From the Cradle to the Grave of an Infection: Host‐Pathogen Interaction Visualized by Intravital Microscopy

New red-shifted fluorescent biosensor for monitoring intracellular redox changes

(2019) Claudia Vanesa Piattoni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Longitudinal proliferation mapping in vivo reveals NADPH oxidase-mediated dampening of Staphylococcus aureus growth rates within neutrophils

(2019) Elena A. Seiß et al.   Scientific Reports

Nonspecific CD8+ T Cells and Dendritic Cells/Macrophages Participate in Formation of CD8+ T Cell-Mediated Clusters against Malaria Liver-Stage Infection

(2018) Masoud Akbari et al.   INFECTION AND IMMUNITY

Host immune responses to Toxoplasma gondii

(2018) Miwa Sasai et al.   INTERNATIONAL IMMUNOLOGY

NAD(P)H Oxidase Activity in the Small Intestine Is Predominantly Found in Enterocytes, Not Professional Phagocytes

(2018) Randall Lindquist et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phasor-Based Endogenous NAD(P)H Fluorescence Lifetime Imaging Unravels Specific Enzymatic Activity of Neutrophil Granulocytes Preceding NETosis

(2018) Ruth Leben et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminatingStaphylococcus aureus

(2018) Ania Bogoslowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intravital imaging by simultaneous label-free autofluorescence-multiharmonic microscopy

(2018) Sixian You et al.   Nature Communications

Leishmania Hijacks Myeloid Cells for Immune Escape

(2018) María Martínez-López et al.   Frontiers in Microbiology

Macrophage Transactivation for Chemokine Production Identified as a Negative Regulator of Granulomatous Inflammation Using Agent-Based Modeling

(2018) Daniel Moyo et al.   Frontiers in Immunology

Human skin commensals augment Staphylococcus aureus pathogenesis

(2018) Emma Boldock et al.   Nature Microbiology

A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses

(2018) Jérémy Postat et al.   IMMUNITY

Macrophage-derived LTB4 promotes abscess formation and clearance of Staphylococcus aureus skin infection in mice

(2018) Stephanie L. Brandt et al.   PLoS Pathogens

CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission

(2018) Sandrina Heyde et al.   PLoS Pathogens

Cytotoxic anti-circumsporozoite antibodies target malaria sporozoites in the host skin

(2018) Eduardo Aliprandini et al.   Nature Microbiology

Salmonella infection: Interplay between the bacteria and host immune system

(2017) Jonathan R Kurtz et al.   IMMUNOLOGY LETTERS

Inside job: Staphylococcus aureus host-pathogen interactions

(2017) Jessica Horn et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

CD11c-Expressing Cells Affect Regulatory T Cell Behavior in the Meninges during Central Nervous System Infection

(2017) Carleigh A. O’Brien et al.   JOURNAL OF IMMUNOLOGY

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

Divergent roles for Ly6C+CCR2+CX3CR1+ inflammatory monocytes during primary or secondary infection of the skin with the intra-phagosomal pathogen Leishmania major

(2017) Audrey Romano et al.   PLoS Pathogens

Pseudomonas aeruginosa Lifestyle: A Paradigm for Adaptation, Survival, and Persistence

(2017) M. Fata Moradali et al.   Frontiers in Cellular and Infection Microbiology

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling

(2017) Lars Philipsen et al.   Science Signaling

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity

(2016) Stephan Halle et al.   IMMUNITY

Identification and treatment of the Staphylococcus aureus reservoir in vivo

(2016) Bas G.J. Surewaard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

iNKT Cell Emigration out of the Lung Vasculature Requires Neutrophils and Monocyte-Derived Dendritic Cells in Inflammation

(2016) Ajitha Thanabalasuriar et al.   Cell Reports

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection

(2016) Kenneth M. Law et al.   Cell Reports

CD8+ T Cells Induce Fatal Brainstem Pathology during Cerebral Malaria via Luminal Antigen-Specific Engagement of Brain Vasculature

(2016) Phillip A. Swanson et al.   PLoS Pathogens

Endothelial cells are a replicative niche for entry of Toxoplasma gondii to the central nervous system

(2016) Christoph Konradt et al.   Nature Microbiology

A three-dimensional culture system recapitulates placental syncytiotrophoblast development and microbial resistance

(2016) C. A. McConkey et al.   Science Advances

Borrelia burgdorferi Pathogenesis and the Immune Response

(2015) Mary Petzke et al.   CLINICS IN LABORATORY MEDICINE

Spatiotemporally Distinct Interactions with Dendritic Cell Subsets Facilitates CD4+ and CD8+ T Cell Activation to Localized Viral Infection

(2015) Jyh Liang Hor et al.   IMMUNITY

Therapeutic antiviral T cells noncytopathically clear persistently infected microglia after conversion into antigen-presenting cells

(2015) Jasmin Herz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity

(2015) Pervinder Sagoo et al.   NATURE MEDICINE

Retroviruses use CD169-mediated trans-infection of permissive lymphocytes to establish infection

