Article
Clinical Neurology
Xia Sun, Jintao Yu, Jia Luo, Shan Xu, Ning Yang, Yan Wang
Summary: There is a significant association between obstructive sleep apnea (OSA) and postoperative adverse events. The severity of OSA increases the risk of complications, while preoperative diagnosis and continuous positive airway pressure (CPAP) therapy can reduce the risks. CPAP treatment can help reduce the incidence of postoperative complications.
Article
Peripheral Vascular Disease
Liyue Xu, Brendan T. Keenan, David Maislin, Thorarinn Gislason, Bryndis Benediktsdottir, Sigrun Gudmundsdottir, Marianna Gardarsdottir, Bethany Staley, Frances M. Pack, Xiaofeng Guo, Yuan Feng, Jugal Chahwala, Pritika Manaktala, Anila Hussein, Maheshwara Reddy-Koppula, Zeba Hashmath, Jonathan Lee, Raymond R. Townsend, Richard J. Schwab, Allan Pack, Samuel T. Kuna, Julio A. Chirinos
Summary: This study investigated the impact of obesity on the effectiveness of PAP therapy and the levels of NT-proBNP in adults with and without OSA. The results indicated that obesity modified the effects of PAP treatment on NT-proBNP and left atrial volume index, suggesting potential differences in cardiac remodeling in obese individuals with OSA.
Article
Anesthesiology
Frances Chung, Rida Waseem, Chew Yin Wang, Edwin Seet, Colin Suen, Matthew T. Chan
Summary: The study aims to determine whether preoperative oximetry-derived hypoxemia can predict postoperative cardiovascular events in surgical patients with unrecognized obstructive sleep apnea.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Article
Respiratory System
Macy Mei-Sze Lui, Hung-Fat Tse, David Chi-Leung Lam, Kui-Kai Lau, Carmen Wing-Sze Chan, Mary Sau-Man Ip
Summary: In subjects with OSA and difficult-to-control hypertension, short-term CPAP treatment improved ambulatory blood pressure, alleviated subclinical myocardial injury and strain. This study suggests potential benefits of CPAP therapy in reducing cardiovascular risk in this high-risk population.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Raquel Lopez-Galvez, Jose Miguel Rivera-Caravaca, Dario Mandaglio-Collados, Esteban Orenes-Pinero, Alvaro Lahoz, Diana Hernandez-Romero, Carlos M. M. Martinez, Marina Carpes, Jose Maria Arribas, Sergio Canovas, Gregory Y. H. Lip, Francisco Marin
Summary: Obstructive sleep apnea (OSA) promotes atrial remodeling and fibrosis, providing a substrate for atrial fibrillation (AF). In this study, the pathophysiological mechanisms of AF in patients with OSA were investigated. Biomarkers reflective of AF pathophysiology and miRNAs involved in AF were assessed. OSA patients exhibited a higher incidence of postoperative AF, dysregulated biomarkers and miRNAs, and increased interstitial fibrosis, all of which contribute to the development of a substrate that increases the AF risk.
Article
Anesthesiology
Thomas J. Altree, Frances Chung, Matthew T. Chan, Danny J. Eckert
Summary: Obstructive sleep apnea is a common comorbidity in surgical patients, with heightened risk of complications. The pathogenesis of OSA is highly variable, including impaired upper airway anatomy, poor upper airway dilator muscle responsiveness, low respiratory arousal threshold, and unstable breathing control. Understanding these traits is crucial for providing personalized care and minimizing postoperative risk.
ANESTHESIA AND ANALGESIA
(2021)
Article
Otorhinolaryngology
Alfonso Caetta, Alisa Timashpolsky, Stephanie M. Tominaga, Neeta D'Souza, Nira A. Goldstein
Summary: The study showed that children over 3 years old without medical comorbidities and with an AHI <24 may be considered for ambulatory discharge after adenotonsillectomy, as they have a low risk of respiratory complications.
INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
(2021)
Review
Medicine, General & Internal
Yanru Ou, Dandan Zong, Ruoyun Ouyang
Summary: This article explores the relationship between obstructive sleep apnea (OSA) and epigenetics, and provides better diagnostic methods and treatment options. Epigenetic modifications, including post-translational modifications in DNA and histone proteins, and regulation of non-coding RNAs, are involved in the progression of OSA and various multiorgan injuries. This article offers deeper insights into the disease mechanism of OSA and potential applications of targeted diagnosis, treatment, and prognosis in OSA complications.
CHINESE MEDICAL JOURNAL
(2023)
Review
Anesthesiology
Shuo Wang, Shiyong Li, Yilin Zhao, Xiaoping Zhao, Zhiqiang Zhou, Quanshui Hao, Ailin Luo, Rao Sun
Summary: This study found that a high risk of obstructive sleep apnea (OSA), as determined by screening tools, was associated with higher incidences of postoperative respiratory, cardiac, and neurological complications. However, the quality of evidence was very low, and caution is needed when interpreting the findings.
