Review
Nutrition & Dietetics
Yan Jiang, Karolin Jarr, Cosima Layton, Christopher D. Gardner, Judith E. Ashouri, Maria T. Abreu, Sidhartha R. Sinha
Summary: Despite being an important issue for patients, the impact of diet on adult inflammatory bowel disease (IBD) is not well explored, with limited guidance. Current evidence on various diets used in the treatment of IBD is summarized, with potential applications of dietary data from related immune-mediated inflammatory diseases (IMIDs) to inform providers. Multiple diets, including Mediterranean, vegetarian/vegan, and reduced-calorie/fasting diets, have shown positive results in other inflammatory diseases, suggesting potential applicability to IBD, but further well-designed clinical trials are needed for guidance.
Review
Nutrition & Dietetics
Srishti Saha, Neha Patel
Summary: Inflammatory bowel disease (IBD) is a chronic disorder caused by enteric inflammation in a genetically susceptible host. Diet is widely accepted as an important factor in the pathogenesis of IBD, and various dietary components have been studied for their roles in causing enteric inflammation. Different diets, such as exclusive enteral nutrition, specific carbohydrate diet, and low FODMAPs diet, have also been explored for their effects on IBD patients. This review summarizes the current evidence on the relationship between dietary components and IBD, and provides guidance for dietary modifications in managing IBD.
Article
Nutrition & Dietetics
Adelaide Teofani, Irene Marafini, Federica Laudisi, Daniele Pietrucci, Silvia Salvatori, Valeria Unida, Silvia Biocca, Giovanni Monteleone, Alessandro Desideri
Summary: This study investigated the impact of lifestyle and dietary habits on the intestinal microbiota diversity and relative abundance in patients with IBD, identifying specific confounders and covariates that influence the association between certain bacterial taxa and disease status. The results suggest that variables related to an IBD-associated lifestyle and dietary habits play a role in modulating the gut microbiota in IBD patients compared to healthy controls.
Article
Medicine, General & Internal
Malgorzata Godala, Ewelina Gaszynska, Lukasz Durko, Ewa Malecka-Wojciesko
Summary: This study investigated dietary perceptions and behaviors in patients with inflammatory bowel disease (IBD). Most patients believed that diet can trigger IBD relapses and imposed food restrictions to prevent relapses. However, these behaviors may not align with current scientific knowledge.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Emily W. Lopes, Simon S. M. Chan, Mingyang Song, Jonas F. Ludvigsson, Niclas Hakansson, Paul Lochhead, Allan Clark, Kristin E. Burke, Ashwin N. Ananthakrishnan, Amanda J. Cross, Domenico Palli, Manuela M. Bergmann, James M. Richter, Andrew T. Chan, Ola Olen, Alicja Wolk, Hamed Khalili
Summary: This study aimed to estimate the proportion of cases of Crohn's disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors. Using several cohorts in the US and Europe, the researchers created modifiable risk scores and healthy lifestyle scores, and found that a significant number of CD and UC cases could be prevented through lifestyle modification.
Review
Biochemistry & Molecular Biology
Vishal Khatri, Ramaswamy Kalyanasundaram
Summary: This review focuses on the association between IBD and gut inflammasome, as well as recent advances in research and therapeutic strategies for IBD, discussing inflammasomes and their components, outcomes from experimental animals and human studies, inflammasome inhibitors, and developments in inflammasome-targeted therapies for IBD.
Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Gastroenterology & Hepatology
Ramit Magen-Rimon, Andrew S. Day, Ron Shaoul
Summary: This review summarizes recent reports on nutritional factors relevant to the development of inflammatory bowel disease (IBD) and also reviews data on nutritional deficiencies seen in individuals with IBD.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Uma Mahadevan, Millie D. Long, Sunanda Kane, Abhik Roy, Marla C. Dubinsky, Bruce E. Sands, Russell D. Cohen, Christina D. Chambers, William J. Sandborn
Summary: The study found that exposure to biologic, thiopurine, or combination therapy during pregnancy did not increase adverse maternal or fetal outcomes, and these treatments can be continued throughout pregnancy for women with IBD to maintain disease control.
Article
Medicine, General & Internal
Silvia Salvatori, Francesco Baldassarre, Michelangela Mossa, Giovanni Monteleone
Summary: Long COVID is common in patients with inflammatory bowel diseases (IBD), with fatigue being the most frequent symptom. It does not influence the frequency of IBD relapses, but is more prevalent in female patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Thomas M. Goodsall, Tran M. Nguyen, Claire E. Parker, Christopher Ma, Jane M. Andrews, Vipul Jairath, Robert Bryant
Summary: The study systematically identified ultrasound scoring indices for assessing inflammatory bowel disease activity, with common components including bowel wall thickness, colour Doppler imaging, and bowel wall stratification. The correlation between ultrasound indices and reference standards, as well as sensitivity, specificity, accuracy, and other properties, varied within certain ranges. However, reliability and responsiveness data were limited, and most studies were rated with unclear or high risk of bias.
