Review
Nutrition & Dietetics
Adriana Mocanu, Roxana Alexandra Bogos, Tudor Ilie Lazaruc, Laura Mihaela Trandafir, Vasile Valeriu Lupu, Ileana Ioniuc, Mirabela Alecsa, Anca Ivanov, Ancuta Lupu, Iuliana Magdalena Starcea
Summary: The human intestinal microbiota plays a crucial role in promoting health and preventing disease. It is influenced by factors such as diet, genetics, and environment. In pediatric patients, the gut microbiota is vulnerable to disruption and has been linked to chronic kidney disease.
Review
Urology & Nephrology
Laetitia Koppe, Christophe O. Soulage
Summary: Chronic kidney disease is associated with changes in the gut microbiota, and diet plays a crucial role in managing the disease. This review discusses the latest research on the interactions between diet and gut microbiota in the context of uremia, and how this knowledge can be used to develop personalized nutrition strategies to prevent the progression of chronic kidney disease to kidney failure and its complications.
KIDNEY INTERNATIONAL
(2022)
Review
Nutrition & Dietetics
Paulina Mertowska, Sebastian Mertowski, Julia Wojnicka, Izabela Korona-Glowniak, Ewelina Grywalska, Anna Blazewicz, Wojciech Zaluska
Summary: Chronic kidney disease is a progressive and irreversible condition that can lead to alterations in the gut microbiota and activation of the immune system, with dietary factors playing a significant role in immune cell activation and microbiota balance. Understanding the relationship between intestinal microbiota and kidney dysfunction is crucial in the progression of kidney diseases.
Review
Pharmacology & Pharmacy
Yinghui Huang, Wang Xin, Jiachuan Xiong, Mengying Yao, Bo Zhang, Jinghong Zhao
Summary: This review discusses the role of gut microbiota in chronic kidney disease and its associated complications, as well as the significance of the gut-kidney-heart axis hypothesis in the pathophysiological mechanisms of these diseases. Regulating gut microbiota may serve as a novel therapeutic approach for CKD progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Urology & Nephrology
Keiichi Sumida, Joseph F. Pierre, Melana Yuzefpolskaya, Paolo C. Colombo, Ryan T. Demmer, Csaba P. Kovesdy
Summary: Recent research has shown the significant role of the gut microbiota in cardiometabolic disorders. Understanding the impact of dysbiosis on disease development has led to the development of potential therapeutic strategies. Current evidence suggests that various interventions can modulate the gut microbiota of CKD patients, improving their clinical outcomes.
SEMINARS IN NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Xinru Guo, Wanling Wang, Yangyang Ma, Yanjun Liang, Yena Zhou, Guangyan Cai
Summary: This study examined the impact of 24-h urinary calcium excretion (UCaE) on renal function decline in hospitalized patients, including those with chronic kidney disease (CKD) and those without CKD. The results showed that increasing UCaE was associated with a decreased risk of renal function decline in both CKD and non-CKD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Alexandru Cosmin Pantazi, Mustafa Ali Kassim Kassim, Wassan Nori, Liliana Ana Tuta, Cristina Maria Mihai, Tatiana Chisnoiu, Adriana Luminita Balasa, Larisia Mihai, Ancuta Lupu, Corina Elena Frecus, Vasile Valeriu Lupu, Sergiu Ioachim Chirila, Anca Gabriela Badescu, Laurentiu-Tony Hangan, Simona Claudia Cambrea
Summary: The gut microbiota plays a vital role in kidney disease, and interventions targeting the gut microbiota show promising results. Challenges remain in terms of patient variability and safety concerns. Further research is needed to understand the mechanisms and validate personalized interventions through clinical trials.
Article
Endocrinology & Metabolism
Jing Liu, Maria Clarissa Tio, Ashish Verma, Insa M. Schmidt, Titilayo O. Ilori, Felix Knauf, Finnian R. Mc Causland, Sushrut S. Waikar
Summary: This study aimed to investigate predictors of urinary calcium excretion and its association with adverse clinical outcomes in chronic kidney disease (CKD). The results showed that estimated glomerular filtration rate (eGFR) was positively correlated with 24-hour urinary calcium excretion. The determinants of urinary calcium excretion differed between sexes and levels of CKD. Lower urinary calcium excretion was associated with higher risks of adverse outcomes, but these associations were greatly attenuated or nullified after adjustment for baseline eGFR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Fernanda G. Rodrigues, Milene S. Ormanji, Ita P. Heilberg, Stephan J. L. Bakker, Martin H. de Borst
Summary: This article explores the deregulation of gut microbiota in patients with chronic kidney disease (CKD) and its impact on vascular and bone diseases. It discusses the influence of diet, medications, and other factors on gut microbiota composition and subsequently on the overall health of CKD patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Biochemistry & Molecular Biology
Ashani Lecamwasam, Tiffanie M. Nelson, Leni Rivera, Elif I. Ekinci, Richard Saffery, Karen M. Dwyer
Summary: Individuals with diabetes and chronic kidney disease show gut dysbiosis, with Firmicutes and Bacteroidetes as predominant phyla. The relative abundance of these gut microbes does not change across the early and late stages of diabetic chronic kidney disease, suggesting it is an early event in disease development.
Article
Pharmacology & Pharmacy
A. Noce, M. Marchetti, G. Marrone, L. Di Renzo, M. Di Lauro, F. Di Daniele, M. Albanese, N. Di Daniele, A. De Lorenzo
Summary: During chronic kidney disease, alterations in gut microbiota composition can lead to increased intestinal permeability, allowing bacterial material to pass through the intestinal wall into the bloodstream, inducing the typical chronic inflammatory state of CKD.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Review
Multidisciplinary Sciences
Siamak Amini Khiabani, Mohammad Asgharzadeh, Hossein Samadi Kafil
Summary: Chronic kidney disease (CKD) is a range of pathological processes correlated with abnormal renal function and progressive loss in GFR. Gut dysbiosis in CKD patients is associated with elevated levels of uremic toxins, which in turn accelerates the progression of CKD.
Article
Pharmacology & Pharmacy
Libin Pan, Hang Yu, Jie Fu, Jiachun Hu, Hui Xu, Zhengwei Zhang, Mengmeng Bu, Xinyu Yang, Haojian Zhang, Jinyue Lu, Jiandong Jiang, Yan Wang
Summary: Studies on the gut-kidney axis have shown that berberine, a natural drug, can significantly improve chronic kidney disease by altering the gut microbiota composition and inhibiting the production of gut-derived uremic toxins. Berberine also increases the content of butyric acid-producing bacteria and butyric acid, while decreasing the renal toxic trimethylamine N-oxide.
ACTA PHARMACEUTICA SINICA B
(2023)
Article
Immunology
Narjess Bostanghadiri, Pardis Ziaeefar, Fatemeh Sameni, Mohammad Mahmoudi, Ali Hashemi, Davood Darban-Sarokhalil
Summary: Nephrolithiasis is a common chronic kidney disease, more prevalent in adult men than women, influenced by genetic and environmental factors. The composition and structure of gut and urinary microbiome play a crucial role in the formation of kidney stones.
MICROBIAL PATHOGENESIS
(2021)
Review
Biochemistry & Molecular Biology
Serena Altamura, Davide Pietropaoli, Francesca Lombardi, Rita Del Pinto, Claudio Ferri
Summary: This article explores the dynamic biological connections between oral health, gut, and renal pathology, emphasizing the importance of the oral-gut-kidney axis. It also discusses the potential role of periodontal diseases and gut microbiota as disease modifiers in CKD.
