Article
Cardiac & Cardiovascular Systems
Ramesh Chennupati, Isabella Solga, Patricia Wischmann, Paul Dahlmann, Feyza Guel Celik, Daniela Pacht, Aslihan Sahin, Vithya Yogathasan, Mohammad Rabiul Hosen, Norbert Gerdes, Malte Kelm, Christian Jung
Summary: Chronic anemia is associated with endothelial dysfunction, possibly due to increased oxidative stress in the endothelium. The study found that chronic anemia leads to impaired vascular function and increased inflammatory response, but inhibition of reactive oxygen species or enzyme inhibitors may help reverse endothelial dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Nadezhda Barvitenko, Elisaveta Skverchinskaya, Alfons Lawen, Elena Matteucci, Carlota Saldanha, Giuseppe Uras, Alessia Manca, Muhammad Aslam, Antonella Pantaleo
Summary: ROS are recognized as important signaling messengers in endothelial cells, with potential positive effects on pro-survival pathways downstream of G(i)-protein-coupled receptors. However, the role of ROS in stabilizing the endothelial barrier remains uncertain.
Article
Medicine, General & Internal
Alex Konstantinovsky, Nina Kuchersky, Khalaf Kridin, Arnon Blum
Summary: The purpose of this research was to explore the mechanistic protective cardiovascular effects of phosphodiesterase-5 inhibitors in males with erectile dysfunction. The study showed that PDE5-Is improved endothelial function and erectile dysfunction, leading to a reduction in cardiovascular events and death risk.
AMERICAN JOURNAL OF MEDICINE
(2023)
Article
Hematology
Arvind K. Pandey, Markus Waldeck-Weiermair, Quinn S. Wells, Wusheng Xiao, Shambhu Yadav, Emrah Eroglu, Thomas Michel, Joseph Loscalzo
Summary: This study reveals that CD70 plays a regulatory role in endothelial NO and reactive oxygen species homeostasis and is associated with vascular phenotypes. CD70 knockdown leads to reduced NO levels and increased reactive oxygen species, which may be related to endothelial dysfunction and cardiovascular diseases, highlighting its significance in human vascular diseases.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Environmental Sciences
Hui Chen, Yongxiang Qin, Jiawei Pu, Jinxing Hu, Yuezhong Wen
Summary: This study investigated the toxicity of the chiral synthetic auxin herbicide DCPP to Arabidopsis, as well as the mutual regulation of NO, H2O2, O-2, and phytohormones at the enantiomeric level. The results revealed the important role of ROS in the enantioselective effect of DCPP and the potential redistribution of phytohormones between leaves and roots.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Hasnae Boughaleb, Irina Lobysheva, Flavia Dei Zotti, Jean-Luc Balligand, Virginie Montiel
Summary: This review focuses on a novel technique of directly measuring HbNO and discusses its correlation with vascular endothelial function as well as its potential applications in disease monitoring and prediction.
Article
Biochemistry & Molecular Biology
Thuan Thai, Fei Zhong, Lei Dang, Enoch Chan, Jacqueline Ku, Ernst Malle, Carolyn L. Geczy, John F. Keaney, Shane R. Thomas
Summary: The study demonstrates that transcytosed MPO in endothelial cells activates eNOS by promoting phospholipase C-dependent calcium signaling and altering eNOS phosphorylation status. This activation occurs despite reduced cellular uptake of the eNOS substrate L-arginine. These findings suggest a compensatory signaling response in endothelial cells to maintain eNOS activity and NO production in the presence of MPO-induced oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Ali Mahdi, Aida Collado, John Tengbom, Tong Jiao, Tigist Wodaje, Niclas Johansson, Filip Farnebo, Anna Farnert, Jiangning Yang, Jon O. Lundberg, Zhichao Zhou, John Pernow
Summary: The mechanisms underlying cardiovascular complications in COVID-19 patients are not well understood. This study reveals the key role of red blood cells in driving vascular dysfunction in COVID-19 patients. Targeting reactive oxygen species or arginase 1 improves vascular dysfunction mediated by red blood cells, suggesting a potential treatment strategy for COVID-19-associated vascular complications.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Medicine, Research & Experimental
Shupeng Hu, Qiangzhong Pi, Xiudan Xu, Jianghong Yan, Yongzheng Guo, Wanying Tan, An He, Zhe Cheng, Suxin Luo, Yong Xia
Summary: This study investigates the role of eNOS in vascular dysfunction induced by sepsis. Increased phosphorylation of eNOS in early sepsis leads to decreased vasodilation, while decreased levels of eNOS in late sepsis result in diminished nitric oxide-dependent relaxation responses.