JOURNAL OF CROHNS & COLITIS
(2021)
Review
Medicine, General & Internal
Katarzyna Akutko, Andrzej Stawarski
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory diseases of the digestive tract with periods of remission and relapses. The etiopathogenesis is not fully understood, leading to only symptomatic treatment. There is a constant need to search for new high safety profile therapies for IBD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Food Science & Technology
Farnaz Farsi, Negin Tahvilian, Azadeh Heydarian, Sara Karimi, Sara Ebrahimi, Nasser Ebrahimi-Daryani, Sanam Tabataba-Vakili, Javad Heshmati, Marjan Mokhtare
Summary: Dietary components play a role in the development and progression of inflammatory bowel disease (IBD). A case-control study found that higher consumption of seafood and cholesterol is associated with an increased risk of IBD and ulcerative colitis, while higher intake of calcium is linked to a lower risk of Crohn's disease. Moreover, honey and jam, seafood, organ meats, salt, fruits on trees, fruit juice, olives, and nuts consumption is positively associated with IBD development, while refined grains, potatoes, salty snacks, legumes, dairy, and cruciferous vegetables are negatively associated with IBD.
FOOD SCIENCE & NUTRITION
(2022)
Review
Biotechnology & Applied Microbiology
Guihua Chen, Jun Shen
Summary: Inflammatory bowel disease (IBD) is a global disease with high morbidity and medical costs. Early diagnosis and intervention are crucial for controlling its progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Peter Bossuyt, Valerie Pittet, Mark Samaan, Monika Tripathi, Wladyslawa Czuber-Dochan, Johan Burisch, Salvatore Leone, Roberto Saldana, Filip Baert, Uri Kopylov, Susanna Jaghult, Michel Adamina, Naila Arebi, Krisztina Gecse
Summary: This study aimed to develop a core outcome set for real-world studies in adult patients with inflammatory bowel disease (IBD). Candidate outcomes and outcome measures were identified through a systematic review and a modified Delphi consensus process. The international panel agreed on the final core outcome set, which will facilitate the synthesis and generation of real-world evidence.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Phillip Gu, Edward Yang, Punya Chittajallu, Cathy McNeill, Amit G. Singal, John H. Kwon, Tasneem F. Ahmed
Summary: The study found that the majority of IBD patients had a favorable perception of IBD-DTCA, believing that the advertisements helped them become aware of new treatments and potential risks. However, IBD-DTCA rarely led to patient-provider discussions or changes in treatment regimens.
DIGESTIVE DISEASES AND SCIENCES
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Phillip Gu, Avneesh Chhabra, Punya Chhittajallu, Christopher Chang, Denisse Mendez, Andrew Gilman, David Fudman, Yin Xi, Linda Feagins
INFLAMMATORY BOWEL DISEASES
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Phillip Gu, Avneesh Chhabra, Punya Chhittajallu, Christopher Chang, Denisse Mendez, Andrew Gilman, David Fudman, Yin Xi, Linda Feagins
INFLAMMATORY BOWEL DISEASES
(2021)
Article
Gastroenterology & Hepatology
Phillip Gu, Avneesh Chhabra, Punya Chittajallu, Christopher Chang, Denisse Mendez, Andrew Gilman, David Fudman, Yin Xi, Linda A. Feagins
Summary: The study found that visceral adipose tissue volume is associated with anti-TNF treatment response in a non-dose dependent manner, while patients with high visceral fat index have a significantly increased risk of surgery after starting anti-TNF treatment.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Phillip Gu, Linda A. Feagins
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
(2022)
Article
Gastroenterology & Hepatology
Phillip Gu, Jiyu Luo, Jihoon Kim, Paulina Paul, Berkeley Limketkai, Jenny S. Sauk, Sunhee Park, Nimisha Parekh, Kai Zheng, Vivek Rudrapatna, Gaurav Syal, Christina Ha, Dermot P. McGovern, Gil Y. Melmed, Phillip Fleshner, Samuel Eisenstein, Sonia Ramamoorthy, Parambir S. Dulai, Brigid S. Boland, Eduardo Grunvald, Uma Mahadevan, Lucila Ohno-Machado, William J. Sandborn, Siddharth Singh
Summary: Obesity is not associated with increased risk of hospitalization, surgery, or serious infections in biologic-treated patients with inflammatory bowel diseases.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Gastroenterology & Hepatology
Phillip Gu, Shishir Dube, Dermot P. B. McGovern
Summary: Alterations in mesenteric adipose tissue play a significant role in Crohn's disease, but their clinical significance is still unclear. Current studies have limitations, but they suggest that mesenteric adipose tissue may serve as a marker for disease severity, surgical risk, and postoperative outcomes. Additionally, it could be a potential target for mitigating postoperative recurrence of Crohn's disease.
