan Hei, Zhou Zhou, Wendi Xiao, Xi Liu, Yanwei Chen
Summary: This study found that macrophages in COPD patients differentiate into M1 phenotype, with increased expression of S1PR1 and decreased expression of HDAC1. The results provide new insights into the pathogenesis and potential treatment options of COPD.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Alexis Gonneaud, Naomie Turgeon, Francois-Michel Boisvert, Francois Boudreau, Claude Asselin
Summary: The deletion of Hdac1 and Hdac2 in intestinal epithelial cells disrupts mucosal tissue architecture and barrier, causing chronic inflammation. The dysregulation of signaling pathways induced by genetic IEC-Hdac1 and Hdac2 deletion may be at least partially responsible for intestinal homeostasis disruption in mutant mice. The study also suggests that IEC-specific JAK/STAT pathway deregulation may play a key role in the regulation of IEC-specific inflammatory responses.
Article
Pharmacology & Pharmacy
Taiyue Li, Xiaoyi Yu, Xuerui Zhu, Yuanyuan Wen, Meizhen Zhu, Weiwei Cai, Bao Hou, Fei Xu, Liying Qiu
Summary: This study found that vaccarin can alleviate endothelial inflammatory injury in diabetes by mediating the miR-570-3p/HDAC1 pathway. The research provides new insights into the molecular mechanisms of diabetic endothelial dysfunction and vascular complications.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, Research & Experimental
Anjali Srivastava, Bhawna Tomar, Divyansh Sharma, Srikanta Kumar Rath
Summary: Chronic kidney disease (CKD) permanently changes the function and structure of the kidney over time and is often characterized by glomerular filtration defect or proteinuria lasting longer than three months. Mitochondrial dysfunction is a common response to CKD damage, leading to altered mitochondrial shape, increased oxidative stress, and decreased biogenesis and ATP generation. This article summarizes the recent advancements in understanding the involvement of mitochondrial remodeling in CKD and emphasizes the importance of understanding mitochondrial biology for developing effective treatment options.
Article
Oncology
Wenqing Huang, Jianxiong Chen, Xunhua Liu, Xuming Liu, Shiyu Duan, Lixia Chen, Xiaoting Liu, Jiawen Lan, Ying Zou, Dan Guo, Jun Zhou
Summary: The study found that MIER3 was upregulated in breast cancer tissue and closely associated with poor patient prognosis. MIER3 can promote proliferation, migration, and epithelial-mesenchymal transition (EMT) of breast cancer cells. Further research showed that MIER3 interacts with HDAC1/HDAC2 and Snail to form a repressive complex that binds to the E-cadherin promoter, leading to its deacetylation.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Irina Lousa, Flavio Reis, Idalina Beirao, Rui Alves, Luis Belo, Alice Santos-Silva
Summary: The global prevalence of chronic kidney disease (CKD) is rising, highlighting the need for earlier biomarkers to improve patient prognosis. Research has identified a range of promising early CKD biomarkers, which still require further validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Urology & Nephrology
Peter Stenvinkel, Glenn M. Chertow, Prasad Devarajan, Adeera Levin, Sharon P. Andreoli, Sripal Bangalore, Bradley A. Warady
Summary: Despite recent advances in the management of chronic kidney disease (CKD), morbidity and mortality rates in these patients remain high. Chronic inflammation, oxidative stress, hypoxia, senescence, and mitochondrial dysfunction are now recognized as key factors in the etiology and progression of CKD. Various mechanisms, such as NF-KB and Nrf2-mediated gene transcription, regulate the inflammatory response in CKD, impacting glomerular filtration rate (GFR) decline and eventual progression to end-stage kidney disease (ESKD) in various kidney diseases.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Cell Biology
Jianjian Zhang, Yao Zhang, Dengyuan Feng, Hai Zhou, Zeping Gui, Ming Zheng, Zhou Hang, Min Gu, Ruoyun Tan
Summary: Chronic allograft dysfunction (CAD) is a major hindrance to the long-term survival of kidney transplants. Epithelial-mesenchymal transition (EMT) plays a significant role in interstitial fibrosis/tubular atrophy (IF/TA), the main histopathological feature of CAD. The expression of the regulator of calcineurin 1 (RCAN1) has been shown to be involved in various kidney diseases, but its role in IF/TA formation in CAD patients is unclear. This study provides evidence that RCAN1.4 is regulated by the YY1/HDAC2 transcription repressor complex, and its expression has a nephroprotective effect by modulating oxidative stress and the calcineurin/NFATc1 signaling pathway.
