Article
Oncology
Hongfeng Zhao, Minping Bi, Meng Lou, Xiaowei Yang, Liwen Sun
Summary: LncRNA SOX2-OT is highly expressed in HCC cells and tissues, with poor prognosis in patients. Inhibiting SOX2-OT decreased malignant behaviors of HCC cells and promoted MSI2 expression by binding to miR-143-3p. Nude mouse tumorigenesis experiments confirmed the role of SOX2-OT in promoting proliferation and invasion of HCC cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Congjing An, Zhigang Hu, Yuehong Li, Pengxin Zhao, Runtian Liu, Qing Zhang, Peiling Zhu, Yanting Li, Ying Wang
Summary: The study identified that LINC00662 is overexpressed in breast cancer and promotes cancer cell progression by competitively binding to miR-144-3p to upregulate SOX2 expression. This suggests that LINC00662 could be a potential therapeutic target for breast cancer treatment.
CANCER CELL INTERNATIONAL
(2022)
Article
Cell Biology
Yongjing Lai, Lihua Dong, Huifang Jin, Hongju Li, Meiling Sun, Jianlan Li
Summary: This study revealed the role of exosomal SOX2-OT in enhancing ovarian cancer malignant phenotypes through the miR-181b-5p/SCD1 axis. Exosomal 50X2-OT, miR-181b-5p, and SCD1 may serve as potential targets for the treatment of ovarian cancer.
Article
Pharmacology & Pharmacy
Hongya Xie, Jie Yao, Yuxuan Wang, Bin Ni
Summary: This study reveals the regulatory mechanism of circRNA circVMP1 in NSCLC progression and cisplatin resistance. circVMP1 promotes the malignant behavior and cisplatin resistance of NSCLC through the miR-524-5p-METTL3/SOX2 axis targeting.
Article
Biochemistry & Molecular Biology
Rong Du, Shiyi Xiong
Summary: This study focuses on the role of hsa_circ_0084912 in cervical cancer (CC) and its molecular pathways. The expression of Hsa_circ_0084912, miR-429, and SOX2 in CC tissues and cells was determined using Western blotting and qRT-PCR. Functional assays including CCK-8, colony formation, Transwell, and xenograft tumor model were performed to analyze the effects of hsa_circ_0084912 on CC cell proliferation, migration, and tumor growth. It was found that hsa_circ_0084912 promoted CC cell malignancies by sponging miR-429 to control SOX2 expression.
MOLECULAR BIOTECHNOLOGY
(2023)
Article
Endocrinology & Metabolism
Z. Li, J. Xu, H. Guan, J. Lai, X. Yang, J. Ma
Summary: Circ_0059354 functions as an oncogene in the progression of PTC through regulating the miR-766-3p/ARFGEF1 axis, leading to suppression of cell proliferation, migration, invasion, and angiogenesis, and promotion of apoptosis in PTC cells. Additionally, circ_0059354 knockdown also blocked tumor growth in vivo.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2022)
Article
Oncology
Yanjing Jia, Jie Zhao, Jinjie Yang, Jie Shao, Zihao Cai
Summary: This study identified miR-301 as a key regulator in breast cancer progression, accelerating malignant phenotype through the CPEB1/SIRT1/SOX2 axis.
MOLECULAR THERAPY-ONCOLYTICS
(2021)
Article
Multidisciplinary Sciences
Syeda Alina Fatima, Mubeen Tabish Nasim, Ambrin Malik, Saif Ur Rehman, Saboora Waris, Manal Rauf, Syed Salman Ali, Farhan Haq, Hassaan Mehboob Awan
Summary: This study identified and verified the upregulation of miR-1183 in colorectal cancer (CRC) and its negative correlation with the cell cycle progression gene CCPG1. The study also found that miR-1183 is upregulated in liver and gastric cancer, which is significant for CRC and hepatocellular carcinoma metastasis. Therefore, miR-1183 may serve as a valuable prognostic marker and therapeutic target for primary and metastatic CRC.
