Article
Neurosciences
Patrycja Orlowska-Feuer, Annette Elisabeth Allen, Timothy Matthew Brown, Hanna Jowita Szkudlarek, Robert James Lucas, Riccardo Storchi
Summary: Neurophysiological activity in the subcortical visual system shows fluctuations in infra-slow and fast oscillatory ranges, with the phase of infra-slow modulating fast beta/gamma oscillations. Genetic ablations reveal that infra-slow and fast oscillations interact uniquely, potentially guiding visual processing. This interaction may play a significant role in vision function and disruptions in these oscillatory behaviors could contribute to vision dysfunction in retinal dystrophy.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Nutrition & Dietetics
Brigitta Brunner, Csilla Ari, Dominic P. D'Agostino, Zsolt Kovacs
Summary: It has been shown that the ketogenic supplement in KEKS food can reduce LPS-induced SWD by increasing adenosine levels with potential modulation through A1R rather than A2AR. The study found that inhibition of A1Rs abolished the alleviating effect of KEKS food on LPS-induced increases in SWD number, while blocking A2ARs did not significantly modify the beneficial effect.
Article
Neurosciences
Gul Ilbay, Zeynep Ikbal Dogan, Aymen Balikci, Seyda Erdogan, Akfer Karaoglan Kahilogullari
Summary: The present study investigated the effects of early caffeine exposure on epileptogenesis, absence seizures, and comorbid depression in adulthood. The results suggest that postnatal caffeine treatment may decrease the number of seizures and depression-like behaviors in WAG/Rij rats in later life.
Article
Clinical Neurology
Lubna Al-Gailani, Ali Al-Kaleel, Gokhan Arslan, Mustafa Ayyildiz, Erdal Agar
Summary: This study investigated the effects of different anesthetics on epileptiform activity in rats with genetic absence epilepsy. The results showed that all the anesthetics, except dexmedetomidine and dexmedetomidine/ketamine, significantly reduced the epileptiform activity. Therefore, dexmedetomidine and dexmedetomidine/ketamine are recommended for electrophysiological studies accompanied by anesthesia.
NEUROLOGICAL RESEARCH
(2022)
Article
Neurosciences
Gabriele Di Cicco, Emanuela Marzano, Luisa Iacovelli, Roberta Celli, Gilles van Luijtelaar, Ferdinando Nicoletti, Richard T. Ngomba, Mark J. Wall
Summary: The study found that abnormalities in metabotropic Glu5 receptor-dependent synaptic plasticity in the hippocampus of WAG/Rij rats are associated with reduced mGlu5 receptor expression and decreased long term depression (LTD). These abnormalities may be related to the pathological phenotype of WAG/Rij rats.
Article
Nutrition & Dietetics
Eniko Rauch, Csilla Ari, Zsolt Kovacs
Summary: The study demonstrates that ketone supplementation can decrease anxiety levels, even in female rats. However, moderately elevated blood R-beta HB levels may be more effective in alleviating symptoms of anxiety compared to highly elevated levels.
Article
Neurosciences
Oznur Gedikli, Metehan Akca, Mehmet Yildirim
Summary: This study investigated the effects of active components of Ginkgo biloba extract on absence seizures in a rat model of absence epilepsy. The results showed that ginkgolide A significantly increased the frequency of spike-wave discharges in the rats. Furthermore, the interactions between ginkgolide A and certain receptor antagonists/blockers also increased the number of discharges. These findings suggest that ginkgolide A's pro-absence effect is mediated by brain circuits other than ionotropic glutamate receptors or L-type calcium channels.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Behavioral Sciences
Hatice Aygun, Mustafa Ayyildiz
Summary: The study demonstrated that vortioxetine has anticonvulsant activity in experimental epilepsy models induced by penicillin and pentylenetetrazole, but exhibited proconvulsant activity in a specific genetic absence epilepsy model. Additionally, vortioxetine did not affect the amplitude of epileptiform activity in any of the experimental epilepsy models.
EPILEPSY & BEHAVIOR
(2021)
Article
Biology
Maxim Zhuravlev, Anastasiya Runnova, Kirill Smirnov, Evgenia Sitnikova
Summary: This study used advanced EEG analysis techniques to investigate the functional links between sleep and spike-wave epilepsy in aging WAG/Rij rats. The results showed that age-related changes in SWDs were associated with changes in NREM sleep, and spike-wave epilepsy itself may promote micro-arousals during NREM sleep.
