Article
Fisheries
Yuya Hasegawa, Shigeho Ijiri, Ryohei Surugaya, Ryuichi Sakai, Shinji Adachi
Summary: This study revealed that the sturgeon hsd17b12L gene encodes 20 beta-H5D, playing a key role in regulating DHP production. Transfection experiments and LC/MS analysis confirmed this function. The expression level of hsd17b12L gene was upregulated during sturgeon oocyte maturation, and stimulation with SPE increased DHP concentration.
Review
Environmental Sciences
J. S. Jenila, Praveen Kumar Issac, Su Shiung Lam, J. Christina Oviya, Sumathi Jones, Ganesh Munusamy-Ramanujam, Soon Woong Chang, Balasubramani Ravindran, Mahesh Mannacharaju, Suresh Ghotekar, Kuan Shiong Khoo
Summary: Gestagens are common pollutants in the aquatic ecosystem, comprising natural and synthetic gestagens. They negatively affect fish reproduction and development by interacting with hormone receptors and disrupting the hormonal regulation of sperm motility and oocyte maturation. Their impacts on fish populations and ecosystems, especially in combination with other pollutants, are not well understood.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Xianrong Xiong, Xiaojian Zhang, Manzhen Yang, Yanjin Zhu, Hailing Yu, Xixi Fei, Fuko Mastuda, Daoliang Lan, Yan Xiong, Wei Fu, Shi Yin, Jian Li
Summary: This study found that KDM2a is involved in follicular and oocyte development in mice, and its knockout leads to female subfertility. Additionally, KDM2a also affects the sensitivity to female hormones.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Lingli Huang, Wenqing Li, Xingxing Dai, Shuai Zhao, Bo Xu, Fengsong Wang, Ren-Tao Jin, Lihua Luo, Limin Wu, Xue Jiang, Yu Cheng, Jiaqi Zou, Caoling Xu, Xianhong Tong, Heng-Yu Fan, Han Zhao, Jianqiang Bao
Summary: This study identified and characterized novel biallelic variants in MAD2L1BP responsible for oocyte maturation arrest at MI, providing new therapeutic avenues for female primary infertility.
Article
Multidisciplinary Sciences
Timothy S. Breton, Casey A. Murray, Sierra R. Huff, Anyssa M. Phaneuf, Bethany M. Tripp, Sarah J. Patuel, Christopher J. Martyniuk, Matthew A. DiMaggio
Summary: Phoenixin (PNX) is a highly conserved hormone with diverse functions in controlling reproduction, modulating appetite, and regulating energy metabolism and inflammation. This study provides insights into the complex actions of PNX in different tissues, highlighting its important roles in immune response, energy metabolism, and cell growth.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Lili Guo, Yongda Zhao, Yanjun Huan
Summary: The study showed that chlorpyrifos had toxic effects on porcine oocytes, including delaying meiotic progression, decreasing polar body extrusion, disrupting spindle assembly and causing DNA damage, as well as impairing cytoplasmic maturation. Pterostilbene was able to effectively alleviate the damage caused by chlorpyrifos and improve oocyte maturation and embryonic development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Reproductive Biology
Zi-Bin Liu, Jia-Bao Zhang, Sheng-Peng Li, Wen-Jie Yu, Na Pei, Hai-Tao Jia, Ze Li, Wen-Fa Lv, Jun Wang, Nam-Hyung Kim, Bao Yuan, Hao Jiang
Summary: This study investigated the effects of inhibiting the expression of ID3 on cumulus cells (CCs) and uncovered the downstream regulatory network of ID3. The results showed that ID3 inhibition disrupted mitochondrial function, progesterone synthesis, and oocyte maturation. GO and KEGG analysis revealed the involvement of cholesterol-related processes and progesterone-mediated oocyte maturation. The study also found that ID3 inhibition led to increased apoptosis, inhibited phosphorylation of ERK1/2, and disrupted mitochondrial dynamics and function, resulting in poor oocyte maturation and quality. These findings contribute to the understanding of the biological roles of ID3 and cumulus cells.
Review
Cell Biology
Ranjha Khan, Xiaohua Jiang, Uzma Hameed, Qinghua Shi
Summary: The quality of oocytes from obese women can be compromised due to imbalanced lipid metabolism, which is crucial for oocyte development and maturation. Lipids play a significant role in various biological processes of oocyte development and are important for determining oocyte quality and cryopreservation for fertilization.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Meina He, Tuo Zhang, Yi Yang, Chao Wang
Summary: Meiosis is essential for sexual reproduction, with oocytes in female mammals beginning meiosis before birth and sustaining it through dictyate stage before ovulation. Fine-tuning of meiotic progression is crucial for fertility, as any disruption can lead to oogenesis failure and impact overall reproductive health. Understanding the regulatory network of oocyte meiosis is key to comprehending mammalian reproduction and the consequences of misregulation on infertility.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Zhi-Yong Yang, Min Ye, Ya-Xin Xing, Qi-Gui Xie, Jian-Hong Zhou, Xin-Rui Qi, Kehkooi Kee, Ri-Cheng Chian
Summary: By performing single-cell analysis, this study identified the differentially expressed genes (DEGs) and pathways related to mitochondria during human oocyte maturation. The results showed that oxidative phosphorylation, pyruvate metabolism, peroxisome, and amino acid metabolism pathways played important roles in oocyte maturation. Additionally, it was observed that mitochondria were regulated by nuclear genes to meet the developmental needs, and the current in vitro maturation culture medium should be optimized based on these findings.
