Article
Pharmacology & Pharmacy
Jackie L. Gottshall, Vivian A. Guedes, Josephine U. Pucci, Daniel Brooks, Nora Watson, Phorum Sheth, Ainslee Gabriel, Sara Mithani, Jacqueline J. Leete, Chen Lai, Bao-Xi Qu, Christina Devoto, Jessica M. Gill, Kimbra Kenney, J. Kent Werner
Summary: The study found a significant relationship between sleep quality and chronic inflammation in mTBI patients, indicating a close connection between sleep and inflammation. Poor sleepers with mTBI tend to have higher levels of inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Maryam Mazhar, Guoqiang Yang, Linshen Mao, Pan Liang, Ruizhi Tan, Li Wang, Houping Xu, Luyin Yang, Wei Ren, Sijin Yang
Summary: This study investigates the protective effects of ZLHXTY capsules against intracerebral hemorrhage (ICH) by targeting the nuclear factor kappa beta (NFk beta) signaling pathway. The results show that ZLHXTY capsules alleviate inflammatory brain injury after ICH induction, as evidenced by neurological scoring and histopathological evaluation. The downregulation of pro-inflammatory factors and the modulation of NFk beta pathway are associated with its neuroprotective effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Yiru Zhou, Ruihua Fan, Benson O. A. Botchway, Yong Zhang, Xuehong Liu
Summary: Traumatic brain injury (TBI) has high morbidity and mortality rates, impacting physical and mental health and causing significant burden to individuals and society. Current management strategies for TBI focus on controlling inflammation, with tumor necrotizing factor alpha (TNF-alpha) playing a crucial role in post-TBI neuroinflammation. Infliximab, a monoclonal anti-TNF-alpha antibody, is recognized for its ability to reduce inflammation in TBI.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ahmad Alshehri, Afza Ahmad, Rohit Kumar Tiwari, Irfan Ahmad, Ali G. Alkhathami, Mohammad Y. Alshahrani, Mohammed A. Asiri, Tahani M. Almeleebia, Mohd Saeed, Dharmendra Kumar Yadav, Irfan Ahmad Ansari
Summary: The study revealed the antioxidant, anticancer, and anti-inflammatory activities of Adenium obesum, commonly known as desert rose, suggesting its potential as a herbal-based medicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Elisa Rubino, Andrea Marcinno, Alberto Grassini, Elisa Maria Piella, Fabio Ferrandes, Fausto Roveta, Silvia Boschi, Aurora Cermelli, Salvatore Gallone, Lidia Savi, Innocenzo Rainero
Summary: Migraine is a common disorder with unsatisfactory response to acute pain-relieving therapies. Functional polymorphism in the TNF-alpha gene is associated with the efficacy of NSAID administration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Andrea Sanchez-Medina, Monica Redondo-Puente, Rudolf Dupak, Laura Bravo-Clemente, Luis Goya, Beatriz Sarria
Summary: Coffee contains hydroxycinnamic acids, which are the main bioactive compounds with potential anti-inflammatory effects. In this study, the researchers tested three of these compounds and found that they have a protective effect against inflammation and oxidative stress in liver cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Malin Collin, Malin Ernberg, Nikolaos Christidis, Britt Hedenberg-Magnusson
Summary: This study investigated the detectability and concentration of cytokines and chemokines in the saliva of children with juvenile idiopathic arthritis (JIA), as well as the saliva flow and the influence of orofacial pain on saliva flow. The results showed that there was no significant difference in the levels of cytokines and chemokines in the saliva between children with JIA and healthy controls. However, there was an association between orofacial pain and reduced saliva flow rate for both groups.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Chen Lin, Ke Chen, Jianjin Yu, Wei Feng, Weihong Fu, Fude Yang, Xiangyang Zhang, Dachun Chen
Summary: This study found that first-episode drug-naive schizophrenia patients had higher TNF-alpha levels before treatment, which were positively correlated with negative symptoms of the disease. In contrast, TNF-alpha levels in chronic patients were negatively correlated with general psychopathology subscales and total scores.
