Article
Food Science & Technology
Jialong Li, Jing Chen, Ping Huang, Zizhe Cai, Ning Zhang, Yong Wang, Ying Li
Summary: Flaxseed linusorbs (FLs), cyclic peptides derived from flaxseed oils, have been found to have anti-cancer, antibacterial, and anti-inflammatory effects. This study discovered that FLs suppress the NF-kappa B/MAPK signaling pathways by targeting TLR4, leading to the inhibition of inflammatory cytokines and mediator proteins. In silico data and HPLC results indicate that FLA and FLE are the major anti-inflammatory monomers in FLs. These findings suggest that FLs derived from food sources could be used as natural anti-inflammatory supplements in daily diet.
Article
Oncology
Hossein Nemati, Masoumeh Fakhre-Taha, Amir-Reza Javanmard, Amin Jahanbakhshi, Seyed Javad Mowla, Bahram M. Soltani
Summary: The study identified that LINC02381 exerts oncogenic effects in glioma cells by sponging miR-128 and miR-150, highlighting their potential as therapeutic targets.
JOURNAL OF NEURO-ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Nevena Gajovic, Sofija Sekulic Markovic, Milena Jurisevic, Marina Jovanovic, Nebojsa Arsenijevic, Zeljko Mijailovic, Marina Jovanovic, Ivan Jovanovic
Summary: Gal-3 is associated with COVID-19 severity and immune response. Patients in critical stage have higher levels of Gal-3, cytokines, and CCR5 expression, indicating more severe inflammation. Gal-3 also correlates with clinical and radiographic findings, as well as peripheral blood immune cell composition.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Huiyuan Yu, Fan Yang, Wentao Zhong, Xin Jiang, Fan Zhang, Xueying Ji, Mengjuan Xue, Yixuan Qiu, Jiaming Yu, Xiaona Hu, Jie Chen, Zhijun Bao
Summary: Galectin-3 plays a crucial role in the early pathogenesis of NAFLD by promoting hepatic steatosis through increased fatty acid uptake. Inhibition of Gal3 can reduce the occurrence of fatty liver, suggesting that targeting Gal3 may be a potential therapeutic approach for the treatment of NAFLD.
CELLULAR SIGNALLING
(2021)
Article
Oncology
Shumei Kato, Robert Porter, Ryosuke Okamura, Suzanna Lee, Ori Zelichov, Gabi Tarcic, Michael Vidne, Razelle Kurzrock
Summary: The study found that patients with tumors harboring RAS alterations with high MAPK activity had significantly longer median progression-free survival (PFS) and overall survival when treated with MEK inhibitors. This correlation between RAS-mutant cancers with greater MAPK signaling and PFS suggests potential clinical benefit of MEK inhibitor treatment.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Oncology
Vid Mlakar, Edouard Morel, Simona Jurkovic Mlakar, Marc Ansari, Fabienne Gumy-Pause
Summary: This review compiles the latest evidence of the involvement of the RAS-MAPK pathway in neuroblastoma, discussing its general functioning, clinical implications of its deregulation in neuroblastoma, and current promising therapeutics targeting proteins involved in signaling.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jun Zhang, Xinqiong Liu, Yali Gao
Summary: MEG3 is expressed at low levels in embryonic villi of URSA patients, promoting cell proliferation and invasion while inhibiting apoptosis, and enhancing mouse embryo implantation. By mediating the histone methylation of the RASA1 gene promoter, MEG3 activates the RAS-MAPK pathway to enhance trophoblast proliferative and invasive capacities.
MOLECULAR MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Selena Bouffette, Iuliana Botez, Frederic De Ceuninck
Summary: This article reviews the key role of Galectin-3 (Gal-3) in cardiac, hepatic, renal, and pulmonary fibrosis and inflammation, respiratory infections caused by COVID-19, and neuroinflammatory disorders. The recent strategic breakthroughs have led to the identification of new-generation Gal-3 inhibitors with improved potency, selectivity, and bioavailability, which have shown promise as valuable tools in proof-of-concept studies in preclinical models of these diseases, particularly those in clinical stages. Critical views and suggestions to expand the therapeutic opportunities provided by this complex target are also discussed.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2023)
Article
Oncology
Jiejun Hu, Dong Cai, Zhibo Zhao, Guo-Chao Zhong, Jianping Gong
Summary: HNRNPC plays a role in promoting proliferation, migration, and invasion of HCC cells, potentially through the Ras/MAPK signaling pathway. Therefore, HNRNPC may have a significant role in the progression of HCC and represents a promising biomarker for prognosis evaluation and a potential therapeutic target.
FRONTIERS IN ONCOLOGY
(2021)
Article
Environmental Sciences
Mengmeng Yang, Xuhong Chang, Qing Gao, Xuefeng Gong, Jinfa Zheng, Han Liu, Kun Li, Haibing Zhan, Xiaoxia Wang, Sheng Li, Xingchang Sun, Sanwei Feng, Yingbiao Sun
Summary: This study found that nickel oxide nanoparticles (NiO NPs) can cause lung inflammatory damage, and over-expression of lncRNA MEG3 can reduce this damage by preventing the activation of the p38 MAPK pathway.
ENVIRONMENTAL TOXICOLOGY
(2022)
Review
Immunology
Sagar Paudel, Laxman Ghimire, Liliang Jin, Duane Jeansonne, Samithamby Jeyaseelan
Summary: This article summarizes the mechanisms of how the hematopoietic system increases neutrophil generation rapidly during acute infectious and inflammatory conditions. Recent studies have identified new concepts, including the direct sensing of pathogens by BM resident or sentinel hematopoietic stem and progenitor cells, the crosstalk between hematopoietic stem and progenitor cells, endothelial cells, and stromal cells, and the direct effects of newly discovered inflammatory molecules on hematopoietic stem and progenitor cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stephen J. Harwood, Christopher R. Smith, J. David Lawson, John M. Ketcham
Summary: This review focuses on recent strategies to inhibit RAS-signaling by disrupting protein-protein interactions (PPIs) associated with SOS1, RAF, PDE delta, Grb2, and RAS, in hopes to provide therapies for patients with KRAS-mutant driven cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nathan Harmston, Jun Yi Stanley Lim, Oriol Arques, Hector G. Palmer, Enrico Petretto, David M. Virshup, Babita Madan
Summary: Aberrant Wnt signaling in cancer drives both widespread gene repression and activation, promoting cancer cell proliferation. Inhibiting Wnt signaling leads to increased gene expression through activation of the ERK and JNK pathways.
Article
Biochemistry & Molecular Biology
Shaoyu Li, Yuejie Zhu, Song Wang, Yujiao Li, Nannan Pang, Mengting An, Fengbo Zhang, Jianbing Ding
Summary: This study investigated the role of Tim-3/Galectin-9 in persistent infection of Echinococcus multilocularis (Em) and found that this signaling pathway may be involved in the development of Em infection by regulating the production of Th1 and Th2 cytokines.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pharmacology & Pharmacy
Jianping Xiao, Deguang Wang
Summary: The contribution of long noncoding RNA-GAS5 in the pathogenesis of systemic lupus erythematosus (SLE) was investigated. It was found that the expression of GAS5 was significantly decreased in peripheral monocytes of SLE patients compared to healthy individuals. GAS5 was shown to inhibit monocyte proliferation and promote apoptosis. The study also revealed the involvement of GAS5 in the TLR4-mediated inflammatory process through the MAPK signaling pathway.
CURRENT PHARMACEUTICAL DESIGN
(2023)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)
