Article
Medicine, Research & Experimental
Navneet Joshi, Farnaz Hajizadeh, Ehsan Ansari Dezfouli, Angelina Olegovna Zekiy, Mohsen Nabi Afjadi, Seyedeh Mahboubeh Mousavi, Mohammad Hojjat-Farsangi, Vahid Karpisheh, Ata Mahmoodpoor, Hadi Hassannia, Sanam Dolati, Hamed Mohammadi, Mehdi Yousefi, Farhad Jadidi-Niaragh
Summary: This study aimed to deliver STAT3 siRNA and DOX to cancer cells using pegylated chitosan lactate nanoparticles (NPs) to enhance cancer cell sensitivity to DOX-induced cell death. The results demonstrated successful delivery of siRNA and DOX by NPs, leading to suppression of STAT3 expression and increased DOX-mediated cell death induction.
Article
Pharmacology & Pharmacy
Sahar Eljack, Emilie Allard-Vannier, Yoann Misericordia, Katel Herve-Aubert, Nicolas Aubrey, Igor Chourpa, Areeg Faggad, Stephanie David
Summary: Breast cancer is a common and deadly disease for women worldwide. Traditional treatment options may not be satisfactory and some patients develop resistance. This study investigates the combination of siRNA nanovectors and Doxorubicin for HER2+ breast cancer treatment, aiming to enhance therapeutic efficacy and reduce side effects. The findings show that the combination treatment has a significant cytotoxic effect on breast cancer cells.
Article
Chemistry, Multidisciplinary
Yongmei Zhao, Tianqing Liu, Aditya Ardana, Nicholas L. Fletcher, Zachary H. Houston, Idriss Blakey, Kristofer J. Thurecht
Summary: This study presents a strategy for developing multicomponent nanomedicines using compatible chemistries to effectively treat chemotherapeutic resistance in cancer. The nanomedicine demonstrated significant DNA damage and inhibition of cancer cells, as well as suppressing cancer cell metabolism. Targeting the cell surface protein EGFR further enhanced the therapeutic efficacy of the nanomedicine.
Article
Nanoscience & Nanotechnology
Qing Hu, Jiayi Yao, Xiaoqin Wang, Yanfang Wang, Xiaoling Fu, Ju Ma, Han Lin, Jiaqi Xu, Longhua Shen, Xiangbin Yu
Summary: This study reports a multifunctional nanocarrier with a pH-sensitive liposome shell and a dendritic core for targeted co-delivery of PD-L1 siRNA and DOX. The nanocarrier showed suitable particle size, good stability, and pH-sensitive drug release. In vitro and in vivo experiments demonstrated that the nanocarrier effectively inhibited cell proliferation, reduced PD-L1 expression, and exhibited high accumulation at the tumor site. It holds promise as a codelivery nanoplatform to improve the treatment of various solid tumors.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Pharmacology & Pharmacy
Dindyal Mandal, Sandeep Lohan, Muhammad Imran Sajid, Abdulelah Alhazza, Rakesh Kumar Tiwari, Keykavous Parang, Hamidreza Montazeri Aliabadi
Summary: In this study, several linear peptides containing tryptophan (W) and arginine (R) residues were designed and synthesized. These peptides were attached to lipophilic fatty acyl chains, cholesterol, or PEG. The newly developed peptides efficiently protected siRNA against early degradation and successfully delivered siRNA into cells, resulting in significant downregulation of target proteins.
