Article
Chemistry, Applied
Tomasz Machalowski, Joanna Idaszek, Adrian Chlanda, Marcin Heljak, Adam Piasecki, Wojciech Swieszkowski, Teofil Jesionowski
Summary: The study developed chitin-based biocomposites through biomimetic ex vivo deposition of calcium carbonate particles in the hemolymph from the cultivated mollusk Cornu aspersum and chitinous matrix from the marine demosponge Aplysina fistularis. The results showed that the biofunctionalized scaffold had about 4 times higher mechanical resistance and exhibited significant topographical changes, indicating its potential for modifying cell delivery systems in future biomedical applications.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Kelly McElvain, Joshua Klister, Alessandra Ebben, Sandeep Gopalakrishnan, Mahsa Dabagh
Summary: Chronic wounds have a significant impact on individuals' health-related quality of life and healthcare systems worldwide. This study investigates the influence of mechanotransduction on the healing process in chronic wounds through the development of three-dimensional tissue models. The results demonstrate that wound dressings with lower stiffness promote force transmission within the wound tissue, with larger dressings exerting higher stresses. These findings highlight the importance of dressing characteristics in promoting healing and provide insights for the design of precision dressings.
Review
Pharmacology & Pharmacy
Yuqing Liang, Yongping Liang, Hualei Zhang, Baolin Guo
Summary: Bacterial infection and resistance pose a significant threat to human health, especially in wound healing. This review focuses on antibacterial wound dressings and discusses various biomaterials and antibacterial agents used in their fabrication. It also explores challenges and future perspectives in this field.
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Yongping Liang, Jiahui He, Baolin Guo
Summary: Hydrogels have shown promising advantages as wound dressings due to their excellent biochemical and mechanical properties. This review summarizes the advanced functions of hydrogel dressings, such as antimicrobial, adhesion, hemostasis, anti-inflammatory, substance delivery, self-healing, stimulus response, and conductivity, as well as the emerging wound monitoring feature. The potential applications for different types of wounds, including chronic wounds and focus on infected, burn, and diabetic wounds, are discussed, along with proposed future directions for hydrogel wound dressings in wound healing.
Review
Engineering, Biomedical
Jacob G. Hodge, David S. Zamierowski, Jennifer L. Robinson, Adam J. Mellott
Summary: In this review, the key principles of polymeric biomaterials in wound healing are discussed, along with how they affect wound dressing design. The importance of collaboration between the clinical and material science realms in developing novel wound care therapies is emphasized.
BIOMATERIALS RESEARCH
(2022)
Review
Polymer Science
Izzat Zulkiflee, Syafira Masri, Mazlan Zawani, Atiqah Salleh, Ibrahim Nor Amirrah, Mohd Farhanulhakim Mohd Razip Wee, Salma Mohamad Yusop, Mh Busra Fauzi
Summary: Silicon-based biomaterials have gained significant breakthroughs in various industries, including clinical and biomedical applications. Their highly favorable properties, such as excellent biocompatibility, high surface area, mechanical strength, and selectivity, make them attractive for applications like film, hydrogel, nanoparticles, etc. Exciting results have also been observed in cell culture, cell growth, and tissue engineering. This article provides a simple review of the unique properties of silicon and discusses its future application perspectives in the biomedical field, with the goal of generating broader interest in silicone-based materials for wound healing research.
Review
Engineering, Biomedical
Xiudan Wang, Yanhua Wang, Yanjiao Teng, Jie Shi, Xinran Yang, Ziling Ding, Xiaoqin Guo, Shike Hou, Qi Lv
Summary: The skin acts as the body's first line of defense and has a complex physiology. Proper wound care is crucial during the healing process to prevent the development of chronic wounds. Three-dimensional (3D) printing technology, known for its high controllability and resolution, is considered the next global industrial and manufacturing revolution and plays a significant role in the development of wound dressings. In this article, we provide a brief overview of the wound healing mechanism, discuss the history and main technologies of 3D bioprinting, and explore the application and future directions of 3D bioprinting technology in the field of wound dressings.
