Article
Biochemistry & Molecular Biology
Huan Deng, Haobiao Liu, Zhihao Yang, Miaoye Bao, Xue Lin, Jing Han, Chengjuan Qu
Summary: Selenium plays a crucial role in maintaining physiological homeostasis of bone and cartilage, and its deficiency is closely associated with the pathogenesis of arthropathies.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2022)
Article
Genetics & Heredity
Lin Wang, Dominik Aschenbrenner, Zhiyang Zeng, Xiya Cao, Daniel Mayr, Meera Mehta, Melania Capitani, Neil Warner, Jie Pan, Liren Wang, Qi Li, Tao Zuo, Sarit Cohen-Kedar, Jiawei Lu, Rico Chandra Ardy, Daniel J. Mulder, Dilan Dissanayake, Kaiyue Peng, Zhiheng Huang, Xiaoqin Li, Yuesheng Wang, Xiaobing Wang, Shuchao Li, Samuel Bullers, Anis N. Gammage, Klaus Warnatz, Ana-Iris Schiefer, Gergely Krivan, Vera Goda, Walter H. A. Kahr, Mathieu Lemaire, Chien-Yi Lu, Iram Siddiqui, Michael G. Surette, Daniel Kotlarz, Karin R. Engelhardt, Helen R. Griffin, Robert Rottapel, Helene Decaluwe, Ronald M. Laxer, Michele Proietti, Sophie Hambleton, Suzanne Elcombe, Cong-Hui Guo, Bodo Grimbacher, Iris Dotan, Siew C. Ng, Spencer A. Freeman, Scott B. Snapper, Christoph Klein, Kaan Boztug, Ying Huang, Dali Li, Holm H. Uhlig, Aleixo M. Muise
Summary: The study identified damaging SYK gain-of-function variants in patients with immune deficiency and inflammatory diseases, which could be treated with bone marrow transplantation or SYK inhibitors. Treatment strategies for patients with SYK mutations were highlighted through knock-in mouse models showing disease amelioration with these interventions.
Article
Medicine, Research & Experimental
Junping Zheng, Jianghui Hu, Yong Yang, Lei Xiong, Huabing Yang, Zhigang Zhang, Nan Jiang, Hongtao Liu
Summary: This study reveals the critical role of bile acid-mediated gut-joint axis and inflammasome in the mechanism of Tripterygium hypoglaucum's alleviation of rheumatoid arthritis. The study shows that Tripterygium hypoglaucum treatment can suppress NLRP3-mediated inflammasome and remodel bile acid profiles, resulting in reduced joint swelling and disease scores in rheumatoid arthritis mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Orthopedics
Chaoming Huang, Yufan Zheng, Jinyu Bai, Ce Shi, Xin Shi, Huajian Shan, Xiaozhong Zhou
Summary: The study found that HGF is overexpressed in RA patients and CIA mice, and it regulates osteoclastogenesis through the JNK and AKT-GSK-3 beta-NFATc1 signaling pathways. Inhibition of HGF/c-Met effectively alleviated bone loss in RA, suggesting its potential as a new target for treating bone loss in RA.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2021)
Article
Plant Sciences
Peraphan Pothacharoen, Rujirek Chaiwongsa, Theerawut Chanmee, Orapin Insuan, Thanchanok Wongwichai, Phornpimon Janchai, Pilanee Vaithanomsat
Summary: Bromelain, a protease mixture found in pineapple, has beneficial biological properties and exhibits anti-arthritic activities. It protects cartilage from degradation and decreases the expression of inflammatory cytokines in synovial fibroblasts by suppressing NF-kappa B and MAPK signaling pathways.
Article
Medicine, Research & Experimental
Yegang Hu, Chuanyun Qian, Huiling Sun, Qiankui Li, Jinde Wang, Hairong Hua, Zichao Dai, Jintao Li, Tao Li, Yi Ding, Xinwang Yang, Wei Zhang
Summary: Exposure to the toxic herbicide paraquat can lead to pulmonary fibrosis and respiratory failure, with studies suggesting that T lymphocytes may be involved in the occurrence and pathological development of lung fibers.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Chemistry, Multidisciplinary
Ayesha Rehman, Peter John, Attya Bhatti
Summary: Selenium nanoparticles (SeNPs) derived from biological sources have shown potential as antirheumatic agents due to their unique properties and toxicological profiles. Their effectiveness in alleviating oxidative stress-mediated inflammation through regulating radical and nonradical species, inflammation markers, and antioxidant defenses highlights their promising role as a remedial alternative in the treatment of rheumatoid arthritis.
