Article
Engineering, Biomedical
Xiaoxue Xie, Yi Feng, Hanxi Zhang, Qingqing Su, Ting Song, Geng Yang, Ningxi Li, Xiaodan Wei, Tingting Li, Xiang Qin, Shun Li, Chunhui Wu, Xiaojuan Zhang, Guixue Wang, Yiyao Liu, Hong Yang
Summary: This study reported a tumor acidity-responsive nanovaccine that can remodel the immunosuppressive tumor microenvironment, enhance recruitment of tumor infiltrating lymphocytes, improve antigen presentation and drug transportation efficiency, leading to tumor growth inhibition and long-term tumor inhibition.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Yixuan Guo, Yu Liu, Wei Wu, Daishun Ling, Qiao Zhang, Peng Zhao, Xi Hu
Summary: This article will discuss different types of IDO inhibitors and relevant clinical trials, especially feasible combined therapeutic modalities. In addition, it will also review cutting-edge nanomedicines that combine IDO inhibitors with other therapeutic modalities to effectively enhance the effectiveness of cancer therapy. Finally, the prospects of IDO inhibitors in clinical application and potential breakthroughs will be briefly discussed.
Article
Engineering, Environmental
Wen Li, Tiantian Ma, Tian He, Yang Li, Shouchun Yin
Summary: This study proposed a biomimetic nanoparticle loaded with indocyanine green (ICG) and NLG919 to enhance tumor immunogenicity through photothermal effect. The nanoparticle can also increase infiltration of cytotoxic T lymphocytes, inhibit IDO-1 enzyme activity, and prevent distant tumor metastasis. It provides long-term immune memory effect and prevents tumor recurrence.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Oncology
Yu Fujiwara, Shumei Kato, Mary K. Nesline, Jeffrey M. Conroy, Paul DePietro, Sarabjot Pabla, Razelle Kurzrock
Summary: Strategies to overcome immunosuppression in the tumor microenvironment, such as IDO1 inhibition, have been explored to address resistance to immune checkpoint blockade. These strategies have shown promising results in preclinical studies and early-phase clinical trials. However, some clinical trials have yielded disappointing results, dampening enthusiasm for IDO inhibitors. Additional potential targets, such as the aryl hydrocarbon receptor and tryptophan 2,3-dioxygenase, have been proposed to enhance clinical effectiveness. The expression level of IDO1 varies among tumors and patients, highlighting the importance of patient selection based on IDO1 expression levels in clinical trials.
CANCER TREATMENT REVIEWS
(2022)
Correction
Materials Science, Biomaterials
Qi Su, Changrong Wang, Huijuan Song, Chuangnian Zhang, Jinjian Liu, Pingsheng Huang, Yumin Zhang, Jianhua Zhang, Weiwei Wang
Summary: The study discusses the use of self-assembled cationic liposomes for co-delivering anionic epitope/CpG vaccine and IDO inhibitor, demonstrating their potential application in combination melanoma immunotherapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biotechnology & Applied Microbiology
Xueyuan Yang, Weizhong Zhang, Wen Jiang, Anil Kumar, Shiyi Zhou, Zhengwei Cao, Shuyue Zhan, Wei Yang, Rui Liu, Yong Teng, Jin Xie
Summary: The study introduces a composite nanoparticle that can co-deliver a photosensitizer and an IDO inhibitor, showing significantly improved tumor suppression and animal survival in vivo. The treatment increases tumor infiltration of CD8(+) T cells while decreasing the frequencies of MDSCs and Tregs, highlighting the potential for combination therapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Solangy Lizcano-Meneses, Rogelio Hernandez-Pando, Ian Garcia-Aguirre, Jose Bonilla-Delgado, Victor Manuel Alvarado-Castro, Bulmaro Cisneros, Patricio Gariglio, Enoc Mariano Cortes-Malagon
Summary: This study investigated the potential role of inhibiting IDO-1 and CXCR-2 on cervical cancer treatment using the K14E7E2 mouse model. The results showed that combined inhibition of IDO-1 and CXCR-2 can significantly reduce tumor size, decrease inflammation, and increase the number of CD8 T cells within the tumor.
Article
Polymer Science
Junfeng Ding, Tianran Wang, Zhixiong Chen, Zhiqiang Lin, Xuesi Chen, Chaoliang He
Summary: In this study, a local chemo-immunotherapy system was developed to improve the immunosuppressive tumor microenvironment and enhance the anti-tumor efficacy. The system achieved sustained release of a chemotherapeutic drug and an immune checkpoint blocking antibody, leading to immunogenic cell death of tumor cells and activation of dendritic cells. Animal experiments showed significant tumor inhibition and prolonged survival time with this system.
