Article
Chemistry, Inorganic & Nuclear
Carley Giffert L. Nongpiur, Danny F. Diengdoh, Nupur Nagar, Krishna Mohan Poluri, Paige M. Gannon, Werner Kaminsky, Mohan Rao Kollipara
Summary: In this study, a series of novel half-sandwich metal complexes were synthesized with different ligands, and the structures were characterized. The antibacterial and antioxidant activities of these compounds were evaluated.
Article
Materials Science, Multidisciplinary
Kalaivani Seenivasan, Thuy Phuong Nhat Tran, Priyank Mohan, Nhan Nu Thanh Ton, Ashutosh Thakur, Patchanee Chammingkwan, Diwan S. Rawat, Toshiaki Taniike
Summary: A novel Ru-based heterogeneous catalyst was developed, in which Ru nanoparticles were confined in the gallery space of graphene oxide frameworks (GOFs) pillared with organic linkers. The Ru@GOF catalysts showed excellent activity and recyclability in the conversion of levulinic acid into gamma-valerolactone using formic acid as a hydrogen source.
JOURNAL OF MATERIALS SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Khadichakhan Rafikova, Nermin Meric, Remziye Guzel, Nevin Arslan, Nil Ertekin Binbay, Cezmi Kayan, Veysi Okumus, Alexey Zazybin, Tulegen Seilkhanov, Veysel Binbay, Murat Aydemir
Summary: Mononuclear transition metal complexes based on ionic liquid have been prepared and characterized. The study evaluated their biological properties, including radical scavenging activity, reducing power, antibacterial effect, DNA binding, and cleavage activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Multidisciplinary Sciences
Maria A. Klyuchnikova, Ilyag. Kvasha, TatianaK. Laktionova, Vera V. Voznessenskaya
Summary: This dataset describes olfactory perception of androstenone in residents of central Russia. The dataset includes sensory testing, odor discrimination procedure, odor intensity and pleasantness ratings, free odor identification, and demographic information. It is useful for assessing the impact of various factors on the perception of volatile steroids and can be used for studying cross-cultural differences in olfactory perception.
Article
Chemistry, Inorganic & Nuclear
Carley Giffert L. Nongpiur, Lincoln Dkhar, Deepak Kumar Tripathi, Krishna Mohan Poluri, Werner Kaminsky, Mohan Rao Kollipara
Summary: A series of half-sandwich platinum group metal complexes containing coumarin-N-acylhydrazone ligands were prepared and studied for antibacterial and antioxidant properties, showing potent effects in both aspects.
INORGANICA CHIMICA ACTA
(2021)
Article
Multidisciplinary Sciences
Vinod Kumar, Govindhaswamy Umapathy
Summary: Developed a non-invasive method to detect and quantify androstenone in faecal and urine samples of pigs using an enzyme immunoassay. Results showed that androstenone could be detected and quantified in faecal and urine samples of pigs.
Article
Chemistry, Medicinal
Urszula K. Komarnicka, Alessandro Niorettini, Sandra Koziel, Barbara Pucelik, Agata Barzowska, Daria Wojtala, Aleksandra Ziolkowska, Monika Lesiow, Agnieszka Kyziol, Stefano Caramori, Marina Porchia, Alina Bienko
Summary: In this study, two novel phosphine ligands and their corresponding metal complexes were synthesized and characterized. The copper(I) complexes were found to be highly unstable, while the ruthenium(II) and iridium(III) complexes showed promising cytotoxicity towards cancer cells. Further analysis revealed that these metal complexes effectively accumulated inside cancer cells, inducing apoptosis and altering the cell cycle. Additionally, the complexes exhibited low genotoxicity towards DNA and were able to generate reactive oxygen species. Furthermore, efficient anticancer action was demonstrated on multicellular tumor spheroids.
Article
Chemistry, Organic
Jerome Klein, Nicole Jung, Stefan Braese
Summary: New oligomers based on quinoxaline units were synthesized through multistep reactions, using Wittig coupling to yield (E)-(quinoxalin-2-yl)ethene oligomers. Diverse quinoxaline-based phosphonium salts were designed and synthesized, providing versatility and compatibility in the oligomer-building process. Characterization of the oligomers revealed excellent stereoisomer specificity, with a fully E-configurated conjugated pi-system. The light absorption/emission profiles of the oligomers indicate potential applications in materials science.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ashraf A. Aly, Elham M. Abdallah, Salwa A. Ahmed, Mohamed K. Awad, Mai M. Rabee, Sara M. Mostafa, Stefan Braese
Summary: Substituted thiocarbohydrazones were synthesized and their complexation capability towards Cu(I), Co(II), and Ni(II) salts was studied. Experimental characterization and theoretical calculations were performed to analyze the synthesized metal complexes.