Article
Biochemistry & Molecular Biology
Andria M. Yaourtis, Aviva Levina, Peter A. Lay
Summary: Tumour cell heterogeneity affects the cytotoxicity of cisplatin but not doxorubicin in two phenotypes of the triple-negative breast cancer cell line, MDA-MB-231. The mesenchymal phenotype showed three times less sensitivity to cisplatin compared to the epithelial-type phenotype, which has significant implications for the efficacy of TNBC chemotherapies.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wei-Hsiang Hsu, Chien-Liang Ku, You-Ren Lai, Steven S. -S. Wang, Shiu-Huey Chou, Ta-Hsien Lin
Summary: This study aimed to develop DOXO-coupled glycated BSA nanoparticles and improve their targeting capability towards GLUT5 transporters over-expressed on breast cancer cells. The synthesized nanoparticles had a spherical shape with a hydrodynamic diameter of approximately 60.74 nm and a zeta-potential of approximately -42.20 mV. Furthermore, the DOXO-coupled glycated BSA nanoparticles exhibited cytotoxicity towards both MCF-7 and MDA-MB-231 cells. Overall, this research demonstrates the potential of drug-coupled glycated BSA nanoparticles as a targeted drug delivery platform for breast cancer therapy. Rating: 9/10.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biology
Angelica A. A. Davenport, Yun Lu, Carlos A. A. Gallegos, Adriana V. F. Massicano, Katherine A. A. Heinzman, Patrick N. N. Song, Anna G. G. Sorace, N. G. Cogan
Summary: Triple-negative breast cancer (TNBC) is a heterogeneous disease characterized by the absence of targetable receptors, resulting in limited treatment options and higher rates of metastasis and recurrence. In this study, a mathematical model using ordinary differential equations is developed to describe the response of TNBC to combination chemotherapy with doxorubicin and paclitaxel. The model is parameterized using noninvasive molecular imaging data and validated with histological data from two murine models. The model accurately predicts tumor volume changes and necrosis volume, providing insights into the effectiveness of different treatment strategies and the role of the immune system in TNBC.
BULLETIN OF MATHEMATICAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Armin Mahmoud Salehi Khesht, Vahid Karpisheh, Parisa Sahami Gilan, Lyubov A. Melnikova, Angelina Olegovna Zekiy, Mahdis Mohammadi, Mohammad Hojjat-Farsangi, Naime Majidi Zolbanin, Ata Mahmoodpoor, Hadi Hassannia, Leili Aghebati-Maleki, Reza Jafari, Farhad Jadidi-Niaragh
Summary: A novel nanocarrier was developed for targeted siRNA/drug delivery to cancer cells, delivering CD73 siRNA and doxorubicin to increase cancer cell death and inhibit proliferation. The nanocarrier reduced chemotherapy side effects and induced anti-tumor immune responses.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Beste Cagdas Tunali, Omer Akturk, Durukan Sahingoz, Mustafa Turk, Ayten Celebi Keskin
Summary: In this study, polyethyleneimine-capped gold nanoparticles (PEI-AuNPs) were synthesized using the pulsed laser ablation in liquid (PLAL) technique, and then combined with Bombyx mori silk fibroin (SF) to form nanocomposites (PEI-SF-AuNPs). The biocompatibility of PEI-AuNPs and PEI-SF-AuNPs in breast cancer cells MCF-7 and MDA-MB231 were tested, and it was found that PEI-AuNP1 showed the least cytotoxicity. Therefore, PEI-AuNP1 nanocomposites can be suggested as siRNA carriers in gene-based breast cancer therapies.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Rodrigo Ce, Gabriela Klein Couto, Barbara Zoche Pacheco, Danieli Rosane Dallemole, Julia Dame Paschoal, Bruna Silveira Pacheco, Silvia Staniscuaski Guterres, Fabiana Seixas, Tiago Collares, Adriana Raffin Pohlmann
Summary: The study developed a promising nanoformulation for the treatment of triple-negative breast cancer (TNBC), showing effectiveness in reducing cell viability, inducing apoptosis, inhibiting cell migration, and colony formation in breast cancer cells. Further studies are needed to demonstrate the in vivo efficacy of this formulation.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Review
Medicine, Research & Experimental
Afsana Sheikh, Shadab Md, Prashant Kesharwani
Summary: Breast carcinomas are a highly prevalent malignancy among women, with approximately 70-80% of early diagnosed cases being treatable. Targeted anti-cancer treatment, particularly using aptamers, is considered significant by scientists. The use of nanoparticles for aptamer delivery shows promise in enhancing treatment efficacy.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Chemistry, Multidisciplinary
Yu Gao, Jiahui Wang, Hao Han, Huaxin Xiao, Wei-kui Jin, Siyu Wang, Shengpei Shao, Zhixuan Wang, Wenjing Yang, Lianhui Wang, Lixing Weng
Summary: The use of implantable drug-containing polymeric scaffolds shows promise in delivering chemotherapy directly to post-resection sites and inhibiting local recurrence of residual tumors. This strategy offers a potential alternative to systemic chemotherapy with lower side effects and may be useful in combating post-resection breast cancer recurrence in clinics.