Article
Cell Biology
Long Jin, Hai-Ying Zhu, Xiang-Jin Kang, Li-Ping Lin, Pu-Yao Zhang, Tao Tan, Yang Yu, Yong Fan
Summary: Oxybenzone, a common UV filter in sunscreens and cosmetics, has been found to have negative effects on oocyte maturation, but melatonin shows protective effects against these detrimental effects.
Article
Reproductive Biology
Jianqiang Sun, Jian Li, Yaodi Wang, Jiadan Qu, Fanglong Bi, Hongxiao Xiang, Xintao Zhao, Mingju Sun, Yanjun Huan
Summary: This study found that cypermethrin (CYP) has a toxic effect on porcine oocyte maturation, while astaxanthin (AST) can protect oocyte maturation. CYP causes DNA damage and endoplasmic reticulum dysfunction in oocytes, while AST can alleviate these defects. This study provides a potential strategy to prevent pesticide toxicity and protect oocyte maturation in mammalian reproduction.
Article
Cell Biology
Song-Hee Lee, Ming-Hong Sun, Dongjie Zhou, Wen-Jie Jiang, Xiao-Han Li, Geun Heo, Xiang-Shun Cui
Summary: Exposure to high temperature has been found to negatively affect the development of porcine oocytes. It induces mitochondrial dysfunction, ER stress, abnormal Golgi apparatus distribution, and lysosomal damage, leading to the failure of meiotic maturation in the oocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Alba Ferre, Francois Chauvigne, Magdalena Gozdowska, Ewa Kulczykowska, Roderick Nigel Finn, Joan Cerda
Summary: The neurohypophysial and paracrine vasopressinergic systems regulate the trafficking of Aqp1ab-type paralogs via a common AVP-AVPR2AA-PKA pathway to avoid competitive occupancy of the same plasma membrane space and maximize water influx during oocyte hydration in marine teleosts.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Fisheries
Robie Allan Bombardelli, Juliana Kasper Mewes, Alexandre Henrique Buzzi, Ahiana Cassia de Oliveira Pedreira, Mirna Adriane Syperreck, Anna Cristina Strieder Dalmaso, Tais Voelkl Chagas, Rogerio Jose Chiella, Fabio Meurer
Summary: The study evaluated the effects of feeding Nile tilapia broodstock with rations containing different levels of crude glycerin, finding that crude glycerin in the feed can have negative impacts on females by decreasing egg production and hatching rates.
Article
Cell Biology
Maria J. Torres, Kim A. Kew, Terence E. Ryan, Edward Ross Pennington, Chien-Te Lin, Katherine A. Buddo, Amy M. Fix, Cheryl A. Smith, Laura A. Gilliam, Sira Karvinen, Dawn A. Lowe, Espen E. Spangenburg, Tonya N. Zeczycki, Saame Raza Shaikh, P. Darrell Neufer
Article
Medical Laboratory Technology
Srivalli Swathi Mamillapalli, Annalisa Smith-Joyner, Lauren Forbes, Kadesha McIntyre, Samantha Poppenfuse, Blake Rushing, Cody Strom, Allison S. Danell, Linda May, Devon Kuehn, Kimberly Kew, Srikanth Ravisankar
THERAPEUTIC DRUG MONITORING
(2020)
Article
Multidisciplinary Sciences
Kelsey L. McLaughlin, Kimberly A. Kew, Joseph M. McClung, Kelsey H. Fisher-Wellman
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Jordan M. Johnson, Anthony R. P. Verkerke, J. Alan Maschek, Patrick J. Ferrara, Chien-Te Lin, Kimberly A. Kew, P. Darrell Neufer, Irfan J. Lodhi, James E. Cox, Katsuhiko Funai
MOLECULAR METABOLISM
(2020)
Article
Biochemistry & Molecular Biology
Margaret-Ann M. Nelson, Jimmy T. Efird, Kimberly A. Kew, Lalage A. Katunga, T. Blake Monroe, Jonathan A. Doorn, Cherese N. Beatty, Qian Shi, Shahab A. Akhter, Hazaim Alwair, Jacques Robidoux, Ethan J. Anderson
Summary: Comprehensive analysis of catecholamine metabolism and mitochondrial energetics in atrial myocardium from patients with type 2 diabetes revealed a unique form of carbonyl toxicity driven by MAO-mediated metabolism, underscoring pathogenic factors underlying cardiometabolic disease. Targeting aldehyde stress and catecholamine metabolism in the heart with pharmacotherapies may be beneficial in patients with diabetes and cardiac disease.
