Article
Nanoscience & Nanotechnology
Xingkun Luan, Zehong Xiang, Jiangtao Dong, Chen Wang, Xiaona Li, Qiang Shi, Xuezhong Du
Summary: A universal strategy for silane functionalization of metal-organic frameworks (MOFs) was developed, which involved the coupling of silanes with hydroxyl groups of MOFs to form metal-O-Si bonds. The strategy enabled the functionalization of MOFs with a wide variety of applications. Furthermore, the construction of supramolecular nanovalves on the surface of silanized MOFs demonstrated excellent controlled drug release and inhibitory effect on tumor growth.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Materials Science, Multidisciplinary
Yingnan Zhang, Changhao Fang, Wildemar S. P. Carvalho, Yongfeng Gao, Michael J. Serpe
Summary: The light- and temperature-responsive poly(N-isopropylacrylamide-co-nitrobenzyl methacrylate) microgels demonstrated efficient release of fluorescein through UV irradiation-induced cleavage and heating-induced deswelling, showing potential applications in triggered cargo release systems.
ACS APPLIED POLYMER MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Soumya Srimayee, Saumya Ranjan Badajena, Nasim Akhtar, Mrinal Kanti Kar, Subhasis Dey, Purusottam Mohapatra, Debasis Manna
Summary: This study attempted to optimize practical applications of hydrophobic ionophores through integrin-mediated cellular delivery, facilitating the transport of Cl- in the cellular environment.
CHEMICAL COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Jianhong Wang, Yingtong Luo, Hanglong Wu, Shoupeng Cao, Loai K. E. A. Abdelmohsen, Jingxin Shao, Jan C. M. van Hest
Summary: Researchers have designed a nanomotor with integrated fluorescence and therapeutic potential based on biodegradable polymersomes equipped with aggregation-induced emission (AIE) agents. These nanomotors can produce reactive oxygen species (ROS) upon laser irradiation and have the potential for cancer cell treatment.
Review
Biochemistry & Molecular Biology
Anum Kayani, Arsalan Raza, Jiale Si, Debabrata Dutta, Qinghao Zhou, Zhishen Ge
Summary: Polymersomes have been extensively studied as nanocarriers for drug delivery for two decades. Although they have many advantages, including high stability and simultaneous encapsulation of hydrophilic and hydrophobic drugs, they often face issues with non-targeted delivery and poor membrane permeability. Recent advancements in surface functionalization and membrane permeability control have addressed these challenges and improved the efficiency of drug delivery using polymersomes. This review provides a detailed overview of the role of polymersome membranes and future developments in promoting them as in vivo drug delivery nanocarriers.
Article
Chemistry, Multidisciplinary
Maria Sancho-Albero, Giada Rosso, Luisa De Cola, Valentina Cauda
Summary: Smart biodegradable nanoparticles with biomimetic lipid bilayers are reported for cancer treatment and diagnostics. These lipid-coated nanocages demonstrate high hemocompatibility, colloidal stability, and biocompatibility, and mediate efficient internalization into cancer cells. The therapeutic agents can be efficiently delivered and the nanoparticles can be effectively destroyed within cancer cells, making the lipid-coated nanocages a promising tool for cancer research and theranostics.
Article
Chemistry, Multidisciplinary
Maria Sancho-Albero, Giada Rosso, Luisa De Cola, Valentina Cauda
Summary: The recent advancements in nanomedicine have brought about various smart nanoparticles for cancer treatment and diagnostics. However, their clinical application faces challenges regarding biocompatibility, elimination, and biodistribution. This study proposes breakable organosilica mesoporous nanoparticles coated with different lipid compositions to improve their biomimetic behavior. The lipid-coated nanocages exhibit high hemocompatibility, colloidal stability, and biocompatibility, and play a key role in enhancing the internalization of the nanocages in cancer cells.