Article
Environmental Sciences
Samar Kamel, Hend M. Tag, Hala Ebeid, Howayda E. Khaled, Amani A. Almallah, Mohamed S. El-Naggar
Summary: This study evaluated the protective effect of Costus extract on the fertility of male rats with Freund's adjuvant-induced rheumatoid arthritis. The results showed that Costus extract improved the decrease in sex organ weight and sperm count caused by RA, and also mitigated testicular degeneration. Additionally, Costus extract was found to have a potential valuable role in improving fertility disorders induced by RA.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Integrative & Complementary Medicine
Bin Liu, Hongtao Guo, Li Li, Qi Geng, Ning Zhao, Yong Tan, Zhixing Nie, Guilin Ouyang, Aiping Lu, Cheng Lu
Summary: This study preliminarily reveals the biological basis of deficiency pattern (DP) and excess pattern (EP) in rheumatoid arthritis (RA) through metabolomics analysis. The unique metabolites identified may serve as potential predictors to distinguish between DP and EP. These findings are significant for further research on traditional medicine patterns in the ICD-11 and personalized precision treatment of RA.
Article
Rheumatology
Joyce Aarts, Debbie M. Roeleveld, Monique M. Helsen, Birgitte Walgreen, Elly L. Vitters, Jay Kolls, Fons A. van de Loo, Peter L. van Lent, Peter M. van der Kraan, Marije Koenders
Summary: The study revealed that systemic overexpression of IL-22 has clear anti-inflammatory effects during collagen-induced arthritis, with reduced disease severity and incidence. Additionally, the protective effect of systemic IL-22 is likely mediated through upregulation of the negative immune regulator SOCS3.
Article
Biochemistry & Molecular Biology
Batool Zamani, Fereshteh Taghvaee, Hossein Akbari, Abbas Mohtashamian, Nasrin Sharifi
Summary: The aim of this study was to evaluate the effect of selenium supplementation on disease activity, inflammation, and oxidative stress in patients with rheumatoid arthritis (RA). It was found that selenium resulted in a small clinically relevant improvement in some RA biomarkers such as erythrocyte sedimentation rate (ESR) and antibodies to cyclic citrullinated protein (anti-CCP). However, there were no significant differences between the selenium group and the placebo group in terms of disease activity and inflammation after adjusting for baseline values.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Microbiology
Jiah Yeom, Dong Joon Yim, Seongho Ma, Young-Hee Lim
Summary: P. freudenreichii MJ2 inhibits osteoclast differentiation and improves rheumatoid arthritis in both in vitro and in vivo studies. Live and dead MJ2 showed similar therapeutic effects in the arthritis model.
Article
Medicine, Research & Experimental
Ghali E. N. Hanuma Kumar, Sandopu Sravan Kumar, Meriga Balaji, Dharmendra Kumar Maurya, Muppuru Kesavulu
Summary: Polyphenols from Pterocarpus santalinus hydroalcoholic extract (PSHE) possess marked antioxidant, anti-inflammatory, and immunomodulatory capacities, which play important roles in the prevention of radiation damage.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Jiahuan Qin, Xia Huang, Naiqi Wang, Pengcheng Zhou, Hao Zhang, Zhian Chen, Kaili Liang, Dongcheng Gong, Qunxiong Zeng, Peng Niu, Anping Chen, Lin Yuan, Zhaohui Yang, Linchong Su, Nan Shen, Jun Deng, Di Yu
Summary: This study indicates that in an area with supranutritional selenium intake, RA patients had lower serum selenium levels, while patients with higher selenium levels showed milder disease and lower inflammatory markers. Mouse model studies demonstrated that selenium supplementation delayed disease onset and reduced joint pathology.
CLINICAL & TRANSLATIONAL IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Shuangqing Wang, Yanhong Liu, Qianwen Sun, Bowen Zeng, Chao Liu, Liming Gong, Hao Wu, Liqing Chen, Mingji Jin, Jianpeng Guo, Zhonggao Gao, Wei Huang
Summary: This study develops an inflammatory microenvironment-responsive hydrogel with ideal mechanical properties, which can inhibit the process of inflammatory diseases by modulating the inflammatory microenvironment. The hydrogel has excellent physical properties and biocompatibility, and exhibits antioxidant and anti-inflammatory effects, making it a promising treatment for typical inflammatory diseases.