Article
Immunology
Megan E. Grund, Eliza Kramarska, Soo Jeon Choi, Dudley H. McNitt, Christopher P. Klimko, Nathaniel O. Rill, Jennifer L. Dankmeyer, Jennifer L. Shoe, Melissa Hunter, David P. Fetterer, Zander M. Hedrick, Ivan Velez, Sergei S. Biryukov, Christopher K. Cote, Rita Berisio, Slawomir Lukomski
Summary: This study examined the immune response to a vaccine formulated with antigens derived from the outer membrane protein Bucl8 in Burkholderia pseudomallei and found that synthetic loop peptides elicited a stronger and more consistent antibody response compared to recombinant protein antigens, resulting in a TH2-skewed response.
Article
Immunology
Isabel Leroux-Roels, Gwenn Waerlop, Jessika Tourneur, Fien De Boever, Catherine Maes, Jacques Bruhwyler, Delphine Guyon-Gellin, Philippe Moris, Judith Del Campo, Paul Willems, Geert Leroux-Roels, Alexandre Le Vert, Florence Nicolas
Summary: OVX836, a vaccine targeting influenza nucleoprotein, demonstrated safety and immunogenicity in a Phase 1 study. It outperformed the reference vaccine in terms of immunological parameters related to nucleoprotein and showed potential in reducing influenza-like illness episodes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Benjamin N. Rome, William B. Feldman, Michael A. Fischer, Rishi J. Desai, Jerry Avorn
Summary: Concurrent administration of influenza and zoster vaccines may lead to a reduction in receipt of the influenza vaccine the following year, possibly due to patients misattributing systemic side effects caused by the zoster vaccine to the influenza vaccine. It is suggested to administer these two vaccines separately or provide enhanced counseling to patients about expected vaccine side effects.
Article
Immunology
Minying Zhang, Ting Zhang, Yang He, Hujun Cui, Hong Li, Zehua Xu, Xu Wang, Yunlong Liu, Hongping Li, Xiaoheng Zhao, Hanliang Cheng, Jianhe Xu, Xiangning Chen, Zhujin Ding
Summary: The study found that both the inactivated vaccine and the OmpA subunit vaccine have a certain protective effect on juvenile M. amblycephala against A. hydrophila infection and can enhance the immune response. Among them, the OmpA subunit vaccine showed better protective effects compared to the inactivated vaccine, which can be attributed to the reduction in bacterial load and enhanced host immunity. In conclusion, the OmpA subunit vaccine is an ideal choice for the A. hydrophila vaccine.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Dejing Yin, Ling He, Erpeng Zhu, Tian Fang, Jun Yue, Ming Wen, Kaigong Wang, Zhentao Cheng
Summary: The study shows that the rFiber2 subunit vaccine and Fiber2 DNA vaccine can induce robust humoral and cellular immune responses in chickens, with the rFiber2 subunit vaccine having significantly higher efficacy compared to the Fiber2 DNA vaccine and a commercial inactivated vaccine, laying foundations for the effective control of HHS.
VETERINARY MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Zhenzhen Wang, Zhenhua Li, Weiwei Shi, Dashuai Zhu, Shiqi Hu, Phuong-Uyen C. Dinh, Ke Cheng
Summary: The combination of SARS-CoV-2 virus-like particle (VLP) vaccine with inactivated influenza A virus provides protection against COVID-19, influenza, and co-infection, inducing strong immune responses and neutralization activity.
Review
Biotechnology & Applied Microbiology
Simin Wen, Zhengyu Wu, Shuyi Zhong, Mao Li, Yuelong Shu
Summary: This paper reviews the factors that may influence the immunogenicity of influenza vaccines, including vaccine factors, adjuvants, individual factors, repeated vaccination, and genetic factors, and emphasizes the importance of fully identifying these factors.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Review
Polymer Science
Probal Basu, Nabanita Saha, Tomas Saha, Petr Saha
Summary: The appropriate delivery of vaccines is crucial for proper immunization. Research has shown that polymer hydrogels can serve as efficient delivery systems for foreign antigens and vaccines, despite the challenges in developing effective vaccine delivery systems.