Article
Oncology
Ece Miser-Salihoglu, Bensu Karahalil, Meric Arda Esmakaya, Ugur Tamer, Sevgi Yardim-Akaydin
Summary: Patients with triple-negative breast cancer are not responsive to hormone therapy, and the main treatment is a combination of chemotherapy and radiotherapy. This study investigates the role of the Tip60 gene in response to radiotherapy in MDA-MB-231 and MCF-7 cells, showing that silenced Tip60 gene leads to increased DNA damage in MCF-7 cells after radiotherapy, while lower DNA damage is observed in MDA-MB-231 cells.
Article
Nanoscience & Nanotechnology
Cao Dai Phung, Tuan Hiep Tran, Ju-Yeon Choi, Jee-Heon Jeong, Sae Kwang Ku, Chul Soon Yong, Jong Oh Kim
Summary: The study introduces a novel multifunctional nanoparticle system for targeted delivery of cFLIP-specific siRNA into cancer cells, effectively suppressing tumor growth by inhibiting cFLIP expression. The nanoparticles showed high tumor accumulation and efficacy in tumor inhibition, particularly in combination with low-dose Vorinostat treatment, indicating a promising approach for cancer therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Immunology
Masoud Ahangari Maleki, Aida Malek Mahdavi, Mohammad Sadegh Soltani-Zangbar, Mehdi Yousefi, Alireza Khabbazi
Summary: This study suggests that synbiotic supplementation has a beneficial effect on the IL-17/IL-23 pathway in patients with axial spondyloarthritis, but does not improve disease activity.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Fahimeh Zahednezhad, Parvin Zakeri-Milani, Javid Shahbazi Mojarrad, Muhammad Sarfraz, Mohammad Mahmoudian, Behzad Baradaran, Hadi Valizadeh
Summary: This study investigates the cellular uptake and cytotoxicity of surface-modified cisplatin (CisP) loaded liposomes in macrophage and cancer cells. Modified/un-modified liposomes were prepared and characterized for various properties. The results show that the modified liposomes demonstrate higher cellular uptake and increased cytotoxicity in the studied cells. Acetyl carnitine modification of CisP-liposomes can be considered an effective approach for increasing cellular uptake and cytotoxicity in cancer and macrophage cells.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Samane Abbasi, Milad Asghari Totmaj, Masoumeh Abbasi, Saba Hajazimian, Pouya Goleij, Javad Behroozi, Behrouz Shademan, Alireza Isazadeh, Behzad Baradaran
Summary: Over the last decade, novel therapeutic approaches like CAR-T-cell immunotherapy have transformed the treatment perspective of human malignancies. However, this therapy is associated with side effects and faces challenges in manufacturing, engineering, applications, and toxicities. Further studies are needed to enhance efficacy and minimize adverse events.
Article
Quantum Science & Technology
Taylor L. Patti, Omar Shehab, Khadijeh Najafi, Susanne F. Yelin
Summary: This article introduces a method that combines classical Markov chain Monte Carlo techniques with variational quantum algorithms, allowing the algorithm to converge to global minima and improve solution quality. The effectiveness of the technique is demonstrated through quantum circuit simulations and tests on large-scale quantum models.
