Article
Immunology
Wei Tang, Hongyang Liu, Lixian Chen, Ke Zhao, Yaoyao Zhang, Ke Zheng, Cheng Zhu, Tiansheng Zheng, Jiahong Liu, Dandan Wang, Lingfang Yu, Xinyu Fang, Chen Zhang, Kuan-Pin Su
Summary: The study revealed that patients with anhedonia in major depressive disorder exhibit different inflammatory characteristics compared to patients without anhedonia. Elevated plasma CFH levels may serve as a potential biomarker for anhedonia in subtyping MDD.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Psychiatry
Sabina Franklyn, Jayme Stewart, Cecile Beaurepaire, Emily Thaw, Robyn J. McQuaid
Summary: Identifying reliable biomarkers for depression has been challenging due to the heterogeneity of symptoms and high rates of comorbidity. This study used principal component analysis and hierarchical cluster analysis to identify six distinct clusters of depression symptoms in a sample of young adults. The study also found that the cluster characterized by neurovegetative depression had significantly elevated levels of inflammation. These findings highlight the importance of understanding the biological underpinnings of symptom dimensions and subtypes in complex mental health disorders like depression.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
F. M. Tjoelker, H. W. Jeuring, I Aprahamian, P. Naarding, R. M. Marijnissen, G. J. Hendriks, D. Rhebergen, A. Lugtenburg, M. W. Lammers, R. H. S. van den Brink, R. C. Oude Voshaar
Summary: The association between a history of child abuse and cognitive performance varies depending on the type of abuse, with physical abuse and emotional neglect linked to poorer interference control, and physical abuse also associated with better visual-verbal memory.
Article
Clinical Neurology
Xiang Wang, Jingjie Lu, Qian Liu, Quanhao Yu, Jie Fan, Feng Gao, Yan Han, Xingze Liu, Rui Yao, Xiongzhao Zhu
Summary: This study provides insight into the impact of different childhood trauma subtypes on depression symptoms. Threat and deprivation were found to differently relate to depressed mood and anhedonia. Threat and deprivation predicted more severe depressed mood, while only deprivation predicted elevated anhedonia. The effects of childhood trauma persisted into early adulthood and varied across gender.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Shuntaro Aoki, Satomi Doi, Satoshi Horiuchi, Koki Takagaki, Asaka Kawamura, Reiji Umeno, Masahiko Fujita, Nobuki Kitagawa, Yuji Sakano
Summary: This study used a mediation analysis to examine the relationship between the three symptoms of depression and avoidance and reduced environmental rewards. The results showed that the relationship differed depending on the individual symptom type.
CURRENT PSYCHOLOGY
(2023)
Article
Psychiatry
Kelci Straka, Mai-Lan Tran, Summer Millwood, James Swanson, Kate Ryan Kuhlman
Summary: Inflammation has complex associations with depressive symptoms, with age potentially playing a significant role. Aging is associated with various changes in brain structure and function, yet the role of inflammation in depressive symptoms within a lifespan developmental framework has not received much attention.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Nick A. Weaver, Jae-Sung Lim, Janniek Schilderinck, Geert Jan Biessels, Yeonwook Kang, Beom Joon Kim, Hugo J. Kuijf, Byung-Chul Lee, Keon-Joo Lee, Kyung-Ho Yu, Hee -Joon Bae, J. Matthijs Biesbroek
Summary: This study used lesion-symptom mapping to identify infarct locations and white matter disconnections associated with poststroke depressive symptoms (PSDS). The results showed that infarcts in the right amygdala, right hippocampus, and right pallidum were consistently associated with PSDS. Disconnectome-based analyses revealed disconnections in the right parahippocampal white matter, right thalamus and pallidum, and right anterior thalamic radiation were significantly associated with PSDS.
