Article
Biochemistry & Molecular Biology
Jihye Seo, Jain Ha, Eunjeong Kang, Haelim Yoon, Sewoong Lee, Shi Yong Ryu, Kwonseop Kim, Sayeon Cho
Summary: Hepatocellular carcinoma (HCC), the most common type of liver cancer, is a major cause of cancer-related deaths worldwide. Glaucarubinone (GCB) has been identified as having the potential to inhibit cancer cell migration and exhibit anti-cancer effects by regulating multiple signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Yang Yang, Pengwei Ren, Xiaofeng Liu, Xiaoyan Sun, Chunfeng Zhang, Xiaojuan Du, Baocai Xing
Summary: This study found that PPP1R26 is upregulated in hepatocellular carcinoma (HCC) and is significantly associated with metastasis and poor patient survival. PPP1R26 promotes glycolysis by enhancing the splicing of PKM2 and activates epithelial-mesenchymal transition (EMT) by forming a PPP1R26-PKM2-TGIF2 complex, driving the progression of HCC.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Hongchi Yu, Jia He, Guanyue Su, Yuelong Wang, Fei Fang, Wenxing Yang, Kaiyun Gu, Naiyang Fu, Yunbing Wang, Yang Shen, Xiaoheng Liu
Summary: The study revealed that fluid shear stress facilitated cytoskeleton rearrangement in hepatocellular carcinoma cells, leading to the release of YAP from integrin beta subunit and subsequent activation of EMT-regulating transcription factor SNAI1 and expression of EMT-related genes. FSS-treated HepG2 cells exhibited significantly increased tumorigenesis and metastasis in vivo.
MOLECULAR ONCOLOGY
(2021)
Article
Oncology
Yuanbiao Zhang, Weiding Wu, Qiang Sun, Longyun Ye, Dongkai Zhou, Weilin Wang
Summary: In this study, it was found that linc-ROR interacts with TWIST1 to induce EMT, leading to increased resistance of HCC cells to DOX. Furthermore, overexpression of TWIST1 was able to inhibit the sensitivity of HCC cells to DOX induced by linc-ROR knockdown.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Sima Ardalan Khales, Sina Mozaffari-Jovin, Dirk Geerts, Mohammad Reza Abbaszadegan
Summary: This study reveals the crucial role of TWIST1 in the establishment of a cancer stem cell-like phenotype, EMT progression, and inhibition of apoptosis in esophageal squamous cell carcinoma (ESCC). These findings provide evidence for TWIST1 as a therapeutic target for suppressing CSC generation and ESCC malignancy.
Article
Biochemistry & Molecular Biology
Yanhong Wang, Na Li, Yanping Zheng, Anqing Wang, Chunlei Yu, Zhenbo Song, Shuyue Wang, Ying Sun, Lihua Zheng, Guannan Wang, Lei Liu, Jingwen Yi, Yanxin Huang, Muqing Zhang, Yongli Bao, Luguo Sun
Summary: KIAA1217 plays a crucial role in hepatocellular carcinoma (HCC) metastasis by promoting cell migration and invasion through inducing epithelial-mesenchymal transition (EMT), and activating JAK1/2 and STAT3. It interacts with the Notch and Wnt/β-catenin pathways to facilitate HCC metastasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Ying Liu, Dao-Hai Cheng, Ke-Dao Lai, Hua Su, Guo-Shou Lu, Li Wang, Ji-Hua Lv
Summary: Ventilagolin suppresses the migration, invasion, and EMT of HCC cells by downregulating Pim-1, showing potential therapeutic effects. In vivo experiments demonstrate that Ventilagolin effectively inhibits HCC tumor growth and regulates the expression of Pim-1 and EMT-related proteins.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Oncology
Rongzhong Xu, Liubing Lin, Bo Zhang, Jian Wang, Fanchen Zhao, Xiaolin Liu, Yiping Li, Yan Li
Summary: The study found that BIRC5 was highly expressed in HCC samples and associated with poor prognosis. Through WGCNA, 180 module genes were screened, overlapped with 241 DEGs, ultimately obtaining 33 candidate genes. Cox regression analyses identified 8 genes which were used to construct a risk signature, showing high accuracy in predicting clinical outcomes and closely related to clinicopathological characteristics of HCC patients. IPA suggested these 8 genes were enriched in cancer and immune-related pathways.