(2015) X. Sewald et al.   SCIENCE

Inhibition of stationary phase respiration impairs persister formation in E. coli

(2015) Mehmet A. Orman et al.   Nature Communications

Intravital Imaging of a Massive Lymphocyte Response in the Cortical Dura of Mice after Peripheral Infection by Trypanosomes

(2015) Jonathan A. Coles et al.   PLoS Neglected Tropical Diseases

Intravital Imaging of Vascular Transmigration by the Lyme Spirochete: Requirement for the Integrin Binding Residues of the B. burgdorferi P66 Protein

(2015) Devender Kumar et al.   PLoS Pathogens

Perivascular Arrest of CD8+ T Cells Is a Signature of Experimental Cerebral Malaria

(2015) Tovah N. Shaw et al.   PLoS Pathogens

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion

(2015) Benjamin P. Hurrell et al.   PLoS Pathogens

Lymph-Node Resident CD8α+ Dendritic Cells Capture Antigens from Migratory Malaria Sporozoites and Induce CD8+ T Cell Responses

(2015) Andrea J. Radtke et al.   PLoS Pathogens

A Three-Dimensional Cell Culture Model To Study Enterovirus Infection of Polarized Intestinal Epithelial Cells

(2015) Coyne G. Drummond et al.   mSphere

In Vivo Nonlinear Optical Imaging of Immune Responses: Tissue Injury and Infection

(2014) Yan Zeng et al.   BIOPHYSICAL JOURNAL

Phenotypic Variation of Salmonella in Host Tissues Delays Eradication by Antimicrobial Chemotherapy

(2014) Beatrice Claudi et al.   CELL

Epithelium-Intrinsic NAIP/NLRC4 Inflammasome Drives Infected Enterocyte Expulsion to Restrict Salmonella Replication in the Intestinal Mucosa

(2014) Mikael E. Sellin et al.   Cell Host & Microbe

Collective nitric oxide production provides tissue-wide immunity during Leishmania infection

(2014) Romain Olekhnovitch et al.   JOURNAL OF CLINICAL INVESTIGATION

Invariant natural killer T cells act as an extravascular cytotoxic barrier for joint-invading Lyme Borrelia

(2014) W.-Y. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Internalization of Salmonella by Macrophages Induces Formation of Nonreplicating Persisters

(2014) S. Helaine et al.   SCIENCE

Neutrophil Crawling in Capillaries; A Novel Immune Response to Staphylococcus aureus

(2014) Mark Geoffrey Harding et al.   PLoS Pathogens

Real-Time Imaging Reveals the Dynamics of Leukocyte Behaviour during Experimental Cerebral Malaria Pathogenesis

(2014) Saparna Pai et al.   PLoS Pathogens

Experimental Cerebral Malaria Pathogenesis—Hemodynamics at the Blood Brain Barrier

(2014) Adéla Nacer et al.   PLoS Pathogens

Three-Dimensional Imaging of Viral Infections

(2014) Cristina Risco et al.   Annual Review of Virology

Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis

(2013) Jansy Sarathy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Transcriptomic Network Identified in Uninfected Macrophages Responding to Inflammation Controls Intracellular Pathogen Survival

(2013) Lynette Beattie et al.   Cell Host & Microbe

Photoconvertible Pathogen Labeling Reveals Nitric Oxide Control of Leishmania major Infection In Vivo via Dampening of Parasite Metabolism

(2013) Andreas J. Müller et al.   Cell Host & Microbe

Staphylococcus aureus virulence factors in evasion from innate immune defenses in human and animal diseases

(2013) Alfonso Zecconi et al.   IMMUNOLOGY LETTERS

Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo

(2013) Tim Lämmermann et al.   NATURE

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection

(2013) Arby Abtin et al.   NATURE IMMUNOLOGY

In vivo imaging of CD8+ T cell-mediated elimination of malaria liver stages

(2013) I. A. Cockburn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From seeing to believing: labelling strategies for in vivo cell-tracking experiments

(2013) F. Progatzky et al.   Interface Focus

Subcapsular sinus macrophages promote NK cell accumulation and activation in response to lymph-borne viral particles

(2012) Z. Garcia et al.   BLOOD

Salmonella Gut Invasion Involves TTSS-2-Dependent Epithelial Traversal, Basolateral Exit, and Uptake by Epithelium-Sampling Lamina Propria Phagocytes

(2012) Andreas J. Müller et al.   Cell Host & Microbe

Intravital two-photon microscopy of host-pathogen interactions in a mouse model ofStaphylococcus aureusskin abscess formation

(2012) Jan Liese et al.   CELLULAR MICROBIOLOGY

CD4+ T Cells Rely on a Cytokine Gradient to Control Intracellular Pathogens beyond Sites of Antigen Presentation

(2012) Andreas J. Müller et al.   IMMUNITY

Staphylococcus aureus Virulence Is Enhanced by Secreted Factors That Block Innate Immune Defenses