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2023)
Article
Psychiatry
Juan Huang, Xiao-Meng Xie, Nan Lyu, Bing-Bing Fu, Qian Zhao, Ling Zhang, Gang Wang
Summary: This study evaluated the treatment outcomes of agomelatine on anhedonic state, anxiety/somatic symptoms, and sexual function in Chinese patients with major depressive disorder (MDD). The results showed that after 9 weeks of treatment, the response rate and remission rate of the agomelatine treatment group were 73.5% and 39.7% respectively, with significant improvement in somatic symptoms and anhedonia. The patients exhibited lower levels of disease severity and higher levels of quality of life during the follow-up period. No serious adverse events occurred during the treatment.
FRONTIERS IN PSYCHIATRY
(2023)
Review
Medicine, Research & Experimental
Nella C. Delva, Gregg D. Stanwood
Summary: Major depressive disorder is a debilitating neuropsychiatric syndrome with genetic, epigenetic, and environmental contributions, affecting more than one in six individuals in the United States. Dysregulation of brain dopamine systems is a key aspect of the pathophysiology of MDD, leading to a vast treatment gap worldwide. Neurodevelopmental factors may modify risk for later emergence of MDD through dopaminergic substrates in the brain.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Health Care Sciences & Services
Natalia Chechko, Susanne Stickel, Elena Losse, Aliaksandra Shymanskaya, Ute Habel
Summary: This study assessed postpartum mood and mother-child attachment in a cohort of 598 young mothers and found multiple distinct patterns. Most women with postpartum depression showed deteriorating behavior, while adjustment disorder cases showed improving behavior. Higher EPDS levels were associated with higher risk factors, while lower EPDS levels were associated with better mother-child attachment.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Neurosciences
Yinghui Li, Yingying Yue, Suzhen Chen, Wenhao Jiang, Zhi Xu, Gang Chen, Zixin Zhu, Liangliang Tan, Yonggui Yuan
Summary: This study found that anhedonic major depressive disorder (MDD) patients have higher serum levels of cytokines and cortisol, and a combination of IL-6, CRP, and cortisol can serve as an early marker for distinguishing anhedonic MDD.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychiatry
Hang-Ju Yang, Wan-Ju Cheng, Mi-Chun Hsiao, Sheng-Che Huang, Tomohide Kubo, Liang-Wen Hang, Wei-Sheng Lee
Summary: This study examined the association between rest-activity rhythm changes and mood symptoms and attention in patients with depressive disorder. The results showed that changes in rest-activity rhythm were associated with depressive symptom severity and attention.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Pengyu Zhang, Yi Piao, Ying Chen, Jiecheng Ren, Longhua Zhang, Bensheng Qiu, Zhengde Wei, Xiaochu Zhang
Summary: The study found that during the COVID-19 pandemic, a more negative memory bias was associated with a greater decrease in future depressive indices in nonclinical depressed participants, possibly due to reduced social stress.
Article
Psychology, Multidisciplinary
Jody L. Greaney, Ashley M. Darling, Jennifer R. Turner, Erika F. H. Saunders, David M. Almeida, Jacqueline Mogle
Summary: Exposure to daily stressors specific to the COVID-19 pandemic is associated with emotional distress, heightened stress reactivity, and increased depressive symptomology. Current depressive symptomology may moderate the association between COVID-19-related daily stressor exposure and negative affective reactivity, particularly in young adults.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychiatry
Christopher A. Crawford, Michelle K. Williams, Aubrey L. Shell, Krysha L. MacDonald, Robert V. Considine, Wei Wu, Kevin L. Rand, Jesse C. Stewart
Summary: This study examined the effects of modernized collaborative care on patients with depression. The results showed that the intervention improved both cognitive/affective and somatic symptoms of depression over 12 months. However, the intervention did not significantly influence the levels of BDNF, and the changes in BDNF did not mediate the intervention effects on depressive symptoms.
