Article
Infectious Diseases
Vannesa Yue May Teng, Yan Ting Chua, Eunice En Ni Lai, Shilpa Mukherjee, Jessica Michaels, Chen Seong Wong, Liang Shen, Yee Sin Leo, Barnaby Young, Sophia Archuleta, Catherine W. M. Ong
Summary: The study found that screening for latent TB infection is low among HIV-TB co-infected patients in Singapore, and initiation of ART treatment may be delayed for some patients. It was also noted that pulmonary TB patients with HIV can still be infectious despite showing a normal chest x-ray.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Zirwatul Adilah Aziz, Noorliza Mohamad Noordin, Wan Mazlina Wan Mohd, Mohd Amin Kasim
Summary: Diagnosis and treatment of tuberculosis infection (TBI) are crucial for tuberculosis elimination. A new digital lateral flow assay, QIAreach QuantiFERON-TB (QIAreach QFT), showed high agreement with QuantiFERON-TB Gold Plus (QFT-Plus) assay in terms of sensitivity, specificity, and overall agreement. QIAreach QFT could serve as an accurate and reliable point-of-need test for TB infection diagnosis, especially in decentralized settings with limited laboratory expertise and infrastructure.
Article
Infectious Diseases
L. Luan, P. Fraisse, H. Cordel, C. Charlois, F. Mechai, G. Ibanez, S. Hargreaves, M. Mechain, N. Vignier
Summary: The study highlighted the lack of awareness and inconsistency in TB/LTBI screening practices among primary and secondary care providers in France when it comes to migrant populations. Improving awareness on TB screening is crucial for better health outcomes in migrants and achieving regional targets in tackling TB.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)
Article
Immunology
Jie Li, Yaguo Wang, Liang Yan, Chunlan Zhang, Yanbin He, Jun Zou, Yanhong Zhou, Cheng Zhong, Xueyu Zhang
Summary: This study identified a combination of 4 proteins as biomarkers to distinguish ATB from LTBI. The biomarker panel showed high sensitivity and specificity, indicating its potential in clinical diagnosis.
MICROBES AND INFECTION
(2022)
Article
Medicine, General & Internal
Andy C. Tran, Eugenia Boariu, Maria Garcia-Bengoa, Mi-Young Kim, Emil Joseph Vergara, Tufaria Mussa, Rajko Reljic
Summary: Serological antibody profiling can identify risk indicators of disease progression and serve as an accessible diagnostic tool for discriminating between tuberculosis (TB) and latent TB infection (LTBI). This study conducted an analysis of serum antibodies in TB patients, LTBI individuals, and healthy controls from Mozambique. The results showed that IgA antibodies to MPT64 antigen were the most discriminatory for TB and LTBI, and an ELISA MPT64-IgA test exhibited high sensitivity and specificity for differentiating TB from LTBI and healthy controls.
FRONTIERS IN MEDICINE
(2023)
Article
Infectious Diseases
Esther Uwimaana, Bernard S. Bagaya, Barbara Castelnuovo, David P. Kateete, Anguzu Godwin, Noah Kiwanuka, Christopher C. Whalen, Moses L. Joloba
Summary: The study investigated the potential role of HO-1 and neopterin in TB diagnosis. While there were differences in concentrations of HO-1 and neopterin among active TB patients and latently infected individuals, both biomarkers showed poor ability to distinguish between active TB and latent TB.
BMC INFECTIOUS DISEASES
(2021)
Article
Dermatology
Yue Xiao, Wenyao Mi, Jinqiu Wang, Dingke Wen, Yiyi Wang, Yuanxia Gu, Dan Hao, Wei Li, Xuerong Chen, Wei Li
Summary: This study provides additional information on the safety of secukinumab in patients with psoriasis and latent tuberculosis infection. The results showed no significant increase in IGRA results in both groups, regardless of whether patients received prophylactic treatment. Further research is needed to determine the necessity of anti-TB medication before administering secukinumab.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Yue Xiao, Wenyao Mi, Jinqiu Wang, Dingke Wen, Yiyi Wang, Yuanxia Gu, Dan Hao, Wei Yan, Xuerong Chen, Wei Li
Summary: This study investigated the safety of using secukinumab in patients with psoriasis with latent tuberculosis infection (LTBI). The results showed no activation of tuberculosis in either group, regardless of whether patients received antituberculosis therapy. The interferon-gamma release assay also did not show a significant increase after balancing the baseline. Therefore, this study indicates that secukinumab is safe in patients with LTBI, even without antituberculosis treatment.
