期刊
CURRENT PHARMACEUTICAL BIOTECHNOLOGY
卷 20, 期 12, 页码 992-1003出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389201020666190731121016
关键词
Collagen; decellularisation; crosslinking; nanofibres; rapid-prototyping; cell; structure
资金
- Ministry of Education, Malaysia [FRGS/1/2016/SKK08/UKM/03/1]
Tissue engineering focuses on developing biological substitutes to restore, maintain or improve tissue functions. The three main components of its application are scaffold, cell and growth-stimulating signals. Scaffolds composed of biomaterials mainly function as the structural support for ex vivo cells to attach and proliferate. They also provide physical, mechanical and biochemical cues for the differentiation of cells before transferring to the in vivo site. Collagen has been long used in various clinical applications, including drug delivery. The wide usage of collagen in the clinical field can be attributed to its abundance in nature, biocompatibility, low antigenicity and biodegradability. In addition, the high tensile strength and fibril-forming ability of collagen enable its fabrication into various forms, such as sheet/membrane, sponge, hydrogel, beads, nanofibre and nanoparticle, and as a coating material. The wide option of fabrication technology together with the excellent biological and physicochemical characteristics of collagen has stimulated the use of collagen scaffolds in various tissue engineering applications. This review describes the fabrication methods used to produce various forms of scaffolds used in tissue engineering applications.
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