A role for IL-1 inhibitors in the treatment of non-alcoholic fatty liver disease (NAFLD)?

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease

(2019) Jesper Falkesgaard Højen et al.   NATURE IMMUNOLOGY

Anti-Inflammatory Therapy With Canakinumab for the Prevention and Management of Diabetes

(2018) Brendan M. Everett et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

NLRP3 Deletion Inhibits the Non-alcoholic Steatohepatitis Development and Inflammation in Kupffer Cells Induced by Palmitic Acid

(2017) Can Cai et al.   INFLAMMATION

NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice

(2017) Auvro R. Mridha et al.   JOURNAL OF HEPATOLOGY

Cause, Pathogenesis, and Treatment of Nonalcoholic Steatohepatitis

(2017) Anna M. Diehl et al.   NEW ENGLAND JOURNAL OF MEDICINE

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endogenous IL-33 has no effect on the progression of fibrosis during experimental steatohepatitis

(2017) Philippe Vasseur et al.   Oncotarget

The Transcriptomic Signature Of Disease Development And Progression Of Nonalcoholic Fatty Liver Disease

(2017) Sophie Cazanave et al.   Scientific Reports

Interleukin-1 and inflammasomes in alcoholic liver disease/acute alcoholic hepatitis and nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2016) Herbert Tilg et al.   HEPATOLOGY

Interleukin-18–deficient mice develop dyslipidemia resulting in nonalcoholic fatty liver disease and steatohepatitis

(2016) Kyosuke Yamanishi et al.   Translational Research

Administration of IL-1ra improves adiponectin levels in chronic hemodialysis patients

(2014) Adriana M. Hung et al.   JOURNAL OF NEPHROLOGY

IL-37 protects against obesity-induced inflammation and insulin resistance

(2014) Dov B. Ballak et al.   Nature Communications

Caspase-1 as a Central Regulator of High Fat Diet-Induced Non-Alcoholic Steatohepatitis

(2013) Laura J. Dixon et al.   PLoS One

Lack of interleukin-1α or interleukin-1β inhibits transformation of steatosis to steatohepatitis and liver fibrosis in hypercholesterolemic mice

(2011) Yehuda Kamari et al.   JOURNAL OF HEPATOLOGY

Serum interleukin 1 receptor antagonist as an independent marker of non-alcoholic steatohepatitis in humans

(2011) Jussi Pihlajamäki et al.   JOURNAL OF HEPATOLOGY

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(2011) Alexander Moschen et al.   MOLECULAR MEDICINE

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

The Inflammasome-Mediated Caspase-1 Activation Controls Adipocyte Differentiation and Insulin Sensitivity

(2010) Rinke Stienstra et al.   Cell Metabolism

Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis

(2010) Herbert Tilg et al.   HEPATOLOGY