Article
Neurosciences
Nicole E. Keller, Augustin C. Hennings, Emily K. Leiker, Jarrod A. Lewis-Peacock, Joseph E. Dunsmoor
Summary: Neurobiological evidence suggests that incorporating reward associations with an extinction memory may be an effective strategy to attenuate threat responses. This study compared rewarded extinction to standard extinction in both short-term and long-term retrieval tests and found that rewarded extinction was more effective in reducing arousal and threat expectancy. The study also identified different patterns of brain activity and connectivity between reward-associated extinction and standard extinction.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Cristian B. Calderon, Esther De Loof, Kate Ergo, Anna Snoeck, Carsten N. Boehler, Tom Verguts
Summary: Behavioral evidence suggests that reward prediction errors play a key role in episodic memory acquisition. In a novel task where RPEs were manipulated, fMRI results confirmed that signed RPEs are encoded in the ventral striatum and mediate their effects on episodic memory accuracy. Connectivity between processing areas and the hippocampus and ventral striatum increased with RPE value, supporting their central role in episodic memory formation.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Filip Grill, Lars Nyberg, Anna Rieckmann
Summary: The study suggests that the fMRI response to rewards in the ventral striatum reflects a mixture of component processes of reward, with an inferior ventral striatal component and hippocampus being involved in reward-based processing during gambling. The more superior ventral striatal component is linked to networks associated with executive functioning and responds to both reward and cognitive control demands.
BRAIN AND BEHAVIOR
(2021)
Article
Neurosciences
Maria Bretzke, Hannes Wahl, Michael M. Plichta, Nicole Wolff, Veit Roessner, Nora C. Vetter, Judith Buse
Summary: Adolescents and adults show differences in their response to rewards and handling uncertainty, possibly influenced by different reward probabilities. Adolescents exhibit faster reaction times under lower reward probabilities in experiments, but overall slower response speed compared to adults.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Psychology, Developmental
Kathryn A. McNaughton, Laura Anderson Kirby, Katherine Rice Warnell, Diana Alkire, Junaid S. Merchant, Dustin Moraczewski, Heather A. Yarger, Audrey Thurm, Elizabeth Redcay
Summary: Challenges in social-interactive exchanges are a key feature of autism spectrum disorder, but research on the neural mechanisms has been limited. Using a social-interactive neuroscience approach, this study examined differences in neural response to chat-based social-interactive reward between youth with autism and typical development. Minimal group differences were found, and variation within both groups was related to self-reported social enjoyment. Furthermore, neural sensitivity to social-interactive reward predicted future enjoyment of face-to-face social interactions. These findings have important implications for understanding social reward and interactions in typical development and individuals with autism.
DEVELOPMENTAL COGNITIVE NEUROSCIENCE
(2023)
Article
Clinical Neurology
Simon Zhornitsky, Isha Dhingra, Thang M. Le, Wuyi Wang, Chiang-Shan R. Li, Sheng Zhang
Summary: The study found that in individuals addicted to cocaine, large rewards are associated with activation in the primary motor cortex, anterior insula, and supplementary motor area, correlating with tonic cocaine craving. Additionally, days of cocaine use in the prior month contribute to higher cocaine craving scores, which in turn affect reward responses.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Behavioral Sciences
Damien Brevers, Chris Baeken, Stefanie De Smet, Beatriz Catoira, Sara De Witte, Qinghua He, Pierre Maurage, Laimi Schulze-Steinen, Guillaume Sescousse, Claudia Vila Verde, Claus Vogele, Joel Billieux
Summary: Brain imaging studies have found that stimulation of the left dorsolateral prefrontal cortex (dlPFC) can modulate brain reactivity to reward-related cues. However, the impact of contextual factors on this modulation effect remains unclear. In this study, researchers tested the effects of high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) on brain reactivity to cues signaling reward availability or unavailability. The results showed that HF-rTMS modulated brain activity in response to game cues, with increases in posterior insula and caudate nucleus activation and a decrease in occipital pole activation. HF-rTMS also increased ventral striatal activity for cues available for betting but had no effect on cues unavailable for betting.
