Article
Oncology
Hongliang Liao, Yaqin Liang, Lin Kang, Yun Xiao, Tao Yu, Renping Wan
Summary: Accumulating studies have suggested the significant role of microRNAs (miRs) in the development and progression of lung cancer, particularly in non-small cell lung cancer (NSCLC). This study investigated the association between miR-454-3p and NSCLC progression and found that miR-454-3p suppressed NSCLC cell proliferation and metastasis by targeting TGFB2, suggesting it as a promising strategy for treating NSCLC.
Article
Biotechnology & Applied Microbiology
Yunfei Wang, Xiaobo Li, Huaqi Wang, Guojun Zhang
Summary: This study reveals a novel mechanism involving circCAMSAP1/miR-1182/BIRC5 axis that promotes the progression of non-small cell lung cancer (NSCLC).
Article
Oncology
Shangbiao Li, Simiao Qiao, Na Li, Xiaoxia Zhu
Summary: MiR-744 plays a key role in the development of non-small cell lung cancer (NSCLC) by up-regulating c-Fos through binding to its promoter, thereby promoting the malignant phenotype of the disease. The findings highlight the potential value of miR-744 as a therapeutic target for NSCLC.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Cell Biology
Li Ding, Yinan Feng, Longguang Li
Summary: This study elucidates the role of circular RNA 0001955 (circ_0001955) in the proliferation and apoptosis of non-small cell lung cancer (NSCLC) cells and its underlying mechanism. The results demonstrate that circ_0001955 is up-regulated in NSCLC tissues and cells, and its overexpression is associated with advanced tumor stage and lymph node metastasis. Overexpression of circ_0001955 enhances cell proliferation and inhibits apoptosis in NSCLC cells, while knockdown of circ_0001955 has the opposite effects. Circ_0001955 directly targets miR-769-5p and negatively regulates its expression. Furthermore, EGFR, a target gene of miR-769-5p, can be indirectly and positively regulated by circ_0001955. Correlation analysis reveals a negative correlation between circ_0001955 and miR-769-5p expression, while circ_0001955 is positively correlated with EGFR expression. Circ_0001955 promotes NSCLC cell proliferation and inhibits apoptosis by modulating the miR-769-5p/EGFR axis.
Article
Multidisciplinary Sciences
Fatemeh Dodangeh, Zahra Sadeghi, Parichehr Maleki, Jamshid Raheb
Summary: This study demonstrates that long non-coding RNA SOX2 overlapping transcript (SOX2-OT) plays an oncogenic role in lung cancer by regulating the miR-122-3p/FOXO1 and miR-194-5p/FOXA1 pathways, affecting the biological behaviors of lung cancer cells.
SCIENTIFIC REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Bing Wang, Fang Lv, Fang Li, Kun Yang, Liang Zhao, Yushun Gao
Summary: The study investigated the expression of POU5F1B in NSCLC patients' serum, tissues, and cell lines and revealed its potential role in NSCLC pathogenesis. POU5F1B expression was found to be significantly increased in NSCLC serum, cancer tissues with lymph node metastasis, and lung cancer cell lines. It was associated with TNM stage, smoking, and lymph node metastasis, and also served as an independent risk factor affecting NSCLC prognosis. Knockdown of POU5F1B reduced lung cancer cell proliferation and increased apoptosis, implying its role in promoting NSCLC development.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Oncology
Miao Li, Yan Rui, Wenjia Peng, Junfeng Hu, Anbang Jiang, Zeyu Yang, Linian Huang
Summary: This study investigated a novel molecular therapeutic target, FIGNL1, for lung cancer and found that its high expression was associated with decreased function and enhanced cell death in lung cancer cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ming Li, Yannan Liu, Xinglin Jiang, Yuanxin Hang, Haiying Wang, Hang Liu, Zhuo Chen, Yubo Xiao
Summary: miR-144-3p inhibits CEP55 expression in non-small cell lung cancer cells, leading to suppression of cell proliferation and migration, and promotion of apoptosis.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2021)
Article
Medicine, Research & Experimental
Ri Chen, Chunfan Zhang, Yuanda Cheng, Shaoqiang Wang, Hang Lin, Heng Zhang
Summary: The long non-coding RNA UCC acts as a competing endogenous RNA of miR-143-3p and upregulates SOX5 by absorbing miR-143-3p, resulting in proliferation and migration of non-small-cell lung cancer (NSCLC) cells both in vitro and in vivo. UCC enhances carcinogenesis of NSCLC cells via the miR-143-3p/SOX5 axis, which may function as a novel target for NSCLC treatment.