CELL DEATH DISCOVERY
(2023)
Review
Biochemistry & Molecular Biology
Ji Bian, Ann Liebert, Brian Bicknell, Xin-Ming Chen, Chunling Huang, Carol A. Pollock
Summary: Chronic kidney disease is a global public health problem, and photobiomodulation therapy may be an innovative, non-pharmacological treatment option. Preliminary studies suggest that photobiomodulation therapy can improve the condition of patients with chronic kidney disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Radhia Hamdi, Amana Saadallah-Kallel, Slima Ferchichi-Trimeche, Raja Mokdad-Gargouri, Abdelhedi Miled, Bachir Benarba
Summary: The study found that DNA hypomethylation of the p66shc promoter in chronic renal failure patients is correlated with oxidative and inflammatory stress as well as disease stages.
Review
Biochemistry & Molecular Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Ana Sanchez, Cristina Contreras, Joaquin Carballido-Rodriguez, Dolores Prieto
Summary: An epidemiological relationship between urolithiasis and cardiovascular diseases has been reported. Endothelial dysfunction is associated with both conditions. Oxidative stress is a key factor in the development of endothelial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hollie Speer, Andrew J. McKune
Summary: Hypertension is a major risk factor for cardiovascular diseases, and studying the factors involved in its progression is crucial for healthy aging. Aging is associated with a loss of skeletal muscle quantity and quality, as well as an increase in Reactive Oxygen and Nitrogen Species, which may accelerate the aging process.
Article
Biochemistry & Molecular Biology
Cleo C. L. van Aanhold, Angela Koudijs, Kyra L. Dijkstra, Ron Wolterbeek, Jan A. Bruijn, Cees van Kooten, Hans J. Baelde
Summary: The study found that transfection with sFLT1 did not aggravate renal fibrosis and peritubular capillary loss, but reduced the expression of pro-fibrotic and pro-inflammatory markers. sFLT1 mRNA levels were not correlated with interstitial fibrosis or PTC loss in human samples.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Food Science & Technology
Joseph Festa, Aamir Hussain, Zakia Al-Hareth, Harprit Singh, Mariasole Da Boit
Summary: Anthocyanins, a type of flavonoid polyphenols, have been studied for their potential in improving cardiovascular health and preventing endothelial dysfunction. However, their poor bioavailability raises questions about the role of their metabolites in the observed biological activity. Recent studies have used different models and concentrations to better understand the mechanisms of action of these compounds. The review highlights the need for further research on improving the bioavailability of the metabolites and exploring the effects of metabolites in mixtures.
Review
Cardiac & Cardiovascular Systems
Pedro Castro, Marta Palomo, Ana Belen Moreno-Castano, Sara Fernandez, Sergi Torramade-Moix, Georgina Pascual, Julia Martinez-Sanchez, Edward Richardson, Adrian Tellez, Josep M. Nicolas, Enric Carreras, Paul G. Richardson, Juan Jose Badimon, Gines Escolar, Maribel Diaz-Ricart
Summary: Patients with COVID-19 can exhibit a wide range of disease severities, with a majority being asymptomatic while some progress to critical illness. The disease timeline typically includes incubation, mild symptoms, severe hyperinflammatory response, and post-acute sequelae. Endothelial dysfunction appears to be a crucial factor in the pathobiology of severe COVID-19 complications, highlighting the potential for targeting the endothelium in prevention and treatment strategies.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Critical Care Medicine
Sara Fernandez, Ana B. Moreno-Castano, Marta Palomo, Julia Martinez-Sanchez, Sergi Torramade-Moix, Adrian Tellez, Helena Ventosa, Ferran Segui, Gines Escolar, Enric Carreras, Josep M. Nicolas, Edward Richardson, David Garcia-Bernal, Carmelo Carlo-Stella, Jose M. Moraleda, Paul G. Richardson, Maribel Diaz-Ricart, Pedro Castro
Summary: COVID-19 patients exhibit increased circulating biomarkers of endothelial damage, complement activation, and fibrinolytic dysregulation, associated with disease severity. COVID-19 endotheliopathy differs from sepsis syndrome, in which endothelial damage is also a critical feature of pathobiology.
