Review
Chemistry, Multidisciplinary
Caiyan Zhao, Xiaoyu Pang, Zuo Yang, Sheng Wang, Hongzhang Deng, Xiaoyuan Chen
Summary: TAMs are key players in tumor progression and can be modulated using nanotechnology-based strategies, such as inhibiting their recruitment, depleting M2-polarized macrophages, and reprogramming them into M1-polarized macrophages. Nanoparticles can also be used to image TAMs for novel treatment options and therapy monitoring.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Oncology
Shuo Wang, Haiyang Jiang, Caiwei Zheng, Ming Gu, Xinyu Zheng
Summary: In this study, the role of tumor-associated macrophages (TAMs) in promoting breast cancer microcalcifications by secreting bone morphogenetic protein 2 (BMP-2) was elucidated. It was found that the presence of microcalcifications was significantly associated with the increased expression of CD168 and BMP-2, as well as poor prognosis. These findings suggest that TAMs contribute to the formation of microcalcifications in breast cancer cells through multiple pathways involving BMP-2 and its downstream factors.
Review
Endocrinology & Metabolism
Zhenxing Wu, Qingqing Xia, Huifeng Huang
Summary: This article reviews the research progress on gastric cancer and tumor-associated macrophages (TAMs). It introduces the definition, classification, and pathogenesis of gastric cancer, as well as the definition, origin, differentiation, and function of TAMs. It discusses the role of TAMs in the development of gastric cancer, their interaction with the tumor microenvironment, and the mechanisms affecting gastric cancer development and progression. The article also summarizes the role of TAMs as targets for the treatment of gastric cancer, including advances in gastric cancer treatment, immunotherapy, and targeted therapy. Future research directions are proposed, including studying the regulatory mechanisms of TAMs, exploring TAMs heterogeneity, investigating the diagnostic and predictive value of TAMs, and developing and optimizing treatment strategies targeting TAMs.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Oncology
Zidi Zhou, Zhilong Yang, Jingzhi Wang, Qiang Wang, Heng Zhang, Xiaoli Ju
Summary: Tumour-associated macrophages (TAMs) play a crucial role in gastric cancer, with their quantity predicting disease progression and metastasis, significantly impacting the treatment and prognosis of patients with gastric cancer.
Article
Oncology
Daniel C. Rabe, Nykia D. Walker, Felicia D. Rustandy, Jessica Wallace, Jiyoung Lee, Shannon L. Stott, Marsha Rich Rosner
Summary: TNBC is a subtype of breast cancer lacking ER, PR, and HER2 receptors. Tumors are infiltrated by TAMs promoting tumorigenesis. Study shows how tumors recruit macrophages through EVs, altering macrophage phenotype and driving metastasis. EVs could serve as biomarkers and play a role in modulating tumor immune response.
Review
Oncology
Shunyao Zhu, Ziyi Luo, Xixi Li, Xi Han, Senlin Shi, Ting Zhang
Summary: Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment by secreting various factors that influence tumor growth and development. Different phenotypes of TAMs have distinct effects on tumors, making them an important target in tumor immunotherapy.
Review
Immunology
Guoqing Wang, Kunhong Zhong, Zeng Wang, Zongliang Zhang, Xin Tang, Aiping Tong, Liangxue Zhou
Summary: This review discusses the characteristics and functions of TAMs in GBM, and evaluates the current state of TAMs-targeting strategies. TAMs are logical therapeutic targets for GBM, and understanding how TAMs promote GBM progression is of great significance for new immune therapeutic approaches for GBM patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aydar Khabipov, Dung Nguyen Trung, Julia van der Linde, Lea Miebach, Maik Lenz, Felix Erne, Wolfram von Bernstorff, Tobias Schulze, Stephan Kersting, Sander Bekeschus, Lars Ivo Partecke
Summary: Pancreatic cancer is characterized by a tumor microenvironment rich in stromal and immune cells that support cancer growth and resistance to therapy. Tumor-associated macrophages (TAMs), specifically, have properties that promote angiogenesis and metastasis, leading to the failure of conventional therapies. This study explores the effects of blocking the C-C chemokine receptor type 4 (CCR4) in pancreatic cancer-bearing mice through genetic or immunotherapeutic methods. The results show that CCR4 is critical for TAM generation and tumor progression in pancreatic cancer, and blockade of CCR4 may improve prognosis and extend the relapse-free period after curative surgery.