Article
Behavioral Sciences
Hatice Aygun
Summary: This study investigated the effects of the GLP-1 receptor agonist exendin-4 on genetic absence epileptic rats. The results showed that exendin-4 increased the intensity of seizures and anxiety and depression-like behaviors. High doses of exendin-4 had the strongest proabsence effect.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Tommi Vayrynen, Heta Helakari, Vesa Korhonen, Johanna Tuunanen, Niko Huotari, Johanna Piispala, Mika Kallio, Lauri Raitamaa, Janne Kananen, Matti Jarvela, J. Matias Palva, Vesa Kiviniemi
Summary: The study found that slow cortical potentials and respiration are both coupled with the amplitude of fast neuronal oscillations, with stronger coupling during sleep. The phases of ISF and respiration drive the amplitude dynamics of fast oscillations in both sleeping and waking states, with different contributions.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Physiology
Jacob Raber, Sarah Holden, Reetesh Sudhakar, Reed Hall, Breanna Glaeser, Marek Lenarczyk, Kristen Rockwell, Natalie Nawarawong, Jennifer Sterrett, Ruby Perez, Scott William Leonard, Jeffrey Morre, Jaewoo Choi, Amy Kronenberg, Alexander Borg, Andy Kwok, Jan Frederik Stevens, Christopher M. Olsen, Jeffrey S. Willey, Gerd Bobe, John Baker
Summary: The study found that simulated space radiation had an impact on the behavioral and cognitive performance of rats, especially in the absence of hindlimb unloading. Radiation exposure was associated with increased depressive-like behaviors, while hindlimb unloading resulted in impaired spatial learning in sham-irradiated rats.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Seyma Ozsoy
Summary: This study found that modafinil may dose-dependently reduce the number and duration of absence seizures in WAG/Rij rats. The results suggest that modafinil may play an important role in preventing epileptic seizures.
JOURNAL OF RADIATION RESEARCH AND APPLIED SCIENCES
(2023)
Article
Neurosciences
Zihao Zhang, Donald Chad Collins, Joost X. Maier
Summary: Research has found that in newborn rat pups, the piriform cortex shows stable 10-15 Hz oscillations in response to odors from birth to P15, followed by rapid changes in cortical responses, coinciding with the emergence of gamma oscillations and fast sniffing behavior. This transition is preceded by an increase in spontaneous activity. Neonatal network oscillations in the olfactory system exhibit similarities with those observed in other sensory systems, providing insight into the development of sensory cortex in general and olfactory processing in particular.
Article
Neurosciences
Ali Al-Kaleel, Oytun Erbas, Hatice Aygun
Summary: The aim of this study was to investigate the effect of Madopar on absence seizures and anxiety-like behavior in WAG/Rij rats. The results showed that Madopar significantly reduced the number and duration of absence seizures and increased activity in the open field test.
ACTA NEUROBIOLOGIAE EXPERIMENTALIS
(2022)
Article
Neurosciences
Lukasz Chrobok, Jagoda Stanislawa Jeczmien-Lazur, Kamil Pradel, Jasmin Daniela Klich, Monika Bubka, Michal Wojcik, Mariusz Kepczynski, Marian Henryk Lewandowski
Summary: The study reveals that biological clocks regulate the circadian rhythm of non-image forming visual structures through the orexinergic system. Orexins show higher levels at night and directly regulate responses to retinal input in the lateral geniculate nucleus. The orexinergic system plays a crucial role in circadian modulation of neurons processing ambient light levels in the brain.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Physiology
Lukasz Chrobok, Michal Wojcik, Jasmin Daniela Klich, Kamil Pradel, Marian Henryk Lewandowski, Hugh David Piggins
Summary: The study explored the phasic neuronal activity in the rodent NTS using multi-electrode array recordings ex vivo, revealing a characteristic phasic pattern displayed by a subset of neurons in the dorsomedial NTS. It found that mice exhibit higher phasic frequency and firing rate compared to rats, peaking at the middle of the night. Additionally, the phasic cells were shown to be sensitive to alpha(2) adrenergic receptors activation and responsive to electrical stimulation of the area postrema, potentially identifying them as downstream targets of the AP noradrenergic system.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Mateusz Jez, Alicja Martyniak, Kalina Andrysiak, Olga Mucha, Krzysztof Szade, Alan Kania, Lukasz Chrobok, Katarzyna Palus-Chramiec, Anna M. Sanetra, Marian H. Lewandowski, Ewelina Pospiech, Jacek Stepniewski, Jozef Dulak
Summary: This study demonstrated for the first time the crucial role of HO-1 in the electrophysiology of human cardiomyocytes using CRISPR/Cas9 technology. While the lack of HO-1 did not affect the differentiation efficiency and metabolism of hiPSCs, it led to alterations in electrophysiological pathways in hiPSC-CMs, potentially impacting the functionality of cardiomyocytes.
