Article
Biochemistry & Molecular Biology
Zahra Sayyar, Hoda Jafarizadeh-Malmiri, Nima Beheshtizadeh
Summary: This study compares the effect of Curcumin nanodispersion and synthesized ZnO nanoparticles on bioavailability at different pH values. The results show that Curcumin nanodispersion exhibits better cellular inhibition and bioavailability at pH 7.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Shadpour Mallakpour, Milad Okhovat
Summary: The biocompatible nanocomposites were fabricated using chitosan and tragacanth gum with varying percentages of ZnO and ZnO@Ag nanoparticles. Characterization of the nanocomposites revealed the formation of hydroxyapatite on their surfaces. Evaluation of antibacterial activity showed that nanocomposites containing ZnO@Ag NPs exhibited stronger inhibition zones against Staphylococcus aureus and Escherichia coli compared to those containing ZnO NPs.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Xiaoyue Xu, Mengyu Ding, Dongmei Liu, Aiying Guo, Aijun Cai, Zichuan Ma
Summary: ZnO mesocrystals synthesized using a DNA template exhibited highly effective antibacterial activity against E. coli and S. aureus compared to commercial ZnO NPs. The study evaluated the impact of DNA concentration, water/glycerin ratio, and reaction time on the morphology of ZnO mesocrystals.
CHEMICAL PHYSICS LETTERS
(2021)
Article
Environmental Sciences
Nallasamy Prakashkumar, Arivalagan Pugazhendhi, Kathirvel Brindhadevi, Hakim A. L. Garalleh, Mazen Garaleh, Natarajan Suganthy
Summary: This study compared the differences in the synthesis of ZnO nanoparticles (ZnO NPs) using chemical method and biogenic method. GC-MS analysis suggested that D-limonene in termite mound extract may be responsible for the synthesis of ZnO(B) NPs. XRD patterns confirmed the hexagonal crystalline structure of ZnO(A) and (B) NPs. The results showed that ZnO(B) NPs exhibited potential antibacterial activity against Pseudomonas aeruginosa, ESBL-1, ESBL-2, and EBSL-3. Furthermore, ZnO(B) NPs showed a stronger cytotoxic effect on lung cancer cell lines A549 compared to ZnO(A) NPs. Overall, the biogenic synthesis of ZnO NPs ensures biosafety and enhanced biological activity compared to chemical synthesis.
ENVIRONMENTAL RESEARCH
(2023)
Article
Food Science & Technology
Hamdi Ali Mohammed, Laouini Salah Eddine, Meneceur Souhaila, Gamil Gamal Hasan, Iman Kir, Johar Amin Ahmed Abdullah
Summary: SnO2 nanoparticles were synthesized using a green method and incorporated into gelatin-based films to enhance their properties and provide antibacterial activity. The functionalized CEF@SnO2 nanocomposite showed stronger antibacterial effects and has potential for extending the shelf life of perishable items.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Water Resources
Belete Yilma Hirphaye, Nafikot Berhanu Bonka, Alemu Mekonnen Tura, Gada Muleta Fanta
Summary: The present study focuses on the synthesis of magnesium oxide nanoparticles using Hagenia abyssinica female flower aqueous extract. The nanoparticles were characterized by various methods, including visual observation, UV-Vis, XRD, FTIR, and SEM. The optimum parameters for synthesis were determined, and the nanoparticles exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli.
APPLIED WATER SCIENCE
(2023)
Article
Environmental Sciences
Anbazhagan Sathiyaseelan, Kandasamy Saravanakumar, Kumar Vishven Naveen, Ki-Seok Han, Xin Zhang, Myeong Seon Jeong, Myeong-Hyeon Wang
Summary: Antimicrobial resistance (AMR) causes global consequences through increased mortality and economic loss. This study aimed to enhance the antibacterial efficiency of existing standard antibiotics by synthesizing and characterizing titanium dioxide nanoparticles (TiO2 NPs) using the aqueous extract of an endophytic fungus. The combination of tetracycline (TCH) and Pb-TiO2 NPs significantly increased the inhibition of E. coli biofilm.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Lin Wang, Meihua Xin, Mingchun Li, Wenfeng Liu, Yangfan Mao
Summary: In this study, three new chitosan quaternary phosphonium compounds were synthesized and characterized. Their antibacterial activities against Escherichia coli and Staphylococcus aureus, as well as their antibiofilm activities, were investigated. The results showed that the chitosan quaternary phosphonium salts exhibited stronger antibacterial and antibiofilm activities compared to chitosan quaternary ammonium salt.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Nanoscience & Nanotechnology
Helal F. Al-Harthi, Abu Baker, Abdallah M. Elgorban, Ali H. Bahkali, Ayaz Mukarram Shaikh, Bela Kovacs, Mohd Sajid Khan, Asad Syed
Summary: In this study, a novel fungus Alternaria sp. was isolated and characterized from the vicinity of medicinal plants, and its extracted proteins were used to synthesize highly biocompatible zinc nanoparticles. The synthesized particles were characterized using various physical techniques and were found to possess regular crystallinity and antibacterial and anticancer activities.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2022)
Article
Chemistry, Physical
Nesrine Bhouri, Faten Debbabi, Mohamed Ali Lassoued, Merghni Abderrahmen, Saber Ben Abdessalem
Summary: Chitosan/Laurus nobilis essential oil emulsion was prepared and fixed on PET braided sutures, showing good antibacterial activity and mechanical performance.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Chemistry, Applied
N. Prakashkumar, M. Vignesh, K. Brindhadevi, Nguyen-Tri Phuong, A. Pugazhendhi, N. Suganthy
Summary: This study fabricated biocompatible neem gum coated palladium nanoparticles and evaluated their pharmacological applications, demonstrating enhanced antimicrobial and anticancer properties of NG@Pd NPs compared to Pd NPs alone, making them promising candidates for antimicrobial and lung cancer therapy.
