Changes in Calcium Homeostasis and Gene Expression Implicated in Epilepsy in Hippocampi of Mice Overexpressing ORAI1

Behavioral and electrophysiological changes in female mice overexpressing ORAI1 in neurons

(2019) Filip Maciąg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Scientists rise up against statistical significance

(2019) Valentin Amrhein et al.   NATURE

CRAC Channels And Disease – From Human CRAC Channelopathies And Animal Models To Novel Drugs

(2019) Stefan Feske   CELL CALCIUM

Differential regulation of Ca2+ influx by ORAI channels mediates enamel mineralization

(2019) Miriam Eckstein et al.   Science Signaling

Signaling through Ca2+ Microdomains from Store-Operated CRAC Channels

(2019) Pradeep Barak et al.   Cold Spring Harbor Perspectives in Biology

Two types of functionally distinct Ca2+ stores in hippocampal neurons

(2019) Hsing-Jung Chen-Engerer et al.   Nature Communications

Deletion of Orai2 augments endogenous CRAC currents and degranulation in mast cells leading to enhanced anaphylaxis

(2018) Volodymyr Tsvilovskyy et al.   CELL CALCIUM

Neuronal calcium signaling via store-operated channels in health and disease

(2018) Tomasz Wegierski et al.   CELL CALCIUM

Epilepsy Genetics: current knowledge, applications and future directions

(2018) Kenneth A. Myers et al.   CLINICAL GENETICS

Ion channelopathies of the immune system

(2018) Martin Vaeth et al.   CURRENT OPINION IN IMMUNOLOGY

Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method

(2018) Jonathan T. Ting et al.   Jove-Journal of Visualized Experiments

Regulation of proto-oncogene Orai3 by miR18a/b and miR34a

(2018) Ayushi Vashisht et al.   CELL CALCIUM

Alzheimer's Disease Modeling: Ups, Downs, and Perspectives for Human Induced Pluripotent Stem Cells

(2018) Urszula Wojda et al.   JOURNAL OF ALZHEIMERS DISEASE

Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons

(2017) Dongyu Wei et al.   Frontiers in Cellular Neuroscience

ORAI2 modulates store-operated calcium entry and T cell-mediated immunity

(2017) Martin Vaeth et al.   Nature Communications

STIM1 Ca 2+ Sensor Control of L-type Ca 2+ -Channel-Dependent Dendritic Spine Structural Plasticity and Nuclear Signaling

(2017) Philip J. Dittmer et al.   Cell Reports

Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from variable nonsense to publication quality data

(2017) Sean C. Taylor et al.   Scientific Reports

Functional Analysis of Orai1 Concatemers Supports a Hexameric Stoichiometry for the CRAC Channel

(2016) Michelle Yen et al.   BIOPHYSICAL JOURNAL

Store-Operated Calcium Channel Complex in Postsynaptic Spines: A New Therapeutic Target for Alzheimer's Disease Treatment

(2016) Hua Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuronal migration disorders: Focus on the cytoskeleton and epilepsy

(2016) Melissa A. Stouffer et al.   NEUROBIOLOGY OF DISEASE

Neuronal SOCE: Myth or Reality?

(2016) Bo Lu et al.   TRENDS IN CELL BIOLOGY

AMPA Receptors Are Involved in Store-Operated Calcium Entry and Interact with STIM Proteins in Rat Primary Cortical Neurons

(2016) Joanna Gruszczynska-Biegala et al.   Frontiers in Cellular Neuroscience

Diseases caused by mutations inORAI1andSTIM1

(2015) Rodrigo S. Lacruz et al.   Annals of the New York Academy of Sciences

SOCE in neurons: Signaling or just refilling?

(2015) Lukasz Majewski et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

STIM2 regulates PKA-dependent phosphorylation and trafficking of AMPARs

(2015) Gisela Garcia-Alvarez et al.   MOLECULAR BIOLOGY OF THE CELL

Data quality aware analysis of differential expression in RNA-seq with NOISeq R/Bioc package

(2015) Sonia Tarazona et al.   NUCLEIC ACIDS RESEARCH

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Stim and Orai proteins in neuronal Ca2+ signaling and excitability

(2015) Francesco Moccia et al.   Frontiers in Cellular Neuroscience

A novel variant inGABRB2associated with intellectual disability and epilepsy

(2014) Siddharth Srivastava et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

STIM1 Controls Neuronal Ca2+ Signaling, mGluR1-Dependent Synaptic Transmission, and Cerebellar Motor Behavior

(2014) Jana Hartmann et al.   NEURON

Reduced Synaptic STIM2 Expression and Impaired Store-Operated Calcium Entry Cause Destabilization of Mature Spines in Mutant Presenilin Mice

(2014) Suya Sun et al.   NEURON

Ca2+dysregulation in neurons from transgenic mice expressing mutant presenilin 2

(2012) Maulilio J. Kipanyula et al.   AGING CELL

Interneuron, interrupted: molecular pathogenesis of ARX mutations and X-linked infantile spasms

(2012) Pedro R Olivetti et al.   CURRENT OPINION IN NEUROBIOLOGY

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Crystal Structure of the Calcium Release-Activated Calcium Channel Orai

(2012) X. Hou et al.   SCIENCE

What We Know and Would Like to Know about CDKL5 and Its Involvement in Epileptic Encephalopathy

(2012) Charlotte Kilstrup-Nielsen et al.   NEURAL PLASTICITY

A girl with early-onset epileptic encephalopathy associated with microdeletion involving CDKL5

(2011) Hirotomo Saitsu et al.   BRAIN & DEVELOPMENT

CDKL5 alterations lead to early epileptic encephalopathy in both genders

(2011) Jao-Shwann Liang et al.   EPILEPSIA

Clinical Phenotype of 5 Females With a CDKL5 Mutation

(2011) Xenia L. Stalpers et al.   JOURNAL OF CHILD NEUROLOGY

Simulation of Postsynaptic Glutamate Receptors Reveals Critical Features of Glutamatergic Transmission

(2011) Renaud Greget et al.   PLoS One

ARX polyalanine expansions are highly implicated in familial cases of mental retardation with infantile epilepsy and/or hand dystonia

(2010) Mireille Cossée et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

SCN9A: another sodium channel excited to play a role in human epilepsies

(2010) CN Doty   CLINICAL GENETICS

Sodium channel gene family: epilepsy mutations, gene interactions and modifier effects

(2010) Miriam H. Meisler et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutations in GABAAreceptor subunits associated with genetic epilepsies

(2010) Robert L. Macdonald et al.   JOURNAL OF PHYSIOLOGY-LONDON

Mutational spectrum ofCDKL5in early-onset encephalopathies: a study of a large collection of French patients and review of the literature

(2009) C Nemos et al.   CLINICAL GENETICS

Ribosome-free Terminals of Rough ER Allow Formation of STIM1 Puncta and Segregation of STIM1 from IP3 Receptors

(2009) Gyorgy Lur et al.   CURRENT BIOLOGY

Neonatal seizures and long QT Syndrome: A cardiocerebral channelopathy?

(2009) Sarah E. Heron et al.   EPILEPSIA

Plasticity in Ca2+ selectivity of Orai1/Orai3 heteromeric channel

(2009) R. Schindl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Role of SCN9A in Human Epilepsies, As a Cause of Febrile Seizures and As a Potential Modifier of Dravet Syndrome

(2009) Nanda A. Singh et al.   PLoS Genetics