Article
Cardiac & Cardiovascular Systems
Samer Noaman, David M. Kaye, Shane Nanayakkara, Anthony M. Dart, Andy S. C. Yong, Martin Ng, Donna Vizi, Stephen J. Duffy, Nicholas Cox, William Chan
Summary: This study aimed to evaluate microcirculatory resistance (MR) and myocardial metabolic adaptations in patients with suspected coronary microvascular dysfunction (CMD) at rest and in response to increased cardiac workload. Microcirculatory assessment and transcardiac blood sampling were conducted during graded exercise with adenosine-mediated hyperaemia in patients with objective ischaemia and/or myocardial injury and non-obstructive coronary artery disease. The results showed that patients with suspected CMD exhibited distinct microcirculatory resistive and myocardial metabolic profiles at rest and in response to exercise.
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Article
Cardiac & Cardiovascular Systems
John F. Beltrame
Summary: Vasospastic angina is a chest pain caused by coronary artery spasm. It can be diagnosed and treated through established pathways, but it is often overlooked in patients presenting with chest pain, highlighting the need for increased clinical awareness.
Review
Cardiac & Cardiovascular Systems
Zaheer Alisiddiq, Harish Sharma, James Cotton, Lampson Fan
Summary: Coronary physiological measurements have revolutionized the treatment of coronary artery disease, allowing for more precise and tailored therapy. Pressure wire guided revascularization has proven to be effective in influencing clinical outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Tetsuji Morishita, Daisuke Takada, Jung-ho Shin, Susumu Kunisawa, Kiyohide Fushimi, Yuichi Imanaka
Summary: The revision of reimbursement policy in Japan in 2018 led to a significant reduction in elective PCI procedures per month, highlighting the importance of documenting ischaemia in patients with stable angina prior to the procedure.
Article
Medicine, General & Internal
Francesco Radico, Augusto Di Castelnuovo, Alberto Aimo, Marco Zimarino, Juhani Knuuti, Serena Rossi, Luigi Emilio Pastormerlo, Luc Zyw, Enrico Orsini, Licia Iacoviello, Danilo Neglia, Michele Emdin, Giovanni de Gaetano, Raffaele De Caterina
Summary: The prognosis of angina patients without obstructive coronary artery disease (CAD) is heterogeneous, with non-obstructive CAD and myocardial ischemia at imaging tests both conferring a higher risk of cardiovascular events.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Kristian Taekker Madsen, Karsten Tange Veien, Pia Larsen, Majed Husain, Lone Deibjerg, Anders Junker, Martin Weber Kusk, Kristian Korsgaard Thomsen, Allan Rohold, Lisette Okkels Jensen, Niels Peter Ronnow Sand
Summary: This study aimed to evaluate the association between CCTA-derived FFRCT and recurrent chest pain in patients with SAP. The results showed that an abnormal FFRCT test result was associated with an increased risk of recurrent chest pain, independent of coronary calcification and stenosis. Additionally, a negative association between per-patient minimal d-FFRCT and recurrent chest pain was demonstrated, highlighting the importance of FFRCT testing in predicting long-term outcomes for patients with SAP.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Yongwhan Lim, Min Chul Kim, Youngkeun Ahn, Kyung Hoon Cho, Doo Sun Sim, Young Joon Hong, Ju Han Kim, Myung Ho Jeong, Sang Hong Baek, Sung-Ho Her, Kwan Yong Lee, Seung Hwan Han, Seung-Woon Rha, Dong-Ju Choi, Hyeon-Cheol Gwon, Hyuck Moon Kwon, Tae-Hyun Yang, Keun-Ho Park, Sang-Ho Jo
Summary: This study investigated the prognostic impact of long-acting vasodilator therapy in patients with vasospastic angina. The results showed that the use of nitrate-based medications was associated with an increased risk of acute coronary syndrome within 2 years, especially in low-risk patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Review
Cardiac & Cardiovascular Systems
Bjarne L. Norgaard, Sara Gaur, Timothy A. Fairbairn, Pam S. Douglas, Jesper M. Jensen, Manesh R. Patel, Abdul R. Ihdayhid, Brian S. H. Ko, Stephanie L. Sellers, Jonathan Weir-McCall, Hitoshi Matsuo, Niels Peter R. Sand, Kristian A. Ovrehus, Campbell Rogers, Sarah Mullen, Koen Nieman, Erik Parner, Jonathon Leipsic, Jawdat Abdulla
Summary: In this study evaluating patients with stable CAD, a lower FFRCT value was associated with a higher risk of adverse outcomes. Negative FFRCT results were correlated with lower event rates within 12 months and a decreased risk compared to positive results.