QUANTUM SCIENCE AND TECHNOLOGY
(2023)
Review
Oncology
Zanyar HajiEsmailpoor, Peyman Tabnak, Behzad Baradaran, Fariba Pashazadeh, Leili Aghebati-Maleki
Summary: The purpose of this study was to evaluate the diagnostic performance of computed tomography (CT) scan-based radiomics in predicting lymph node metastasis (LNM) in gastric cancer (GC) patients. The results showed that there were differences in sensitivity, specificity, diagnostic odds ratio (DOR), and area under the curve (AUC) between radiomics models and combined models. Subgroup analysis also found that different CT scan phases, regions of interest (ROIs), and segmentation methods had an impact on diagnostic accuracy. In conclusion, CT scan-based radiomics approach has the potential to predict LNM in GC patients preoperatively as a non-invasive diagnostic tool.
FRONTIERS IN ONCOLOGY
(2023)
Review
Multidisciplinary Sciences
Omid Rahbar Farzam, Niloofar Mehran, Farzaneh Bilan, Ehsan Aghajani, Reza Dabbaghipour, Ghazale Asemani Shahgoli, Behzad Baradaran
Summary: Colorectal cancer, a common malignancy with high mortality, can be effectively treated using imaging-guided photothermal therapy combined with nanotechnology. This approach minimizes side effects and improves treatment outcomes, making it significant for colorectal cancer treatment.
Review
Chemistry, Applied
Mahdi Asghari Ozma, Edris Nabizadeh, Mir Reza Valiollahzadeh, Jalil Rashedi, Behroz Mahdavi Poor, Vahid Asgharzadeh, Hossein Samadi Kafil, Ehsaneh Khodadadi, Zahra Taghinejad, Amin Abbasi, Ali Esmaeili, Mohammad Asgharzadeh
Summary: SARS-CoV-2 in China originated from animal to human transmission in late 2019. It quickly spread worldwide through human-to-human transmission, resulting in high mortality, especially among people with underlying diseases like hypertension. The virus binds to ACE2, a receptor that regulates the renin-angiotensin system and degrades vasoconstrictor angiotensin 2 (Ang II). Infection reduces ACE2 levels, leading to decreased Ang II degradation and increased complications associated with hypertension. Additionally, the anti-inflammatory effects of Ang1-7 are diminished. Lung damage and reduced oxygen delivery occur due to viral multiplication, inflammation, and edema of lung tissue. Careful management of hypertension patients can prevent infection and possibly reduce mortality with oxygen therapy and exogenous ACE2 supplements.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Article
Genetics & Heredity
Peyvand Kashi, Farzaneh Pakdel, Mohammad Hossein Soroush Barhaghi, Mohammad Ahangarzadeh Rezaee, Sepehr Taghizadeh, Javid Sadeghi, Mehdi Yousefi, Reza Ghotaslou, Mohammad Asgharzadeh, Pourya Gholizadeh, Hossein Samadi Kafil
Summary: In this study, the epidemiology of tuberculosis during the COVID-19 era was examined using MIRU-VNTR. The results showed that the pandemic had a direct effect on the transmission and diagnosis of tuberculosis. The decrease in diagnosis and clustering can be attributed to public controls, hygiene measures, and the use of masks. However, there may be a decrease in the focus on other respiratory infections during the pandemic. Further research on the co-infection of COVID-19 and tuberculosis, as well as the role of masks and sanitization in combating tuberculosis, is strongly recommended.