BIOMEDICAL MATERIALS
(2023)
Review
Engineering, Biomedical
Shuduan Mao, Junjie Man, Jialei Wang, Li Fu, Chengliang Yin, Hassan Karimi-Maleh
Summary: As the largest organ in the body, the skin plays vital roles in barrier function, immune response, water loss prevention, and waste excretion. Traditional treatment methods for skin lesions are still inadequate in terms of repair time, costs, and results. The rapid development of bioprinting technology has provided new ideas to overcome these challenges.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2023)
Article
Biochemistry & Molecular Biology
Alexa-Maria Croitoru, Musa Ayran, Eray Altan, Yasin Karacelebi, Songul Ulag, Ali Sahin, Mehmet Mucahit Guncu, Burak Aksu, Oguzhan Gunduz, Bianca-Maria Tihauan, Denisa Ficai, Anton Ficai
Summary: In this study, novel fibers based on ethylcellulose (EC) loaded with gallic acid (GA) were designed using the electrospinning technique to investigate their potential as wound dressings. The EC_GA fibers showed increased antimicrobial activity and cell viability with higher concentrations of GA.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Engineering, Biomedical
M. K. Ahmed, M. A. Zayed, S. El-dek, Mayssa Abdel Hady, Doaa H. El Sherbiny, Vuk Uskokovic
Summary: In this study, magnetite nanoparticles doped with antimicrobial silver ions were incorporated into electrospun nanofibrous epsilon-polycaprolactone scaffolds. The results demonstrated that increasing silver content in the scaffolds enhanced cell adhesion and growth, as well as antibacterial activity against E. coli and S. aureus. The wound healing rate in rats also increased proportionally with the concentration of silver in the scaffolds, indicating the potential of these composite nanofibrous scaffolds for wound dressings and reconstructive skin therapies.
BIOACTIVE MATERIALS
(2021)
Article
Nanoscience & Nanotechnology
Matthew McGrath, Karolina Zimkowska, Katelyn J. Genoud, Jack Maughan, Javier Gutierrez Gonzalez, Shane Browne, Fergal J. O'Brien
Summary: A biomimetic, bilayered antimicrobial collagen-based scaffold was developed to deal with the etiology of diabetic foot ulcers (DFUs). The scaffold exhibited high structural stability, successfully inhibited the growth and infiltration of Staphylococcus aureus, and supported the proliferation of epidermal cells and vascularization. These results suggest that the bilayered scaffold is a promising candidate for enhancing diabetic wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Applied
Xinghuan Lin, Hao Zhang, Shanshan Li, Lin Huang, Rongrong Zhang, Lina Zhang, Aixi Yu, Bo Duan
Summary: Metal-polyphenol networks have attracted attention for biomedical applications. A new non-covalent driven assembly strategy was developed to fabricate chitin-polyphenol-metal hydrogels. The hydrogel showed antibacterial properties and promoted wound healing.
CARBOHYDRATE POLYMERS
(2022)
Article
Polymer Science
Eray Altan, Yasin Karacelebi, Elif Saatcioglu, Songul Ulag, Ali Sahin, Burak Aksu, Alexa-Maria Croitoru, Cosmin Iulian Codrea, Denisa Ficai, Oguzhan Gunduz, Anton Ficai
Summary: This study found that adding juglone can enhance the antibacterial properties of PLA scaffolds but may reduce mechanical strength. In terms of cytotoxicity, there was toxicity initially, but with an increase in juglone ratio, fibroblast cell metabolic activity increased.
Article
Engineering, Biomedical
Yingshuai Wang, Yanxia Zhu, Penghe Zhao, Bin Wei, Mingjian Fan, Danyang Chen, Zhaokui Jin, Qianjun He
Summary: In this study, a new concept of nanoconcrete welding polymer chains is proposed, which significantly enhances the mechanical performances of polymers. The constructed porous membrane, used as a wound dressing, exhibits improved strength, toughness, and anti-fatigue properties. This nanoconcrete-welding-polymer strategy breaks a new pathway for improving the mechanical performances of polymers.
