期刊
CORTEX
卷 119, 期 -, 页码 417-427出版社
ELSEVIER MASSON, CORP OFF
DOI: 10.1016/j.cortex.2019.07.014
关键词
Huntington's disease; Hippocampus; Spatial memory; Cognition; Neuropsychology
资金
- National Institute for Health Research Rare Diseases Translational Research Collaboration (NIHR RD-TRC)
- NIHR Cambridge Biomedical Research Centre, Dementia and Neurodegeneration Theme [146281]
- WT/MRC Stem Cell Institute [203151/Z/16/Z]
- NIHR [NF-SI-0616-10011]
- Wellcome Trust [203151/Z/16/Z] Funding Source: Wellcome Trust
- MRC [MC_UU_00005/6] Funding Source: UKRI
Background: Cognitive disturbances occur early in Huntington's disease (HD) and place a significant burden on the lives of patients and family members. Whilst these impairments are typically attributed to deterioration of the frontal-striatal pathways, accumulating evidence suggests that hippocampal dysfunction may also contribute to such impairments. Here, we employ a novel spatial memory task that has previously been shown to elicit impairments in individuals with focal hippocampal lesions, as a means to further investigate the role of hippocampal dysfunction in HD. Method: Sixty-four individuals participated in the study, including 32 healthy controls, 11 patients with diagnosed HD and 16 premanifest HD gene carriers. We also included an additional control group of 5 individuals with focal unilateral basal ganglia lesions. Participants undertook a task that measured perception and short-term spatial memory using computer-generated visual scenes. Results: HD patients experienced significant impairments in spatial perception and memory, which strongly correlated with disease burden score (DBS). Premanifest gene carriers performed at a similar level to healthy controls throughout all aspects of the task indicating that the effects seen in the HD patients represent a deterioration in function. Interestingly, basal ganglia lesion patients were not impaired in any aspects of the task. Conclusion: There is evidence of significant deficits in hippocampal- dependent spatial cognition in HD that cannot be explained as a function of degeneration to the basal ganglia. The impairments were greatest in individuals with higher DBSs, suggesting that deficits relate to the disease process in HD. (C) 2019 The Authors. Published by Elsevier Ltd.
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