JOURNAL OF CLINICAL ANESTHESIA
(2022)
Review
Medicine, General & Internal
Pei-Kang Liu, Tzu-Yu Chiu, Nan-Kai Wang, Sarah R. Levi, Ming-Ju Tsai
Summary: Obstructive sleep apnea (OSA) is a common sleep disorder that can lead to ocular consequences, clinicians should understand the eye diseases in patients with OSA and provide comprehensive care.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Wei-Quian Wu, Wen-Biao Zheng, Hai-Bao Wang, Jian-Hua Han, Yang Huang, Chong-Yang Wang
Summary: This study aimed to investigate the influence of obstructive sleep apnea (OSA) on postoperative cognitive function in elderly patients undergoing joint replacement. The results suggest that patients with OSA have poorer postoperative cognitive function and treatment outcomes.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Psychology, Multidisciplinary
Nader Salari, Amin Hosseinian-Far, Amir Sharafkhaneh, Behnam Khaledi-Paveh, Masoud Mohammadi, Hooman Ghasemi, Shabnam Rasoulpoor, Shna Rasoulpoor, Habibolah Khazaie
Summary: This meta-analysis evaluated the relationship between cTnT level and OSA and found that OSA patients have higher serum cTnT level compared to individuals without OSA. This suggests that individuals with OSA may have an increased risk of cardiovascular disease and should be prioritized for screening and early intervention.
CURRENT PSYCHOLOGY
(2023)
Review
Medicine, Research & Experimental
Weiqian Wu, Wenbiao Zheng, Haibao Wang, Jianhua Han, Yang Huang, Chongyang Wang
Summary: The meta-analysis showed that patients with sleep apnea (SA) undergoing joint arthroplasty or revision joint arthroplasty have a higher risk of postoperative pulmonary complications and mortality compared to those without SA. Other postoperative complications were not significantly different between the two groups.
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2021)
Review
Health Care Sciences & Services
Sy Duong-Quy, Hoang Nguyen-Huu, Dinh Hoang-Chau-Bao, Si Tran-Duc, Lien Nguyen-Thi-Hong, Thai Nguyen-Duy, Tram Tang-Thi-Thao, Chandat Phan, Khue Bui-Diem, Quan Vu-Tran-Thien, Thu Nguyen-Ngoc-Phuong, Vinh Nguyen-Nhu, Huong Le-Thi-Minh, Timothy Craig
Summary: Obstructive Sleep Apnea (OSA) is a common disease that is often underestimated and undertreated in all age groups. Personalized diagnosis and treatment approaches are necessary for clinical practice due to morphological differences, clinical phenotype diversity, and variations in diagnosis and treatment of OSA in children and adults. Treatment should be based on individual tolerance to sleep-quality-related parameters, the harmful effects of hypoxia on the cardiovascular system, and patients' comorbidities.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Medicine, General & Internal
Samuel Knoedler, Leonard Knoedler, Helena Baecher, Martin Kauke-Navarro, Doha Obed, Cosima C. Hoch, Yannick F. Diehm, Peter S. Vosler, Ulrich Harreus, Ulrich Kneser, Adriana C. Panayi
Summary: This study retrospectively analyzed the outcomes of OSA surgery at a national level, and identified risk factors for complications such as alkaline phosphatase levels, male gender, extreme BMI, and diabetes.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Madelyn E. Rosenthal, M. Melanie Lyons, Jessica Schweller, Vedat O. Yildiz, Eugene G. Chio, Meena S. Khan
Summary: The study found higher anxiety and emotional distress scores in the non-adherent group, suggesting that anxiety and emotional distress may impact HNS therapy adherence. Screening patients with GAD-7 and PHQ-9 prior to implantation may be helpful in evaluating patient adherence to therapy.
SLEEP AND BREATHING
(2022)
Article
Critical Care Medicine
Steven J. Holfinger, M. Melanie Lyons, Brendan T. Keenan, Diego R. Mazzotti, Jesse Mindel, Greg Maislin, Peter A. Cistulli, Kate Sutherland, Nigel McArdle, Bhajan Singh, Ning-Hung Chen, Thorarinn Gislason, Thomas Penzel, Fang Han, Qing Yun Li, Richard Schwab, Allan I. Pack, Ulysses J. Magalang
Summary: Prediction tools using machine learning without patient-reported symptoms provide better diagnostic performance than logistic regression in identifying OSA. In clinical and community-based samples, the symptomless ANN tool has diagnostic performance similar to that of a widely used prediction tool that includes patient symptoms.
