Serine 474 phosphorylation is essential for maximal Akt2 kinase activity in adipocytes

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

(2019) Jacqueline Stöckli et al.   Molecular Metabolism

Membrane Topology of Trafficking Regulator of GLUT4 1 (TRARG1)

(2018) Xiaowen Duan et al.   BIOCHEMISTRY

Genetic code expansion and live cell imaging reveal that Thr-308 phosphorylation is irreplaceable and sufficient for Akt1 activity

(2018) Nileeka Balasuriya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Decoding Mechanisms of the Temporal Patterns of Blood Insulin by the Insulin-AKT Pathway in the Liver

(2018) Hiroyuki Kubota et al.   Cell Systems

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

(2018) Nam Chu et al.   CELL

Muscle and adipose tissue insulin resistance: malady without mechanism?

(2018) Daniel J. Fazakerley et al.   JOURNAL OF LIPID RESEARCH

An improved Akt reporter reveals intra- and inter-cellular heterogeneity and oscillations in signal transduction

(2017) Dougall M. Norris et al.   JOURNAL OF CELL SCIENCE

PI(3,4,5)P 3 Engagement Restricts Akt Activity to Cellular Membranes

(2017) Michael Ebner et al.   MOLECULAR CELL

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

(2017) Muheeb Beg et al.   eLife

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

(2016) Yuefeng Tang et al.   Nature Communications

Development of a new model system to dissect isoform specific Akt signalling in adipocytes

(2015) Esi Kajno et al.   BIOCHEMICAL JOURNAL

Akt/PKB: one kinase, many modifications

(2015) Guillermo Risso et al.   BIOCHEMICAL JOURNAL

Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses

(2015) Deborah Balzano et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteomic Analysis of GLUT4 Storage Vesicles Reveals Tumor Suppressor Candidate 5 (TUSC5) as a Novel Regulator of Insulin Action in Adipocytes

(2015) Daniel J. Fazakerley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective Insulin Resistance in Adipocytes

(2015) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt signaling dynamics in individual cells

(2015) Sean M. Gross et al.   JOURNAL OF CELL SCIENCE

What Macromolecular Crowding Can Do to a Protein

(2014) Irina Kuznetsova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

(2014) Pengda Liu et al.   NATURE

Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

(2013) Sean J. Humphrey et al.   Cell Metabolism

PDK1 selectively phosphorylates Thr(308) on Akt and contributes to human platelet functional responses

(2013) Carol Dangelmaier et al.   THROMBOSIS AND HAEMOSTASIS

The Rab GTPase-Activating Protein TBC1D4/AS160 Contains an Atypical Phosphotyrosine-Binding Domain That Interacts with Plasma Membrane Phospholipids To Facilitate GLUT4 Trafficking in Adipocytes

(2012) S.-X. Tan et al.   MOLECULAR AND CELLULAR BIOLOGY

Temporal Coding of Insulin Action through Multiplexing of the AKT Pathway

(2012) Hiroyuki Kubota et al.   MOLECULAR CELL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Abnormal SDS-PAGE migration of cytosolic proteins can identify domains and mechanisms that control surfactant binding

(2012) Yunhua Shi et al.   PROTEIN SCIENCE

Novel Systems for Dynamically Assessing Insulin Action in Live Cells Reveals Heterogeneity in the Insulin Response

(2012) James G. Burchfield et al.   TRAFFIC

Akt phosphorylation on Thr308 but not on Ser473 correlates with Akt protein kinase activity in human non-small cell lung cancer

(2011) E E Vincent et al.   BRITISH JOURNAL OF CANCER

mTORC2 Protein-mediated Protein Kinase B (Akt) Serine 473 Phosphorylation Is Not Required for Akt1 Activity in Human Platelets

(2011) Samantha F. Moore et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross-talk between the Androgen Receptor and the Liver X Receptor

(2011) James Robert Krycer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amplification and Demultiplexing in Insulin-regulated Akt Protein Kinase Pathway in Adipocytes

(2011) Shi-Xiong Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

(2010) Craig Cherrin et al.   CANCER BIOLOGY & THERAPY

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Recent Development of Anticancer Therapeutics Targeting Akt

(2010) John K. Morrow et al.   Recent Patents on Anti-Cancer Drug Discovery

Decoupling of Receptor and Downstream Signals in the Akt Pathway by Its Low-Pass Filter Characteristics

(2010) K. A. Fujita et al.   Science Signaling

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Rapid Activation of Akt2 Is Sufficient to Stimulate GLUT4 Translocation in 3T3-L1 Adipocytes

(2008) Yvonne Ng et al.   Cell Metabolism

IRS1-Independent Defects Define Major Nodes of Insulin Resistance

(2008) Kyle L. Hoehn et al.   Cell Metabolism

Mechanism and Management of AKT Inhibitor-Induced Hyperglycemia

(2008) M.-C. Crouthamel et al.   CLINICAL CANCER RESEARCH

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

Use of Akt Inhibitor and a Drug-resistant Mutant Validates a Critical Role for Protein Kinase B/Akt in the Insulin-dependent Regulation of Glucose and System A Amino Acid Uptake

(2008) Charlotte J. Green et al.   JOURNAL OF BIOLOGICAL CHEMISTRY