Article
Biochemistry & Molecular Biology
Natasa Djalinac, Ewald Kolesnik, Heinrich Maechler, Susanne Scheruebel-Posch, Brigitte Pelzmann, Peter P. Rainer, Ines Foessl, Markus Wallner, Daniel Scherr, Akos Heinemann, Simon Sedej, Senka Ljubojevic-Holzer, Dirk von Lewinski, Egbert Bisping
Summary: A comparative characterization of the effects of stretch and tachycardia on early remodeling events in human myocardium reveals that both cardiac insults consistently regulate the expression of miR-1183 and its downstream targets. Elevated expression of miR-1183 may serve as a tissue biomarker for atrial remodeling and have potential functional significance in cardiac disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Jing Nie, Yao Feng, He Wang, Xiao-Yu Lian, Ying-Fu Li
Summary: The study reveals SNHG6 and Notch1 as valid targets for glioma therapy, as their regulation can inhibit EMT and the expression of cancer stem cell marker Sox2, leading to apoptosis of glioma cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
Danni Zheng, Lingli Jin, Buran Chen, Yufeng Qi, Adheesh Bhandari, Jialiang Wen, Bangyi Lin, Xiaohua Zhang, Wei Zhang
Summary: ETNK2 is associated with the occurrence and development of papillary thyroid carcinoma, and may be an oncogene associated with PTC.
Article
Pediatrics
Lingling Zhou, Zhengke Zhi, Pingfa Chen, Chunxia Du, Binyu Wang, Xiang Fang, Weibing Tang, Hongxing Li
Summary: This study aimed to reveal the role of lncRNA rhabdomyosarcoma 2-associated transcript (RMST) in Hirschsprung's disease (HSCR). The results showed that RMST interacted with SOX2 to co-regulate the expression of miR-1251 and AHNAK, leading to the occurrence of HSCR. This finding provides potential targets for the diagnosis and treatment of HSCR.
FRONTIERS IN PEDIATRICS
(2022)
Article
Anatomy & Morphology
Kun Guo, Jialiang Wang, Ling Shu, Guangjun Zhou
Summary: This study revealed that miR-200c is upregulated in human PTC tissues and associated with poor clinical prognosis. Overexpression of miR-200c promotes PTC cell proliferation, migration, and invasion while knockdown has an inhibitory effect. PTEN is identified as a downstream target of miR-200c, playing a crucial role in promoting PTC progression. Targeting the miR-200c/PTEN axis may have therapeutic significance in PTC patients.
Article
Oncology
Pratheesh Kumar Poyil, Abdul K. Siraj, Divya Padmaja, Sandeep Kumar Parvathareddy, Roxanne Diaz, Saravanan Thangavel, Rafia Begum, Wael Haqawi, Falah Hassan Al-Mohanna, Saif S. Al-Sobhi, Fouad Al-Dayel, Khawla S. Al-Kuraya
Summary: This study investigated the expression and functional role of furin in Middle Eastern papillary thyroid carcinoma (PTC). Furin overexpression was observed in 44.6% of PTC cases and was associated with aggressive clinicopathological parameters and poor outcomes. Knockdown of FURIN suppressed tumor growth, migration, invasion, and epithelial-to-mesenchymal transition (EMT) in BRAF mutant cells, while overexpression of FURIN reversed these effects in BRAF wild-type cells. FURIN inhibition showed a synergistic antitumor effect with anti-MEK inhibitor treatment.
MOLECULAR ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wojciech Gierlikowski, Katarzyna Broniarek, Lukasz Cheda, Zbigniew Rogulski, Marta Kotlarek-Lysakowska
Summary: In the context of papillary thyroid carcinoma, miR-181a-5p has been found to directly regulate the expression of SLC5A5, potentially reducing the efficacy of radioiodine treatment. This suggests that miR-181a-5p could serve as a promising target to enhance the efficacy of radioactive iodine therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)