Article
Nutrition & Dietetics
Eduardo Sanches, Yohan van de Looij, Sadou Sow, Audrey Toulotte, Analina da Silva, Laura Modernell, Stephane Sizonenko
Summary: This study demonstrates that lactoferrin (Lf) supplementation attenuates acute and long-term cerebral injuries caused by hypoxia-ischemia in a dose-dependent manner. The optimal dose of 1 g/kg of Lf showed the best effects, reducing brain volume decreases and other detrimental effects. The research emphasizes the need for better understanding of Lf's effects and potential harmful effects on immature brains.
Article
Biochemistry & Molecular Biology
Juan David Olivares-Hernandez, Martha Carranza, Jerusa Elienai Balderas-Marquez, David Epardo, Rosario Baltazar-Lara, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Maricela Luna, Carlos Aramburo
Summary: This study investigates the neuroprotective and regenerative effects of growth hormone (GH) in prenatal hypoxic-ischemic (HI) injury using chicken embryo models. The results demonstrate that GH has an anti-apoptotic effect and promotes cell survival and proliferation in HI-injured pallial neurons through the activation of ERK1/2 and Bcl-2 signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Andrey Vinicios S. Carvalho, Rafael T. Ribeiro, Luz Elena Duran-Carabali, Ana Paula R. Martini, Eduarda Hoeper, Eduardo F. Sanches, Eduardo Luis Konrath, Carla Dalmaz, Moacir Wajner, Carlos Alexandre Netto
Summary: This study demonstrates that the Plinia trunciflora fruit extract (PTE) has a neuroprotective role in neonatal rats with experimental brain hypoxia-ischemia (HI). PTE effectively prevents oxidative stress and inflammatory response induced by HI, as evidenced by reduced lipoperoxidation levels and interleukin-1 beta levels. PTE also prevents neuronal loss, astrocyte reactivity, anxiety-like behavior, spatial memory impairment, and neural tissue loss caused by HI.
Article
Biochemistry & Molecular Biology
Rosario Baltazar-Lara, Jose Avila-Mendoza, Carlos G. Martinez-Moreno, Martha Carranza, Santiago Pech-Pool, Olivia Vazquez-Martinez, Mauricio Diaz-Munoz, Maricela Luna, Carlos Aramburo
Summary: GH and IGF-1 have been shown to have protective effects against neural damage, leading to increased cell viability and decreased apoptosis and necrosis in embryonic chicken cerebellar cell cultures exposed to acute HI injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Nutrition & Dietetics
Helene Roumes, Pierre Goudeneche, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Polyphenols, including resveratrol, have potential neuroprotective effects against neonatal hypoxia-ischemia-induced damage due to their anti-apoptotic, anti-inflammatory, and anti-oxidative properties, and may enhance brain energy metabolism. Maternal supplementation at nutritional doses shows promising results and could be a novel prophylactic treatment for neonatal hypoxia-ischemia.
Article
Biochemistry & Molecular Biology
Kenta H. T. Cho, Mhoyra Fraser, Bing Xu, Justin M. Dean, Alistair J. Gunn, Laura Bennet
Summary: The TLR7 agonist GDQ shows transient neuroprotective effects post-asphyxia by modulating blood pressure and suppressing early seizures, while inducing prolonged epileptiform activity later.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Jose Martinez-Orgado, Maria Villa, Aaron del Pozo
Summary: CBD shows neuroprotective effects in newborn pigs and rodents with HIBI, modulating the major components of HIBI pathophysiology. It has the potential to be an effective treatment for neonatal HIBI.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Helene Roumes, Ursule Dumont, Stephane Sanchez, Leslie Mazuel, Jordy Blanc, Gerard Raffard, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore
Summary: Lactate has shown neuroprotective effects in a neonatal hypoxia-ischemia model, reducing brain lesion volume rapidly and efficiently. Lactate metabolism plays a key role in this protection, and lactate administration holds promise as an effective therapy for neonatal HI insult.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Review
Neurosciences
Jia Liu, Yakun Gu, Mengyuan Guo, Xunming Ji
Summary: The brain, as the organ with the highest oxygen demand, has poor tolerance to ischemia and hypoxia. Ischemic/hypoxic preconditioning has been studied as an effective strategy to improve tolerance and is considered significant in treating CNS diseases. It involves multiple protective mechanisms and is a research frontier in neurotherapy, with challenges in translating from basic research to clinical application.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Neurosciences
Aminah Sheikh, Xiangying Meng, Joseph P. Y. Kao, Patrick O. Kanold
Summary: The study reveals that neonatal hypoxia-ischemia injuries lead to persistent changes in intracortical connections, which may interfere with brain development and impact the subsequent development of disorders.
