Article
Chemistry, Applied
Jasmine Esposito Salsano, Diana Pinto, Francisca Rodrigues, Alessandro Saba, Clementina Manera, Maria Digiacomo, Marco Macchia
Summary: The study focused on developing a method to isolate and purify oleocanthalic acid from olive oil, and then used the pure oleocanthalic acid to develop a high performance liquid chromatography method for qualitative and quantitative analysis of oleocanthalic acid content in olive oil. Preliminary assessment showed that oleocanthalic acid has a higher quenching efficiency for HOCl than O-2(center dot-).
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Biochemistry & Molecular Biology
Francesca Felice, Maria Michela Cesare, Luca Fredianelli, Marinella De Leo, Veronica Conti, Alessandra Braca, Rossella Di Stefano
Summary: Tomatoes and their derivates contain natural biologically active components that have a protective effect on muscle aging. This study found that tomato peel extracts grown in drought stress conditions significantly reduced muscle atrophy induced by dexamethasone and decreased the expression of the muscle atrophy-related protein FOXO1, thereby providing protection against sarcopenia in an in vitro model.
Article
Oncology
Maria Donatella Mariniello, Matteo Ghilli, Benedetta Favati, Irini Gerges, Livio Colizzi, Margherita Tamplenizza, Alessandro Tocchio, Federico Martello, Maria Ghilardi, Maria Cristina Cossu, Serena Danti, Manuela Roncella
Summary: This study aimed to investigate the use of a biomimetic polyurethane-based scaffold for regenerating soft tissue in patients undergoing breast conserving surgery (BCS) for non-malignant breast lesions. The results showed positive outcomes in terms of safety and performance, suggesting that this innovative approach has the potential to significantly impact clinical application of tissue engineering.
Article
Nutrition & Dietetics
Doretta Cuffaro, Simone Bertini, Marco Macchia, Maria Digiacomo
Summary: This study examines the combination of olive leaf extract and extra virgin olive oil extract, which shows improved antioxidant and anti-inflammatory properties compared to the singular olive oil extract. This extract may have potential in the field of nutraceuticals.
Editorial Material
Oncology
Nicola Contessi Negrini, Alessandro Franchi, Serena Danti
Article
Engineering, Biomedical
Norma Mallegni, Mario Milazzo, Caterina Cristallini, Niccoletta Barbani, Giulia Fredi, Andrea Dorigato, Patrizia Cinelli, Serena Danti
Summary: Type-1 diabetes is a prevalent metabolic disorder that requires the regulation of insulin production through a tailored administration of insulin. Recent advancements have been made in developing an implantable artificial pancreas, but improvements are still needed in terms of biomaterials and technologies for the insulin reservoir. This study discusses the use of cyclic olefin copolymers for fabricating the insulin reservoir and presents Topas 8007S-04 as a potential candidate material due to its strength and ability to prevent insulin aggregation.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Claudio Ricci, Bahareh Azimi, Luca Panariello, Benedetta Antognoli, Beatrice Cecchini, Roberta Rovelli, Meruyert Rustembek, Patrizia Cinelli, Mario Milazzo, Serena Danti, Andrea Lazzeri
Summary: This study evaluated the physico-mechanical and morphological properties of electrospun PCL and PLA scaffolds, and created a 3D model of colorectal adenocarcinoma. The metabolic activity of Caco-2 cells showed opposite trends in PLA and PCL scaffolds regardless of fiber alignment, increasing in PLA and decreasing in PCL. The best scaffolds for Caco-2 cell culture were PCL500 (randomly oriented fibers) and PLA2500 (aligned fibers).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Doretta Cuffaro, Diana Pinto, Ana Margarida Silva, Andrea Bertolini, Simone Bertini, Alessandro Saba, Marco Macchia, Francisca Rodrigues, Maria Digiacomo
Summary: This study investigates the antioxidant effects of high-value polyphenol oleocanthal (OC) and its main metabolites, tyrosol (Tyr) and oleocanthalic acid (OA), as well as their impact on cell viability. The results demonstrate the promising properties of OC, OA, and Tyr against oxidative diseases, including their ability to scavenge reactive oxygen species and permeate the intestinal membrane.
Article
Nutrition & Dietetics
Doretta Cuffaro, Andrea Bertolini, Simone Bertini, Claudio Ricci, Maria Grazia Cascone, Serena Danti, Alessandro Saba, Marco Macchia, Maria Digiacomo
Summary: This study aims to investigate the polyphenolic composition and nutraceutical properties of olive mill wastewaters (OMWWs) from two Tuscan olive cultivars. The results show that OMWW extracts exhibit antioxidant, antiradical, and anti-inflammatory activities, and could serve as potential functional ingredients in dietary supplements, pharmaceuticals, and cosmetics.
Article
Polymer Science
Bahareh Azimi, Claudio Ricci, Teresa Macchi, Cemre Guenday, Sara Munafo, Homa Maleki, Federico Pratesi, Veronika Tempesti, Caterina Cristallini, Luca Bruschini, Andrea Lazzeri, Serena Danti, Nazende Guenday-Tuereli
Summary: In this study, a dual drug-loaded patch was fabricated using electrospinning and electrospray technologies for local drug delivery through the skin and tympanic membrane. In vitro tests demonstrated the biocompatibility of the patch and its ability to release drugs over a sustained period of 4 weeks.
Article
Otorhinolaryngology
Serena Danti, Claudio Ricci, Teresa Macchi, Iacopo Dallan, Stefano Berrettini, Alessandro Franchi
Summary: SWI/SNF-deficient sinonasal tumors are rare and treatment-resistant malignancies that are poorly differentiated and usually detected at a late stage. Emerging therapies, such as immunotherapy and personalized treatments, are being developed. Establishing tumor cell lines could enhance in-depth study of these tumors.
CURRENT OTORHINOLARYNGOLOGY REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Beatrice Cecchini, Roberta Rovelli, Lorenzo Zavagna, Bahareh Azimi, Teresa Macchi, Esingul Kaya, Semih Esin, Luca Bruschini, Mario Milazzo, Giovanna Batoni, Serena Danti, Chaoqun Dong
Summary: This study demonstrates the application of electrospinning and electrospray techniques to develop a tympanic membrane patch for delivering probiotics and/or postbiotics to the middle ear. The incorporation of probiotic-laden sodium alginate microparticles within electrospun sodium alginate/poly(ethylene oxide) fiber meshes offers a versatile and safe treatment strategy for chronic otitis media. This innovative approach holds promise for addressing complex healing processes of chronic upper respiratory diseases and mitigating antimicrobial resistance.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemistry & Molecular Biology
Saeed Ismaeilimoghadam, Mehdi Jonoobi, Alireza Ashori, Afsaneh Shahraki, Bahareh Azimi, Serena Danti
Summary: In this study, the practical properties of sodium alginate-based hydrogels were improved by grafting with acrylic acid and incorporating cellulose nanocrystals. The interpenetrating and semi-interpenetrating network hydrogels showed excellent absorption performance and cost savings, making them suitable for adult incontinence pads.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Meeting Abstract
Cell & Tissue Engineering
Bahareh Azimi, Marta Feula, Mario Milazzo, Arti Ahluwalia, Stefano Berrettini, Serena Danti
TISSUE ENGINEERING PART A
(2022)