Article
Biology
Daniel Gradeci, Anna Bove, Giulia Vallardi, Alan R. Lowe, Shiladitya Banerjee, Guillaume Charras
Summary: Studies have shown that cell competition can be driven by short-range biochemical signalling or long-range mechanical stresses in the tissue. In mechanical competition, the key determinant is the difference in homeostatic density between winners and losers, while in biochemical competition, the outcome and kinetics are strongly influenced by local tissue organisation.
Review
Multidisciplinary Sciences
Rocio Tapia, Gail A. Hecht
Summary: Cell migration requires various proteins that interact with the cytoskeleton. Sperm flagella protein-1 (Spef1) is a multifunctional protein that interacts with cytoskeletal structures. It plays important roles in flagellar and ciliary motility, microtubule binding and stability, regulation of cell polarity, and maintenance of actin-based structures during cell migration.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2022)
Article
Engineering, Environmental
Ulyana Fuchylo, Hattan A. Alharbi, Alper James Alcaraz, Paul D. Jones, John P. Giesy, Markus Hecker, Markus Brinkmann
Summary: The integrity of tight junctions in the epithelial cell layer of fish gills controls the permeation of chemicals. Inflammation induced by bacterial lipopolysaccharides (LPS) affects tight junctions and the bioavailability of chemicals. This study shows that exposure to LPS reduces the integrity of tight junctions in rainbow trout gill cells, leading to increased permeation of chemicals from oil sands process-affected water (OSPW).
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tahani W. Baakdhah, Brenda Coles, Derek van der Kooy
Summary: Research shows that retinal stem cells have the ability to generate various retinal cell types, with central pigmented spheres exhibiting high proliferative capacity and the capability to produce a large number of retinal pigment epithelial cells. In contrast, the other sphere types primarily generate neural cells.
Article
Gastroenterology & Hepatology
Jilei Zhang, Yongguo Zhang, Callum J. McGrenaghan, Vincent P. Kelly, Yinglin Xia, Jun Sun
Summary: This study found that the expression of QTRT1 was significantly downregulated in patients with inflammatory bowel disease (IBD). The 4 Q-tRNA-related tRNA synthetases were also decreased in IBD patients. These changes were associated with alterations in epithelial cell proliferation and junction formation. Further investigation revealed that queuine treatment enhanced cell proliferation and junction activity, and reduced inflammation in epithelial cells. These findings uncover a novel role for tRNA modifications in the pathogenesis of IBD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Susana Lechuga, Alexander X. Cartagena-Rivera, Afshin Khan, Bert Crawford, Vani Narayanan, Daniel E. Conway, Jaakko Lehtimaki, Pekka Lappalainen, Florian Rieder, Michelle S. Longworth, Andrei I. Ivanov
Summary: The actomyosin cytoskeleton plays a crucial role in maintaining and remodeling epithelial barriers. UNC-45A, a cytoskeletal chaperone, is found to be important in the assembly of myosin structures and the protection of the intestinal epithelial barrier. Decreased expression of UNC-45A in patients with ulcerative colitis may contribute to barrier disruption and worsen the symptoms of the disease.
Article
Biochemistry & Molecular Biology
Desislava Kolchakova, Dzhemal Moten, Tsvetelina Batsalova, Balik Dzhambazov
Summary: Claudins play a crucial role in cell migration and metastasis, making them potential therapeutic targets for cancer treatment. Experimental results show that anti-claudin-12 antibodies and inhibitory peptides can significantly reduce the migration and proliferation of claudin-12 expressing cells, suggesting their potential in inhibiting cancer cell migration.
Article
Biophysics
David Choi, Zachary Gonzalez, Sum Yat Ho, Alexandra Bermudez, Neil Y. C. Lin
Summary: Epithelial cells are influenced by the mechanical and molecular cues from the substrate they reside on and their surrounding neighbors, with cell-substrate and cell-cell interactions masking each other's influence in confluent epithelia. Combinatorial changes in the physical microenvironment are necessary to alter cell morphology and gene expression.