(2012) Ilse Jongerius et al.   Journal of Innate Immunity

The β3-integrin ligand ofBorrelia burgdorferiis critical for infection of mice but not ticks

(2012) Laura C. Ristow et al.   MOLECULAR MICROBIOLOGY

HIV-infected T cells are migratory vehicles for viral dissemination

(2012) Thomas T. Murooka et al.   NATURE

Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo

(2012) Bryan G Yipp et al.   NATURE MEDICINE

B Cell: T Cell Interactions Occur within Hepatic Granulomas during Experimental Visceral Leishmaniasis

(2012) John W. J. Moore et al.   PLoS One

Tissue-resident memory CD8+ T cells continuously patrol skin epithelia to quickly recognize local antigen

(2012) S. Ariotti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo

(2012) B. Stolp et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fresh Approaches to Anti-Infective Therapies

(2012) C. Nathan   Science Translational Medicine

In vivo imaging of virological synapses

(2012) Xaver Sewald et al.   Nature Communications

Neuroimmunological Blood Brain Barrier Opening in Experimental Cerebral Malaria

(2012) Adela Nacer et al.   PLoS Pathogens

Staphylococcus aureusphenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection

(2011) Lorena Tuchscherr et al.   EMBO Molecular Medicine

Intravital Imaging Reveals Limited Antigen Presentation and T Cell Effector Function in Mycobacterial Granulomas

(2011) Jackson G. Egen et al.   IMMUNITY

The Integrins Mac-1 and  4 1 Perform Crucial Roles in Neutrophil and T Cell Recruitment to Lungs during Streptococcus pneumoniae Infection

(2011) A. Kadioglu et al.   JOURNAL OF IMMUNOLOGY

Innate and adaptive immune responses against Staphylococcus aureus skin infections

(2011) Sheila Krishna et al.   Seminars in Immunopathology

Neutrophils cascading their way to inflammation

(2011) Christian D. Sadik et al.   TRENDS IN IMMUNOLOGY

Dynamic Imaging of the Effector Immune Response to Listeria Infection In Vivo

(2011) Janelle C. Waite et al.   PLoS Pathogens

Dynamic Imaging of Experimental Leishmania donovani-Induced Hepatic Granulomas Detects Kupffer Cell-Restricted Antigen Presentation to Antigen-Specific CD8+ T Cells

(2010) Lynette Beattie et al.   PLoS Pathogens

Production of Extracellular Traps against Aspergillus fumigatus In Vitro and in Infected Lung Tissue Is Dependent on Invading Neutrophils and Influenced by Hydrophobin RodA

(2010) Sandra Bruns et al.   PLoS Pathogens

The Use of Carboxyfluorescein Diacetate Succinimidyl Ester (CFSE) to Monitor Lymphocyte Proliferation

(2010) Benjamin J. C. Quah et al.   Jove-Journal of Visualized Experiments

Caught in the Act: Intravital Multiphoton Microscopy of Host-Pathogen Interactions

(2009) Heather D. Hickman et al.   Cell Host & Microbe

A Dynamic Map of Antigen Recognition by CD4 T Cells at the Site of Leishmania major Infection

(2009) Orchidée Filipe-Santos et al.   Cell Host & Microbe

Red Fluorescent Protein pH Biosensor to Detect Concentrative Nucleoside Transport

(2009) Danielle E. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Visualizing B cell capture of cognate antigen from follicular dendritic cells

(2009) Kazuhiro Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A genetically encoded fluorescent reporter of ATP:ADP ratio

(2009) Jim Berg et al.   NATURE METHODS

Risk factors and healing impact of multidrug-resistant bacteria in diabetic foot ulcers

(2008) J.-L. Richard et al.   DIABETES & METABOLISM

Cell tracking with optical imaging

(2008) Elizabeth J. Sutton et al.   EUROPEAN RADIOLOGY

Dynamics of Neutrophil Migration in Lymph Nodes during Infection

(2008) Tatyana Chtanova et al.   IMMUNITY

Macrophage and T Cell Dynamics during the Development and Disintegration of Mycobacterial Granulomas

(2008) Jackson G. Egen et al.   IMMUNITY

SAP-controlled T–B cell interactions underlie germinal centre formation

(2008) Hai Qi et al.   NATURE

Direct priming of antiviral CD8+ T cells in the peripheral interfollicular region of lymph nodes

(2008) Heather D Hickman et al.   NATURE IMMUNOLOGY

In Vivo Imaging Reveals an Essential Role for Neutrophils in Leishmaniasis Transmitted by Sand Flies

(2008) N. C. Peters et al.   SCIENCE

Live cell imaging of the HIV-1 life cycle

(2008) Edward M. Campbell et al.   TRENDS IN MICROBIOLOGY

Migratory Dermal Dendritic Cells Act as Rapid Sensors of Protozoan Parasites

(2008) Lai Guan Ng et al.   PLoS Pathogens

Real-Time High Resolution 3D Imaging of the Lyme Disease Spirochete Adhering to and Escaping from the Vasculature of a Living Host

(2008) Tara J. Moriarty et al.   PLoS Pathogens