4.7 Article

Exposure to nickel oxide nanoparticles insinuates physiological, ultrastructural and oxidative damage: A life cycle study on Eisenia fetida

期刊

ENVIRONMENTAL POLLUTION
卷 254, 期 -, 页码 -

出版社

ELSEVIER SCI LTD
DOI: 10.1016/j.envpol.2019.113032

关键词

Earthworms; Gastrointestinal tract; Histology; Enzyme activity; DNA damage

资金

  1. National Key R&D Program of China [2017YFD0801300, 2017YFD0801103]
  2. NSFC-Guangdong Joint Fund [U1401234]
  3. National Natural Science Foundation of China [41371471, 31501791]
  4. Key National Natural Science Foundation of China [41130526]

向作者/读者索取更多资源

Although, health and environmental hazards of Ni are ironclad; however, that of Nickle oxide nanoparticles (NiO-NPs) are still obscure. Therefore, impact of NiO-NPs exposure (0, 5, 50, 200, 500 and 1000 mg kg(-1) soil) on the earthworm (Eisenia fetida) survival (at 28th day), reproduction (at 56th day), histopathology, ultrastructures, antioxidant enzymes and oxidative DNA damage was appraised in full life cycle study. Lower concentrations of NiO-NPs (5, 50 and 200) did not influence the survival, reproduction and growth rate of adult worms significantly. However, reproduction reduced by 40-50% with 500 and 1000 mg kg(-1) exposure, which also induced oxidative stress leading to DNA damage in earthworms. Ultrastructural observation and histology of earthworms exposed to higher NiO-NPs concentrations revealed abnormalities in epithelium layer, microvilli and mitochondria with underlying pathologies of epidermis and muscles, as well as adverse effects on the gut barrier. To the best of our knowledge, this is the first study unveiling the adverse effects of NiO-NPs on a soil invertebrate (Eisenia fetida). Our findings clue towards looking extensively into the risks of NiO-NPs on soil organisms bearing agricultural and environmental significance. (C) 2019 Elsevier Ltd. All rights reserved.

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