Article
Cardiac & Cardiovascular Systems
Jules Mesnier, Gregory Ducrocq, Nicolas Danchin, Roberto Ferrari, Ian Ford, Jean-Claude Tardif, Michal Tendera, Kim M. Fox, Philippe Gabriel Steg
Summary: The study found that angina affects almost one-quarter of stable coronary artery disease patients, but resolves without events or coronary revascularization in most cases. Patients whose angina resolved within one year with conservative management had outcomes similar to those without angina, while persistence or occurrence of angina was associated with worse outcomes.
Review
Biochemistry & Molecular Biology
Chun Yeung Kei, Kuljit Singh, Rustem F. Dautov, Thanh H. Nguyen, Yuliy Y. Chirkov, John D. Horowitz
Summary: Until now, it was believed that stable angina pectoris (SAP) was caused by epicardial coronary artery stenoses due to atheromatous plaques, while acute myocardial infarction (AMI) resulted from thrombus formation on ruptured plaques. However, recent studies have challenged this concept by showing that angioplasty/stenting does not significantly relieve SAP symptoms or prevent AMI or death. These studies have focused on anomalies of small coronary physiology, where the microvasculature is often both structurally and physiologically abnormal.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Timothy Cartlidge, Mila Kovacevic, Eliano Pio Navarese, Gerald Werner, Vijay Kunadian
Summary: Contemporary randomised trials show no difference in all-cause mortality or myocardial infarction between patients with chronic coronary syndrome treated with conservative or invasive strategy. However, open-label trials consistently demonstrate greater improvement in symptoms and quality of life with PCI. It remains an important option for patients with favorable characteristics. Despite contentious evidence, elective PCI for CCS continues to play a significant role in UK clinical practice.
Review
Peripheral Vascular Disease
Daria Frestad Bechsgaard, Eva Prescott
Summary: Recent findings have shown that a significant proportion of patients with angina and no obstructive CAD suffer from CMD, which is associated with poor cardiovascular outcomes. Despite the feasibility and availability of non-invasive and invasive evaluation of coronary microvascular function, CMD remains underdiagnosed and undertreated. Patient-tailored treatment approaches guided by complete evaluation of epicardial anatomy and macro- and microvascular function may help improve symptom burden and quality of life outcomes. More research is needed to determine the long-term impact of these patient-tailored therapies on risk reduction in CMD.
CURRENT ATHEROSCLEROSIS REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Kerstin Welen Schef, Per Tornvall, Joakim Alfredsson, Emil Hagstrom, Annica Ravn-Fischer, Stefan Soderberg, Troels Yndigegn, Tomas Jernberg
Summary: The objective of this study was to assess the prevalence of angina pectoris symptoms and investigate their relationship with coronary atherosclerosis in a middle-aged general population. The results showed that angina symptoms were common among the general population of Sweden, but were not strongly associated with obstructive coronary atherosclerosis. Sociodemographic and psychological factors were found to be highly associated with angina symptoms, regardless of the degree of coronary atherosclerosis.
Article
Hematology
T. Gori
Summary: The coronary circulation is a complex system comprising the epicardial, microvascular, and venous districts. Understanding of coronary microvascular disease remains incomplete and specific therapy is lacking. The role of the coronary venous circulation is not well explored but may have potential in improving coronary perfusion.
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
(2021)
Review
Cardiac & Cardiovascular Systems
Divaka Perera, Colin Berry, Stephen P. Hoole, Aish Sinha, Haseeb Rahman, Paul D. Morris, Rajesh K. Kharbanda, Ricardo Petraco, Keith Channon
Summary: Nearly half of patients with angina have non-obstructive coronary artery disease (ANOCA), with two-thirds of these patients having coronary microvascular disease (CMD). Impaired coronary flow reserve (CFR) is associated with myocardial ischemia and adverse cardiovascular outcomes. The CMD workstream aims to improve accuracy of diagnosis and treatment through standardized procedures and various assessment methods.