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Plant Sciences
Yu-Ying Sun, Jia-Qi Wang, Ru-Hua Xiang, Zhong-Guang Li
Summary: This study found that nitric oxide (NO) can enhance thermotolerance in maize seedlings by triggering the LCD/H2S signaling pathway. Additionally, NO also improves the adaptability of maize seedlings to heat stress by regulating the activity of the ROS scavenging system.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Medicine, Research & Experimental
Jun -Ha Hwang, Woong Heo, Jung Il Park, Kyung Min Kim, Ho Taek Oh, Gi Don Yoo, Jeekeon Park, Somin Shin, Youjin Do, Mi Gyeong Jeong, Eun Sook Hwang, Jeong-Ho Hong
Summary: Endothelial TAZ is involved in the production of nitric oxide (NO) and inhibits damage-induced liver fibrosis. It regulates NO production by transcriptional regulation of Nos3. Loss of TAZ leads to capillarization of liver sinusoidal endothelial cells and a decrease in NO concentration, accelerating liver fibrosis.
Article
Biochemistry & Molecular Biology
Naris Thengchaisri, Lih Kuo, Travis W. Hein
Summary: In diabetes, the increased activity of the enzyme arginase competes with endothelial nitric oxide synthase (eNOS) for their common substrate L-arginine, leading to compromised vasodilation mediated by nitric oxide (NO). However, eNOS uncoupling in diabetes may result in the production of superoxide and compensatory hydrogen peroxide (H2O2) formation to restore NO deficiency. This study found that in early type 1 diabetes, the vasodilation response in coronary arterioles was partially impaired due to reduced availability of L-arginine as a result of upregulated arginase activity. Nevertheless, the increased production of H2O2 during eNOS uncoupling and PI3K activation seemed to compensate for the NO deficiency and mask the disturbance caused by arginase activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Abdullah Shaito, Karl Aramouni, Roland Assaf, Astrid Parenti, Alexander Orekhov, Ahmed El Yazbi, Gianfranco Pintus, Ali H. Eid
Summary: Cardiovascular disease is a major cause of global mortality, and oxidative stress plays a crucial role in its pathogenesis. Studies have shown that reactive oxygen species can lead to endothelial dysfunction, contributing to the development of cardiovascular diseases. This review aims to explore the mechanisms underlying oxidative stress-induced endothelial dysfunction in cardiovascular disease, with a focus on the impact of ROS on NO bioavailability, ROS-induced inflammation, and ROS-induced mitochondrial dysfunction.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Multidisciplinary Sciences
Wenpeng Song, Yiming Yuan, Xiaohui Tan, Yangyang Gu, Jianyu Zeng, Weidong Song, Zhongcheng Xin, Dong Fang, Ruili Guan
Summary: This study investigated the effect and mechanism of Icariside II on the rapid phosphorylation of eNOS. The results demonstrated that Icariside II can promote cell proliferation and nitric oxide release, and regulate the phosphorylation of eNOS through multiple signaling pathways.
Article
Immunology
Kazuo Yamagata, Natsumi Takahashi, Nozomi Akita, Toru Nabika
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Cell Biology
Kazuo Yamagata, Yuri Izawa, Daiki Onodera, Motoki Tagami
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2018)
Review
Pharmacology & Pharmacy
Kazuo Yamagata
CURRENT PHARMACEUTICAL DESIGN
(2019)
Review
Cardiac & Cardiovascular Systems
Kazuo Yamagata
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
Kazuo Yamagata, Kazuki Hashiguchi, Hiroaki Yamamoto, Motoki Tagami
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2019)
Review
Cardiac & Cardiovascular Systems
Kazuo Yamagata
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Kazuo Yamagata, Yukio Yamori
Summary: Isoflavones, mainly found in soybean, are polyphenols with beneficial effects on various chronic diseases as phytoestrogens. Metabolic syndrome increases the risk of death due to arteriosclerosis in individuals with conditions like obesity, hypertension, hyperglycemia, and dyslipidemia. While the health benefits of soy-derived isoflavones are well-known, their effects on metabolic syndrome pathogenesis remain incomplete.