PROGRESS IN ORGANIC COATINGS
(2021)
Article
Environmental Sciences
Selvam Sathiyavimal, Seerangaraj Vasantharaj, Thamaraiselvi Kaliannan, Hakim AL Garalleh, Mazen Garaleh, Kathirvel Brindhadevi, Nguyen Thuy Lan Chi, Ashutosh Sharma, Arivalagan Pugazhendhi
Summary: In this study, CuO-CS nanocomposite was synthesized using Sida cordifolia aqueous leaf extract and was found to possess antimicrobial activity against both Gram-positive and Gram-negative bacteria. It also exhibited cytotoxic effects on breast cancer and lung cancer cells. Additionally, the nanocomposite showed efficient photocatalytic dye degradation, suggesting its potential applications in biomedical and industrial wastewater treatment.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Ankush Agrawal, Ruhani Sharma, Ankita Sharma, Kailash Chand Gurjar, Sanjay Kumar, Samit Chatterjee, Harsh Pandey, Kamlendra Awasthi, Anjali Awasthi
Summary: In this study, green synthesized zinc oxide nanoparticles (ZnO NPs) were found to exhibit excellent antibacterial and antibiofilm activity against biofilm-producing Bacillus subtilis bacteria. The nanoparticles were shown to inhibit biofilm formation and damage bacterial cell membranes, indicating their potential as an alternative treatment for biofilms and drug-resistant bacteria.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Darren Yi Sern Low, Camille Keisha Mahendra, Janarthanan Supramaniam, Loh Teng Hern Tan, Learn Han Lee, Sivakumar Manickam, Bey Hing Goh, Khang Wei Tan, Siah Ying Tang
Summary: This study utilized ultrasonically driven biosynthesis to create zinc oxide nanoparticles using Swietenia macrophylla seed ethyl acetate fraction, demonstrating a pure hexagonal wurtzite structure. The biologically synthesized ZnO particles showed significant anticancer activity against colon cancer cells, suggesting their potential as an anticancer agent for biomedical applications.
NANOTECHNOLOGY REVIEWS
(2021)
Article
Polymer Science
E. M. Abdelfattah, H. Elzanaty, W. B. Elsharkawy, M. A. Azzam, Z. M. Elqahtani, S. Alotibi, M. Alyami, T. Fahmy
Summary: Poly (vinyl alcohol)/chitosan/ZnO (PVA/Cs/ZnO) nanocomposite films were prepared through an environmentally friendly approach and characterized using various techniques. The results showed that the PVA/Cs blend matrix encapsulated the ZnO nanoparticles. The addition of ZnO NPs increased the glass transition and melting temperature values of the PVA/Cs blend. The ATR-FTIR spectra indicated the existence of hydrogen bonding between the OH groups of PVA/Cs and ZnO nanoparticles. The nanocomposites exhibited better thermal stability and enhanced optical properties with increasing concentration of ZnO nanoparticles. Moreover, PVA/Cs/ZnO nanocomposites showed significant antibacterial activity.
Article
Chemistry, Inorganic & Nuclear
Sekar Vijayakumar, Jingdi Chen, Zaira Gonzalez-Sanchez, Esteban F. Duran-Lara, Mani Divya, Krishnan Shreema, Hushnaara Hadem, R. Mathammal, Murugesan Prasannakumar, Baskaralingam Vaseeharan
Summary: Nanomaterials, particularly metal oxide nanoparticles, are being considered as potential alternatives to traditional treatments in medicine. This study demonstrated a sustainable and simple synthesis of zinc oxide nanoparticles using almond gum Prunus dulcis as the capping agent. The synthesized nanoparticles showed significant antibacterial and antibiofilm activities against Staphylococcus aureus and Proteus vulgaris, as well as anti-colon cancer activity on a human colon cancer cell line.