Article
Neurosciences
Jana Lieberz, Simone G. Shamay-Tsoory, Nira Saporta, Alisa Kanterman, Jessica Gorni, Timo Esser, Ekaterina Kuskova, Johannes Schultz, Rene Hurlemann, Dirk Scheele
Summary: This study aimed to investigate the behavioral and neural correlates of social avoidance in loneliness, revealing that lonely individuals show a distinct pattern of behavioral and neural responsiveness to social decision-making and social feedback compared to social anxiety.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Tian Lin, Didem Pehlivanoglu, Maryam Ziaei, Peiwei Liu, Adam J. Woods, David Feifel, Hakan Fischer, Natalie C. Ebner
Summary: The study found that older adults show dampened response to faces with lower trustworthiness compared to young adults, supporting the idea of reduced sensitivity to cues of untrustworthiness in aging. Additionally, the results extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiaohang Che, Jialing Cai, Yueyang Liu, Tianyu Xu, Jingyu Yang, Chunfu Wu
Summary: This article discusses the role of oxytocin in treating drug addiction, including its effects on drug reward, stress responses, and social impairments. Studies have shown that oxytocin administration can alleviate drug-induced neurobehavioral changes and be beneficial in reducing substance use disorders of various drugs.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Behavioral Sciences
Keri S. Rosch, Mitchell A. Batschelett, Deana Crocetti, Stewart H. Mostofsky, Karen E. Seymour
Summary: The study investigates the integrity of white matter connections in the fronto-subcortical neural circuitry of children with ADHD and typically developing (TD) controls. The findings suggest that there are differences in these connections between the two groups, which may contribute to the pathophysiology of ADHD. Additionally, the study suggests that the integrity of these connections is related to individual differences in delay discounting, a behavior associated with ADHD, and that there may be sex differences in these relationships.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Neurosciences
Margaret Prenger, Madeline Gilchrist, Kathryne Van Hedger, Ken N. Seergobin, Adrian M. Owen, Penny A. Macdonald
Summary: Humor comprehension and appreciation are cognitive processes involving different brain regions. The dorsal striatum is important for humor comprehension, while the ventral striatum plays a critical role in humor appreciation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Sanja Klein, Onno Kruse, Isabell Tapia Leon, Lukas Van Oudenhove, Sophie R. van 't Hof, Tim Klucken, Tor D. Wager, Rudolf Stark
Summary: Sharing and comparing imaging data across psychological tasks is becoming more feasible with the advancement of open science movement. This study validates the commonalities between aversive and appetitive classical conditioning through a multivariate approach, providing an empirical method to integrate fMRI findings across paradigms.
Article
Neurosciences
Xiaoxue Gao, Hongbo Yu, Lu Peng, Xiaoliang Gong, Yang Xiang, Changjun Jiang, Xiaolin Zhou
Summary: In this study, researchers used a social interactive game and fMRI technology to investigate the emotional responses of transgressors after being forgiven or blamed by victims. The findings suggest that the victim's attitude and the severity of harm interactively modulate the transgressor's social emotions, with expectation violation serving as a mediator.
Article
Neurosciences
Eva R. Pool, David Munoz Tord, Sylvain Delplanque, Yoann Stussi, Donato Cereghetti, Patrik Vuilleumier, David Sander
Summary: Different subregions of the ventral striatum play distinct roles in the motivational and hedonic components of reward processing. Understanding the neural mechanisms underlying the interplay between pavlovian incentive and hedonic processes is crucial for comprehending compulsive reward-seeking behaviors such as addiction, binge eating, or gambling.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Jonathan Repple, Marius Gruber, Marco Mauritz, Siemon C. de Lange, Nils Ralf Winter, Nils Opel, Janik Goltermann, Susanne Meinert, Dominik Grotegerd, Elisabeth J. Leehr, Verena Enneking, Tiana Borgers, Melissa Klug, Hannah Lemke, Lena Waltemate, Katharina Thiel, Alexandra Winter, Fabian Breuer, Pascal Grumbach, Hannes Hofmann, Frederike Stein, Katharina Brosch, Kai G. Ringwald, Julia Pfarr, Florian Thomas-Odenthal, Tina Meller, Andreas Jansen, Igor Nenadic, Ronny Redlich, Jochen Bauer, Tilo Kircher, Tim Hahn, Martijn van den Heuvel, Udo Dannlowski