Review
Hematology
Gines Escolar, Maribel Diaz-Ricart, Jeffrey McCullough
Summary: Standard platelet concentrates stored at 22 degrees C have a limited shelf life of 5 days due to potential bacterial contamination. To prevent infections and ensure safety, pathogen reduction technologies (PRTs) have been adapted to treat platelet products, extending their shelf life and providing an additional safety layer. The impact of different PRTs on platelet quality, function, and clinical effectiveness is under constant examination, with the potential to prevent new emerging blood-borne diseases from reaching cellular blood components.
Article
Hematology
Francisco Maduell, Jose Jesus Broseta, Diana Rodriguez-Espinosa, Jimena Del Risco-Zevallos, Miquel Gomez, Lida M. Rodas, Marta Arias-Guillen, Manel Vera, Nestor Fontsere, Maria del Carmen Salgado, Nayra Rico
Summary: This study evaluated the safety and efficacy of the new Elisio HX dialyzer compared to other hemodialysis treatments. The results showed that the Elisio HX dialyzer performed similarly to the Theranova 400 in terms of medium and large molecule removal. The dialysate albumin loss was higher in HDx and HDF compared to HD.
BLOOD PURIFICATION
(2023)
Review
Urology & Nephrology
Aleix Cases
Summary: Diabetic kidney disease, a common complication in patients with type 2 diabetes mellitus, is associated with increased morbidity and mortality, particularly of cardiovascular origin. Current treatment focuses on controlling cardiovascular risk factors and renin-angiotensin system blockade. However, GLP-1 receptor agonists, which can reduce blood glucose, promote weight loss, and provide cardiovascular and renal protection, are needed. The recent availability of oral semaglutide may facilitate the early introduction of these drugs.
Article
Biophysics
Julia Martinez-Sanchez, Roger Pascual-Diaz, Marta Palomo, Ana Belen Moreno-Castano, Helena Ventosa, Maria Queralt Salas, Montserrat Rovira, Gines Escolar, Enric Carreras, Maribel Diaz-Ricart
Summary: Post-transplantation cyclophosphamide (PTCy) reduces the occurrence of graft-versus-host disease (GVHD). Endothelial damage in allogeneic hematopoietic cell transplantation (allo-HCT) is caused by various factors and plays a role in HCT-related complications like GVHD. The impact of PTCy on the endothelium is not well understood. In this study, the researchers compared the effects of the cyclophosphamide analog MAF and cyclosporine A (CSA) on endothelial cells (ECs), and found that both compounds caused endothelial damage, but with different characteristics and intensities.
