Article
Respiratory System
Min Qiao, Yiyu Xie, Armand Wolff, Jeff Kwon
Summary: Studies have shown that long-term compliance with CPAP treatment is low in patients with mild sleep apnea. Compliance during the first three months of treatment can predict long-term adherence to CPAP.
BMC PULMONARY MEDICINE
(2023)
Review
Medicine, General & Internal
Benjamin Ka Seng Thong, Grace Xin Yun Loh, Jia Jan Lim, Christina Jia Liang Lee, Shu Ning Ting, Hong Peng Li, Qing Yun Li
Summary: This article reviews the efficacy of telehealth system in enhancing CPAP adherence. It recommends applying telemonitoring in clinical practice and advocating the development of a biopsychosocial telemedicine model with the integration of several interventions.
FRONTIERS IN MEDICINE
(2022)
Article
Clinical Neurology
Indra Narang, Tetyana Kendzerska, Austin Heffernan, Uzair Malik, Carolina G. Carvalho, Clodagh M. Ryan
Summary: There is a significant reduction in PAP adherence during the first year of transition from pediatric to adult healthcare system for adolescents with OSA.
NATURE AND SCIENCE OF SLEEP
(2022)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Ronni Baran, Daniela Grimm, Manfred Infanger, Markus Wehland
Summary: OSA is a common disease affecting millions worldwide, with CPAP therapy being a common treatment method to prevent complications such as hypertension by improving airway patency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Piero Giuseppe Meliante, Federica Zoccali, Francesca Cascone, Vanessa Di Stefano, Antonio Greco, Marco de Vincentiis, Carla Petrella, Marco Fiore, Antonio Minni, Christian Barbato
Summary: Obstructive sleep apnea syndrome (OSAS) is a disease characterized by intermittent hypoxia (IH) during sleep due to recurrent upper airway obstruction. The associated oxidative stress (OS) leads to various complications that affect both sleep-wake rhythm and systemic functions. This literature review investigates the molecular changes, diagnostic markers, and potential medical therapies for OSAS. The findings suggest that IH increases oxygen free radicals (ROS) and impairs antioxidant capacities, resulting in endothelial dysfunction, osteoporosis, systemic inflammation, increased cardiovascular risk, pulmonary remodeling, and neurological alterations in OSAS patients. The most promising pharmacological therapies include N-acetylcysteine (NAC), Vitamin C, Leptin, Dronabinol, or Atomoxetine + Oxybutynin, but further research is needed. Continuous positive airway pressure (CPAP) remains the approved therapy for reversing most molecular changes, while future drugs may target the remaining dysfunctions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Health Care Sciences & Services
Andreea Zabara-Antal, Ionela Grosu-Creanga, Mihai Lucian Zabara, Andrei Tudor Cernomaz, Bogdan Mihnea Ciuntu, Oana Melinte, Cristian Lupascu, Antigona Carmen Trofor
Summary: This review discusses the role of surgery in the treatment of sleep apnea and emphasizes the importance of individualized therapy. Depending on the type and severity of the apnea, the causal factor, obesity, hypercapnia, and associated pathologies, the optimal therapeutic method is determined for each individual case.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ralph Pries, Christian Lange, Nicole Behn, Karl-Ludwig Bruchhage, Armin Steffen
Summary: This study investigated the influence of hypoglossal nerve stimulation (HNS) on the distribution and differentiation of circulating monocyte subsets in patients with obstructive sleep apnea syndrome (OSAS). The results showed that HNS therapy significantly improved the apnea-hypopnea index (AHI) and Epworth Sleepiness Scale (ESS) scores in OSAS patients. HNS also had the potential to ensure normal distributions of blood monocyte subsets and even improve monocyte dynamics in selected patients. However, there were no significant correlations between HNS usage and daytime sleepiness.