Article
Psychology, Multidisciplinary
Jorge Bravo-Benitez, Francisco Cruz-Quintana, Manuel Fernandez-Alcantara, Maria Nieves Perez-Marfil
Summary: The study adapted a grief intervention program for family caregivers of dementia patients and found that it effectively improved grief symptoms, caregiver burden, resilience, post-traumatic growth, and quality of life for the caregivers involved.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Environmental Sciences
Jia-Xiang Zhang, Yi Yang, Hua Huang, Hai-Bo Xie, Meng Huang, Wei Jiang, Bai-Wang Ding, Qi-Xing Zhu
Summary: This study aimed to investigate the role of TNF-alpha and its receptors in regulating Kupffer cell polarization and downstream inflammation pathways during TCE sensitization, in order to clarify the mechanism of TCE-mediated immune liver injury. The results showed that TCE sensitization led to exacerbated liver injury, activation and polarization of M1 type Kupffer cells, increased expression of TNF-alpha and its receptors, and upregulation of downstream inflammatory factors. Inhibition of TNF-alpha/TNER1 pathway with R7050 reduced M1 Kupffer cell polarization, downstream signaling pathway activation, and inflammatory factor secretion, alleviating liver damage.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Geriatrics & Gerontology
Tara Dehpour, Jonathan Koffman
Summary: There are multiple tools available for measuring anticipatory grief among caregivers of dementia patients, with Marwit-Meuser Caregiver Grief Inventory (MM-CGI) and Caregiver Grief Scale (CGS) scoring the highest in terms of quality.
AGING & MENTAL HEALTH
(2023)
Article
Pharmacology & Pharmacy
Sumanta Kumar Goswami, Prabhat Ranjan, Roshan Kumar Dutta, Suresh Kumar Verma
Summary: Cardiovascular disease is the leading cause of morbidity and mortality worldwide, with inflammation playing a key role in its development. Immune cells and cytokines are crucial in regulating cardiac inflammation, with IL-10 playing a significant role in reducing cardiovascular inflammation and protecting the cardiovascular system.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yiyoung Kwon, Eun-Sil Kim, Yoon-Zi Kim, Yon-Ho Choe, Mi-Jin Kim
Summary: This study aims to measure the concentration of cytokines produced during the inflammation process to investigate if there are any differences in response to treatment of pediatric Crohn's disease and to determine if the initial tumor necrosis factor-alpha (TNF-alpha) level affected the trough concentration of infliximab (IFX).
Article
Plant Sciences
Mariam Sharif, Irfan Anjum, Arham Shabbir, Muhammad Naveed Mushtaq
Summary: The study found that A. lanata herbal extract has immunomodulatory and anti-inflammatory effects on allergic asthmatic mice, reducing the number of inflammatory cells, lowering the level of inflammatory mediators, and increasing the expression levels of aquaporin.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Marina Masetto Antunes, Guilherme Godoy, Laureane Nunes Masi, Rui Curi, Roberto Barbosa Bazotte
Summary: Both HCD and HFD diets induced inflammation in the prefrontal cortex, but hippocampus showed greater sensitivity to HFD. Proinflammatory cytokines IL-1 beta and TNF-alpha were found to be higher in specific brain regions following different diets, indicating potential impact on brain function and disorders.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Obstetrics & Gynecology
Sandi Tenfelde, Dina Tell, Lindsey Garfield, Herbert Mathews, Linda Janusek
Summary: This study provides preliminary evidence that yoga is a feasible complementary therapy that reduces incontinence symptom burden, along with improving quality of life, depressive symptoms, and sleep quality. Additionally, yoga may lower inflammatory biomarkers associated with incontinence.
FEMALE PELVIC MEDICINE AND RECONSTRUCTIVE SURGERY
(2021)
Article
Health Care Sciences & Services
Bella Etingen, Rachael N. Martinez, Bridget M. Smith, Timothy P. Hogan, Laura Miller, Karen L. Saban, Dawn Irvin, Becky Jankowski, Frances M. Weaver
BMC HEALTH SERVICES RESEARCH
(2020)
Article
Nursing
Linda Witek Janusek, Dina Tell, Herbert L. Mathews
Summary: Mindfulness-based interventions show psychological benefits for women with breast cancer, particularly in the areas of nonjudgment and nonreactivity to inner experiences, leading to reduced stress, improved depressive symptoms, fatigue, sleep, and increased quality of life. Additionally, women with childhood adversity show greater improvements in stress, depressive symptoms, and quality of life when there is a greater increase in nonreactivity to inner experiences.
WESTERN JOURNAL OF NURSING RESEARCH
(2021)
Article
Nursing
Christine Pajunar Li-Grining, Elizabeth Vera, Linda Janusek, Karen Saban, Yarina Liston, Zahra Naqi, Mackenzie Troske
Summary: Using a participatory action research approach, this pilot project investigated the integration of mindfulness techniques into classroom routines in Head Start programs. The study found that teachers generally implemented Project CaLM more frequently and for longer durations than expected, and there was positive acceptance and interest in mindfulness strategies among teachers and parents.
WESTERN JOURNAL OF NURSING RESEARCH
(2021)
Article
Nursing
Anitha Saravanan, Prempreet Bajaj, Herbert L. Mathews, Dina Tell, Angela Starkweather, Linda Janusek
Summary: The study aimed to identify behavioral symptom clusters in individuals with chronic low back pain and found a two-class model, with one class experiencing more severe depressive mood, fatigue, and sleep disturbance, leading to worse quality of life. Pain severity and interference were not significantly different across classes. Levels of IL-6 were significantly higher in the class with more severe behavioral symptoms, correlating with greater pain severity and sleep disturbances.