EGYPTIAN JOURNAL OF MEDICAL HUMAN GENETICS
(2023)
Article
Immunology
Ali Sayadmanesh, Vahid Yekehfallah, Amir Valizadeh, Ali Abedelahi, Hajar Shafaei, Dariush Shanehbandi, Mohsen Basiri, Behzad Baradaran
Summary: CAR T cell therapy has shown promising efficacy in patients with hematologic malignancies, but it also presents potential toxicity and adverse effects. This study focuses on the unexpected side effects of targeting normal host tissues and discusses recent safety strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Farid Mostafaei, Somayeh Mahdinloo, Hadi Valizadeh, Salar Hemmati, Mahdieh Abdi, Muhammad Sarfraz, Behzad Baradaran, Parvin Zakeri-Milani
Summary: Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer, usually diagnosed in advanced stages. Chemotherapy is commonly used to treat advanced liver cancer but faces challenges that reduce its effectiveness. This review discusses the prevalence, staging, and treatment methods for liver cancer. It also explores recent studies on smart drug- and gene-delivery systems designed specifically for HCC, aiming to improve treatment efficacy.
Article
Biochemistry & Molecular Biology
Ehsan Aminsobahni, Maryam Hosseini, Nasim Gholizadeh, Mohammad Sadegh Soltani-Zangbar, Golaleh Savari, Kimia Motlagh Asghari, Tannaz Pourlak, Mohammadali Zolfaghari, Forough Chakari-Khiavi, Roza Motavalli, Aref Chakari-Khiavi, Ali Akbar Shekarchi, Ata Mahmoodpoor, Javad Ahmadian Heris, Khadijeh Pouya, Amir Mehdizadeh, Zohreh Babalou, Mehdi Yousefi
Summary: Physiological changes during pregnancy increase the susceptibility to severe respiratory diseases, including COVID-19. This study investigated the effects of COVID-19 on T cell response and serum cytokine profile in pregnant women. The findings showed decreased lymphocyte count and poor T cell response, as well as elevated levels of inflammatory cytokines in infected pregnant women. Hypertension and metabolic changes were identified as potential prognostic factors in COVID-19 pregnant patients.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2023)
Review
Oncology
Najibeh Shekari, Dariush Shanehbandi, Tohid Kazemi, Habib Zarredar, Behzad Baradaran, Seyed Amir Jalali
Summary: This article summarizes current evidence on V-domain immunoglobulin suppressor of T cell activation (VISTA), its related ligands, their interactions and effects, as well as preclinical and clinical targeting agents. Investigating VISTA ligands helps understand their functions and roles, and may facilitate the discovery of alternative therapeutic approaches targeting the VISTA pathway.
CANCER CELL INTERNATIONAL
(2023)
Article
Genetics & Heredity
Masoumeh Hajizadeh, Farnaz Hajizadeh, Sevil Ghaffarei, Mohammad Amin Doustvandi, Khadijeh Hajizadeh, Seyyed Mohammad Yaghoubi, Fateme Mohammadnejad, Nadia Allahyarzadeh Khiabani, Pegah Mousavi, Behzad Baradaran
Summary: This review summarizes the role and potential efficacy of miRNAs in promoting and inhibiting cell proliferation and apoptosis in HCC, as well as the role of miRNAs in therapy resistance in HCC.
Article
Medicine, Research & Experimental
Maryam Tohidast, Neda Memari, Mohammad Amini, Seyed Samad Hosseini, Asiyeh Jebelli, Mohammad Amin Doustvandi, Behzad Baradaran, Ahad Mokhtarzadeh
Summary: This study demonstrates that the combination of miR-145 and paclitaxel can inhibit cell proliferation and migration in prostate cancer cells, and enhance chemosensitivity. This combination therapy may be a promising approach for the treatment of prostate cancer.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2023)
Review
Chemistry, Applied
Mandi Asghari Ozma, Masoud Lahouty, Amin Abbasi, Mohammad Ahangarzadeh Rezaee, Hossein Samadi Kafil, Mohammad Asgharzadeh
Summary: Tuberculosis is a global health-threatening disease, with different lineages of Mycobacterium tuberculosis having varying transmission rates and pathogenicity. Rapid diagnosis and timely treatment are crucial in controlling the disease.
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
