Article
Chemistry, Medicinal
Lei Wang, Hye-Won Yang, Ginnae Ahn, Xiaoting Fu, Jiachao Xu, Xin Gao, You-Jin Jeon
Summary: In the study, SFPS demonstrated potent anti-inflammatory effects in both in vitro and in vivo models, improving cell viability and reducing inflammatory markers in LPS-stimulated RAW 264.7 macrophages and zebrafish. These results suggest that SFPS could potentially be used as an anti-inflammatory ingredient in functional food and pharmaceutical industries.
Article
Pharmacology & Pharmacy
Chiara De Stefani, Marzia Vasarri, Maria Cristina Salvatici, Lucia Grifoni, Jose Carlos Quintela, Anna Rita Bilia, Donatella Degl'Innocenti, Maria Camilla Bergonzi
Summary: The study formulated oleanolic acid (OA) into two different microemulsions (ME-1 and ME-2) to enhance its solubility and intestinal permeability, leading to a significant increase in bioavailability. Both MEs showed enhanced intestinal permeability compared to free OA according to PAMPA assay results. The study suggests that MEs could be a promising formulation to improve the oral bioavailability of OA with potential clinical applications.
Article
Agriculture, Multidisciplinary
Y. J. Choi, I. Y. Bae
Summary: White-spotted flower chafer (Protaetia brevitarsis) is an edible insect used in traditional Oriental medicine. The study investigated the anti-inflammatory effects of P. brevitarsis larvae ethanol extract (PBLE) on lipopolysaccharide-stimulated macrophages and identified its molecular mechanisms. PBLE effectively inhibited the synthesis of nitric oxide and pro-inflammatory cytokines, potentially through selective inhibition of NF-kappa B, ERK, and p38 MAPK signaling pathways. Further research is needed to confirm and understand the anti-inflammatory actions of PBLE for potential therapeutic applications.
JOURNAL OF INSECTS AS FOOD AND FEED
(2023)
Article
Biology
Shanshan Guo, Xian Wu, Jinkai Zheng, Mingyue Song, Ping Dong, Hang Xiao
Summary: This study is the first to report on the inhibitory mechanism of 5-Demethylnobiletin (5DN) and its metabolites on LPS-induced inflammation in macrophage cells. The metabolites showed stronger anti-inflammatory activity than the parent compound. Further investigation is needed to understand the relationship between the structural properties of the compounds and their anti-inflammatory effects.
Article
Chemistry, Multidisciplinary
Chang Min Lee, Mi-Ae Kang, Jongbok Lee, Kyungmoon Park, Hee Taek Kim, Yung-Hun Yang, Jongsung Lee, See-Hyoung Park
Summary: This study demonstrated that Hibiscus syriacus L. extract effectively suppressed LPS-stimulated Raw 264.7 cells by reducing proinflammatory factors and inducing apoptosis. Therefore, HSE has the potential to treat inflammation.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Immunology
Su Zhang, Yaya Liu, Xuefeng Zhou, Min Ou, Guohui Xiao, Fang Li, Zhongyuan Wang, Zhaoqin Wang, Lei Liu, Guoliang Zhang
Summary: This study identified a SIRT7-mediated protective mechanism against Mycobacterial infection by regulating NO production and apoptosis, indicating the potential of SIRT7 as a novel effective target for HDT of TB.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemical Research Methods
Gazanfar Ahmad, Reyaz Hassan, Neerupma Dhiman, Asif Ali
Summary: This study isolated 3-Acetylmyricadiol, a pentacyclic triterpenoid, from the ethyl acetate bark extract of Myrica esculenta, and evaluated its anti-inflammatory potential. The results showed that 3-Acetylmyricadiol inhibited the production of nitric oxide, IL-6, and TNF-alpha in a dose-dependent manner, suggesting its potential as an effective anti-inflammatory molecule.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Integrative & Complementary Medicine
Su-Hyeon Cho, Song Rae Kim, Myeong Seon Jeong, Miri Choi, SeonJu Park, Kil-Nam Kim
Summary: The experiment demonstrated that Brassica napus L. hydrosols exhibit significant anti-inflammatory activity in LPS-stimulated RAW 264.7 cells by reducing the generation of nitric oxide and prostaglandin E-2, inhibiting the expression of inducible nitric oxide synthase and cyclooxygenase-2, and blocking the NF-kappa B signaling pathways.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Andrea Bonvini, Marcelo Macedo Rogero, Audrey Yule Coqueiro, Raquel Raizel, Leonardo Mendes Bella, Ricardo Ambrosio Fock, Primavera Borelli, Julio Tirapegui
Summary: The study investigated the effects of BCAA supplementation on the inflammatory response of macrophages, finding that BCAA supplementation can increase cell viability, NO, and IL-10 synthesis, with the synthesis of inflammatory mediators being influenced by the treatment protocol. Additionally, isoleucine supplementation significantly increased these parameters, highlighting a potential area for further research.