Review
Cardiac & Cardiovascular Systems
Aletta E. Schutte, Tazeen H. Jafar, Neil R. Poulter, Albertino Damasceno, Nadia A. Khan, Peter M. Nilsson, Jafar Alsaid, Dinesh Neupane, Kazuomi Kario, Hind Beheiry, Sofie Brouwers, Dylan Burger, Fadi J. Charchar, Myeong Chan Cho, Tomasz J. Guzik, Ghazi F. Haji Al-Saedi, Muhammad Ishaq, Hiroshi Itoh, Erika S. W. Jones, Taskeen Khan, Yoshihiro Kokubo, Praew Kotruchin, Elizabeth Muxfeldt, Augustine Odili, Mansi Patil, Udaya Ralapanawa, Cesar A. Romero, Markus P. Schlaich, Abdulla Shehab, Ching Siew Mooi, U. Muscha Steckelings, George Stergiou, Rhian M. Touyz, Thomas Unger, Richard D. Wainford, Ji-Guang Wang, Bryan Williams, Brandi M. Wynne, Maciej Tomaszewski
Summary: Hypertension is the leading cause of preventable death globally, but there are significant challenges in its detection, treatment, and control, particularly in low-resource settings. Disparities based on resources, sociodemographic environment, and race contribute to the disproportionate burden of hypertension-related outcomes. Immediate action is needed to address these challenges and reduce inequities in hypertension care.
CARDIOVASCULAR RESEARCH
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Jaclyn Carberry, Daniel Ang, Colin Berry
Article
Cardiac & Cardiovascular Systems
Martha Gulati, Najah Khan, Maria George, Colin Berry, Alaide Chieffo, Paolo G. Camici, Filippo Crea, Juan-Carlos Kaski, Mario Marzilli, C. Noel Bairey Merz
Summary: This study investigated the impact of INOCA (Ischemia with No Obstructive Coronary Arteries) on the quality of life of patients and found that INOCA symptoms were associated with adverse physical, social, and mental health. The study calls for increased patient awareness, physician recognition and diagnosis, and clinical trials to develop evidence-based guidelines for this increasingly recognized cardiovascular disorder.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Leanne Mooney, Colette E. Jackson, Carly Adamson, Alex McConnachie, Paul Welsh, Rachel C. Myles, John J. V. McMurray, Pardeep S. Jhund, Mark C. Petrie, Ninian N. Lang
Summary: Circulating levels of interleukin-6 may identify patients at greater risk of adverse outcomes following hospitalization with heart failure with preserved ejection fraction.
CIRCULATION-HEART FAILURE
(2023)
Article
Peripheral Vascular Disease
Hannah E. Morris, Karla B. Neves, Margaret Nilsen, Augusto C. Montezano, Margaret R. MacLean, Rhian M. Touyz
Summary: This study found that Notch3 plays an important role in vascular diseases, particularly pulmonary arterial hypertension. It was discovered that increased activation of Notch3 leads to oxidative and endoplasmic reticulum stress, which in turn triggers redox signaling associated with procontractile pulmonary artery state, pulmonary vascular dysfunction, and the development of pulmonary arterial hypertension.
Editorial Material
Peripheral Vascular Disease
Livia L. Camargo, Rhian M. Touyz
Article
Neurosciences
Matthew Jamieson, Heather McClelland, Nicola Goudie, Jean McFarlane, Breda Cullen, Marilyn Lennon, Stephen Brewster, Bethany Stanley, Alex McConnachie, Jonathan Evans
Summary: Mobile phone reminding apps are useful for people with acquired brain injury to compensate for memory impairments. This pilot feasibility trial aimed to establish the feasibility of a randomized controlled trial comparing reminder apps in an ABI community treatment setting. The results showed that most participants could learn to use the apps and a larger trial would require 72 participants.