Article
Clinical Neurology
Carolina Cisneros, Gorane Iturricastillo, Elisa Martinez-Besteiro, Jose Maria Eiros, Celeste Marcos, Victoria Mugica, Carlos Melero, Ana Martinez-Meca, Pedro Landete, Enrique Zamora
Summary: This study aimed to analyze the symptomatic control in asthmatic patients with obstructive sleep apnea (OSA) after using continuous positive airway pressure (CPAP). The results showed that after using CPAP, both clinical asthma control and perceived asthma control significantly improved.
Review
Clinical Neurology
Francesco Di Bello, Luigi Napolitano, Marco Abate, Claudia Colla Ruvoloa, Simone Morra, Gianluigi Califano, Marco Capece, Massimiliano Creta, Cristiano Scandurra, Benedetta Muzii, Claudio Di Nola, Vincenzo Bochicchio, Riccardo Nocini, Vincenzo Abbate, Nelson Mauro Maldonato, Giovanni Dell ' Aversana Orabona, Nicola Longo, Elena Cantone
Summary: Lower urinary tract symptoms, especially nocturia, are a significant public health problem worldwide, particularly in elderly individuals, and are associated with sleep disorders and obstructive sleep apnea syndrome. However, the causes and pathophysiology of nocturia in OSAS patients have not been thoroughly examined. The effect of treatment on managing nocturia in OSAS patients also remains unclear.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Sabrina Cancelliere, Tracy Heung, Simone Fischbach, Paula Klaiman, Anne S. Bassett
Summary: We evaluated adult-onset obstructive sleep apnea (OSA) and related risk factors in individuals with 22q11.2 deletion syndrome (22q11.2DS), including history of pediatric palatal/pharyngeal surgery. The results showed that pediatric pharyngoplasty was a significant independent predictor for adult-onset OSA in individuals with 22q11.2DS, along with other factors such as asthma, higher body mass index, older age, and male sex. This study highlights the importance of increased awareness and suspicion of OSA in adults with 22q11.2 microdeletion.
Article
Chemistry, Multidisciplinary
Jing Liu, Haiyan Wang, Tao Liu, Qinan Wu, Yonghui Ding, Rongxian Ou, Chuigen Guo, Zhenzhen Liu, Qingwen Wang
Summary: In this study, a multimodal hydrogel sensor with excellent comprehensive performance was developed for monitoring respiration and diagnosing obstructive sleep apnea syndrome (OSAS). The hydrogel sensor exhibited good mechanical properties and extreme temperature tolerance, enabling independent monitoring of mechanical variation and thermal change. This sensor provides a new and practical way for real-time respiratory monitoring and preventing the occurrence of sleep-related diseases.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Medicine, General & Internal
Hyunjin Jo, Sujung Choi, Dongyeop Kim, Eunyeon Joo
Summary: Patients with epilepsy have milder characteristics of obstructive sleep apnea (OSA), but because of the high coexistence of OSA and epilepsy, continuous positive airway pressure (CPAP) therapy can reduce the frequency of seizures. Therefore, it is important to evaluate the presence of OSA in patients with epilepsy and provide concurrent treatment.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Emily Jane Meyer, Gary Allen Wittert
Summary: Obstructive sleep apnea (OSA) and obesity are closely associated; OSA is often unrecognized in women; OSA increases the risk of developing comorbid chronic disorders and impairs quality of life; appropriate treatment can improve symptoms and related diseases.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Health Care Sciences & Services
Cecilia Turino, Ivan D. Benitez, Xavier Rafael-Palou, Ana Mayoral, Alejandro Lopera, Lydia Pascual, Rafaela Vaca, Anunciacion Cortijo, Anna Moncusi-Moix, Mireia Dalmases, Eloisa Vargiu, Jordi Blanco, Ferran Barbe, Jordi de Batlle
Summary: The study demonstrates that the intelligent monitoring system MiSAOS can improve CPAP compliance and is cost-effective. Patient satisfaction is high, and there is no significant increase in costs.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)