Article
Plant Sciences
Rami S. Najjar, Neda S. Akhavan, Shirin Pourafshar, Bahram H. Arjmandi, Rafaela G. Feresin
Summary: Cornus officinalis var. koreana Kitam extract (COE) attenuated the inflammatory response induced by LPS in RAW 264.7 macrophages, possibly through Akt inhibition.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Zhi-Hu Lin, Jinsong Hu, Huagang Shi, Chia-Ching Liaw, Wei-Lun Qiu, Wei-Hung Hsu, Tung-Yi Lin
Summary: The study demonstrated that water extract of medical ink (WEMI) had no cytotoxic effect on murine macrophage Raw264.7 cells and slightly rescued LPS-suppressed cell viability. WEMI did not induce NO production or IL-6 secretion, but significantly induced secretion of TNF-alpha. Additionally, WEMI effectively reduced LPS-induced NO production.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Food Science & Technology
Ji-Eun Lee, Jae Hoon Lee, Byungrok Min, Kee-Tae Kim, Dong Uk Ahn, Hyun- Dong Paik
Summary: This study found that phosphovitins phosphopeptides (PPPs) have immunostimulatory effects on RAW 264.7 macrophages by activating the TLR2-mediated MAPK signaling pathway, increasing nitric oxide (NO) production, and enhancing the expression and secretion of pro-inflammatory cytokines (TNF-α and IL-6).
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Engineering, Biomedical
Alex C. Alavarse, Mahta Mirzaei, Amin Shavandi, Denise F. S. Petri
Summary: Bioactive peptides from natural resources have attracted attention for their beneficial biological properties in skin wound healing. Polysaccharides, known for their biocompatibility, biodegradability, and ease of modification, were used as carriers for peptide delivery to wounds. Xanthan hydrogels modified with the peptide VW-9 showed increased swelling and efficient release of the peptide. These modified hydrogels were compatible with fibroblast and macrophage cells, and effectively reduced the levels of inflammatory cytokines in activated cells. Consequently, VW-9-modified xanthan hydrogels hold promise for skin wound healing applications.
BIOMEDICAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Dahae Lee, Seoung Rak Lee, Ki Sung Kang, Ki Hyun Kim
Summary: The study evaluated the anti-inflammatory effects of compounds from white mulberry fruits in mouse RAW 264.7 macrophages. Compound cyclo(L-Pro-L-Val) (5) was identified as a potential therapeutic agent for inflammation-associated disorders as it significantly suppressed phosphorylations and activations of inflammatory mediators.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Hamsalakshmi, Suresh Joghee, Sreeram P. Kalarikkal, Gopinath M. Sundaram, T. Durai Ananda Kumar, Saravana Babu Chidambaram
Summary: The study demonstrated the anti-inflammatory effects of extracts from the aerial parts of Trichodesma indicum, with fraction FE showing the strongest ability to reduce inflammatory cytokines without cytotoxicity. The major compound in FE, 1,2-benzenedicarboxylic acid diisooctyl ester, exhibited good inhibition against key inflammatory targets.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)