期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 23, 页码 -出版社
MDPI
DOI: 10.3390/ijms20236004
关键词
Ca2+ signaling; intracellular organelles; plasma membrane; inositol-1,4,5-receptors; ryanodine receptors; ionotropic receptors; metabotropic receptors; TRP channels; two-pore channels; STIM and Orai; neurodegenerative diseases; autophagy; apoptosis
资金
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (Sao Paulo Research Foundation - FAPESP) [2016/20796-2, 2017/10863-7, 2017/23616-8, 2013/20073-2]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - CNPq [421603/2008-8, 141246/2019-7, 153704/2018-7]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]
Calcium (Ca2+) homeostasis is essential for cell maintenance since this ion participates in many physiological processes. For example, the spatial and temporal organization of Ca2+ signaling in the central nervous system is fundamental for neurotransmission, where local changes in cytosolic Ca2+ concentration are needed to transmit information from neuron to neuron, between neurons and glia, and even regulating local blood flow according to the required activity. However, under pathological conditions, Ca2+ homeostasis is altered, with increased cytoplasmic Ca2+ concentrations leading to the activation of proteases, lipases, and nucleases. This review aimed to highlight the role of Ca2+ signaling in neurodegenerative disease-related apoptosis, where the regulation of intracellular Ca2+ homeostasis depends on coordinated interactions between the endoplasmic reticulum, mitochondria, and lysosomes, as well as specific transport mechanisms. In neurodegenerative diseases, alterations-increased oxidative stress, energy metabolism alterations, and protein aggregation have been identified. The aggregation of alpha-synuclein, beta-amyloid peptide (A beta), and huntingtin all adversely affect Ca2+ homeostasis. Due to the mounting evidence for the relevance of Ca2+ signaling in neuroprotection, we would focus on the expression and function of Ca2+ signaling-related proteins, in terms of the effects on autophagy regulation and the onset and progression of neurodegenerative diseases.
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