JOURNAL OF SULFUR CHEMISTRY
(2023)
Article
Chemistry, Organic
Joao Macara, Catarina Caldeira, Jose Cunha, Jaime A. S. Coelho, Maria J. S. A. Silva, Konrad Kramer, Christoph W. Grathwol, Stefan Brase, M. Manuel B. Marques
Summary: A methodology for the synthesis of sulfonyl hydrazides mediated by hypervalent iodine is described. The polarity of sodium sulfinate salts is reversed by hypervalent iodine reagents to generate a key intermediate, which can react with mono- and disubstituted hydrazines. Various sulfonyl hydrazides were successfully synthesized with yields up to 62%, demonstrating the practical utility of this protocol. Mechanistic studies, including DFT calculations, were performed and the bioactivity of the synthesized compounds was evaluated.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Vincent Hahn, N. Maximilian Bojanowski, Pascal Rietz, Florian Feist, Mariana Kozlowska, Wolfgang Wenzel, Eva Blasco, Stefan Braese, Christopher Barner-Kowollik, Martin Wegener
Summary: Most light-based 3D printing methods rely on optical or chemical nonlinearities for polymerization reactions. Two-photon absorption is commonly used in 3D micro-and nanoprinting, but this article reviews three emerging processes that allow for quadratic nonlinearity without relying on two-photon absorption, namely upconversion luminescence, two-step absorption, and triplet-triplet annihilation. These (1 + 1)-photon absorption processes enable the use of continuous-wave lasers at lower peak powers and cost compared to two-photon absorption. The article discusses recent progress, challenges, and future perspectives.
Article
Biochemistry & Molecular Biology
Vivek Kumar, Jennifer S. Lin, Natalia Molchanova, John A. Fortkort, Carolin Reckmann, Stefan Braese, Havard Jenssen, Annelise E. Barron, Archana Chugh
Summary: Visceral leishmaniasis (VL) is a neglected tropical disease and the use of cell-permeating peptides as potential drug candidates to treat VL is limited due to their limited biological stability. In this study, peptoids, which are peptide mimics with good biostability, were tested against Leishmania donovani. The addition of N-alkyl hydrophobic chains and bromination yielded compounds with good antileishmanial activity against both intracellular amastigotes and promastigotes, indicating the potential of these peptoids as drug candidates for VL.
Article
Chemistry, Organic
Sarah Al Muthafer, Christoph Schissler, Vanessa Koch, Hannes Kuhner, Martin Nieger, Stefan Brase
Summary: In this study, the concise semisynthesis of natural cardenolide uzarigenin and its diastereoisomer allo-uzarigenin was achieved in nine and seven steps, respectively, starting from epi-androsterone. The stereoselective introduction of the beta-hydroxy group at C-14 via Mukaiyama oxidation and the installation of the butenolide ring at C-17 using a Stille-cross-coupling reaction were discussed. By directing the hydrogenation via a protecting group strategy, both the C-17 beta isomer and allo-uzarigenin were obtained stereoselectively.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Dimitry Schmidt, Patrizia Gartner, Ivan Berezkin, Jens Rudat, Maximilian Bilger, Tom Gruenert, Nadine Zimmerer, Philipp Quarz, Philip Scharfer, Julian Brueckel, Andre P. Jung, Pooja Singh, Pooja Pooja, Benno Meier, Mareen Stahlberger, Wilhelm Schabel, Stefan Braese, Gisela Lanza, Alexander Nesterov-Mueller
Summary: This study presents a method to screen for selective peptide binders to perfluorinated sulfonic acid ionomers, such as Nafion, using ultra-high density peptide arrays. The peptide WIWHCW with a helix structure is identified as a selective binder to Nafion, and the invariant amino acids responsible for binding are also determined. The dissociation constant of WIWHCW to Nafion is measured at approximately 140 μM.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Valentina Ferraro, Clara R. Adam, Aleksandra Vranic, Stefan Braese
Summary: The use of visible light for polymerization is appealing for its potential in improving the sustainability of the process. Transition metal complexes, with their long-lived excited states and reversible redox properties, are a viable option for photoinitiating systems. This review provides an overview of the transition metal complexes used in photopolymerization reactions, with particular emphasis on recent applications in 3D printing and the challenges in achieving highly efficient and sustainable processes.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Payam Kalhor, Nicole Jung, Stefan Braese, Christof Woell, Manuel Tsotsalas, Pascal Friederich