Editorial Material
Surgery
Tara C. Anderson, Nina B. Masters, Angela Guo, Leah Shepersky, Andrew J. Leidner, Grace M. Lee, Camille N. Kotton, Kathleen L. Dooling
Summary: The Advisory Committee on Immunization Practices (ACIP) has recommended the use of two doses of Zoster Vaccine Recombinant, Adjuvanted (RZV) for the prevention of herpes zoster and complications in immunosuppressed adults. RZV is the first approved vaccine for immunocompromised individuals, providing the potential to lower the incidence and complications of herpes zoster among transplant candidates and recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Ivan T. Lee, Raffael Nachbagauer, David Ensz, Howard Schwartz, Lizbeth Carmona, Kristi Schaefers, Andrei Avanesov, Daniel Stadlbauer, Carole Henry, Ren Chen, Wenmei Huang, Daniela Ramirez Schrempp, Jintanat Ananworanich, Robert Paris
Summary: Despite vaccine availability, influenza remains a significant global public health concern. Preliminary results from a phase 1/2 clinical trial show that mRNA-1010, a quadrivalent mRNA vaccine against seasonal influenza, is safe and elicits a strong immune response in adults. The vaccine produces higher or comparable levels of hemagglutination inhibition (HAI) antibodies compared to the licensed comparator vaccine.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, General & Internal
Melissa A. Rolfes, H. Keipp Talbot, Huong Q. McLean, Melissa S. Stockwell, Katherine D. Ellingson, Karen Lutrick, Natalie M. Bowman, Emily E. Bendall, Ayla Bullock, James D. Chappell, Jessica E. Deyoe, Julie Gilbert, Natasha B. Halasa, Kimberly E. Hart, Sheroi Johnson, Ahra Kim, Adam S. Lauring, Jessica T. Lin, Christopher J. Lindsell, Son H. McLaren, Jennifer K. Meece, Alexandra M. Mellis, Miriana Moreno Zivanovich, Constance E. Ogokeh, Michelle Rodriguez, Ellen Sano, Raul A. Silverio A. Francisco, Jonathan E. Schmitz, Celibell Y. Vargas, Amy Yang, Yuwei Zhu, Edward A. Belongia, Carrie Reed, Carlos G. Grijalva
Summary: The COVID-19 pandemic resulted in a decrease in global influenza virus infections. However, there was an increased risk of influenza virus infection during the 2021-2022 influenza season due to loss of natural immunity and antigenic changes in circulating viruses.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Immunology
Joanne Marie M. Del Rosario, Kelly A. S. da Costa, Benedikt Asbach, Francesca Ferrara, Matteo Ferrari, David A. Wells, Gurdip Singh Mann, Veronica O. Ameh, Claude T. Sabeta, Ashley C. Banyard, Rebecca Kinsley, Simon D. Scott, Ralf Wagner, Jonathan L. Heeney, George W. Carnell, Nigel J. Temperton
Summary: A library of influenza hemagglutinin (HA) pseudotypes was developed for use in influenza neutralization assays, demonstrating high sensitivity and specificity for detecting virus-specific neutralizing antibodies and assessing antibody functionality. These HA pseudotypes can serve as substitutes for wildtype viruses in experiments and are valuable for evaluating cross-subtype immune responses elicited by vaccines.
Review
Biotechnology & Applied Microbiology
Lucy Denly
Summary: Current evidence does not support the existence of sex differences in the immunogenicity, effectiveness, or efficacy of seasonal influenza vaccines, but females report adverse events following immunization more frequently than males. Further controlled studies are needed to draw conclusions about potential sex differences in response to these vaccines.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Immunology
Michelle Clarke, Louise M. Goodchild, Sue Evans, Lynne C. Giles, Sheena G. Sullivan, Ian G. Barr, Stephen Lambert, Helen Marshall
Summary: This study investigated the impact of body mass index (BMI) on vaccine responses following influenza vaccination during pregnancy, and found that high BMI did not impair seroprotection levels. Additionally, the gestation at vaccination may be an important consideration for optimizing vaccine protection. Further assessment of first trimester influenza vaccine responses is recommended.
Article
Immunology
Sara H. Mahmoud, Ahmed A. Khalil, Noura M. Abo Shama, Marwa F. El Sayed, Reem A. Soliman, Naglaa M. Hagag, Nahed Yehia, Mahmoud M. Naguib, Abdel-Sattar Arafa, Mohamed A. Ali, Mounir M. El-Safty, Ahmed Mostafa
Summary: Controlling avian influenza viruses (AIVs) is mainly done through culling infected bird flocks or using inactivated vaccines. New avian influenza virus subtypes have been reported in Egypt, calling for an updated vaccine. In this study, three H5Nx vaccines were generated using reverse genetic system, and their immunogenicity and cross-reactivity were assessed. The results showed that rgH5N1_2.3.4.4 vaccine induced high immunogenicity and provided efficient protection against different H5Nx HPAIVs.