Article
Biochemistry & Molecular Biology
Lukasz Chrobok, Jagoda Stanislawa Jeczmien-Lazur, Monika Bubka, Kamil Pradel, Aleksandra Klekocinska, Jasmin Daniela Klich, Amalia Ridla Rahim, Jihwan Myung, Mariusz Kepczynski, Marian Henryk Lewandowski
Summary: The study reveals a coordination between the orexin system and the rodent superior colliculus across the day-night cycle, with orexin input predominantly occurring nocturnally and the SC neurons responding to orexin A and exhibiting circadian expression of clock genes.
Article
Neurosciences
Lukasz Chrobok, Jasmin D. Klich, Jagoda S. Jeczmien-Lazur, Kamil Pradel, Katarzyna Palus-Chramiec, Anna M. Sanetra, Hugh D. Piggins, Marian H. Lewandowski
Summary: Recent research has shown that the dorsal vagal complex possesses strong circadian timekeeping capabilities, with specific areas showing robust clock properties. The dorsal motor nucleus of the vagus, as an executory part of this complex, plays a role in regulating gastric motility and energy homeostasis. This study found that neuronal activity in the DMV varies with time of day and diet, providing important insights into the daily control of vagal efferents and parasympathetic outflow.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Lukasz Chrobok, Jasmin D. Klich, Anna M. Sanetra, Jagoda S. Jeczmien-Lazur, Kamil Pradel, Katarzyna Palus-Chramiec, Mariusz Kepczynski, Hugh D. Piggins, Marian H. Lewandowski
Summary: Short-term consumption of a high-fat diet increases daytime food intake and blunts daily rhythms in NTS neuronal discharge, while also decreasing responsiveness to metabolic neuropeptides and orexin immunoreactive fibres. These alterations occur without prominent body weight gain, suggesting that a high-fat diet initially reduces activity in the dorsal vagal complex to disinhibit mechanisms that suppress daytime feeding.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Neurosciences
Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Lukasz Chrobok, Marian Henryk Lewandowski
Summary: The dorsomedial hypothalamus (DMH) plays a crucial role in regulating feeding behavior and metabolism, particularly in relation to circadian rhythmicity and energy homeostasis. This study exposed rats to short-term high-fat diet (HFD) and found that it disrupted the firing frequency of DMH cells, leading to abnormal daytime feeding and potentially contributing to the development of obesity. Additionally, the study identified distinct anatomical and functional subpopulations of DMH neurons, providing insight into the complex electrophysiological characteristics of this brain structure.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Physiology
Kamil Pradel, Gniewosz Drwiega, Lukasz Chrobok, Tomasz Blasiak
Summary: The dopaminergic system is regulated by circadian rhythms, which affect animal motivation, responsiveness to rewards and punishment, exploratory behaviors, and motor performance. This regulation is likely achieved through changes in core clock genes, ion channels, neurotransmitter receptors, dopamine-synthesizing enzymes, and dopamine transporters.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Lukasz Chrobok, Jake Ahern, Hugh D. Piggins
Summary: This article evaluates how intrinsic circadian signals regulate the activity of the dorsal vagal complex (DVC) and proposes possible functions of DVC in circadian control of feeding behavior.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Jagoda S. Jeczmien-Lazur, Anna M. Sanetra, Kamil Pradel, Gabriela Izowit, Lukasz Chrobok, Katarzyna Palus-Chramiec, Hugh D. Piggins, Marian H. Lewandowski
Summary: The intergeniculate leaflet and ventral lateral geniculate nucleus (IGL/VLG) play an important role in entraining the brain's circadian system to various cues. We investigated the sensitivity of IGL/VLG neurons to metabolism-related peptides and found that they responded to most of the substances tested, suggesting their involvement in the body's energy homeostasis.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Nutrition & Dietetics
Anna Magdalena Sanetra, Katarzyna Palus-Chramiec, Lukasz Chrobok, Jagoda Stanislawa Jeczmien-Lazur, Emilia Gawron, Jasmin Daniela Klich, Kamil Pradel, Marian Henryk Lewandowski
Summary: Obesity is a growing health problem and studying its developmental mechanism is crucial. This study found that a high-fat diet disrupts the circadian rhythmicity of the dorsomedial hypothalamus (DMH) in male rats, indicating its possible role in obesity development. Additionally, time-restricted feeding can prevent the disruptive effects of a high-fat diet on the DMH clock.