DERMATOLOGY AND THERAPY
(2023)
Article
Infectious Diseases
Chelsie Cintron, Prakash Babu Narasimhan, Lindsey Locks, Senbagavalli Babu, Pranay Sinha, Nonika Rajkumari, Vaishnavi Kaipilyawar, Anurag Bhargava, Kimberly Maloomian, Padma Chandrasekaran, Sheetal Verma, Noyal Joseph, W. Evan Johnson, Christine Wanke, C. Robert Horsburgh, Jerrold J. Ellner, Sonali Sarkar, Padmini Salgame, Subitha Lakshminarayanan, Natasha S. Hochberg
Summary: This study aims to investigate the impact of undernutrition and parasitic infections on immune responses and tuberculosis risk, analyzing gene signatures and immune mechanisms involved in disease progression. It also evaluates the potential benefits of nutritional supplementation and parasite treatment in improving immune response to Mycobacterium tuberculosis infection, potentially reducing the overall burden of TB disease progression in the population.
BMC INFECTIOUS DISEASES
(2021)
Article
Immunology
Cheng Chen, Xinsong Hu, Yan Shao, Honghuan Song, Guoli Li, Wei Lu, Leonardo Martinez, Jianfang Xu, Limei Zhu
Summary: This study evaluated the level of QFT TB antigen among individuals with different diabetes statuses, and found that diabetes status had little influence on the level of QFT TB antigen response among IGRA-positive individuals. However, fasting plasma glucose, age, and smoking were important risk factors for increasing levels of QFT TB antigen.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Federica Fregonese, Lika Apriani, Leila Barss, Andrea J. Benedetti, Victoria Cook, Dina Fisher, Greg Fox, James Johnston, Richard Long, Thu Anh Nguyen, Viet Nhung Nguyen, Rovina J. Ruslami, Dick J. Menzies
Summary: This trial aims to test the safety of high dose rifampin monotherapy to shorten the duration of the currently recommended TB preventive treatment of 4 months rifampin.
Article
Multidisciplinary Sciences
Ester Lilian Acen, Irene Andia Biraro, Mudarshiru Bbuye, David Patrick Kateete, Moses L. Joloba, William Worodria
Summary: The aim of this study was to determine the association between vitamin D deficiency and TB status among patients with active TB, latent TB infection (LTBI) and those without TB infection. The study found that the vitamin D levels of active TB patients were significantly lower compared to individuals with LTBI and those without TB infection.
SCIENTIFIC REPORTS
(2022)
Article
Public, Environmental & Occupational Health
K. Sullivan, C. Pease, A. Zwerling, R. Mallick, D. Van Dyk, S. Mulpuru, C. Allen, H. Alsdurf, G. G. Alvarez
Summary: This study examined the LTBI cascade of care and identified barriers to treatment completion among adults referred from primary care to a regional tertiary care TB clinic in Ottawa, Canada. Treatment completion rates were significantly decreased for patients referred back to primary care from the TB clinic, indicating a need for improved education and communication between tertiary care TB clinics and primary care teams to address the TB burden in low incidence communities in Canada.
Article
Medicine, General & Internal
Jessica Lovatt, Deborah Gascoyne-Binzi, Thomas Hussey, Maya Garside, Fiona McGill, Christian P. Selinger
Summary: The study found that there is a higher chance of indeterminate IGRA results in inpatients, which is mainly associated with laboratory parameters reflecting inflammation (such as high CRP, low albumin) and exposure to steroids.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Infectious Diseases
S. Naqvi, Y. Cantu, S. Ong Uti, D. Cavazos, A. Johnson, C. Salazar, G. Morrow, T. Camden, N. Santos, L. Armitige, L. Ringsdorf, B. S. Taylor
Summary: In South Texas, a multi-site IGRA-based testing and LTBI treatment program targeted high-risk populations, with over 9,000 patients screened and a high prevalence of IGRA positivity. However, confirming LTBI, initiating, and completing treatment were challenging, with patient barriers including lack of knowledge, misconceptions, and treatment toxicities. Clinic staff also identified toxicity as a barrier to treatment, along with limited resources for new process implementation.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2021)