JOURNAL OF CLUSTER SCIENCE
(2023)
Review
Chemistry, Analytical
Palaniyandi Velusamy, Chia-Hung Su, Palaniappan Ramasamy, Viswanathan Arun, Narayanan Rajnish, Pachaiappan Raman, Vaseeharan Baskaralingam, Sakkarapalayam Murugesan Senthil Kumar, Subash C. B. Gopinath
Summary: Biomarkers are biological molecules associated with physiological changes of the body, aiding in the detection and prediction of disease onset. Breath analysis, as a noninvasive, rapid, and inexpensive method, has become a research focus in early detection of health issues.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Raman Krishnamoorthi, Balasubramanian Malaikozhundan, Pambayan Ulagan Mahalingam
Summary: This study successfully synthesized non-toxic, eco-friendly, and stable silver nanoparticles, which exhibited inhibitory effects against six human pathogens and strong free radical scavenging activity without significant toxicity to normal cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
Murugeswaran Dayana Senthamarai, Balasubramanian Malaikozhundan
Summary: In this study, A. marmelos unripe fruit extract stabilized ZnO NPs (Am-ZnO NPs) were synthesized and characterized. The results showed that Am-ZnO NPs have greater medicinal value as antibacterial, antibiofilm and antioxidant agents. Additionally, the study also found that Am-ZnO NPs are toxic to the environment.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Environmental Sciences
Sekar Vijayakumar, Jingdi Chen, Viswanathan Kalaiselvi, Kanchanlata Tungare, Mustansir Bhori, Zaira Gonzalez-Sanchez, Esteban F. Duran-Lara
Summary: In this study, the green synthesis of laminarin embedded ZnO nanoparticles (Lm-ZnO NPs) and their based chitosan capped ZnO nanocomposites (Ch-Lm-ZnO NCmps) was described for the first time. The cytotoxicity, phytotoxicity, and in vivo toxicity of these nanomaterials were evaluated. The results showed dose-dependent cytotoxicity and phytotoxicity, as well as deformities and increased mortality in zebrafish embryos.
ENVIRONMENTAL RESEARCH
(2022)
Article
Chemistry, Inorganic & Nuclear
Balasubramanian Malaikozhundan, Raman Krishnamoorthi, Jayaraj Vinodhini, Kalaiselvi Sivalingam Nathiga Nambi, Subramanian Palanisamy
Summary: In this study, Fe2O3 nanoparticles coated with papaya fruit extract were synthesized and characterized. The results showed that these nanoparticles have antibacterial activity, radical scavenging activity, and dye degradation ability.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Raman Krishnamoorthi, Moovendran Srinivash, Pambayan Ulagan Mahalingam, Balasubramanian Malaikozhundan, Paulraj Suganya, Krishnamoorthy Gurushankar
Summary: The current study aimed to screen bacteriocin producing LAB from different dairy products and evaluate their biological properties. Among the isolated LAB species, one strain (CH3) showed better antimicrobial effects and its purified bacteriocin demonstrated strong antimicrobial and anti-biofilm activity against selected human pathogens. These findings suggest the potential application of bacteriocin in combating antimicrobial-resistant pathogens and preserving food without contamination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Raman Krishnamoorthi, Moovendran Srinivash, Pambayan Ulagan Mahalingam, Balasubramanian Malaikozhundan
Summary: The present study evaluated the dietary nutrient levels and medicinal value of A. bisporus mushroom. It found that the mushroom has high levels of carbohydrates and crude proteins, as well as various mycochemicals and minerals. The mushroom extract showed significant antimicrobial and free radical scavenging effects, indicating its potential use as a food supplement.
PROCESS BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Sekar Vijayakumar, Jingdi Chen, Zaira I. Gonzalez Sanchez, Kanchanlata Tungare, Mustansir Bhori, Esteban F. Duran-Lara, Periasamy Anbu
Summary: Nano-based drug delivery research is on the rise due to its potential applications in healthcare. However, traditional chemical synthesis methods have unwanted toxicity effects, making green synthesis-based and biocompatible methods necessary. This study presents the green synthesis of Moringa gum-capped MgO nanoparticles (Mgm-MgO NPs) and investigates their properties such as antioxidant activity, hemolysis potential, cytotoxicity, phytotoxicity, CAM assay, and embryotoxicity in zebrafish.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Green & Sustainable Science & Technology
Tamil Elakkiya Mathizhagan, Vijayakumar Subramaniyan, Sangeetha Renganathan, Vidhya Elavarasan, Prathipkumar Subramaniyan, Sekar Vijayakumar
Summary: Recent advances in nanotechnology have led to the development of environmentally friendly processes for sustainable growth. In this study, bio-augmented ZnO nanoparticles were generated using a simple and affordable green technique. The nanoparticles showed significant antimicrobial and anticancer activities, as well as effective photocatalytic activity. This combination has the potential to be utilized for dye pollution removal from wastewater and for combating lung cancer in the pharmaceutical sector.