BIOACTIVE MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Xin Meng, Yang Lu, Ying Gao, Suying Cheng, Feng Tian, Yuliang Xiao, Fan Li
Summary: Polyelectrolyte complexes wound dressing based on chitosan/alginate/hyaluronic acid crosslinked with genipin were prepared, showing excellent biocompatibility and adjustable physical, mechanical, and biological properties. The dressing promoted wound healing in a rat model and exhibited great potential for use as promising wound dressings.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Food Science & Technology
Esmaeil Sheibani, Asieh Hosseini, Ali Sobhani Nasab, Kourosh Adib, Mohammad Reza Ganjali, Seied Mahdi Pourmortazavi, Farhad Ahmadi, Elnaz Marzi Khosrowshahi, Somayeh Mirsadeghi, Mehdi Rahimi-Nasrabadi, Hermann Ehrlich
Summary: This paper reviews the reports on the extraction and determination of organic and inorganic analytes using polysaccharide-based biopolymers as solid phase sorbents for sample preparation. It explores the suitability of biopolymers as a choice for sample preparation methods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Chemistry, Applied
Ahmet Kertmen, Izabela Dziedzic, Hermann Ehrlich
Summary: Cationic chitosan, as a derivative of chitin, has specific physicochemical properties, biodegradability, and biocompatibility, and is widely used in patents related to biomedical, material science, biotechnology, and chemical fields.
CARBOHYDRATE POLYMERS
(2023)
Review
Chemistry, Analytical
Azadeh Gharehzadehshirazi, Mashaalah Zarejousheghani, Sedigheh Falahi, Yvonne Joseph, Parvaneh Rahimi
Summary: Despite progress in treating childhood cancer, it remains a leading cause of death among children globally. Due to overlapping symptoms with other diseases, early tumor prediction is difficult, leading to more aggressive and rapid progression in pediatric cancer. Early and accurate detection methods are urgently needed, and biosensors have emerged as potential tools for biomarker detection. This review provides an overview of important biomarkers and biosensors for early detection of pediatric cancer, offering a platform for ongoing research and the development of rapid diagnostics and treatment, ultimately reducing mortality rates.
Article
Endocrinology & Metabolism
Alessa Fischer, Simon Kloos, Umberto Maccio, Juliane Friemel, Hanna Remde, Martin Fassnacht, Christina Pamporaki, Graeme Eisenhofer, Henri J. L. M. Timmers, Mercedes Robledo, Stephanie M. J. Fliedner, Katharina Wang, Julian Maurer, Astrid Reul, Kathrin Zitzmann, Nicole Bechmann, Gintare Zygiene, Susan Richter, Constanze Hantel, Diana Vetter, Kuno Lehmann, Hermine Mohr, Natalia S. Pellegata, Martin Ullrich, Jens Pietzsch, Christian G. Ziegler, Stefan R. Bornstein, Matthias Kroiss, Martin Reincke, Karel Pacak, Ashley B. Grossman, Felix Beuschlein, Svenja Noelting
Summary: This study investigated the relationship between SSTR2 immunoreactivity and SDHB immunoreactivity, mutational status, and clinical behavior of PPGLs. It also evaluated SSTR-based therapies in metastatic PPGLs. The results showed that SSTR2 expression was associated with SDHB/SDHx mutations and metastatic disease. Somatostatin receptor-based therapies had a high disease control rate in metastatic PPGLs.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Charlotte Steenblock, Nicole Bechmann, Felix Beuschlein, Christian Wolfrum, Stefan R. Bornstein
Summary: Obesity is associated with a higher risk of severe COVID-19 and increased mortality. The expression of ACE2, NRP1, and HMGB1 in adipose tissue was investigated in this study. SARS-CoV-2 was detected in the adipocytes of COVID-19 patients even after 3 weeks of acute infection. Increased macrophage infiltration was observed in the adipose tissue of COVID-19 patients, suggesting that this may contribute to the increased severity and mortality of COVID-19 in obese individuals.
JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Bruna Calsina, Elena Pineiro-Yanez, Angel M. Martinez-Montes, Eduardo Caleiras, Angel Fernandez-Sanroman, Maria Monteagudo, Rafael Torres-Perez, Coral Fustero-Torre, Marta Pulgarin-Alfaro, Eduardo Gil, Rocio Leton, Scherezade Jimenez, Santiago Garcia-Martin, Maria Carmen Martin, Juan Maria Roldan-Romero, Javier Lanillos, Sara Mellid, Maria Santos, Alberto Diaz-Talavera, Angeles Rubio, Patricia Gonzalez, Barbara Hernando, Nicole Bechmann, Margo Dona, Maria Calatayud, Sonsoles Guadalix, Cristina Alvarez-Escola, Rita M. Regojo, Javier Aller, Maria Isabel Del Olmo-Garcia, Adria Lopez-Fernandez, Stephanie M. J. Fliedner, Elena Rapizzi, Martin Fassnacht, Felix Beuschlein, Marcus Quinkler, Rodrigo A. Toledo, Massimo Mannelli, Henri J. Timmers, Graeme Eisenhofer, Sandra Rodriguez-Perales, Orlando Dominguez, Geoffrey Macintyre, Maria Curras-Freixes, Cristina Rodriguez-Antona, Alberto Cascon, Luis J. Leandro-Garcia, Cristina Montero-Conde, Giovanna Roncador, Juan Fernando Garcia-Garcia, Karel Pacak, Fatima Al-Shahrour, Mercedes Robledo
Summary: The mechanisms of metastasis in pheochromocytoma/paraganglioma (mPPGL) are unknown. Genomic and immunogenomic profiling of mPPGL tumors reveal potential biomarkers for risk of metastasis and immunotherapy response.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Analytical
Franz Selbmann, Soumya Deep Paul, Maulik Satwara, Frank Roscher, Maik Wiemer, Harald Kuhn, Yvonne Joseph
Summary: This paper introduces a new method of transferring structures, dies, and electronic components to a flexible substrate by lift-off. This approach combines the advantages of established semiconductor and microsystem fabrication technologies and packaging technologies with those of flexible substrates, including high precision, miniaturization, adaptability to various materials and processes, geometry adaptivity, lightweight structures, and low costs.
Review
Endocrinology & Metabolism
Nicole Bechmann, Frank Westermann, Graeme Eisenhofer
Summary: Pediatric neural crest-derived adrenal neoplasms, such as neuroblastoma and pheochromocytoma, exhibit clinical heterogeneity with varying outcomes. Increased HIF2α expression and MYCN amplification contribute to aggressiveness and poor prognosis. Understanding HIF and MYC signaling pathways can provide insights into tumorigenesis and potential therapeutic targets for these pediatric adrenal neoplasms.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Engineering, Multidisciplinary
Alona Voronkina, Eliza Romanczuk-Ruszuk, Robert E. Przekop, Pawel Lipowicz, Ewa Gabriel, Korbinian Heimler, Anika Rogoll, Carla Vogt, Milosz Frydrych, Pawel Wienclaw, Allison L. Stelling, Konstantin Tabachnick, Dmitry Tsurkan, Hermann Ehrlich
Summary: Structural bioinspiration is a current trend in modern material science and biomimetics, which is based on the diversity of invertebrate skeletons, particularly the honeycomb structures. In this study, we investigated the unique bioarchitecture principles of the biosilica-based honeycomb-like skeleton of the deep-sea glass sponge Aphrocallistes beatrix. Experimental data provided convincing evidence of the location of actin filaments within the hierarchical siliceous walls of the honeycomb structure. Inspired by the poriferan honeycomb biosilica, we designed various models using 3D printing and microtomography-based 3D reconstruction with PLA, resin, and synthetic glass materials.
Article
Polymer Science
Johanna Phuong Nong, Paul Nawroth, Franz Selbmann, Martina Bremer, Bjoern Guenther, Joerg Adam, Yvonne Joseph, Steffen Fischer
Summary: The manufacturing of sensors based on sustainable and renewable materials is increasingly important. Hydrogels made from lignin, a polyphenolic biopolymer in lignocellulosic biomass, can react to environmental influences and be used for sensor applications. In this study, lignosulfonate hydrogel was synthesized and bound to glass surfaces through a two-step process.