BONE MARROW TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Francisco Maduell, Jose J. Broseta, Diana Rodriguez-Espinosa, Joaquim Casals, Victor Escudero, Miquel Gomez, Lida M. Rodas, Marta Arias-Guillen, Manel Vera, Nestor Fontsere
Summary: A new automated dialysate Na control biosensor was implemented in this study to optimize dialysis treatment and reduce discomfort symptoms by reducing the diffusive load of Na. The module showed significant differences in serum Na values and changes in pre- to postdialysis plasma Na levels.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Francisco Maduell, Ester Cholbi, Laura Morantes, Victor Joaquin Escudero-Saiz, Julia Olle, Marta Martinez-Chillaron, Lida M. Rodas, Diana Rodriguez-Espinosa, Marta Arias-Guillen, Manel Vera, Nestor Fontsere, Jose Jesus Broseta
Summary: The objective of this study was to evaluate the effect of dietary sodium (Na) restriction monitored with a Na biosensor in hemodialysis patients. The results showed that restricted Na intake decreased patients' sodium level and interdialytic weight gain, and improved blood pressure control. This study suggests that monitoring Na intake with a Na biosensor in hemodialysis patients can provide more precise personalized dietary recommendations.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Editorial Material
Biophysics
Selim Corbacioglu, Stephan A. Grupp, Paul Gerard Richardson, Rafael Duarte, Antonio Pagliuca, Tapani Ruutu, Kris Mahadeo, Enric Carreras
BONE MARROW TRANSPLANTATION
(2023)
Article
Cell Biology
Julia Martinez-Sanchez, Marta Palomo, Alexandra Pedraza, Ana Belen Moreno-Castano, Sergi Torramade-Moix, Montserrat Rovira, Maria Queralt Salas, Joan Cid, Gines Escolar, Olaf Penack, Enric Carreras, Maribel Diaz-Ricart
Summary: This study compared the endothelial proteomic profiles in response to serum from steroid-refractory acute GVHD (SR-aGVHD) and steroid-sensitive acute GVHD (SS-aGVHD) patients. The differentially expressed proteins were mainly associated with oxidative phosphorylation, inflammation and angiogenesis, cell survival, and oxidative stress. These findings provide insights into the mechanisms of response to steroids and may serve as potential biomarkers for steroid-treatment response in SR-aGVHD patients.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Ana Belen Moreno-Castano, Sara Fernandez, Helena Ventosa, Marta Palomo, Julia Martinez-Sanchez, Alex Ramos, Valentin Ortiz-Maldonado, Julio Delgado, Carlos Fernandez de Larrea, Alvaro Urbano-Ispizua, Olaf Penack, J. M. Nicolas, Adrian Tellez, Gines Escolar, Enric Carreras, Francesc Fernandez-Aviles, Pedro Castro, Maribel Diaz-Ricart
Summary: CAR-T cell-based immunotherapy for hematological malignancies may lead to cytokine release and immune effector cell-associated neurotoxicity syndromes. This study found that markers of endothelial dysfunction, innate immunity activation, and hemostatic imbalance could potentially be used as laboratory tools for predicting and differentiating toxicities, as well as determining their severity.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Ana Belen Moreno-Castano, Maria Queralt Salas, Marta Palomo, Julia Martinez-Sanchez, Montserrat Rovira, Francesc Fernandez-Aviles, Carmen Martinez, Joan Cid, Pedro Castro, Gines Escolar, Enric Carreras, Maribel Diaz-Ricart
Summary: This work reviews the role of endothelial dysfunction in early complications after autologous and allogeneic hematopoietic cell transplantation. It finds that endothelial dysfunction is not only involved in sinusoidal obstruction syndrome, but also in other complications such as acute graft-versus-host disease and transplant-associated thrombotic microangiopathy. Moreover, endotheliopathy is not limited to hematopoietic cell transplantation, as there is evidence of its implication in complications from other cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Maria Queralt Salas, Paola Charry, Alexandra Pedraza, Nuria Martinez-Cibrian, Maria Teresa Solano, Ariadna Domenech, Maria Suarez-Lledo, Meritxell Nomdedeu, Joan Cid, Miquel Lozano, Noemi de-LLobet, Jordi Arcarons, Laura Rosinol, Gonzalo Gutierrez-Garcia, Enric Carreras, Jordi Esteve, Alvaro Urbano-Ispizua, Francesc Fernandez-Aviles, Montserrat Rovira, Carmen Martinez
Summary: This study compared the outcomes of PTCY-tacrolimus (TK) prophylaxis and conventional GVHD prophylaxis in patients aged >50 years undergoing peripheral blood alloHSCT. The results showed that the PTCY-TK group had lower incidence of acute and chronic GVHD and better GVHD-free/relapse-free survival.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)