Article
Oncology
Siqi Peng, Yutong Chen, Ting Li, Junjie Mao, Pengfei Yang, Baojia Zou, Lisi Luo, Weiyu Zhang, Wen Wang, Rongzhi Xie, Jian Li, Linjuan Zeng
Summary: In this study, the researchers found that interleukin-8 (IL-8) promotes metastasis and invasion in hepatocellular carcinoma (HCC) by downregulating miR-370-3p expression and activating the STAT3 pathway. MiR-370-3p directly interacts with Snail and Twist1, attenuating the protumoral effects of IL-8 on liver cancer cells. Patients with high levels of miR-370-3p and low levels of IL-8 had longer overall survival, indicating the diagnostic and therapeutic potential of miR-370-3p in HCC metastasis.
Article
Biotechnology & Applied Microbiology
Qiannan Zhao, Fen Jiang, Hui Zhuang, Yanfeng Chu, Fang Zhang, Chenghong Wang
Summary: miR-124-3p inhibits HCC proliferation and epithelial-mesenchymal transition (EMT) by targeting ARRDC1.
Article
Oncology
Gongmin Zhu, Hongwei Xia, Qiulin Tang, Feng Bi
Summary: The study identified an EMT-related 5-gene signature (PDCD6, TCOF1, TRIM28, EZH2 and FAM83D) for predicting the prognosis of HCC patients. The signature accurately and independently predicted HCC prognosis, and its predictive capacity was validated in external cohorts. Functional experiments revealed that PDCD6 promoted cell migration and invasion in HCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Weihao Kong, Zhongxiang Mao, Chen Han, Zhenxing Ding, Qianqian Yuan, Gaosong Zhang, Chong Li, Xuesheng Wu, Jia Chen, Manyu Guo, Shaocheng Hong, Feng Yu, Rongqiang Liu, Xingyu Wang, Jianlin Zhang
Summary: In this study, a nine-gene signature related to epithelial-mesenchymal transition (EMT) was identified to predict the survival outcome of hepatocellular carcinoma (HCC) patients. The predictive nomogram based on the EMT risk score showed good distinguishing ability and consistency. The EMT risk score was also found to be correlated with immune infiltration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Xianjue Wang, Ping Wei, Ling Yang, Fangyuan Liu, Xin Tong, Xiaoyu Yang, Liya Su
Summary: The study revealed that miR-20a-5p is significantly upregulated in HCC tissues, promoting cell proliferation, migration, and invasion while suppressing apoptosis through regulating the EMT process. Additionally, by downregulating RUNX3, miR-20a-5p activates the EMT pathway, enhancing the malignant behavior of HCC cells.
CHINESE MEDICAL JOURNAL
(2022)
Article
Cell Biology
Xiao Dong, Yang Han, Encheng Zhang, Yuqi Wang, Pingzhao Zhang, Chenji Wang, Lin Zhong, Qi Li
Summary: This study demonstrates that ZEB1 is a substrate of the CRL4-DCAF15 E3 ubiquitin ligase complex, with DCAF15 specifically recognizing the N-terminal zinc finger domain of ZEB1 for degradation through the ubiquitin-proteasome pathway. Knockdown of DCAF15 leads to upregulation of ZEB1 and activation of EMT in HCC, while overexpression of DCAF15 suppresses ZEB1 and inhibits EMT progression, ultimately impacting HCC cell proliferation and invasion. Low DCAF15 expression in HCC patients is associated with poor prognosis, highlighting the importance of the CUL4-DCAF15 E3 ubiquitin ligase complex in regulating ZEB1-mediated malignancy in HCC.
Article
Cell Biology
Yang Zhang, Weixing Ni, Lei Qin
Summary: In this study, the researchers aimed to investigate the role and mechanism of RUFY3 in hepatocellular carcinoma (HCC) progression. Results showed that high expression of RUFY3 was significantly associated with tumor size, microvascular invasion, clinical stage, and poor prognosis in HCC patients. Furthermore, RUFY3 was found to promote HCC cell growth, invasion, and metastasis through activating NF-kappa B-mediated epithelial-mesenchymal transition (EMT). These findings suggest that RUFY3 may serve as a novel target for HCC treatment.