Summary: The development of new functional materials is essential for addressing global challenges. Machine learning models and data extraction methods from scientific literature can accelerate the discovery of functional materials, while ensuring their stability, synthesis capability, scalability, and sustainability.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Benedikt Zerulla, Chun Li, Dominik Beutel, Simon Osswald, Christof Holzer, Jochen Buerck, Stefan Braese, Christof Woell, Ivan Fernandez-Corbaton, Lars Heinke, Carsten Rockstuhl, Marjan Krstic
Summary: Electronic circular dichroism is an important optical phenomenon for studying chiral molecular materials. Metal-organic frameworks (MOFs) are crystalline porous thin-film materials with tailored chemical and physical properties. Combining these two aspects, researchers aim to create devices with unprecedented functionality. However, advanced modeling techniques are needed to address the complexity of material choices and structural details. A computational workflow that combines quantum chemical methods with optical simulations is proposed, focusing on chiral properties in UiO-67-BINOL MOFs.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jimin Song, Xiaojuan Yu, Alexei Nefedov, Peter G. Weidler, Sylvian Grosjean, Stefan Braese, Yuemin Wang, Christof Woell
Summary: This study demonstrates a method to observe UV-induced photochemical reactions of aryl azides within a crystalline matrix in vacuum. By using metal-organic frameworks (MOFs) and surface-mounted MOFs (SURMOFs) as model systems, the azide-related chemical processes can be studied under ultrahigh vacuum (UHV) conditions, excluding solvent effects and in a wide temperature range. In situ infrared reflection absorption spectroscopy (IRRAS) was used to monitor the photoreaction of azide in SURMOFs, revealing the reaction mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Yunzhe Jiang, Yidong Liu, Sylvain Grosjean, Volodymyr Bon, Patrick Hodapp, Anemar Bruno Kanj, Stefan Kaskel, Stefan Braese, Christof Woell, Lars Heinke
Summary: In this research, we achieved a directed responsive behavior of light-induced deformation by assembling light-powered molecules into a surface-mounted metal-organic framework film. The molecular extension changes were multiplied at the mesoscopic scale and transferred to the macroscopic scale, resulting in the bending of a cantilever and performing work.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Lamya H. Al-Wahaibi, Hesham A. Abou-Zied, Mohamed Hisham, Eman A. M. Beshr, Bahaa G. M. Youssif, Stefan Brase, Alaa M. Hayallah, Mohamed Abdel-Aziz
Summary: A series of novel 3-cyanopyridone/pyrazoline hybrids exhibiting dual inhibition against EGFR and BRAF(V600E) have been developed and demonstrated remarkable antiproliferative activity and promising anticancer potential.
Article
Biochemistry & Molecular Biology
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Brase, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha
Summary: A novel series of 1,2,3-triazole/1,2,4-triazole hybrids were designed and synthesized as antiproliferative agents targeting aromatase enzymes. Compounds 6a and 6b demonstrated the highest antiproliferative activity and aromatase inhibitory action, indicating their potential as anticancer candidates. Molecular docking investigations further supported these findings.
Article
Chemistry, Inorganic & Nuclear
Christoph Schissler, Erik K. Schneider, Michael Rotter, Silke Notter, Carsten Geier, Patrick Weis, Manfred M. Kappes, Stefan Braese
Summary: We have developed a synthetic route to achieve cofacial stacking of N-fused porphyrins and regular porphyrins using an o-substituted phenylene linker. This approach involves a crucial Suzuki-Miyaura cross-coupling reaction to introduce a phenyl moiety into the tri-pentacyclic ring of the N-fused porphyrin, enabling the formation of a spatial arrangement that can hold both N-fused porphyrin and regular porphyrin in close proximity. The resulting ligand system was obtained with a 0.77% yield in five steps and was characterized using various techniques.