Summary: This study investigated the structural connectivity changes in a large sample of patients with schizophrenia, bipolar disorder, and major depressive disorder. Common and specific abnormalities were found, with machine learning algorithms able to differentiate each disorder from healthy controls. Differences between disorders were also identified. Patients with an early disease onset showed the most pronounced connectivity abnormalities. These results highlight compromised brain communication across a spectrum of major psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Simon Schmitt, Kai G. Ringwald, Tina Meller, Frederike Stein, Katharina Brosch, Julia-Katharina Pfarr, Tim Hahn, Hannah Lemke, Susanne Meinert, Jonathan Repple, Katharina Thiel, Lena Waltemate, Alexandra Winter, Dominik Grotegerd, Astrid Dempfle, Andreas Jansen, Axel Krug, Udo Dannlowski, Igor Nenadic, Tilo Kircher
Summary: Epidemiological studies have shown that gestational age and birth weight are associated with cognitive performance in adults. This study examined the relationships between gestational age, cortical gyrification, and specific neuropsychological factors in healthy adults. The findings suggest that gestational age is positively associated with cortical folding in certain brain regions, and these associations are moderated by gestational age. Additionally, gyrification is related to specific neuropsychological abilities. These results have important implications for understanding the cortical neurodevelopment of cognitive domains and mental health.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Psychology, Clinical
Katharina Thiel, Susanne Meinert, Alexandra Winter, Hannah Lemke, Lena Waltemate, Fabian Breuer, Marius Gruber, Ramona Leenings, Lucia Wueste, Kathrin Rueb, Julia-Katharina Pfarr, Frederike Stein, Katharina Brosch, Tina Meller, Kai Gustav Ringwald, Igor Nenadic, Axel Krug, Jonathan Repple, Nils Opel, Katharina Koch, Elisabeth J. Leehr, Jochen Bauer, Dominik Grotegerd, Tim Hahn, Tilo Kircher, Udo Dannlowski
Summary: Patients with bipolar disorder (BD) show reduced fractional anisotropy (FA) compared to patients with major depressive disorder (MDD), independent of mood state and acute symptom severity. This suggests that disruptions in white matter microstructure in BD may be a trait effect of the disorder.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Alexandra Winter, Katharina Thiel, Susanne Meinert, Hannah Lemke, Lena Waltemate, Fabian Breuer, Regina Culemann, Julia-Katharina Pfarr, Frederike Stein, Katharina Brosch, Tina Meller, Kai Gustav Ringwald, Florian Thomas-Odenthal, Andreas Jansen, Igor Nenadic, Axel Krug, Jonathan Repple, Nils Opel, Katharina Dohm, Elisabeth J. Leehr, Dominik Grotegerd, Harald Kugel, Tim Hahn, Tilo Kircher, Udo Dannlowski
Summary: This study found that healthy individuals with familial risk for major depressive disorder (MDD) showed widespread increase in fractional anisotropy (FA) compared to a low-risk sample. The effect of risk on FA was only significant in the healthy control group, not in the MDD sample. These findings may reflect compensatory neural mechanisms associated with resilience in healthy adults at risk for MDD.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Julia Elina Stocker, Erfan Nozari, Marieke van Vugt, Andreas Jansen, Hamidreza Jamalabadi
Summary: Recent progress in network sciences has allowed for the application of control theory to the study of networks, referred to as network control theory. However, in the field of neuroscience, mathematical understanding of network nodes and connections is uncertain, which could lead to deviations in the controllability metrics estimated over subnetworks compared to the full network.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Neurosciences
Kira Flinkenfluegel, Susanne Meinert, Katharina Thiel, Alexandra Winter, Janik Goltermann, Lea Strathausen, Katharina Brosch, Frederike Stein, Florian Thomas-Odenthal, Ulrika Evermann, Adrian Wroblewski, Paula Usemann, Julia-Katharina Pfarr, Dominik Grotegerd, Tim Hahn, Elisabeth J. Leehr, Katharina Dohm, Jochen Bauer, Hamidreza Jamalabadi, Benjamin Straube, Nina Alexander, Andreas Jansen, Igor Nenadic, Axel Krug, Tilo Kircher, Udo Dannlowski
Summary: This study investigated the effects of negative stressful life events and social support on white matter integrity in patients with major depressive disorder (MDD) and healthy control participants. The results showed that negative stressful life events were negatively correlated with white matter integrity, while social support was positively correlated with white matter integrity, and these associations did not differ between MDD patients and healthy controls. Furthermore, social support appeared to independently contribute to improved white matter integrity.
BIOLOGICAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Frederike Stein, Simon Schmitt, Katharina Brosch, Tina Meller, Julia-Katharina Pfarr, Kai Ringwald, Gunnar Lemmer, Alexandra Philipsen, Susanne Meinert, Hannah Lemke, Lena Waltemate, Katharina Thiel, Michael Franz, Ulrich W. Preuss, Florian G. Metzger, Arne Nagels, Igor Nenadic, Udo Dannlowski, Tilo Kircher, Axel Krug
Summary: This study aimed to investigate the relationship between dimensional psychopathological syndromes and neurocognitive functions, particularly across major psychiatric disorders. The results showed that negative syndrome, positive formal thought disorder, and paranoid-hallucinatory syndrome were associated with neurocognition in an illness state-dependent manner, while depression and increased appetite only showed weak associations.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Psychology, Clinical
Sean R. McWhinney, Christoph Abe, Martin Alda, Francesco Benedetti, Erlend Boen, Caterina del Mar Bonnin, Tiana Borgers, Katharina Brosch, Erick J. Canales-Rodriguez, Dara M. Cannon, Udo Dannlowski, Ana M. Diaz-Zuluaga, Lorielle M. F. Dietze, Torbjorn Elvsashagen, Lisa T. Eyler, Janice M. Fullerton, Jose M. Goikolea, Janik Goltermann, Dominik Grotegerd, Bartholomeus C. M. Haarman, Tim Hahn, Fleur M. Howells, Martin Ingvar, Neda Jahanshad, Tilo T. J. Kircher, Axel Krug, Rayus T. Kuplicki, Mikael Landen, Hannah Lemke, Benny Liberg, Carlos Lopez-Jaramillo, Ulrik F. Malt, Fiona M. Martyn, Elena Mazza, Colm McDonald, Genevieve McPhilemy, Sandra Meier, Susanne Meinert, Tina Meller, Elisa M. T. Melloni, Philip B. Mitchell, Leila Nabulsi, Igor Nenadic, Nils Opel, Roel A. Ophoff, Bronwyn J. Overs, Julia-Katharina Pfarr, Julian A. Pineda-Zapata, Edith Pomarol-Clotet, Joaquim Radua, Jonathan Repple, Maike Richter, Kai G. Ringwald, Gloria Roberts, Alex Ross, Raymond Salvador, Jonathan Savitz, Simon Schmitt, Peter R. Schofield, Kang Sim, Dan J. Stein, Frederike Stein, Henk S. Temmingh, Katharina Thiel, Sophia I. Thomopoulos, Neeltje E. M. van Haren, Cristian Vargas, Eduard Vieta, Annabel Vreeker, Lena Waltemate, Lakshmi N. Yatham, Christopher R. K. Ching, Ole A. Andreassen, Paul M. Thompson, Tomas Hajek
Summary: This study found that body mass index (BMI) and bipolar disorder (BD) have an impact on brain structure, particularly in cortical thickness. Both BMI and BD negatively affect the same brain regions, and BMI has a greater effect on brain alterations in individuals with BD. It is important to assess the neuroanatomical changes in BD caused by BMI and the effects of psychiatric medications on the brain.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Katharina Forster, Dominik Grotegerd, Katharina Dohm, Hannah Lemke, Verena Enneking, Susanne Meinert, Ronny Redlich, Walter Heindel, Jochen Bauer, Harald Kugel, Thomas Suslow, Patricia Ohrmann, Angela Carballedo, Veronica O'Keane, Andrew Fagan, Kelly Doolin, Hazel McCarthy, Philipp Kanske, Thomas Frodl, Udo Dannlowski
Summary: Repeated hospitalizations are characteristic of severe disease courses in patients with affective disorders. A longitudinal case-control study was conducted to investigate how a hospitalization during a nine-year follow-up in patients with affective disorders affects brain structure. The study found that patients with affective disorders showed decline in gray matter volume in temporo-limbic regions over nine years, and hospitalization during follow-up was associated with intensified decline in gray matter volume in the insula and hippocampus.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Amke Mueller, Stefan Konigorski, Carina Meissner, Tahmine Fadai, Claire V. Warren, Irina Falkenberg, Tilo Kircher, Yvonne Nestoriuc
Summary: The study aims to assess the effectiveness of open-label placebo (OLP) treatment in reducing antidepressant discontinuation symptoms through a series of N-of-1 trials. The trials will be conducted on patients with fully remitted major depressive disorder, and the primary outcome will be self-reported discontinuation symptoms and expectations, as well as mood.
