Article
Nanoscience & Nanotechnology
Ning Duan, Li Mei, Liting Hu, Xiaoni Yin, Xiangyang Wei, Ying Li, Qinghua Li, Guiqiu Zhao, Qihui Zhou, Zhaodong Du
Summary: A hydrogel intravitreal drug delivery system (DDS) named HP@Ran was developed for sustained release of ranibizumab to treat retinal neovascularization. The hydrogel system exhibited excellent injectability, self-healing ability, structural stability, cytocom-patibility, and blood compatibility. It continuously released ranibizumab for more than 7 weeks and showed superior anti-angiogenic efficacy compared to ranibizumab treatment in a rabbit model. The HP@Ran hydrogel system has great potential for intravitreal DDS in the treatment of retinal neovascularization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Seung Hun Park, Richard S. Kim, Wesley R. Stiles, Minjoo Jo, Lingxue Zeng, Sunghoon Rho, Yoonji Baek, Jonghan Kim, Moon Suk Kim, Homan Kang, Hak Soo Choi
Summary: Deferoxamine (DFO) is an FDA-approved iron-chelating agent with good therapeutic efficacy, but its short blood half-life poses challenges for patients who require frequent administrations. By integrating crosslinked hyaluronic acid and Pluronic F127 into an injectable hydrogel formulation, a prolonged release of DFO nanochelators is achieved, significantly extending the half-life and demonstrating potential for the treatment of iron overload disorders.
Article
Pharmacology & Pharmacy
Sang Jun Kim, Youngbo Choi, Khee Tae Min, Surin Hong
Summary: This study proposes radially mesoporous silica nanoparticles as a carrier for dexamethasone, achieving sustained anti-inflammatory effects in rheumatoid arthritis. The nanoparticles demonstrate high-capacity loading and sustained release of the drug, resulting in improved delivery efficiency compared to traditional silica nanoparticles. In vivo evaluation confirms the sustained anti-inflammatory effects and cartilage recovery in a rat model of the disease.
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Pharmacology & Pharmacy
Yuping Yang, Shiqin Luo, Xiong Peng, Ting Zhao, Qin He, Mengying Wu, Wei Zhang, Tao Gong, Zhirong Zhang
Summary: Researchers have developed a phospholipids-based controlled-release gel for sustained intra-articular delivery of anti-rheumatic drugs. The gel can release drugs slowly and stably, producing therapeutic effects in the joint. Compared to traditional repeated injections, the gel shows better anti-arthritic efficacy and reduces systemic toxicity.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hesam Khorsandi, Ali Reza Karimi, Farnaz Azadikhah
Summary: To overcome the burst release issue of thermo-responsive hydrogels, the drug SDMO was conjugated to the PNIPAAm hydrogel via an amide bond. The resulting P[NIPAAm-co-NMSDMO] hydrogel showed sustained drug release.
Article
Pharmacology & Pharmacy
Zhijun Cao, Xing Tang, Yu Zhang, Tian Yin, Jingxin Gou, Yanjiao Wang, Haibing He
Summary: The study introduces a solvent-exchange in-situ depot system that incorporates progesterone-loaded PLGA nanoparticles into a matrix of SAIB and PLGA, for long-term treatment in Assisted Reproductive Technology. Results show that different solvents and PLGA contents can affect the drug release rate of the system. In vivo experiments demonstrate higher drug concentration and AUC over the testing period compared to commercial solutions.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Polymer Science
Kassahun Alula Akulo, Terin Adali, Mthabisi Talent George Moyo, Tulin Bodamyali
Summary: Glaucoma is often treated with eye drops, but their efficacy is limited due to physiological and anatomical barriers of the eye. Injectable hydrogels as nanocarriers have the potential to overcome these limitations and improve drug effectiveness and bioavailability. Natural biopolymers, with their favorable properties, offer great potential for biomedical applications.
Article
Chemistry, Multidisciplinary
Sicheng Yang, Jiaoyu Ren, Hong Wang
Summary: An injectable micromotor@hydrogel drug delivery system is proposed to protect micromotors from the external environment, showing excellent antibacterial effect and enhanced diffusion in the surroundings of bacteria.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Sicheng Yang, Jiaoyu Ren, Hong Wang
Summary: The drug delivery system based on nano/micromotors has attracted significant research interest. In this study, an injectable micromotor@hydrogel drug delivery system was developed to protect micromotors from the external environment and enhance sustained drug release.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Xiong Peng, Yuping Yang, Chenqi Guo, Qin He, Yan Li, Tao Gong, Jia Li
Summary: This study developed a phospholipid-based phase separation gel (BBR-PPSG) loaded with berberine to achieve sustained drug release and long-term therapeutic effect. The stability of BBR-PPSG was verified, and it was found to be able to be stored for a long time. Pharmacokinetic studies on rats and rabbits showed that BBR-PPSG achieved sustained release for one month, significantly increased the area under the curve (AUC) by nearly 9-fold, and prolonged the half-life (t(1/2)) by 10-fold. Animal experiments also demonstrated that BBR-PPSG administration once a month effectively alleviated joint swelling and reduced TNF-a levels.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Mahsa Haghighattalab, Abdolmohammad Kajbafzadeh, Mostafa Baghani, Ziba Gharehnazifam, Bahareh Mohammadi Jobani, Majid Baniassadi
Summary: The study developed magnetic silk fibroin hydrogel for controlled drug release, showing great potential for future applications in noninvasive and remotely controlled drug delivery systems.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Engineering, Environmental
Li Zhao, Fei Wang, Zhengwei Cai, Qi Zhou, Bo Chen, Chen Zhang, Hua Liu, Liwen Hong, Tianyu Zhang, Jie Zhong, Wenguo Cui, Zhengting Wang
Summary: The use of G4 PAMAM dendrimer to construct G4-ASA nanoparticles significantly increased the solubility of 5-ASA, resulting in the development of an injectable adhesive 5-ASA-loaded hydrogel. This new formulation demonstrated superior efficacy in alleviating symptoms of ulcerative colitis in experimental models.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Pakama Mahlumba, Pradeep Kumar, Lisa C. du Toit, Madan S. Poka, Philemon Ubanako, Yahya E. Choonara
Summary: A biocompatible, biodegradable injectable photo-responsive nanosystem for sustained release of macromolecular IgG was successfully developed through a series of experiments, confirming its applicability and safety.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Biomedical
Seung Yong Lee, Seong Ik Jeon, Sung Bo Sim, Youngro Byun, Cheol-Hee Ahn
Summary: The F127-Ad/CDP hydrogel, developed through host-guest interactions, serves as a versatile protein delivery system with controllable durability and drug release characteristics. By adjusting the number of adamantane molecules in the system, the stability and injectability of the hydrogel can be modulated.
ACTA BIOMATERIALIA
(2021)