期刊
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
卷 139, 期 -, 页码 1009-1017出版社
ELSEVIER
DOI: 10.1016/j.ijbiomac.2019.08.069
关键词
Polysaccharides; Physicochemical properties; Antioxidant activity; Hypoglycemic activity
资金
- National Natural Science Foundation of China [31801542]
- Natural Science Foundation of Guangdong Province [2018A030310383]
- National International Science and Technology Cooperation Base for Tropical Health Food [2017D01005]
- China Postdoctoral Science Foundation [2016M602474]
- 111 Project [B17018]
A polysaccharide, designated as PSP-1, was isolated and purified from Sargassum pallidum. Physicochemical characterization showed that PSP-1 with the average molecular weight of 1.036 x 10(6) Da was composed of fucose, arabinose, galactose, glucose, xylose, mannose, galacturonic acid and glucuronic acid in a molar ratio of 18.45:2.15:19.06:1.89:16.07:1.00:5.74:20.09. The results of antioxidant assays indicated that PSP-1 had good DPPH radical scavenging activity, hydroxyl radical scavenging activity, cellular antioxidant activity, and reactive oxygen species inhibition activity, and could significantly improve cellular antioxidant enzymes of ABAP-induced HepG2 cell model. The results of hypoglycemic assays showed that PSP-1 possessed favorable alpha-amylase and alpha-glucosidase inhibitory activities, and could remarkably enhance glucose consumption, glycogen synthesis and the activities of pyruvate kinase and hexokinase in insulin-resistance HepG2 cells. The results suggest that PSP1 can be exploited as a potential antioxidant and hypoglycemic candidate for functional and nutraceutical applications. (c) 2019 Elsevier B.V. All rights reserved.
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