Letter
Critical Care Medicine
Diego R. Mazzotti, Brendan T. Keenan, Elin H. Thorarinsdottir, Thorarinn Gislason, Allan I. Pack
Editorial Material
Clinical Neurology
Allan I. Pack
Article
Clinical Neurology
Brian Geuther, Mandy Chen, Raymond J. Galante, Owen Han, Jie Lian, Joshy George, Allan Pack, Vivek Kumar
Summary: This study explores the use of modern computer vision methods to directly classify sleep substages from video data, avoiding the need for invasive surgery and expert scoring. The visual sleep classifier proved to be highly accurate in classifying wake, non-rapid eye movement sleep (NREM), and rapid eye movement sleep (REM) states, enabling noninvasive high-throughput sleep studies. Additionally, the study discovers video features that correlate with breathing rates and detects sleep stage disturbances induced by amphetamine administration. This research provides a viable alternative to EEG/EMG-based scoring and significantly reduces the barrier to screening mutant mice for sleep abnormalities.
Article
Clinical Neurology
Magdy Younes, Bethany Gerardy, Allan Pack, Samuel T. Kuna, Cecilia Castro-Diehl, Susan Redline
Summary: Conventional metrics for measuring sleep quantity/depth have limitations. An ORP-based approach provides additional information on sleep disorders that is not captured by traditional metrics. The ORP histogram offers unique insights into the neurophysiological characteristics of sleep disorders, potentially advancing diagnosis and management.
Editorial Material
Critical Care Medicine
Allan I. Pack, Brendan T. Keenan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Editorial Material
Clinical Neurology
Allan Pack, Antoine Adamantidis, Katie L. Stone, David Gozal
Article
Critical Care Medicine
Jaejin An, Henry A. Glick, Amy M. Sawyer, Jessica Arguelles, Charles J. Bae, Brendan T. Keenan, Samuel T. Kuna, Greg Maislin, Diego R. Mazzotti, Allan I. Pack, Jiaxiao M. Shi, Alexa J. Watach, Dennis Hwang
Summary: This study investigated the association between adherence to positive airway pressure (PAP) therapy and healthcare costs in participants with obstructive sleep apnea (OSA) over a 3-year period. The results showed that higher adherence to PAP therapy was associated with significantly lower healthcare costs.
Article
Clinical Neurology
Jennifer R. Goldschmied, Samuel T. Kuna, Greg Maislin, Pongsakorn Tanayapong, Allan Pack, Magdy Younes
Summary: This study used delta power and ORP as measures to investigate the effects of acute sleep deprivation on sleep depth and to assess the heritability of sleep homeostasis in humans. The results showed that during recovery sleep, ORP decreased and delta power increased, indicating deeper sleep. Furthermore, both ORP and delta power demonstrated a certain level of heritability of sleep homeostasis.
Article
Clinical Neurology
Elin H. Thorarinsdottir, Thorarinn Gislason, Allan Pack, Samuel T. Kuna, Thomas Penzel, Fang Han, Qing Yun Li, Peter A. Cistulli, Ulysses J. Magalang, Nigel McArdle, Bhajan Singh, Brendan T. Keenan
Article
Anesthesiology
David R. R. Hillman, Melissa Carlucci, Jean G. G. Charchaflieh, Tom V. V. Cloward, Bhargavi Gali, Peter C. C. Gay, M. Melanie Lyons, Margaret M. M. McNeill, Mandeep Singh, Meltem Yilmaz, Dennis H. H. Auckley
Summary: This article emphasizes the importance of patient sleep during hospitalization and suggests the need for wider consideration by health authorities. Insufficient sleep during hospitalization can lead to various negative effects on health, including cardiovascular dysfunction, impaired cognitive function, increased pain perception, and psychological disturbance. Challenges to sleep in hospitals can be addressed through staff education, protocol implementation, and improvement in hospital design. The Society of Anesthesia and Sleep Medicine calls for systematic changes and further research in this area.
ANESTHESIA AND ANALGESIA
(2023)
Editorial Material
Clinical Neurology
Allan Pack
Article
Clinical Neurology
Bethany Gerardy, Samuel T. Kuna, Allan Pack, Clete A. Kushida, James K. Walsh, Bethany Staley, Grace W. Pien, Magdy Younes
Summary: This study proposes a new approach to evaluate inter-scorer variability in sleep staging. By recognizing the existence of equivocal sleep epochs, the proposed method provides a more accurate assessment of scorer's competence and reduces disagreements among scorers.
Article
Education & Educational Research
Alexa J. Watach, Miranda V. McPhillips, Bruno Saconi, Rebecca Lang-Gallagher, M. Melanie Lyons, Susan M. Renz, Ilene M. Rosen, Amy M. Sawyer
Summary: The aim of this study was to explore nurse practitioner (NP) students' perceptions of a sleep e-learning program. Sleep assessment is uncommon as nursing curricula lack sleep education. By preparing NPs to conduct sleep assessment and screening and understand basic sleep diagnostics, sleep health is more likely to be part of the differential diagnosis.
NURSING EDUCATION PERSPECTIVES
(2023)