INFLAMMATORY BOWEL DISEASES
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Angela Mujukian, Dalin Li, Philip Debbas, Andrea Banty, Edward J. Feldman, Christina Ha, Susie Lee, Shervin Rabizadeh, Theodore Stein, Theodore Solomon, Gaurav Syal, Stephan R. Targan, Eric A. Vasiliauskas, David Ziring, Nirupama Bonthala, Melissa Hampton, Valeriya Pozdnyakova, Phillip Gu, Joseph Ebinger, Sandy Joung, Jane C. Figueiredo, Akil Merchant, Noah Merin, Karen L. Reckamp, Keren Appel, Rashmi Kumar, Brigid Boland, Aline Charabaty, Michael V. Chiorean, Erica Cohen, Ann D. Flynn, John F. Valentine, Adam C. Ehrlich, David Fudman, Sarah C. Glover, Arash A. Horizon, Dmitry Karayev, Benjamin Kretzmann, Jason K. Hou, Caroline Hwang, Mark Lazarev, Donald Lum, Rebecca Fausel, Swapna Reddy, Ryan McConnell, Mark Mattar, Mark Metwally, Arthur Ostrov, Parekh Nimisha, Laura H. Raffals, David T. Rubin, Sarah Sheibani, Corey A. Siegel, Douglas C. Wolf, Ziad H. Younes, Susan Cheng, Jonathan G. Braun, Dermot P. B. Mcgovern, Gil Melmed
Meeting Abstract
Gastroenterology & Hepatology
Phillip Gu, Shishir Dube, Norman Gellada, Dalin Li, Talin Haritunians, Eric A. Vasiliauskas, Christina Ha, Gaurav Syal, Nirupama Bonthala, Shaohong Yang, Phillip Fleshner, Gil Melmed, Mazen Noureddin, Cindy Kallman, Stephan R. Targan, Dermot P. B. Mcgovern
Meeting Abstract
Gastroenterology & Hepatology
Phillip Gu, Jiyu Luo, Paulina Paul, Berkeley N. Limketkai, Jenny S. Sauk, Sunhee Park, Nimisha K. Parekh, Kai Zheng, Vivek A. Rudrapatna, Gaurav Syal, Christina Ha, Dermot P. B. Mcgovern, Gil Melmed, Phillip Fleshner, Samuel Eisenstein, Sonia Ramamoorthy, Parambir Dulai, Brigid Boland, Uma Mahadevan, Lucila Ohno-Machado, William J. Sandborn, Siddharth Singh
Meeting Abstract
Gastroenterology & Hepatology
Dalin Li, Alexander Xu, Joseph Ebinger, Philip Debbas, Andrea Banty, Edward J. Feldman, Christina Ha, Susie Lee, Shervin Rabizadeh, Theodore Stein, Theodore Solomon, Gaurav Syal, Stephan R. Targan, Eric A. Vasiliauskas, David Ziring, Nirupama Bonthala, Melissa Hampton, Angela Mujukian, Valeriya Pozdnyakova, Phillip Gu, Sandy Joung, Keren Appel, Rashmi Kumar, Brigid S. Boland, Aline Charabaty, Michael V. Chiorean, Erica Cohen, Oriana M. Damas, Ann D. Flynn, John F. Valentine, Adam C. Ehrlich, David Fudman, Sarah C. Glover, Arash A. Horizon, Dmitry Karayev, Benjamin Kretzmann, Jason K. Hou, Caroline Hwang, Mark Lazarev, Donald Lum, Rebecca Fausel, Swapna Reddy, Ryan McConnell, Mark Mattar, Mark Metwally, Arthur Ostrov, Nimisha K. Parekh, Laura H. Raffals, David T. Rubin, Sarah Sheibani, Corey A. Siegel, Douglas C. Wolf, Ziad H. Younes, Ian M. Kaplan, John Prostko, Kimia Sobhani, Akil Merchant, Susan Cheng, Jonathan G. Braun, Dermot P. B. Mcgovern, Gil Melmed
Meeting Abstract
Gastroenterology & Hepatology
Shishir Dube, Norman Gellada, Dalin Li, Talin Haritunians, Phillip Gu, Shaohong Yang, Gregory J. Botwin, Stephan R. Targan, Damini Dey, Yaniv Raphael, Cindy Kallman, Dermot P. B. Mcgovern
Meeting Abstract
Gastroenterology & Hepatology
Shishir Dube, Dalin Li, Norman Gellada, Talin Haritunians, Phillip Gu, Shaohong Yang, Gregory J. Botwin, Stephan R. Targan, Damini Dey, Yaniv Raphael, Cindy Kallman, Dermot P. B. Mcgovern
Meeting Abstract
Gastroenterology & Hepatology
Jane Lim, Maryann Osayande, Phillip Gu, Kerry Dunbar
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Meeting Abstract
Gastroenterology & Hepatology
Phillip Gu, Avneesh Chhabra, Punya Chittajallu, Christopher Chang, Denisse Mendez, Andrew J. Gilman, David Fudman, Yin Xi, Linda A. Feagins