LABORATORY INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Zhihua Teng, Jie Yao, Ling Zhu, Lufeng Zhao, Gang Chen
Summary: This study revealed that ZNF655 is abundantly expressed in NSCLC, and its knockdown can inhibit the malignant behaviors of tumor cells, leading to decreased tumorigenesis. ZNF655 may regulate apoptosis of NSCLC cells through the PI3K/Akt and p53 signaling pathways.
Article
Biochemistry & Molecular Biology
Weiwei Chen, Fei Wang, Xinyuan Yu, Jingjing Qi, Hongliang Dong, Bingjie Cui, Qian Zhang, Yan Wu, Jiajia An, Na Ni, Cuilan Liu, Yuchen Han, Shuo Zhang, Clemens A. Schmitt, Jiong Deng, Yong Yu, Jing Du
Summary: Non-coding RNA plays a crucial role in oncogenesis and stemness development in various cancers, including lung cancer. MIR31HG, a lncRNA, is significantly upregulated in lung cancer tissues and peripheral sera of patients, indicating a poor prognosis. Mechanistically, MIR31HG promotes stemness-associated malignant features of non-small cell lung cancer cells by modulating GLI2 expression via H3K4me and H3K27Ace modifications mediated by the WDR5/MLL3/P300 complex. In vivo studies showed that repression of MIR31HG attenuated tumor growth and distal organ metastasis, while its promotion encouraged cellular invasion in lung and liver tissues. Hence, MIR31HG has the potential to serve as a diagnostic indicator and therapeutic target for lung cancer patients.
Article
Cell Biology
Changhui Li, Jiaqi Zhang, Xiaohua Yang, Cheng Hu, Tianqing Chu, Runbo Zhong, Yinchen Shen, Fang Hu, Feng Pan, Jianlin Xu, Jun Lu, Xiaoxuan Zheng, Hai Zhang, Wei Nie, Baohui Han, Xueyan Zhang
Summary: The study has demonstrated the significant role of hsa_circ_0003222 in NSCLC progression and resistance, with its high expression associated with disease stage, metastasis, and patient survival rate. Silencing hsa_circ_0003222 led to reduced stemness-like properties and chemoresistance in tumor cells.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Qing Ye, Rehab Mohamed, Duaa Dakhlallah, Marieta Gencheva, Gangqing Hu, Martin C. Pearce, Siva Kumar Kolluri, Clay B. Marsh, Timothy D. Eubank, Alexey V. Ivanov, Nancy Lan Guo
Summary: This study demonstrated that high expression of ZNF71 KRAB is associated with poor survival outcomes in NSCLC patients, as well as with epithelial-to-mesenchymal transition and chemotherapy resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Lanwei Ouyang, Min Yang, Xiaolin Wang, Jidan Fan, Xing Liu, Yong Zhang, Yusheng Shu
Summary: The study revealed that FER1L4 is significantly downregulated in NSCLC plasma, tissues, and lung cancer cell lines. Overexpression of FER1L4 led to a decrease in cell proliferation, migration, and invasion. FER1L4 promoted PTEN and p53 expression, inhibited AKT phosphorylation, and increased the proportion of apoptotic cells, suggesting it may serve as a novel potential therapeutic target for NSCLC.
Article
Pathology
Changqing Dong, Hui Cao, Zhengcheng Liu, Lei Xi, Ye Shi, Rusong Yang
Summary: The study reveals that CHML is an oncogene in NSCLC, promoting the proliferation and inhibiting apoptosis of NSCLC cells through binding to Rab5A. miR-199a3p targets CHML in this cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2021)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)