PSYCHIATRY RESEARCH
(2023)
Article
Health Policy & Services
Peter P. Zandi, Yu-Hsun Wang, Paresh D. Patel, David Katzelnick, Carolyn L. Turvey, Jesse H. Wright, Olusola Ajilore, William Coryell, Christopher D. Schneck, Constance Guille, Erika F. H. Saunders, Sophie A. Lazarus, Valeria A. Cuellar, Sudhakar Selvaraj, Patricia Dill Rinvelt, John F. Greden, J. Raymond Depaulo
PSYCHIATRIC SERVICES
(2020)
Article
Cardiac & Cardiovascular Systems
Jody L. Greaney, Agus Surachman, Erika F. H. Saunders, Lacy M. Alexander, David M. Almeida
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2020)
Article
Psychiatry
Kelly Ann Ryan, Pallavi Babu, Rebecca Easter, Erika Saunders, Andy Jinseok Lee, Predrag Klasnja, Lilia Verchinina, Valerie Micol, Brent Doil, Melvin G. McInnis, Amy M. Kilbourne
JMIR MENTAL HEALTH
(2020)
Article
Clinical Neurology
Marzieh Majd, Joshua M. Smyth, Nan Lv, Lan Xiao, Mark B. Snowden, Elizabeth M. Venditti, Leanne M. Williams, Olusola A. Ajilore, Trisha Suppes, Jun Ma
Summary: The study examined latent factors of depression symptoms in patients with obesity and elevated depressive symptoms using the depression Symptom Checklist (SCL-20) and the Patient Health Questionnaire (PHQ-9). Results showed that the SCL-20 was more sensitive than the PHQ-9 in differentiating symptom profiles in this population, possibly due to differences in scale items and aspects of depression they measure.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Guodong Liu, Lan Kong, Ritika Baweja, Djibril Ba, Erika F. H. Saunders
Summary: This study aimed to examine gender disparities in the diagnosis of bipolar disorder within a privately insured population in the United States. The results showed that males had a lower diagnosis rate compared to females, with gender differences remaining significant even after adjusting for demographics, comorbidity, and healthcare utilizations. Gender disparity was consistently strong among most age groups, but varied in other demographic subgroups.
Article
Clinical Neurology
Erika F. H. Saunders, Dahlia Mukherjee, Tiffany Myers, Emily Wasserman, Ahmad Hameed, Venkatesh Bassappa Krishnamurthy, Beth Maclntosh, Anthony Domenichiello, Christopher E. Ramsden, Ming Wang
Summary: The study investigated the preliminary efficacy of a high n-3 plus low n-6 (H3-L6) dietary intervention in improving mood stability in Bipolar Disorder (BD) patients. Results showed that the H3-L6 group had reduced variability in mood, energy, irritability, and pain compared to the control group, but no significant differences were found in mean ratings of mood symptoms between the two groups. The dietary intervention showed potential in improving mood symptom variability in BD participants.
Article
Cardiac & Cardiovascular Systems
Ann-Katrin Grotle, Ashley M. Darling, Erika F. Saunders, Paul J. Fadel, Daniel W. Trott, Jody L. Greaney
Summary: This study provides the first evidence of augmented T-cell mitochondrial reactive oxygen species (T-cell mitoROS) in young, otherwise healthy adults with MDD. Although the elevated T-cell mitoROS did not correspond to a proinflammatory profile, these findings suggest that elevated T-cell mitoROS may be an early marker of immune system dysregulation in young adults with MDD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Clinical Neurology
Ashley M. Darling, Rauchelle E. Richey, John D. Akins, Erika F. H. Saunders, R. Matthew Brothers, Jody L. Greaney
Summary: In young adults with major depressive disorder (MDD), cerebral vasodilatory reactivity is blunted and further modulated by current depressive symptomology, suggesting that improving depressive symptoms may have a positive impact on cerebrovascular health.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Cardiac & Cardiovascular Systems
Jody L. Greaney, Erika F. H. Saunders, Lacy M. Alexander
Summary: Activation of NF-kappa B, through increased vascular ROS production, contributes to reduced NO-dependent endothelial dilation in young adults with MDD. Short-term treatment with NF-kappa B inhibitor salsalate improves NO-mediated endothelium-dependent dilation in MDD patients, while acute localized ROS scavenging with apocynin enhances NO-dependent dilation before salsalate administration.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Psychiatry
Caitlin E. Millett, Alexandra A. Corrigan, Alexandra Adamis, Candice Roquemore Bonner, Julia G. Lebovitz, Stephan T. Palm, Marzieh Majd, Faith M. Gunning, Katherine E. Burdick
Summary: This study suggests an exaggerated negativity bias in bipolar disorder (BD) and little is known about whether people with BD experience the 'positivity effect' with increasing age. By conducting a cross-sectional study, it was found that the accuracy of positive stimulus identification in the healthy control group increased with age, but this pattern was not observed in participants with BD. This finding is important in gaining a clearer picture of the effects of BD on the brain in later life.