Article
Biochemistry & Molecular Biology
Wenhao Xu, Yuhao Wu, Wangrui Liu, Aihetaimujiang Anwaier, Xi Tian, Jiaqi Su, Haineng Huang, Gaomeng Wei, Yuanyuan Qu, Hailiang Zhang, Dingwei Ye
Summary: This study first revealed the predictive value of chemokine CCL5 in the progression and tumor microenvironment of ccRCC. Different prognostic clusters and immune phenotypes associated with CCL5 expression were identified, providing new strategies for the treatment of ccRCC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Xinping Luo, Dehong Hu, Duyang Gao, Yuenan Wang, Xinhua Chen, Xin Liu, Hairong Zheng, Minjie Sun, Zonghai Sheng
Summary: The study focused on developing metabolizable DN-ICG nanoprobes for dynamic imaging of TAMs in pancreatic cancer, showing high biocompatibility and degradability.
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: This review examines the effects of the tumor microenvironment and cancer stem cells on the progression and therapy resistance of gastric cancer, highlighting the potential for developing successful anti-tumor therapy by targeting the tumor microenvironment and cancer stem cells.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
Ruoyu Mu, Zhe Zhang, Congwei Han, Yiming Niu, Zhen Xing, Zhencheng Liao, Jinzhi Xu, Ningyi Shao, Guokai Chen, Junfeng Zhang, Lei Dong, Chunming Wang
Summary: Nonhealing diabetic wounds can be effectively healed by training macrophages to mimic the reparative functions of tumor-associated macrophages (TAMs), which produce immunosuppressive and proliferative factors. These TAM-educated macrophages (TAMEMs) outperform other macrophage phenotypes in reducing inflammation, promoting angiogenesis, and activating fibroblasts. A nine-factor cocktail has also been developed to train human primary monocytes into TAMEMs, enabling the preparation of safer and autologous cells. This study demonstrates the potential of recapitulating TAMs' reparative activities in non-tumor cells for regenerative medicine.
EMBO MOLECULAR MEDICINE
(2023)
Review
Oncology
Xinqun Huang, Jingsong Cao, Xuyu Zu
Summary: In breast cancer, tumor-associated macrophages (TAMs) play a crucial role in promoting tumor growth through various mechanisms, but can promote tumor regression by repolarizing into M1 macrophages. TAMs are established as effective targets for breast cancer treatment.
Review
Immunology
Zhen Li, Qijun Yu, Qingyuan Zhu, Xiaojing Yang, Zhaobin Li, Jie Fu
Summary: The evaluation of tumor-host interaction and intratumoral heterogeneity in the tumor microenvironment (TME) is gaining attention in cancer therapies. Machine learning algorithms are increasingly being used to analyze TAMs, leading to a better understanding of their role in tumor biology and potential applications in tumor diagnosis, treatment stratification, and survival predictions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Karim Rihawi, Angela Dalia Ricci, Alessandro Rizzo, Stefano Brocchi, Giovanni Marasco, Luigi Vincenzo Pastore, Fabiola Lorena Rojas Llimpe, Rita Golfieri, Matteo Renzulli
Summary: Gastric cancer is the fifth most commonly diagnosed cancer worldwide, with poor prognosis in advanced stage patients despite improvements in treatment. Research efforts have focused on identifying novel therapeutic targets, with the tumor microenvironment emerging as a potential target. Various agents and strategies targeting the TME are currently being evaluated in preclinical and clinical studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)