Article
Neurosciences
Anita Lewczuk, Barbara Zablocka, Malgorzata Beresewicz-Haller
Summary: The transcription factor Nrf2 plays a crucial role in regulating genes involved in antioxidant and anti-inflammatory processes, metabolic regulation, and other cellular functions. This study investigates the activation of Nrf2 in different regions of the hippocampus and its impact on endogenous neuroprotection against ischemia-reperfusion (I/R) injury. The results reveal that CA2-4,DG in the hippocampus exhibits higher Nrf2 activity compared to CA1, indicating a potential mechanism explaining the different sensitivities of these regions to I/R injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Bongki Cho, Seung-Jun Yoo, So Yeon Kim, Chang-Hun Lee, Yun-Il Lee, Seong-Ryong Lee, Cheil Moon
Summary: In this study, divergently modified peptide analogs derived from EPO showed potent neuroprotective effects against oxidative stress without inducing cell proliferation. One of the peptides, ML1-h3, exhibited unique binding potency to EPOR and inhibited neuronal death and brain injury under hypoxic stress.
Review
Biochemistry & Molecular Biology
Patricia G. G. Valles, Andrea Fernanda Gil Lorenzo, Rodrigo D. D. Garcia, Valeria Cacciamani, Maria Eugenia Benardon, Valeria Victoria Costantino
Summary: Acute kidney injury (AKI) is a common and devastating condition with no effective pharmacological treatment. Toll-like receptor 4 (TLR4) and its ligands play a crucial role in the pathogenesis of AKI by mediating inflammatory responses. Excessive activation of TLR4 can lead to chronic inflammation. This review discusses the role of TLR4 in ischemic/reperfusion-induced AKI and sepsis-associated AKI, as well as its potential signaling patterns in kidney injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Sanches, Yohan van de Looij, Dini Ho, Laura Modernell, Analina da Silva, Stephane Sizonenko
Summary: Combining early oral administration of lactoferrin with whole body hypothermia can enhance neuroprotection in neonatal hypoxic-ischemic encephalopathy, preventing lactate accumulation, reducing inflammation, and mitigating brain damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Liang Liu, Tian-Ce Xu, Zi-Ai Zhao, Nan-Nan Zhang, Jing Li, Hui-Sheng Chen
Summary: TLR4 signaling in neurons plays a crucial role in neuronal death and neuroinflammatory responses following brain ischemia. Deletion of TLR4 reduces neuronal death and intracellular Ca2+ influx induced by oxygen and glucose deprivation or lipopolysaccharide treatment. TLR4 interacts with NMDAR2B and affects the interaction between nNOS and PSD-95, contributing to ischemic injury.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Wenhui Qu, Kiall F. Suazo, Wenfeng Liu, Shaowu Cheng, Angela Jeong, David Hottman, Li-Lian Yuan, Mark D. Distefano, Ling Li
Summary: Protein prenylation is crucial for regulating cellular signaling pathways, with FT and GGT enzymes playing essential roles in the process. FT haplodeficiency rescues cognitive function in Alzheimer's disease models, whereas GGT deficiency leads to synaptic and cognitive deficits. A novel prenylomic analysis identifies distinct pools of prenylated proteins affected by specific knockout of FT and GGT in forebrain neurons, indicating their essential roles in synaptic and cognitive functions.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wanfeng Wu, Yihang Sun, Ning Luo, Cheng Cheng, Chengting Jiang, Qingping Yu, Shaowu Cheng, Jinwen Ge
Summary: The study aimed to investigate the association between gut microbiota and plasma metabolites in ischemic stroke (IS) using 16S rRNA gene sequencing and LC-MS analysis. Results showed significant differences in microbiota composition and diversity between IS and control rats, along with distinct patterns in plasma metabolites. The integrated analysis suggested a potential diagnostic and therapeutic role of microflora-related metabolites in IS.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Angela Jeong, Shaowu Cheng, Rui Zhong, David A. Bennett, Martin O. Bergo, Ling Li
Summary: This study found that levels of FT and membrane-associated H-Ras were increased in individuals with AD and MCI compared to those with no cognitive impairment. Deleting neuronal FT mitigated memory impairment and amyloid neuropathology in transgenic AD model mice by suppressing amyloid generation and reversing hyperactivation of mTORC1 signaling. Targeting FT or its downstream signaling pathways could be a potential therapeutic strategy against AD.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yupei Yang, Yuqing Jian, Shaowu Cheng, Yanzhe Jia, Yongbei Liu, Huanghe Yu, Liang Cao, Bin Li, Caiyun Peng, Muhammad Iqbal Choudhary, Atta-ur Rahman, Wei Wang
Summary: The phytochemical investigation of Kadsura coccinea roots led to the discovery of five new dibenzocyclooctadiene lignans, named heilaohusuins A-E. Among a series of dibenzocyclooctadiene derivatives, compounds 2, 10, 13, 21, 32, 41, 46, and 49 showed significant hepatoprotective effects, with heilaohusuin B identified as attenuating hepatotoxicity by inhibiting oxidative stress through the Nrf2 pathway. This study offers insights into the structure-activity relationships for hepatoprotective activity of dibenzocyclooctadiene derivatives.
