期刊
JOURNAL OF ANTIBIOTICS
卷 73, 期 2, 页码 108-111出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41429-019-0242-4
关键词
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资金
- National Natural Science Foundation of China [31330009]
- Natural Science Foundation of Shandong Province [ZR2018BD031]
- China Postdoctoral Science Foundation [2018M632732]
- Taishan Scholar Program from Shandong Province
The coculture of marine red algal-derived endophytic fungi Aspergillus terreus EN-539 and Paecilomyces lilacinus EN-531 induced the production of a new terrein derivative, namely asperterrein (1) and a known dihydroterrein (2), which were not detected in the axenic cultures of both strains. The production of the known secondary metabolites terrein (3), butyrolactone I (4), and dankasterone (6), derived from A. terreus EN-539, were depressed significantly in the coculture. Compounds 1-3 exhibited inhibitory activity against Alternaria brassicae, Escherichia coli, Physalospora piricola, and Staphylococcus aureus with MIC values ranging from 4 to 64 mu g ml(-1).
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