PAIN MANAGEMENT NURSING
(2021)
Editorial Material
Nursing
Karen L. Saban, Linda Janusek
WESTERN JOURNAL OF NURSING RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Karen L. Saban, Darnell Motley, Lamise Shawahin, Herbert L. Mathews, Dina Tell, Paula de la Pena, Linda Witek Janusek
Summary: The pilot study evaluated the psychobehavioral and anti-inflammatory benefits of the RiSE program for Black women at risk for CVD. Participation in RiSE was associated with a faster decline in avoidance coping strategies, and reductions in TNF-alpha and hsCRP approached statistical significance over time. These preliminary findings suggest that RiSE may be an effective intervention for promoting improved coping in minorities facing racism and discrimination.
COMPLEMENTARY THERAPIES IN MEDICINE
(2021)
Article
Public, Environmental & Occupational Health
Mary Jo Knobloch, Jackson Musuuza, Kelsey Baubie, Karen L. Saban, Katie J. Suda, Nasia Safdar
Summary: Outpatient nurse practitioners are satisfied with resources such as convenient access to pharmacists and infectious disease specialists, with a focus on building patient trust to increase prescription confidence levels. Veterans indicate the need to better understand the differences between viral and bacterial infections. NP antibiotic prescribing patterns reveal a decrease in prescriptions for upper respiratory illnesses over a 3-year period.
AMERICAN JOURNAL OF INFECTION CONTROL
(2021)
Article
Nursing
Anitha Saravanan, Prempreet Bajaj, Herbert L. Mathews, Dina Tell, Angela Starkweather, Linda Janusek
Summary: The study found that increased social support is associated with lower sleep disturbance, lower inflammation, and lower pain severity in patients with CLBP. Strengthening social support systems and cultivating support from family and informal social networks may reduce symptom burden and improve quality of life for these patients.
Article
Rehabilitation
Alison M. Cogan, Theresa L. Bender Pape, Jason Yeaw, Mitch DeKoven, Ruthwik Anupindi, Neil Jordan
Summary: The study quantified the economic burden of all-cause health care resource utilization among adults with chronic vestibular impairment (CVI) after a mild traumatic brain injury (mTBI) compared to those without CVI. Results showed that, after controlling for baseline variables, the costs of care for CVI patients were 1.5 times higher than those without CVI.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Article
Health Care Sciences & Services
Kelly A. Krese, Kyla Z. Donnelly, Bella Etingen, Theresa L. Bender Pape, Sarmistha Chaudhuri, Alexandra L. Aaronson, Rachana P. Shah, Dulal K. Bhaumik, Andrea Billups, Sabrina Bedo, Mary Terese Wanicek-Squeo, Sonia Bobra, Amy A. Herrold
Summary: This study aims to develop a combined iTBS and yoga intervention for mTBI and chronic pain, assess the feasibility and acceptability of the intervention, and gather preliminary clinical outcome data. The results will provide evidence on the safety, feasibility, and acceptability of this novel intervention.
JMIR RESEARCH PROTOCOLS
(2022)
Review
Clinical Neurology
Karen L. Saban, Dina Tell, Paula De La Pena
Summary: This research discusses the use of mindfulness-informed interventions (MBIs) in stroke survivors and their family caregivers. It emphasizes the potential benefits of MBIs in managing the consequences of stroke and recommends further research to cater to the unique needs of this population.
Article
Health Care Sciences & Services
Karen L. Saban, Eileen G. Collins, Herbert L. Mathews, Fred B. Bryant, Dina Tell, Beverly Gonzalez, Sudha Bhoopalam, Christopher P. Chroniak, Linda Witek Janusek
Summary: This study examined the impact of MBSR on the psychological well-being of women veterans at risk for CVD. The results showed that women who participated in MBSR reported less perceived stress, loneliness, and symptoms of PTSD. In addition, MBSR led to a more rapid decline in diurnal salivary cortisol.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Clinical Neurology
Amy A. Herrold, Sandra L. Kletzel, Eileen M. Foecking, Karen L. Saban, Magdalena M. Przybycien-Szymanska, Michael Zilliox, Dulal Bhaumik, Dustin Lange, Jay R. Radke, Ilse Salinas, Theresa L. Bender Pape
Summary: miRNAs show potential as biomarkers for TBI, but further longitudinal studies using rigorous and standardized methods are needed to replicate consistent miRNA changes.
JOURNAL OF HEAD TRAUMA REHABILITATION
(2021)