Review
Infectious Diseases
Thi Thu Hao Van, Zuwera Yidana, Peter M. Smooker, Peter J. Coloe
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2020)
Article
Immunology
Carina C. D. Joe, Sayantani Chatterjee, George Lovrecz, Timothy E. Adams, Morten Thaysen-Andersen, Renae Walsh, Stephen A. Locarnini, Peter Smooker, Hans J. Netter
Article
Nanoscience & Nanotechnology
Aya C. Taki, Jasmine E. Francis, Ivana Skakic, Chaitali Dekiwadia, Thomas R. McLean, Vipul Bansal, Peter M. Smooker
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2020)
Article
Chemistry, Applied
Ida May Jen Ng, Siau Hui Mah, Caroline Lin Lin Chua
Summary: Macluraxanthone promotes polarization of M1-like pro-inflammatory macrophages in human macrophages, but significantly decreases the production of inflammatory cytokines in the presence of pro-inflammatory stimuli.
NATURAL PRODUCT RESEARCH
(2021)
Article
Biotechnology & Applied Microbiology
F. H. Tan, J. C. Kong, J. F. Ng, N. B. Alitheen, C. L. Wong, C. Y. Yong, K. W. Lee
Summary: The study successfully displayed a 10-residue peptide on the surface of TYMVcHis(6) VLPs, showing high stability under different pH and temperature conditions, and the ability to reassemble into VLPs after chemical denaturation.
JOURNAL OF APPLIED MICROBIOLOGY
(2021)
Review
Immunology
Caroline L. L. Chua, Wina Hasang, Stephen J. Rogerson, Andrew Teo
Summary: Pregnant women in malaria-endemic regions are at risk of malaria in pregnancy, leading to adverse birth outcomes such as low birthweights and increased infant mortality. Plasmodium falciparum-infected erythrocytes express a unique variant surface antigen during malaria in pregnancy, contributing to placental inflammation and dysregulated development, ultimately affecting fetal growth. Effective prevention and management strategies, along with potential therapeutic interventions, are discussed in this review to improve birth outcomes and reduce the health burden of malaria in pregnancy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Infectious Diseases
Caroline Lin Lin Chua, Ida May Jen Ng, Bryan Ju Min Yap, Andrew Teo
Summary: There are seven known species of Plasmodium spp. that infect humans and the human immune response to these parasites involves phagocytosis, with specific opsonins and phagocyte sub-populations playing a crucial role in clinical protection against malaria. Cellular and molecular studies have enhanced our understanding of the immunological pathways following phagocytosis of malaria parasites. Factors affecting phagocytosis, immunological consequences, and potential therapies for malaria are discussed in this review.
Article
Microbiology
Andrew Teo, Caroline Lin Lin Chua, Po Ying Chia, Tsin Wen Yeo
Review
Microbiology
Caroline Lin Lin Chua, Sebastian Kah Ming Khoo, Jun Long Ernest Ong, Gaurav Kumar Ramireddi, Tsin Wen Yeo, Andrew Teo
Summary: Malaria during pregnancy can lead to the development of placental malaria, which may impair placental development and function, ultimately causing placental insufficiency, intrauterine growth restriction, preterm delivery and low birth weight.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Microbiology
Andrew Teo, Caroline Lin Lin Chua, Louisa L. Y. Chan
Article
Microbiology
Andrew Teo, Hao Dong Tan, Thomas Loy, Po Ying Chia, Caroline Lin Lin Chua
Article
Biochemical Research Methods
Foo Hou Tan, Jeck Fei Ng, Noorjahan Banu Mohamed Alitheen, Azira Muhamad, Chean Yeah Yong, Khai Wooi Lee
Summary: This study presents a non-chromatographic method for the purification of virus-like particles (VLPs) using C-terminally His-tagged TYMVc (TYMVcHis6) as a protein model. The results show that nickel affinity precipitation can successfully recover over 50% of TYMVcHis6 with a purity above 0.90, and the formed VLPs exhibit similar structures to those purified using conventional chromatography methods.
JOURNAL OF VIROLOGICAL METHODS
(2023)