Article
Green & Sustainable Science & Technology
Thiyakarajan Sutharappa Kaliyamoorthy, Vijayakumar Subramaniyan, Sangeetha Renganathan, Vidhya Elavarasan, Jagatheesvaran Ravi, Praseetha Prabhakaran Kala, Prathipkumar Subramaniyan, Sekar Vijayakumar
Summary: This work discusses the bio-synthesis of zinc oxide nanoparticles (ZnO NPs) using aqueous leaf extract of Pisonia grandis, presenting an effective and environmentally friendly method. The study fabricates bio-augmented ZnO-NPs from Pisonia grandis extracts and analyzes their properties using various techniques. The synthesized nanoparticles show excellent cytotoxic and antimicrobial properties, as well as effective photodegradation of methylene blue dye. These bio-fabricated ZnO nanoparticles hold great promise in biomedical and environmental applications due to their eco-friendliness, non-toxicity, and cytocompatibility.
Article
Green & Sustainable Science & Technology
Punitha Nagarajan, Vijayakumar Subramaniyan, Vidhya Elavarasan, Nilavukkarasi Mohandoss, Prathipkumar Subramaniyan, Sekar Vijayakumar
Summary: This study focuses on the synthesis of aluminium oxide nanoparticles (Al2O3 NPs) using Citrus aurantium peel extract as a green and efficient method. Various characterisation techniques were used to evaluate the morphology of Al2O3 NPs, as well as their antimicrobial and photocatalytic properties. The results showed that the biosynthesised Al2O3 NPs exhibited feasible antimicrobial, anti-proliferative, and photocatalytic activities, making them potential candidates for various applications.
Article
Chemistry, Multidisciplinary
Nilavukkarasi Mohandoss, Sangeetha Renganathan, Vijayakumar Subramaniyan, Punitha Nagarajan, Vidhya Elavarasan, Prathipkumar Subramaniyan, Sekar Vijayakumar
Summary: In this study, iron oxide nanoparticles were successfully synthesized using Capparis zeylanica leaf extract. The nanoparticles exhibited spherical shape and high crystallinity. They showed significant antimicrobial activity against various pathogenic organisms and also demonstrated concentration-dependent cytotoxicity against lung cancer cells.
APPLIED SCIENCES-BASEL
(2022)
Article
Pharmacology & Pharmacy
Alfredo Pereira, Elizabeth Valdes-Munoz, Adolfo Marican, Gustavo Cabrera-Barjas, Sekar Vijayakumar, Oscar Valdes, Diana Rafael, Fernanda Andrade, Paulina Abaca, Daniel Bustos, Esteban F. Duran-Lara
Summary: Due to the growing bacterial resistance to antibiotics, there is a need for new antimicrobial treatment options. This study focused on the rational design of hydrogels as potential delivery systems for cationic antimicrobial peptides (cAMPs). The researchers used docking and Molecular Dynamics simulations to select the best hydrogel candidates based on their interaction with two types of cAMPs. The results showed that MN4-CM5-CL1 hydrogel (HG2) was the most promising candidate for future in vitro or in vivo experiments.
Article
Biochemistry & Molecular Biology
Jose Vinoth Raja Antony Samy, Rajeswari Ranga Anantha Sayanam, Chitra Balasubramanian, Natesan Vijayakumar, Sung-Jin Kim, Sekar Vijayakumar, Mansour K. Gatasheh, Mohammad Shamsul Ola, Omar Ahmed Basudan, Mohamed Saad Daoud, Moneera Saud Al-Bagmi, Badr Tayeb Hazazi
Summary: Hyperthyroidism is characterized by excess thyroid hormones in the blood. Prescription medications for its treatment have adverse effects and symptoms often recur after discontinuation. This study investigated the use of polyherbal extract from four medicinal plants for hyperthyroidism treatment. The extract showed high concentration of phytochemicals, antioxidant capacity, and the presence of 13 bioactive compounds. Treatment with the extract normalized thyroid function and improved thyroid follicles. These findings suggest that polyherbal formulations could be an effective and protective alternative to synthetic thyroid medications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)