Article
Environmental Sciences
Ritu Sharma, Rajinder Jindal, Caterina Faggio
Summary: Chronic exposure to cypermethrin leads to elevated antioxidant enzyme activity, increased lipid peroxidation, significant tissue and ultrastructural changes in the kidney of Catla catla, potentially interfering with normal excretory mechanisms.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ritu Sharma, Rajinder Jindal, Caterina Faggio
Summary: The study evaluated the protective effects of Cassia fistula in Catla catla exposed to the synthetic pyrethroid cypermethrin. Fish exposed to a sub-lethal concentration of the pesticide showed decreased antioxidant activity, increased lipid peroxidation, and histopathological alterations. Dietary supplementation of Cassia fistula bark extract improved antioxidant activity, reduced lipid peroxidation, and prevented histopathological alterations, suggesting its potential in mitigating pesticide-induced toxic effects.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2021)
Article
Engineering, Environmental
Siqing Yue, Qixian Yuan, Qiqi Shen, Yaqi Xu, Ping Wang, Min Si, Meirong Zhao
Summary: The present study focused on the toxicological effects of Cypermethrin (CP) at environmentally relevant concentrations in pubertal male rats and found histopathological and organosomatic alterations in the liver, brain, and epididymis. Multiomics network analysis revealed the involvement of specific gut microbiota in CP-induced hepatic lipid accumulation and brain neurotoxicity. The study provides important insights into CP-induced toxicity and highlights the potential for targeted interventions to mitigate the adverse effects of environmental toxins through the gut-organ axis.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Environmental Sciences
Hongjing Zhao, Yu Wang, Menghao Guo, Yachen Liu, Hongxian Yu, Mingwei Xing
Summary: The study found that exposure to cypermethrin and sulfamethoxazole, as well as their mixture in water environment, significantly affects the brain function, oxidative stress, and apoptosis of grass carp. The results showed that these two chemicals induce similar biological responses and may enhance each other's toxic effects.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Camila F. Rutkoski, Natani Macagnan, Alexandre Folador, Vrandrieli J. Skovronski, Aline M. B. do Amaral, Jossiele Wesz Leitemperger, Maiara Dorneles Costa, Paulo A. Hartmann, Caroline Muller, Vania L. Loro, Marilia T. Hartmann
Summary: This study revealed that cypermethrin and fipronil had neurotoxic and oxidative stress effects on Physalaemus gracilis, including reduced enzyme activity and increased antioxidant enzyme activity. Biochemical biomarkers can be utilized for monitoring the toxicity of insecticides on P. gracilis for preservation purposes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Environmental Sciences
Satabdi Ganguly, Anupam Adhikari, Debalina Sadhukhan, Subhashree Subhasmita Raut, V. Santhana Kumar, Subir Kumar Nag, Basanta Kumar Das
Summary: This study revealed the molecular mechanisms underlying endocrine disruption and reproductive toxicity of cypermethrin in fish exposed to environmentally relevant concentrations. It was found that cypermethrin can affect the sex hormone levels and gene expression in the reproductive system of fish, leading to reduced reproductive potential and recruitment.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Review
Agriculture, Dairy & Animal Science
Mayada R. Farag, Mahmoud Alagawany, Rana M. Bilal, Ahmed G. A. Gewida, Kuldeep Dhama, Hany M. R. Abdel-Latif, Mahmoud S. Amer, Nallely Rivero-Perez, Adrian Zaragoza-Bastida, Yaser S. Binnaser, Gaber El-Saber Batiha, Mohammed A. E. Naiel
Summary: Pyrethroid insecticides, particularly Cypermethrin, are extensively used in agriculture and livestock for pest control, but their improper disposal and runoff can lead to aquatic ecosystem contamination and harmful toxic effects on fish. Studies have shown serious toxic effects and high mortalities in various fish species due to exposure to these pesticides.
Article
Biochemistry & Molecular Biology
Saumya Mishra, Charul Rajput, Mahendra Pratap Singh
Summary: The study revealed that cypermethrin activation of microglia leads to an increase in the release and expression of inflammatory proteins, potentially contributing to neurodegeneration. Additionally, treatments with inhibitors such as minocycline and rottlerin reduced the toxicity induced by cypermethrin-treated microglia conditioned media on rat primary neurons.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Jianan Li, Haoran Bi
Summary: The study combined network pharmacology analysis and in vitro models to investigate the effect and mechanism of CMN-induced hippocampal neurotoxicity, revealing 88 targets and signaling pathways involved. Cell viability assays demonstrated CMN's toxicity, while TUNEL staining showed an increase in apoptotic cells after CMN treatment.
Article
Environmental Sciences
Selcuk Ozdemir, Harun Arslan
Summary: This study provides the first investigation into the role of circular RNAs in acute brain toxicity caused by cypermethrin and chlorpyrifos exposure. It identifies and characterizes several circRNAs involved in the regulation of key signaling pathways, shedding new light on pesticide toxicity research.