Article
Neurosciences
Edward Ody, Tilo Kircher, Benjamin Straube, Yifei He
Summary: This study investigated the pre-movement electroencephalography (EEG) activity of active and passive movements and found evidence that it may represent action-feedback prediction in which information about the subsequent sensory outcome is encoded. The results showed distinct neural markers for visual and auditory conditions, and multivariate pattern analysis revealed decoding accuracies for active and passive movements. The study highlights the importance of pre-movement EEG activity in predicting action feedback.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Christina V. Schmitter, Konstantin Kufer, Olaf Steinstraeter, Jens Sommer, Tilo Kircher, Benjamin Straube
Summary: Through the study of behavioral and neural correlates of temporal recalibration, it was found that the hippocampus plays an important role in encoding and retrieving temporal stimulus associations, the activation in the cerebellum may reflect the retention of multiple representations of temporal stimulus associations, and sensorimotor predictions modulate recalibration-related processes, explaining the perceptual advantage of sensorimotor versus intersensory temporal recalibration.
HUMAN BRAIN MAPPING
(2023)
Article
Oncology
Maria Eveslage, Philipp Rassek, Arne Riegel, Ziad Maksoud, Jochen Bauer, Dennis Goerlich, Benjamin Noto
Summary: ADC is a candidate marker for treatment response in osteoblastic metastases. This study confirms that ADC meets the basic requirement for reliable treatment response evaluation.
Review
Neurosciences
Maya Jammoul, Dareen Jammoul, Kevin K. Wang, Firas Kobeissy, Ralph G. Depalma
Summary: This article reviews the possible mechanisms by which traumatic brain injury (TBI) may stimulate the development of opioid use disorder (OUD) and discusses the interaction between these two processes. CNS damage due to TBI appears to drive adverse effects of subsequent OUD, with pain being a risk factor for opioid use after TBI.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Danusa Mar Arcego, Jan-Paul Buschdorf, Nicholas O'Toole, Zihan Wang, Barbara Barth, Irina Pokhvisneva, Nirmala Arul Rayan, Sachin Patel, Euclides Jose de Mendonca Filho, Patrick Lee, Jennifer Tan, Ming Xuan Koh, Chu Ming Sim, Carine Parent, Randriely Merscher Sobreira de Lima, Andrew Clappison, Kieran J. O'Donnell, Carla Dalmaz, Janine Arloth, Nadine Provencal, Elisabeth B. Binder, Josie Diorio, Patricia Pelufo Silveira, Michael J. Meaney
Summary: This study investigates the impact of environmental influences on mental health by integrating transcriptomic data from animal models with human data. The results suggest that hippocampal glucocorticoid-related transcriptional activity mediates the effects of early adversity on neural mechanisms implicated in psychiatric disorders.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Milenna T. van Dijk, Ardesheer Talati, Pratik Kashyap, Karan Desai, Nora C. Kelsall, Marc J. Gameroff, Natalie Aw, Eyal Abraham, Breda Cullen, Jiook Cha, Christoph Anacker, Myrna M. Weissman, Jonathan Posner
Summary: This study found that maternal stress is associated with future depressive symptoms and alterations in microstructure of the dentate gyrus (DG) in offspring. These results were consistent across two independent cohorts.
BIOLOGICAL PSYCHIATRY
(2024)
Article
Neurosciences
Josephine C. McGowan, Liliana R. Ladner, Claire X. Shubeck, Juliana Tapia, Christina T. LaGamma, Amanda Anqueira-Gonzalez, Ariana DeFrancesco, Briana K. Chen, Holly C. Hunsberger, Ezra J. Sydnor, Ryan W. Logan, Tzong-Shiue Yu, Steven G. Kernie, Christine A. Denny
Summary: Traumatic brain injury (TBI) leads to fear generalization by altering fear memory traces, and this symptom can be improved with (R,S)-ketamine.
BIOLOGICAL PSYCHIATRY
(2024)