Heterogeneity of microglia and their differential roles in white matter pathology

Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk

(2019) Iris E. Jansen et al.   NATURE GENETICS

Transcriptional profiling of human microglia reveals grey–white matter heterogeneity and multiple sclerosis-associated changes

(2019) Marlijn van der Poel et al.   Nature Communications

Impaired behavioural flexibility related to white matter microgliosis in the TgAPP21 rat model of Alzheimer disease

(2019) Alexander Levit et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter

(2019) Miho Sato-Hashimoto et al.   eLife

The pro-remyelination properties of microglia in the central nervous system

(2019) Amy F. Lloyd et al.   Nature Reviews Neurology

Activin receptors regulate the oligodendrocyte lineage in health and disease

(2018) Alessandra Dillenburg et al.   ACTA NEUROPATHOLOGICA

High-Dimensional Single-Cell Mapping of Central Nervous System Immune Cells Reveals Distinct Myeloid Subsets in Health, Aging, and Disease

(2018) Dunja Mrdjen et al.   IMMUNITY

Brain-selective mild hypothermia promotes long-term white matter integrity after ischemic stroke in mice

(2018) Li-Qiang Liu et al.   CNS Neuroscience & Therapeutics

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model

(2018) Giuseppe Locatelli et al.   NATURE NEUROSCIENCE

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes

(2018) Timothy R. Hammond et al.   IMMUNITY

Dimethyl fumarate improves white matter function following severe hypoperfusion: Involvement of microglia/macrophages and inflammatory mediators

(2017) Jill H Fowler et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Minocycline plus N-acteylcysteine induces remyelination, synergistically protects oligodendrocytes, and modifies neuroinflammation in a rat model of mild traumatic brain injury

(2017) Margalit Haber et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Neuroprotection of brain-permeable iron chelator VK-28 against intracerebral hemorrhage in mice

(2017) Qian Li et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Microglia activation triggers oligodendrocyte precursor cells apoptosis via HSP60

(2017) Yunhong Li et al.   Molecular Medicine Reports

Intrathecal insulin-like growth factor 1 but not insulin enhances myelin repair in young and aged rats

(2017) Martin Hlavica et al.   NEUROSCIENCE LETTERS

Correlations between Gray Matter and White Matter Degeneration in Pure Alzheimer’s Disease, Pure Subcortical Vascular Dementia, and Mixed Dementia

(2017) Hyemin Jang et al.   Scientific Reports

Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque

(2015) Josa M. Frischer et al.   ANNALS OF NEUROLOGY

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MSX3 Switches Microglia Polarization and Protects from Inflammation-Induced Demyelination

(2015) Z. Yu et al.   JOURNAL OF NEUROSCIENCE

Genetics ignite focus on microglial inflammation in Alzheimer’s disease

(2015) Manasi Malik et al.   Molecular Neurodegeneration

HDAC inhibition prevents white matter injury by modulating microglia/macrophage polarization through the GSK3β/PTEN/Akt axis

(2015) Guohua Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage subsets and microglia in multiple sclerosis

(2014) Jeroen F. J. Bogie et al.   ACTA NEUROPATHOLOGICA

Identification of endothelin 2 as an inflammatory factor that promotes central nervous system remyelination

(2013) Tracy J. Yuen et al.   BRAIN

Screening for Inhibitors of Microglia to Reduce Neuroinflammation

(2013) Shazia Samanani et al.   CNS & Neurological Disorders-Drug Targets

Microglia/Macrophage Polarization Dynamics in White Matter after Traumatic Brain Injury

(2013) Guohua Wang et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

NG2 Cells in White Matter But Not Gray Matter Proliferate in Response to PDGF

(2013) R. A. Hill et al.   JOURNAL OF NEUROSCIENCE

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Protective Effect of Carnosine on Subcortical Ischemic Vascular Dementia in Mice

(2012) Jing Ma et al.   CNS Neuroscience & Therapeutics

Microglia: actively surveying and shaping neuronal circuit structure and function

(2012) Hiroaki Wake et al.   TRENDS IN NEUROSCIENCES

Galectin-3 drives oligodendrocyte differentiation to control myelin integrity and function

(2011) L A Pasquini et al.   CELL DEATH AND DIFFERENTIATION

The Yin and Yang of Microglia

(2011) Melinda Czeh et al.   DEVELOPMENTAL NEUROSCIENCE

Identification of a microglia phenotype supportive of remyelination

(2011) Marta Olah et al.   GLIA

Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis

(2011) Ruth Huizinga et al.   GLIA

The prospects of minocycline in multiple sclerosis

(2011) Xiaohong Chen et al.   JOURNAL OF NEUROIMMUNOLOGY

Physiology of Microglia

(2011) Helmut Kettenmann et al.   PHYSIOLOGICAL REVIEWS

White matter damage and cognitive impairment after traumatic brain injury

(2010) K. M. Kinnunen et al.   BRAIN

Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis

(2010) Áine C. Murphy et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Regional differences between grey and white matter in cuprizone induced demyelination

(2009) Viktoria Gudi et al.   BRAIN RESEARCH

Protective effects of microglia in multiple sclerosis

(2009) Isabella Napoli et al.   EXPERIMENTAL NEUROLOGY

Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: An in vivo study with TBSS and VBM

(2009) Benedetta Bodini et al.   HUMAN BRAIN MAPPING

Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

(2008) L. Dimou et al.   JOURNAL OF NEUROSCIENCE

Remyelination in the CNS: from biology to therapy

(2008) Robin J. M. Franklin et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of oligodendrocyte precursor cell differentiation by myelin-associated proteins

(2008) Yasir A. Syed et al.   Neurosurgical Focus