BIOORGANIC CHEMISTRY
(2021)
Article
Integrative & Complementary Medicine
Zhenyan Song, Deyong Luo, Yuke Wang, Yushan Zheng, Peiying Chen, Xiaofang Xia, Chunxiang He, Wenjing Yu, Ping Li, Chen Xiao, Shaowu Cheng
Summary: The study found that giving medium and high doses of Danggui Shaoyao San significantly improved the learning and memory abilities of AD rats, while promoting autophagy in the hippocampus. Additionally, Danggui Shaoyao San inhibited neuronal apoptosis in AD rats by activating the PINK1-Parkin-mediated mitophagy signaling pathway.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2021)
Review
Cell Biology
Heyan Tian, Xiangyu Chen, Jun Liao, Tong Yang, Shaowu Cheng, Zhigang Mei, Jinwen Ge
Summary: Mitochondrial quality control plays a critical role in stroke by preserving mitochondrial structure and function, promoting neuronal survival, and alleviating pathological processes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhou, Jin Liu, Lan-Lan Bu, Duan-Fang Liao, Shao-Wu Cheng, Xi-Long Zheng
Summary: The novel compound curcumin acetylsalicylate (CA) was found to extend the lifespan of Caenorhabditis elegans in a dose-dependent manner, decrease oxidative stress, and increase the expression of antioxidative genes. Activation of the DAF-16 transcription factor by CA may contribute to delaying aging in C. elegans.
Article
Biotechnology & Applied Microbiology
Zhenyan Song, Chunxiang He, Wenjing Yu, Miao Yang, Ze Li, Ping Li, Xu Zhu, Chen Xiao, Shaowu Cheng
Summary: Baicalin was found to promote cell survival and proliferation, and inhibit apoptosis in an AD cell model. It also improved A beta-induced cell cycle arrest and apoptosis. Moreover, baicalin inhibited Ras-ERK signaling induced by A beta, and this effect could be reversed by the MEK activator.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Rui Fang, Hua Hu, Yue Zhou, Shanshan Wang, Zhigang Mei, Ruining She, Xiwen Peng, Qiling Jiang, Xiangyuan Wang, Le Xie, Hongyuan Lin, Pan Meng, Kun Zhang, Wei Wang, Yao Xie, Litao Liu, Jiao Tong, Dahua Wu, Yunhua Luo, Chang Liu, Yifang Lu, Shangzhen Yu, Shaowu Cheng, Linyong Xu, Zhuyuan Fang, Hongcai Shang, Jinwen Ge
Summary: This multicenter randomized controlled trial aims to evaluate the efficacy and safety of naotaifang capsules on hypertensive cerebral small vessel disease. A total of 388 eligible subjects were recruited and divided into intervention and control groups for 6 months of treatment. The primary outcomes include Fazekas scores, dilated Virchow-robin spaces grades, and the number of lacunar infarctions and cerebral microbleeds on magnetic resonance imaging, while secondary outcomes include clinical blood pressure, traditional Chinese medicine syndrome scores, mini-mental state examination scale, and safety outcomes. The findings from this study will contribute to the understanding of Chinese herbs for treating hypertensive cerebral small vessel disease.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Ze Li, Zhenyan Song, Chunxiang He, Jialong Fan, Wenjing Yu, Miao Yang, Ping Li, Rongsiqing Luo, Jinyong Zhou, Sijie Xu, Bin Liu, Shaowu Cheng
Summary: This study developed a nano delivery system that can reverse microglia polarization, improve learning and memory, alleviate glial cell activation, and enhance cognitive function in Alzheimer's disease treatment, indicating its promising therapeutic potential.
