Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function

L1 drives IFN in senescent cells and promotes age-associated inflammation

(2019) Marco De Cecco et al.   NATURE

Genomic Accumulation of Retrotransposons Was Facilitated by Repressive RNA-Binding Proteins: A Hypothesis

(2019) Jan Attig et al.   BIOESSAYS

A LINE1-Nucleolin Partnership Regulates Early Development and ESC Identity

(2018) Michelle Percharde et al.   CELL

Evaluating different DNA binding domains to modulate L1 ORF2p-driven site-specific retrotransposition events in human cells

(2018) Catherine M. Ade et al.   GENE

L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution

(2018) Thu H.M. Nguyen et al.   Cell Reports

Human LINE-1 retrotransposition requires a metastable coiled coil and a positively charged N-terminus in L1ORF1p

(2018) Elena Khazina et al.   eLife

LINE-1 protein localization and functional dynamics during the cell cycle

(2018) Paolo Mita et al.   eLife

Dissection of affinity captured LINE-1 macromolecular complexes

(2018) Martin S Taylor et al.   eLife

Heteromeric RNP Assembly at LINEs Controls Lineage-Specific RNA Processing

(2018) Jan Attig et al.   CELL

Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators

(2017) Nian Liu et al.   NATURE

L1 Mosaicism in Mammals: Extent, Effects, and Evolution

(2017) Geoffrey J. Faulkner et al.   TRENDS IN GENETICS

The Evolution of Line-1 in Vertebrates

(2016) Stéphane Boissinot et al.   Genome Biology and Evolution

Identification of L1 ORF2p sequence important to retrotransposition using Bipartile Alu retrotransposition (BAR)

(2016) Claiborne M. Christian et al.   NUCLEIC ACIDS RESEARCH

Roles for retrotransposon insertions in human disease

(2016) Dustin C. Hancks et al.   Mobile DNA

A 3′ Poly(A) Tract Is Required for LINE-1 Retrotransposition

(2015) Aurélien J. Doucet et al.   MOLECULAR CELL

LINE-1 expression and retrotransposition in Barrett’s esophagus and esophageal carcinoma

(2015) Tara T. Doucet-O'Hare et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long Interspersed Element-1 Protein Expression Is a Hallmark of Many Human Cancers

(2014) Nemanja Rodić et al.   AMERICAN JOURNAL OF PATHOLOGY

Sleeping dogs of the genome

(2014) Vera Gorbunova et al.   SCIENCE

SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

(2014) Michael Van Meter et al.   Nature Communications

Genome reduction as the dominant mode of evolution

(2013) Yuri I. Wolf et al.   BIOESSAYS

Affinity Proteomics Reveals Human Host Factors Implicated in Discrete Stages of LINE-1 Retrotransposition

(2013) Martin S. Taylor et al.   CELL

L1 retrotransposons, cancer stem cells and oncogenesis

(2013) Patricia E. Carreira et al.   FEBS Journal

Mapping the LINE1 ORF1 protein interactome reveals associated inhibitors of human retrotransposition

(2013) John L. Goodier et al.   NUCLEIC ACIDS RESEARCH

Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model

(2013) K. A. O'Donnell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The carboxy-terminal segment of the human LINE-1 ORF2 protein is involved in RNA binding

(2013) Olga Piskareva et al.   FEBS Open Bio

Active Transposition in Genomes

(2012) Cheng Ran Lisa Huang et al.   Annual Review of Genetics

Rules of Engagement: Molecular Insights from Host-Virus Arms Races

(2012) Matthew D. Daugherty et al.   Annual Review of Genetics

Poly(A) Binding Protein C1 Is Essential for Efficient L1 Retrotransposition and Affects L1 RNP Formation

(2012) L. Dai et al.   MOLECULAR AND CELLULAR BIOLOGY

hnRNPL and nucleolin bind LINE-1 RNA and function as host factors to modulate retrotransposition

(2012) Suresh Peddigari et al.   NUCLEIC ACIDS RESEARCH

Endogenous MOV10 inhibits the retrotransposition of endogenous retroelements but not the replication of exogenous retroviruses

(2012) Shetal Arjan-Odedra et al.   Retrovirology

Landscape of Somatic Retrotransposition in Human Cancers

(2012) E. Lee et al.   SCIENCE

MOV10 RNA Helicase Is a Potent Inhibitor of Retrotransposition in Cells

(2012) John L. Goodier et al.   PLoS Genetics

Trimeric structure and flexibility of the L1ORF1 protein in human L1 retrotransposition

(2011) Elena Khazina et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolutionary Conservation of the Functional Modularity of Primate and Murine LINE-1 Elements

(2011) Bradley J. Wagstaff et al.   PLoS One

LINE-1 Retrotransposition Activity in Human Genomes

(2010) Christine R. Beck et al.   CELL

Characterization of LINE-1 Ribonucleoprotein Particles

(2010) Aurélien J. Doucet et al.   PLoS Genetics

L1 retrotransposition occurs mainly in embryogenesis and creates somatic mosaicism

(2009) H. Kano et al.   GENES & DEVELOPMENT

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame

(2009) Elena Khazina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Evidence That the Non-Homologous End-Joining Repair Pathway Is Involved in LINE Retrotransposition

(2009) Jun Suzuki et al.   PLoS Genetics

The Take and Give Between Retrotransposable Elements and their Hosts

(2008) Arthur Beauregard et al.   Annual Review of Genetics