ANTIOXIDANTS & REDOX SIGNALING
(2021)
Article
Multidisciplinary Sciences
Kelsey L. McLaughlin, James T. Hagen, Hannah S. Coalson, Margaret A. M. Nelson, Kimberly A. Kew, Ashley R. Wooten, Kelsey H. Fisher-Wellman
SCIENTIFIC REPORTS
(2020)
Article
Chemistry, Physical
Mitul P. Patel, Nathaneal T. Green, Jacob K. Burch, Kimberly A. Kew, Robert M. Hughes
Article
Biochemistry & Molecular Biology
Kassondra Balestrieri, Kimberly Kew, Moses McDaniel, Mohamed Ramez, H. Keith Pittman, Gina Murray, Nasreen A. Vohra, Kathryn M. Verbanac
Summary: This study used proteomics to reveal high expression of Galectin-1 protein and RNA in primary and metastatic claudin-low breast cancer, providing insight into the mechanisms of tumor progression.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2021)
Article
Endocrinology & Metabolism
Xin-Jun Wu, Marcus Jermaul Williams, Kimberly Ann Kew, Aubrey Converse, Peter Thomas, Yong Zhu
Summary: The study on a gper zebrafish mutant line suggests that Gper is involved in the control of ovarian follicle development through regulation of vitellogenesis and Egfr expression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biology
Margaret A. M. Nelson, Kelsey L. McLaughlin, James T. Hagen, Hannah S. Coalson, Cameron Schmidt, Miki Kassai, Kimberly A. Kew, Joseph M. McClung, P. Darrell Neufer, Patricia Brophy, Nasreen A. Vohra, Darla Liles, Myles C. Cabot, Kelsey H. Fisher-Wellman
Summary: This study focuses on targeting mitochondrial oxidative phosphorylation (OXPHOS) in cancer, particularly acute myeloid leukemia (AML). It reveals intrinsic bioenergetic vulnerabilities in cancerous mitochondria and highlights the limitations of OXPHOS in leukemic cells. Leukemic mitochondria show high ATP consumption and restoring oxidative ATP synthesis is cytotoxic to leukemic blasts, suggesting a potential therapeutic avenue for combating hematological malignancy and chemoresistance.
Article
Clinical Neurology
Helen M. Rodgers, Ryan Patton, Jacob Yow, Tonya N. Zeczycki, Kimberly Kew, Stefan Clemens, Kori L. Brewer
Summary: The study demonstrates that opioids are not universally effective for treating neuropathic pain following spinal cord injury (SCI). The researchers investigated the analgesic response of morphine-responsive and nonresponsive SCI rats to adjunct treatment with dopamine modulators and found distinct metabolomic profiles associated with these animal groups.
Article
Environmental Sciences
Cody J. Strom, Samantha M. McDonald, Mary-Margaret Remchak, Kimberly A. Kew, Blake R. Rushing, Joseph A. Houmard, David A. Tulis, Roman Pawlak, George A. Kelley, Lisa Chasan-Taber, Edward Newton, Christy Isler, James DeVente, Madigan Raper, Linda E. May
Summary: Exercise and PUFA supplementation independently improve lipid profiles. This study found that exercise during pregnancy can increase HDL and reduce TG levels at 36 weeks. Exercise dose controls the rise in TG levels during pregnancy. Regardless of PUFA levels, exercising at recommended levels helps maintain appropriate TG levels during pregnancy.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Cody J. Strom, Samantha M. McDonald, Mary-Margaret Remchak, Kimberly A. Kew, Blake R. Rushing, Joseph A. Houmard, David A. Tulis, Roman Pawlak, George A. Kelley, Lisa Chasan-Taber, Edward Newton, Christy Isler, James DeVente, Madigan Raper, Linda E. May
Summary: This study evaluated the effects of aerobic exercise during pregnancy on infant body composition, finding that infants born to women who participated in aerobic exercise had lower skinfold thickness and body fat percentage compared to the control group. The study concluded that exercise dose, but not blood DHA or EPA levels, was a negative predictor of infant adiposity.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemical Research Methods
Stephan R. Hlohowskyj, Kimberly Kew, Libby Stern, Carl R. Yamnitz
Summary: Improvised explosive devices, particularly those using smokeless powder, are a threat to public safety due to terrorism and criminal activities. Traditional forensic examinations can determine the physical and chemical characteristics of smokeless powder, but are limited when comparing materials that are physically and/or chemically similar. Stable isotope analysis of carbon and nitrogen can provide additional information to differentiate the origin of smokeless powder. By combining bulk and component isotope analyses, geographic relationships can be identified, although it may be challenging to distinguish between different manufacturers.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)