EUROPEAN POLYMER JOURNAL
(2023)
Article
Chemistry, Medicinal
Tomas Duminis, Marcin Heljak, Wojciech Swieszkowski, Alexander Ereskovsky, Izabela Dziedzic, Marek Nowicki, Martyna Pajewska-Szmyt, Alona Voronkina, Stefan R. Bornstein, Hermann Ehrlich
Summary: Skeletal constructs of marine sponges, especially those isolated from cultivated demosponges, have the potential to be sustainable sources of biocompatible porous biopolymer-based 3D scaffolds for tissue engineering. These chitinous scaffolds have shown promising results in biomimetics and tissue engineering due to their renewability and broad diversity of cells. However, the mechanical features of these constructs have been poorly studied before.
Article
Chemistry, Medicinal
Anita Kubiak, Martyna Pajewska-Szmyt, Martyna Kotula, Bartosz Lesniewski, Alona Voronkina, Parvaneh Rahimi, Sedigheh Falahi, Korbinian Heimler, Anika Rogoll, Carla Vogt, Alexander Ereskovsky, Paul Simon, Enrico Langer, Armin Springer, Maik Foerste, Alexandros Charitos, Yvonne Joseph, Teofil Jesionowski, Hermann Ehrlich
Summary: This study presents a new biomimetic approach for the development of a lepidocrocite-containing 3D spongin scaffold using artificial seawater and iron. The research proposes a mechanism of lepidocrocite formation and suggests the potential application of the biocomposite as an electrochemical dopamine sensor.
Article
Multidisciplinary Sciences
Anke Witt, Ivona Mateska, Alessandra Palladini, Anupam Sinha, Michele Woelk, Akiko Harauma, Nicole Bechmann, Christina Pamporaki, Andreas Dahl, Michael Rothe, Irakli Kopaliani, Christian Adolf, Anna Riester, Ben Wielockx, Stefan R. Bornstein, Matthias Kroiss, Mirko Peitzsch, Toru Moriguchi, Maria Fedorova, Michal Grzybek, Triantafyllos Chavakis, Peter Mirtschink, Vasileia Ismini Alexaki
Summary: Corticosteroids play a crucial role in regulating various physiological processes, and their production is influenced by the polyunsaturated fatty acid (PUFA) content in mitochondrial phospholipids in adrenocortical cells. Inhibition of the enzyme FADS2, which is involved in PUFA synthesis, disrupts mitochondrial lipid composition and reduces steroidogenesis. FADS2 expression is elevated in obese mice, leading to increased corticosterone levels, but this can be countered by using FADS2 inhibitors or PUFA supplementation. Furthermore, FADS2 expression is elevated in aldosterone-producing adenomas in humans, indicating its role in adrenal steroidogenesis in health and disease.
Article
Microbiology
Omkar Pokharkar, Harshavardhan Anumolu, Grigory V. Zyryanov, Mikhail V. Tsurkan
Summary: The aim of this research was to identify natural products (NPs) with potential anti-SARS-CoV-2 activity. Using molecular docking and simulations, nine shortlisted NPs were found to exhibit strong interactions with key residues in the AS1 and AS2 regions of RdRp. Among them, bromophycoic acid C showed promising dual inhibition by interacting favorably with nsp15 protein and the N-terminal of RdRp.
MICROBIOLOGY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Faezeh Gandomi, Mohammad Javad Taghizadeh, Elnaz Marzi Khosrowshahi, Maryam Saleh Mohammadnia, Neda Irannejad, Esmail Sohouli, Hermann Ehrlich, Yvonne Joseph, Mehdi Rahimi-Nasrabadi
Summary: Azaperone is a phenylbutanone-based neurotransmitter used in veterinary clinics. In this study, a Fe3O4@SiO2-NH2/CS2 nanocomposite was synthesized and used to modify a glassy carbon electrode, creating a sensor for the analysis of Azaperone in ostrich meat and rat plasma. The electrochemical behavior of Azaperone was tested, and the optimal experimental variables, including pH and accumulation time, were determined. The sensor showed a linear response to Azaperone concentration in the range of 0.01-100.0 mu M.
JOURNAL OF NANOSTRUCTURE IN CHEMISTRY
(2023)
