期刊
BIOLOGY OF REPRODUCTION
卷 94, 期 6, 页码 -出版社
SOC STUDY REPRODUCTION
DOI: 10.1095/biolreprod.115.137497
关键词
meiosis; primordial folliculogenesis; Pumilio; RNA binding protein; subfertility; translational regulator
资金
- National Institutes of Health [2K12HD047018-11]
- American Society of Reproductive Medicine
- G. Harold and Leila Y. Mathers Award
Pumilio/FBF (PUF) proteins are a highly conserved family of translational regulators. The Drosophila PUF protein, Pumilio, is crucial for germline establishment and fertility. In mammals, primordial folliculogenesis is a key process that establishes the initial cohort of female mammalian germ cells prior to birth, and this primordial follicle pool is a prerequisite for female reproductive competence. We sought to understand whether PUF proteins have a conserved role in mammals during primordial folliculogenesis and female reproductive competency. In mammals, two homologs of Pumilio exist: Pumilio 1 (Pum1) and Pum2. Here, we report that PUMILIO (PUM) 1 plays an important role in the establishment of the primordial follicle pool, meiosis, and female reproductive competency, whereas PUM2 does not have a detectable function in these processes. Furthermore, we show that PUM1 facilitates the transition of the late meiotic prophase I oocyte from pachytene to diplotene stage by regulating SYCP1 protein. Our study reveals an important role of translational regulation in mammalian female germ cell development.
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