Article
Biophysics
Ewelina Waglewska, Agata Pucek-Kaczmarek, Urszula Bazylinska
Summary: The rapid development of colloid chemistry has enabled the use of nanocarriers for targeted drug delivery and controlled release, leading to reduced side effects and improved therapeutic efficacy. In this study, the influence of temperature and pH on in vitro controlled release of phytochemicals/dyes from a modified bilosome was investigated. The study also examined the effect of encapsulated bioactive compounds on nanoparticle structure. The results showed that the obtained double-loaded bilosomes have great potential as bioinspired nanoplatforms for oral, intravenous, and topical drug delivery in future biomedical applications.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Biophysics
Dan Zheng, Bo Bai, Hao Zhao, Xiaohui Xu, Na Hu, Honglun Wang
Summary: A novel intelligent pesticide delivery system was synthesized to reduce volatilization and leaching of pesticides, and increase their residence time on crop surfaces. This system showed high control efficacy by combining different materials to enhance pesticide adhesion and release, with the potential for huge application prospects in agriculture.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Polymer Science
Shuqi Dong, Li Liu, Hanying Zhao
Summary: In this study, oxidation-responsive amphiphilic block copolymers were synthesized and self-assemblies with different morphologies were achieved by adjusting the hydrophobic block length. Hybrid polymersomes with Cu2+-cross-linked membrane were fabricated, featuring a responsive property to competitive ligands, thanks to the metal-ligand interaction.
Review
Chemistry, Physical
Wenjing Xiao, Lin Zhao, Yang Sun, Xiao Yang, Qinrui Fu
Summary: This review provides a comprehensive overview of the recently reported studies on stimuli-responsive nanomaterials for tumor radio-sensitization, including endogenous and exogenous responses, dual stimuli-response, and multi stimuli-response approaches. It also discusses the challenges and perspectives related to stimuli-responsive nanomaterials for tumor radio-sensitization.
Article
Materials Science, Biomaterials
Sai Geetika Surapaneni, Shakeb N. Choudhari, Shankarrao V. Avhad, Ashootosh V. Ambade
Summary: A series of dual stimuli-responsive block copolymers were synthesized, composed of temperature-responsive PVCL and biodegradable pH-responsive PLL. The block copolymers formed micelles and polymersomes in response to temperature and pH changes, respectively, in aqueous solution. The release of the drug Doxorubicin (DOX) from the polymersomes was controlled by stimuli-induced increased permeability, and an increase in cellular uptake was observed at hyperthermia conditions.
BIOMATERIALS ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
Pooyan Makvandi, Rezvan Jamaledin, Guojun Chen, Zahra Baghbantaraghdari, Ehsan Nazarzadeh Zare, Concetta Di Natale, Valentina Onesto, Raffaele Vecchione, Jesse Lee, Franklin R. Tay, Paolo Netti, Virgilio Mattoli, Ana Jaklenec, Zhen Gu, Robert Langer
Summary: Microneedle (MN) patches, made up of miniature needles, have emerged as a promising tool for minimally invasive translocation of biomolecules into the dermis. Stimuli-responsive MN patches are a new drug delivery system that can release cargos in response to internal or external triggers, with various mechanisms of action for different indications. Future opportunities and challenges in clinical translation are also discussed.
Review
Polymer Science
Jinlong Qin, Min Sun, Wei Hu, Jiajing Cheng, Zhen Fan, Jianzhong Du
Summary: Immunotherapy plays an important role in cancer treatment, but there are challenges in delivering immunotherapeutic agents and activating them effectively at tumor sites. Hydrogels, combined with immunotherapies, offer a chance to enhance the immune response against tumors with reduced side effects. Stimuli-responsiveness is also applied to optimize pharmacokinetics and improve therapeutic outcomes. This review discusses the opportunities of combining immunotherapy with stimuli-responsive hydrogels, such as light, temperature, ultrasound, and magnetically responsive hydrogels, for effective cancer treatment. It also explores the potential of stimuli-responsive hydrogels as vaccine implants against cancer and Covid-19.
Article
Chemistry, Multidisciplinary
Claudia Martins, Marco Araujo, Alessio Malfanti, Catarina Pacheco, Stuart J. J. Smith, Bernard Ucakar, Ruman Rahman, Jonathan W. W. Aylott, Veronique Preat, Bruno Sarmento
Summary: Report the development of hypothesis-driven stimuli-responsive nanoparticles (NPs) for glioblastoma (GBM) therapy. These NPs have multifunctional features that overcome the insufficient blood-brain barrier (BBB) trafficking and lack of GBM targeting, two major challenges in anti-GBM treatments. In preclinical studies, the stimuli-responsive NPs effectively targeted GBM cells, enhanced cell uptake, increased cytotoxicity, improved BBB permeability, and demonstrated antitumor efficacy in GBM models.