PSYCHIATRY RESEARCH
(2023)
Article
Psychology, Applied
Marzieh Majd, Michelle A. Chen, Diana A. Chirinos, Ryan L. Brown, Angie S. Leroy, Kyle W. Murdock, E. Lydia Wu-Chung, Julian F. Thayer, Christopher P. Fagundes
Summary: This study examines the trajectories of depressive symptoms after spousal loss and finds associations between different trajectories and childhood maltreatment, attachment style, and risk of prolonged grief. Individuals with higher childhood maltreatment and attachment anxiety are more likely to belong to the chronic depression group, and those with persistent depressive symptoms up until 6 months are more likely to exhibit prolonged grief at 12 months post-loss.
Proceedings Paper
Computer Science, Information Systems
Johnna Blair, Dahlia Mukherjee, Erika F. H. Saunders, Saeed Abdullah
Summary: This paper explores the acceptance, needs, and concerns regarding a preemptive assessment and intervention system for bipolar disorder management. Through interviews with individuals living with bipolar disorder, requirements for effective behavioral monitoring during illness episodes were identified, and design recommendations were proposed to support dynamic, longitudinal interventions.
PROCEEDINGS OF THE 2023 CHI CONFERENCE ON HUMAN FACTORS IN COMPUTING SYSTEMS (CHI 2023)
(2023)
Article
Psychology, Clinical
Erika F. H. Saunders, Dahlia Mukherjee, Daniel A. Waschbusch, Duanping Liao, Amanda M. Pearl, Errol Aksu, Edward O. Bixler
Summary: The use of structured interviews helped physicians identify major depressive disorder by the second visit in patients with complex psychopathology. Patients with high complexity/severity of symptoms and more difficulty with functioning were less commonly identified with bipolar disorder even with the assistance of a structured interview.Structured assessment tools may improve the detection of psychiatric illness by clinicians at the first visit.
DEPRESSION AND ANXIETY
(2021)
Editorial Material
Education & Educational Research
Erika F. H. Saunders, Ashley Rice
ACADEMIC PSYCHIATRY
(2020)
Article
Psychology, Clinical
Natania A. Crane, Alvaro Verges, Masoud Kamali, Runa Bhaumik, Kelly A. Ryan, David F. Marshall, Erika F. H. Saunders, Michelle T. Kassel, Anne L. Weldon, Melvin G. McInnis, Scott A. Langenecker
Review
Endocrinology & Metabolism
Francesca R. Luberti, Justin M. Carre
Summary: This study comprehensively reviewed the evidence on the impact of testosterone on human mating and parenting behaviors. The findings suggest that basal testosterone levels are related to mating and parenting behaviors in both men and women. Testosterone responds to reproduction-relevant cues and acute changes in testosterone levels are associated with subsequent mating and parenting behaviors. Single-dose exogenous testosterone administration may causally affect mating and parenting behaviors. However, the support for trade-off interpretations of testosterone's adaptive function is mixed, indicating that the role of testosterone in modulating human mating and parenting is complex and context-dependent.
FRONTIERS IN NEUROENDOCRINOLOGY
(2024)