Article
Biochemistry & Molecular Biology
Agnese Graziosi, Giulia Sita, Camilla Corrieri, Sabrina Angelini, Roberta d'Emmanuele di Villa Bianca, Emma Mitidieri, Raffaella Sorrentino, Patrizia Hrelia, Fabiana Morroni
Summary: Endocrine-disrupting chemicals (EDCs) are a group of chemicals that may have adverse effects on human beings and wildlife. Research suggests that exposure to certain pesticides at low doses can influence gene expression and contribute to human diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Engineering, Marine
Muhammad Saleem, Javed Iqbal, Zongbo Shi, Scott H. Garrett, Munir H. Shah
Summary: Although fish are recommended as part of a healthy diet, the accumulation of heavy metals in many fish species has raised concerns about the potential health risks. This study analyzed the levels of essential and toxic metals in Catla catla fish from Mangla Lake in Pakistan and found that the concentrations of several metals exceeded international safety limits for human consumption. The study also evaluated the health risks to consumers and found that the intake of these fish could result in lifetime non-carcinogenic health risks.
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2022)
Review
Biochemistry & Molecular Biology
Zhe Li, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Zinc is an abundant metal ion in the CNS, playing a crucial role in physiological and pathological brain functions. It promotes antioxidant effects, neurogenesis, and immune system responses. Zinc regulates gene expression, activates enzymes, and acts as a regulator of synaptic activity and neuronal plasticity. Changes in zinc status can impact neurological diseases, including stroke, neurodegenerative diseases, traumatic brain injuries, and depression. This review explores the mechanisms of brain zinc balance, the role of zinc in neurological diseases, and strategies for prevention and treatment.
Article
Biochemistry & Molecular Biology
Mohammad Ashafaq, Sohail Hussain, Saeed Alshahrani, Rahimullah Siddiqui, Mohammad Intakhab Alam, Manal Mohamed Elhassan Taha, Yosif Almoshari, Saad S. Alqahtani, Abdulmajeed M. Jali, Hashim M. Aljohani
Summary: Cypermethrin (CPM), a toxic synthetic pyrethroid, causes neurotoxicity by inducing oxidative stress and neurochemical agitation in rats. Curcumin nanoparticles (NC), with potent antioxidant and anti-inflammatory properties, can attenuate CPM-induced neurotoxicity in rat brains. This study supports the use of NC as an effective treatment option for CPM-induced neurotoxicity.
Article
Toxicology
Ana Dias-Carvalho, Mariana Ferreira, Ana Reis-Mendes, Rita Ferreira, Maria Lourdes Bastos, Eduarda Fernandes, Susana Isabel Sa, Joao Paulo Capela, Felix Carvalho, Vera Marisa Costa
Summary: This study evaluated the neurotoxic pathways of mitoxantrone in the brain of adult mice and found that it caused significant damage in regions associated with memory and cognition.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Environmental Sciences
Rajinder Jindal, Sakshi Verma
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2015)
Article
Fisheries
Rajinder Jindal, Sakshi Verma
INDIAN JOURNAL OF FISHERIES
(2017)
Article
Environmental Sciences
Mandeep Kaur, Rajinder Jindal
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2018)
Article
Environmental Sciences
Rajinder Jindal, Reshma Sinha
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2019)
Article
Environmental Sciences
Rajinder Jindal, Reshma Sinha, Prabhjeet Brar
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2019)
Article
Fisheries
Reshma Sinha, Rajinder Jindal
AQUACULTURE RESEARCH
(2019)
Article
Environmental Sciences
Rajinder Jindal, Kriti Handa
Article
Environmental Sciences
Kriti Handa, Rajinder Jindal
Article
Environmental Sciences
Ritu Sharma, Rajinder Jindal
ENVIRONMENTAL RESEARCH
(2020)
Article
Environmental Sciences
Reshma Sinha, Rajinder Jindal
Summary: The study evaluated the effects of malachite green on the gills of Cyprinus carpio, revealing histopathological lesions and ultrastructural alterations at both cellular and tissue levels. The findings indicated damage to cellular nuclei and mitochondria, as well as impairment of antioxidative enzymes, ultimately leading to branchial toxicity in the fish.
BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
(2022)
Article
Environmental Sciences
Sakshi Verma, Smriti Batoye, Rajinder Jindal
Summary: This study investigated the protective role of naringenin (NG) against cadmium chloride (CdCl2) toxicity in Labeo rohita. Exposure to CdCl2 for 15 and 30 days induced adaptive mechanisms, but on the 60th day, oxidative damage was observed. Oral administration of NG restored altered levels of antioxidants and enzymes, suggesting a protective role against Cd-induced oxidative insult.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ritu Sharma, Rajinder Jindal
Summary: This study elucidates the genotoxic effects of commercial grade cypermethrin on peripheral erythrocytes of Catla catla. It shows that exposure to cypermethrin at environmentally relevant concentrations can induce DNA damage and erythrocyte abnormalities, potentially harming non-target aquatic organisms.