MATERIALS TODAY ADVANCES
(2022)
Article
Neurosciences
Wenzhu Wang, Zihan Li, Yitong Yan, Shuo Wu, Xinyu Yao, Chen Gao, Lanxiang Liu, Yan Yu
Summary: This study investigated the reparative mechanisms of low-intensity pulsed ultrasound (LIPUS) in traumatic brain injury (TBI) and found that LIPUS promotes hippocampal neurogenesis, enhances neural electrical activity and neural plasticity, ultimately restoring neuronal function and cognitive capabilities in TBI mice.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Wenmin Yi, Fei Chen, Minghao Yuan, Chuanling Wang, Shengyuan Wang, Jie Wen, Qian Zou, Yinshuang Pu, Zhiyou Cai
Summary: The study suggests that a high-fat diet may lead to tau hyperphosphorylation and synaptic dysfunction by inhibiting the SIRT1/AMPK pathway and disrupting autophagy flux, ultimately resulting in cognitive decline.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Kim M. Hemsley, Helen Beard, Glyn Chidlow, Teresa Mammone, Leanne K. Winner, Daniel Neumann, Barbara King, Marten F. Snel, Paul J. Trim, Robert J. Casson
Summary: Optical coherence tomography (OCT) is a non-invasive method that can be used to rapidly and quantitatively examine the integrity of the neuroretina. It has been shown that OCT can be used to observe retinal thinning in patients with childhood dementia, and to assess the improvement of retinal structure after treatment. Furthermore, OCT can provide insights into other childhood dementias based on the correlation between retinal and brain degeneration in Sanfilippo syndrome.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Alice McDouall, Guido Wassink, Sumudu Ranasinghe, Kelly Q. Zhou, Rashika N. Karunasinghe, Justin M. Dean, Joanne O. Davidson
Summary: This study found that blocking connexin 43 hemichannels can attenuate brain injury and promote neurodevelopment in infants with mild hypoxic-ischemic encephalopathy, without causing hypothermia.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Hannah Sweetman, Mahmudur Rahman, Aditya Vedantam, Kajana Satkunendrarajah
Summary: Degenerative cervical myelopathy (DCM) is a neurological condition characterized by chronic compression of the cervical spinal cord, leading to impaired limb function. While respiratory dysfunction is not a common symptom of DCM, it can affect the ventilatory response to respiratory challenges. Surgical decompression improves sensorimotor function in DCM, but its impact on respiratory function is unclear. This study evaluates respiratory function and adaptive ventilation in a DCM model, showing that DCM impairs acute adaptive ventilatory ability and surgical decompression does not fully restore it.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Chengmei Sun, Muhammad Saif Ur Rahman, Budbazar Enkhjargal, Jianhua Peng, Keren Zhou, Zhiyi Xie, Lingyun Wu, Tongyu Zhang, Qiquan Zhu, Jiping Tang, Yujia Zeng, John H. Zhang, Shanshan Xu
Summary: This study found that Osteopontin (OPN) can attenuate inflammatory responses after subarachnoid hemorrhage (SAH) by promoting an anti-inflammatory microglial state. This effect may be mediated through the integrin-FAK-STAT3 and NF-kappa B signaling pathways.
EXPERIMENTAL NEUROLOGY
(2024)
Article
Neurosciences
Yang Yang, Xuezhu Chen, Chuanyan Yang, Mei Liu, Qianying Huang, Likun Yang, Yuhai Wang, Hua Feng, Zhongyang Gao, Tunan Chen
Summary: The study explores the effects of specific chemogenetic stimulation of intact corticospinal tract on functional recovery after stroke in mice. The findings demonstrate that combining chemogenetic activation with rehabilitation training leads to significant motor functional recovery by promoting axon sprouting and rewiring new functional circuits.
EXPERIMENTAL NEUROLOGY
(2024)