JOURNAL OF POLYMER SCIENCE
(2022)
Article
Engineering, Environmental
Ali Chen, Ni Yang, Wei Zhang, Rongrong Zheng, Rui Yu, Renjing Kong, Yuqing Wang, Hong Cheng, Xiyong Yu, Shiying Li
Summary: The ternary biomedicine CNS constructed through self-assembly can induce pyroptosis through photodynamic therapy, activate immune responses, and improve the immunosuppressive microenvironment through indoleamine 2,3-dioxygenase inhibition, thereby enhancing immunotherapy effectiveness.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Ji Li, Ming Zhao, Yunhua Xu, Xiaoyun Hu, Yinghui Dai, Dongkai Wang
Summary: This study demonstrated the potential of hybrid micelles delivering SK and siIDO1 in enhancing immune response, inducing immunogenic cell death, and moderating immunosuppression for tumor therapy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Nanoscience & Nanotechnology
Qingfei Zhang, Gaizhen Kuang, Yunru Yu, Xiaoya Ding, Haozhen Ren, Weijian Sun, Yuanjin Zhao
Summary: Research has shown that using novel hierarchical hydrogel microparticles (M-DDP) to deliver drugs can release them at the tumor site, reducing systemic toxicity. This approach not only induces immunogenic cell death in tumor cells, but also suppresses immunosuppressive cells within the tumor. These hierarchical microparticles exhibit superior synergistic antitumor efficacy in cell experiments.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Medicine, Research & Experimental
Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Valerio Nardone, Salvatore Cappabianca, Immacolata Cozzolino, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren Averett Byers, Fortunato Ciardiello, Floriana Morgillo
Summary: The combined inhibition of MEK and PD-L1 shows significant synergistic effect in immune-dependent cancer cell death in non-small cell lung cancer (NSCLC), but may lead to the activation of the Ido-1 pathway as an escape mechanism.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Chemistry, Medicinal
Kunshan Huang, Meiqi Yan, Han Zhang, Jinping Xue, Juanjuan Chen
Summary: In this study, indoximod, an inhibitor of indoleamine 2,3-dioxygenase (IDO), was introduced to concatenate with zinc phthalocyanines (ZnPc), effectively improving the intracellular uptake and reactive oxygen species (ROS) generation of the photosensitizer 1-MT-Pc. It showed remarkable photocytotoxicity towards TNBC cells and negligible damage to normal cells, effectively inhibited the metastasis and invasion of TNBC cells, and exhibited elevated inhibitory effect on 4T1 tumor by enhanced PDT and immunotherapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Hongmei Liu, Huan Gao, Cheng Chen, Wenyu Jia, Delong Xu, Guan Jiang
Summary: In this study, a molecule called GM composed of IDO inhibitor 1MT and gallic acid GA was synthesized and found to have therapeutic effects on B16F10 melanoma cells and a mouse model. GM increased the solubility of 1MT, enhanced drug efficacy, and inhibited melanoma growth while regulating immune response.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Peng Liu, Jianzhou Chen, Liwei Zhao, Antoine Hollebecque, Oliver Kepp, Laurence Zitvogel, Guido Kroemer
Summary: Preclinical experimentation revealed that established cancers treated with oxaliplatin sensitize to PD-1 immune checkpoint inhibitors, while no such effect is observed with cisplatin. Clinical trials targeting gastric and gastro-esophageal junction carcinomas validated this observation. Therefore, choosing appropriate ICD-inducing cytotoxicants is crucial for chemoimmunotherapeutic regimens.
Article
Pharmacology & Pharmacy
Greta Camilla Magnano, Marika Quadri, Elisabetta Palazzo, Roberta Lotti, Francesca Loschi, Stefano Dall'Acqua, Michela Abrami, Francesca Larese Filon, Alessandra Marconi, Dritan Hasa
Summary: This study aimed to investigate the loading of sildenafil citrate in three commercial transdermal vehicles using 3D full-thickness skin equivalent and compare the results with permeability experiments using porcine skin. The results showed that the results obtained using the 3D skin equivalent were comparable to those obtained using porcine skin, suggesting that the 3D skin model can be a valid alternative for ex-vivo skin absorption experiments.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
Article
Pharmacology & Pharmacy
James W. Mckeage, Andrew Z. H. Tan, Andrew J. Taberner
Summary: Needle-free jet injection is a promising alternative drug delivery technique that offers rapid, non-invasive, and large-volume injections. The study presents a prototype multi-orifice nozzle and a computational fluid dynamic model to demonstrate the feasibility and effectiveness of this technology.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2024)