BIOPHYSICAL JOURNAL
(2022)
Article
Cell Biology
Saima Usman, Ahmad Jamal, Antesar Bushaala, Naushin H. H. Waseem, Hebah Al-Dehlawi, William Andrew Yeudall, Muy-Teck Teh, Hemanth Tummala, Ahmad Waseem
Summary: In advanced metastatic cancers, the expression of vimentin is frequently observed and it is associated with reduced patient survival and poor prognosis. Vimentin can change the shape of breast cancer cells and increase cell migration by suppressing epithelial characteristics and affecting gene expression related to cell-cell adhesion. Additionally, the presence of vimentin can alter nuclear architecture and downregulate genes involved in cell-cell adhesion, leading to increased cell migration.
Article
Multidisciplinary Sciences
Wipasiri Soonthornchai, Pattarin Tangtanatakul, Kornvalee Meesilpavikkai, Virgil Dalm, Patipark Kueanjinda, Jongkonnee Wongpiyabovorn
Summary: Psoriasis is a chronic autoimmune skin disease, where microRNA miR-378a may contribute to its pathogenesis by disturbing cell cycle progression and impacting biological mechanisms related to inflammation and tight junctions. Target mRNA analysis identified bone morphogenetic protein 2 as a novel target gene of miR-378a, providing insights into the molecular mechanisms underlying psoriasis.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Ilaria Di Meglio, Anastasiya Trushko, Pau Guillamat, Carles Blanch-Mercader, Shada Abuhattum, Aurelien Roux
Summary: This study reveals that epithelia growing under confinement accumulate pressure that inhibits cell proliferation, but when the pressure exceeds a threshold, cell proliferation can be reactivated within folds. This reactivation is correlated with the reactivation of the mechano-sensing pathway YAP/TAZ.
Article
Multidisciplinary Sciences
Geert de Vreede, Stephan U. Gerlach, David Bilder
Summary: Animals have evolved mechanisms to remove dangerous or nonfunctional cells from tissues. This study reveals that polarity defects associated with malignant transformation can activate tumor necrosis factor signaling, which eliminates clonal malignancies. This process is different from cell competition and can promote tissue homeostasis by monitoring epithelial integrity.
Article
Chemistry, Multidisciplinary
Mark Skamrahl, Hongtao Pang, Maximilian Ferle, Jannis Gottwald, Angela Ruebeling, Riccardo Maraspini, Alf Honigmann, Tabea A. Oswald, Andreas Janshoff
Summary: This study demonstrates the essential role of ZO proteins in efficient collective cell migration by maintaining tissue fluidity and controlling proliferation. Loss of ZO1 and ZO2 leads to actomyosin remodeling in individual cells, altering their viscoelastic properties and resulting in a tug-of-war between subpopulations with distinct morphological and mechanical properties. Co-cultures of wildtype and dKD cells migrate inefficiently due to differences in contractility rather than adhesion.
Article
Cell Biology
Mengna Zhang, Lingxian Zhang, Ajun Geng, Xiao Li, Yu Zhou, Liming Xu, Yi Arial Zeng, Jinpeng Li, Cheguo Cai
Summary: In this study, the researchers investigated the function of cyclin-dependent kinase 14 (CDK14) in mammary development and breast cancer progression. The results showed that CDK14 is expressed in mammary basal cells and elevated in triple negative breast cancer (TNBC). CDK14 knockdown or inhibition was found to suppress mammary regeneration and the progression of TNBC.
Article
Physics, Multidisciplinary
Jintao Li, Simon K. Schnyder, Matthew S. Turner, Ryoichi Yamamoto
Summary: Cells coexist in colonies or tissues, their behavior is controlled by intercellular forces and biochemical regulation. Researchers develop a simple model of the cell cycle and couple it with physical forces within the cell collective, analyzing it through computer simulations and a continuum theory. The study focuses on 2D colonies confined in a channel, showing the relationship between substrate friction and cell-cycle parameters in measuring these parameters experimentally.
Article
Ophthalmology
Monica Diaz-Coranguez, Daniel L. Chao, Enrique L. Salero, Jeffrey L. Goldberg, David A. Antonetti
EXPERIMENTAL EYE RESEARCH
(2017)
Review
Biochemistry & Molecular Biology
Lorenza Gonzalez-Mariscal, Miguel Quiros, Monica Diaz-Coranguez
ANTIOXIDANTS & REDOX SIGNALING
(2011)
Article
Multidisciplinary Sciences
Monica Diaz-Coranguez, Jose Segovia, Adolfo Lopez-Ornelas, Henry Puerta-Guardo, Juan Ludert, Bibiana Chavez, Noemi Meraz-Cruz, Lorenza Gonzalez-Mariscal