NEUROPSYCHOLOGICAL REHABILITATION
(2023)
Article
Cardiac & Cardiovascular Systems
Hajime Nagasawa, Hidehiro Kaneko, Yuta Suzuki, Akira Okada, Katsuhito Fujiu, Norifumi Takeda, Hiroyuki Morita, Akira Nishiyama, Yuichiro Yano, Koichi Node, Anthony J. Viera, Robert M. Carey, Suzanne Oparil, Hideo Yasunaga, Rhian M. Touyz, Issei Komuro
Summary: This study found that patients with a history of cancer have a higher risk of developing hypertension, including those receiving active antineoplastic therapy and those not receiving it. The risk of developing hypertension varies among different types of cancer.
EUROPEAN HEART JOURNAL-QUALITY OF CARE AND CLINICAL OUTCOMES
(2023)
Article
Medicine, General & Internal
Jesse Dawson, Michele Robertson, David Alexander Dickie, Phillip Bath, Kirsten Forbes, Terence Quinn, Niall M. Broom, Krishna Dani, Alex Doney, Graeme Houston, Kennedy R. Lees, Keith W. Muir, Allan Struthers, Matthew Walters, Mark Barber, Ajay Bhalla, Alan Cameron, Alexander Dyker, Paul Guyler, Ahamad Hassan, Mark T. Kearney, Breffni Keegan, Sekaran Lakshmanan, Mary Joan Macleod, Marc Randall, Louise Shaw, Ganesh Subramanian, David Werring, Alex McConnachie
Summary: This study investigated whether allopurinol could reduce the progression of white matter hyperintensity (WMH) and blood pressure after an ischaemic stroke or transient ischaemic attack (TIA). The results showed that allopurinol had no significant effect on the progression of WMH and blood pressure.
Article
Cardiac & Cardiovascular Systems
Kenneth Mangion, Andrew J. Morrow, Robert Sykes, Anna Kamdar, Catherine Bagot, George Bruce, Paul Connelly, Christian Delles, Vivienne B. Gibson, Lynsey Gillespie, Pauline Hall Barriento, Vera Lennie, Giles Roditi, Naveed Sattar, David Stobo, Sarah Allwood-Spiers, Alex McConnachie, Colin Berry
Summary: A study found sex differences in myocardial inflammation in female post-COVID-19 patients, who also reported worse outcomes at index admission and 28-60 days follow-up, although they had lower rates of cardiovascular hospitalization.
BMC CARDIOVASCULAR DISORDERS
(2023)
Review
Cardiac & Cardiovascular Systems
Francisco J. Rios, Augusto C. Montezano, Livia L. Camargo, Rhian M. Touyz
Summary: This article discusses the impact of environmental factors on hypertension and highlights the interconnectedness of these factors and the importance of socioeconomic factors.
CANADIAN JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Jessica Artico, Hunain Shiwani, James C. Moon, Miroslawa Gorecka, Gerry P. McCann, Giles Roditi, Andrew Morrow, Kenneth Mangion, Elena Lukaschuk, Mayooran Shanmuganathan, Christopher A. Miller, Amedeo Chiribiri, Sanjay K. Prasad, Robert D. Adam, Trisha Singh, Chiara Bucciarelli-Ducci, Dana Dawson, Daniel Knight, Marianna Fontana, Charlotte Manisty, Thomas A. Treibel, Eylem Levelt, Ranjit Arnold, Peter W. Macfarlane, Robin Young, Alex McConnachie, Stefan Neubauer, Stefan K. Piechnik, Rhodri H. Davies, Vanessa M. Ferreira, Marc R. Dweck, Colin Berry, John P. Greenwood
Summary: This study aimed to assess the presence, nature, and extent of myocardial damage in hospitalized patients with troponin elevation and COVID-19. The study found that patients with COVID-19 and elevated cardiac troponin levels had more ventricular impairment and myocardial scar compared to the control group. However, the proportion of myocarditis was low and scar pathogenesis was diverse.
Article
Rheumatology
L. Paul, M. T. Mcdonald, A. Mcconnachie, S. Siebert, E. H. Coulter
Summary: This study investigated the adherence and effects of an online physiotherapy program on individuals with axial spondyloarthritis (axSpA), as well as the factors influencing adherence. The study found that adherence decreased over the intervention period, and there was no association between adherence and baseline variables or demographics. Interviews revealed that support from others, routine, and perceived benefits positively influenced adherence, while lack of motivation, life events, and symptoms negatively affected adherence.
RHEUMATOLOGY INTERNATIONAL
(2023)