ENVIRONMENTAL AND MOLECULAR MUTAGENESIS
(2022)
Article
Environmental Sciences
Kriti Handa, Rajinder Jindal
Summary: This study assessed the ameliorative effects of Boerhavia diffusa leaf extract on chronic exposure to hexavalent chromium in Ctenopharyngodon idellus. The results showed that the extract reduced kidney damage caused by hexavalent chromium and regulated oxidative stress, kidney function markers, histopathology, and gene expression. This suggests that Boerhavia diffusa leaf extract has a protective effect against renal injury.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Water Resources
C. Sharma, R. Jindal, Uday Bhan Singh, A. S. Ahluwalia
SUSTAINABLE WATER RESOURCES MANAGEMENT
(2018)
Article
Biodiversity Conservation
Yongcui Lan, Jinliang Wang, Qianwei Liu, Fang Liu, Lanfang Liu, Jie Li, Mengjia Luo
Summary: This study focuses on the five major plateau lake basins in central Yunnan, China, and constructs an ecological security pattern using the source-resistance surface-corridor-pinch point framework. The study simulates land use/cover change in the region and identifies early warning regions where future urban expansion poses a threat to current ecological source areas and corridors.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Pingping Huang, Feng Zhao, Bailing Zhou, Kuidong Xu
Summary: This study investigates the distribution of benthic microeukaryotes in the China Seas and finds that they can stride over the ecological barrier of 32 degrees N. The study also highlights the significant influence of depth, temperature, and latitude on communities in the China Seas.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Federico Morelli, Yanina Benedetti, Jesse Stanford, Leszek Jerzak, Piotr Tryjanowski, Paolo Perna, Riccardo Santolini
Summary: Species distribution models (SDMs) are numerical tools used for predicting species' spatial distribution. This study found that ecological characteristics, such as habitat specialization, play a role in improving the accuracy of SDMs.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Xiaoxuan Wu, Hang Liu, Wei Liu
Summary: Global climate change, urbanization, and economic development have increased the need for sustainable human development, urban ecological governance, and low-carbon energy transformation. This study analyzes the green ecological transition in Chengdu based on panel data from 2010 to 2020, exploring its spatiotemporal evolution and key factors. The results show an overall upward trend in Chengdu's green ecological development and positive spatial autocorrelation in certain districts.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Castaldi Simona, Formicola Nicola, Mastrocicco Micol, Morales Rodriguez Carmen, Morelli Raffaella, Prodorutti Daniele, Vannini Andrea, Zanzotti Roberto
Summary: Sustainable agricultural practices are increasingly important for global and national environmental policies and economy. This study compared the sustainability of grape production under integrated and organic management using multiple indicators. The results showed that organic management was more beneficial for most environmental aspects of the agroecosystem compared to integrated management, without affecting grape yield.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Gaia Vaglio Laurin, Alexander Cotrina-Sanchez, Luca Belelli-Marchesini, Enrico Tomelleri, Giovanna Battipaglia, Claudia Cocozza, Francesco Niccoli, Jerzy Piotr Kabala, Damiano Gianelle, Loris Vescovo, Luca Da Ros, Riccardo Valentini
Summary: Phenology monitoring is important for understanding forest functioning and climate impacts. This research compares the phenological behavior of European beech forests using Tree-Talker (TT+) and Sentinel 2 satellite data. The study finds differences in the information derived by the two sensor types, particularly in terms of season length, phenology changepoints, and leaf period variability. TT+ with its higher temporal resolution demonstrates precision in capturing the phenological changepoints, especially when satellite image availability is limited.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Huanhuan Pan, Ziqiang Du, Zhitao Wu, Hong Zhang, Keming Ma
Summary: The land use and cover changes resulting from coal mining activities and ecological restoration have had a significant impact on ecosystem services in mining areas. This study investigates the relationship between ecosystem services and land use intensity in coal mining areas, emphasizing the importance of understanding this interdependence for balanced human-land system development. The research examines the evolving relationship across different reclamation stages in Shanxi, China, using a coupling coordination degree model. The findings suggest the need for timely and judicious reclamation of coalfields, considering the land's bearing capacity.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Jingjuan He, Yijun Shi, Lihua Xu, Zhangwei Lu, Mao Feng
Summary: This study examines the spatial interplay between changes in the blue-green spatial distribution and modifications in land surface temperature grades in Shanghai. The findings reveal that the transformation of the blue-green spatial pattern differs between different sectors of the city, and the impact on the thermal environment varies spatially.
ECOLOGICAL INDICATORS
(2024)
Article
Biodiversity Conservation
Yi Xu, Di Zhang, Junqiang Lin, Qidong Peng, Xiaohui Lei, Tiantian Jin, Jia Wang, Ruifang Yuan
Summary: This study analyzed the response relationship between phytoplankton growth and water environmental parameters in the Middle Route of the South-to-North Water Diversion Project in China using long-term monitoring data and machine learning models. The results revealed the differences between monitoring sites and identified the key parameters that affect phytoplankton growth.
ECOLOGICAL INDICATORS
(2024)